Ifitm5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ifitm5
Entrez Gene ID	73835
Full Name	interferon induced transmembrane protein 5
Synonyms	1110003J06Rik,AW213665,Bril,DSPA1,Hrmp1,Hrtm1
General protein information	Preferred Names interferon induced transmembrane protein 5 Names interferon-induced transmembrane protein 5 bone-restricted interferon induced transmembrane protein-like protein dispanin subfamily A member 1 fragilis family member 4 fragilis4 haemopoiesis related membrane protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F5

mRNA and Protein(s)

mRNA	Protein	Name
NM_053088.2	NP_444318.1	interferon-induced transmembrane protein 5
NM_053088.3	NP_444318.1	interferon-induced transmembrane protein 5

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IFITM5	NP_001075193.1
Xenopus tropicalis (tropical clawed frog)	LOC100498002	XP_002937679.1
Homo sapiens (human)	IFITM5	NP_001020466.1
Rattus norvegicus (Norway rat)	Ifitm5	XP_002728878.1
Gallus gallus (chicken)	IFITM5	NP_001186427.1
Pan troglodytes (chimpanzee)	IFITM5	NP_001185698.1
	IFITM5	XP_001085215.1
Mus musculus (house mouse)	Ifitm5	NP_444318.1

Gene Ontology
Bibliography

Related articles in PubMed

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P
Bone107131-142(2018 Feb)

The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice.
Patoine A, Husseini A, Kasaai B, Gaumond MH, Moffatt P
PloS one12(9)e0184568(2017)

A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation.
Lietman CD, Marom R, Munivez E, Bertin TK, Jiang MM, Chen Y, Dawson B, Weis MA, Eyre D, Lee B
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research30(3)489-98(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that expression of mutant IFITM5 causes abnormal skeletal development, low bone mass, and abnormal osteoblast differentiation
Title: A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation.

The purpose of the current study was to re-assess the topology, localization, and biochemical properties of BRIL and compare it to the osteogenesis imperfecta type V mutant in MC3T3 osteoblasts.
Title: Topological mapping of BRIL reveals a type II orientation and effects of osteogenesis imperfecta mutations on its cellular destination.

Key roles for the Sp members and GLI2 that possibly cooperate to activate Bril when the promoter becomes demethylated.
Title: Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation.

These results indicate that the S-palmitoylation on IFITM5 promotes the interaction with FKBP11.
Title: Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells.

Natural antisense transcripts enhance bone formation by increasing sense IFITM5 transcription.
Title: Natural antisense transcripts enhance bone formation by increasing sense IFITM5 transcription.

The following Ifitm5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ifitm5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu21743	NM_053088.3 Latest version!	Mus musculus interferon induced transmembrane protein 5 (Ifitm5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OMu21743	NM_053088.2	Mus musculus interferon induced transmembrane protein 5 (Ifitm5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ifitm5 ( NM_053088.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444318.1 Mus musculus interferon induced transmembrane protein 5 (Ifitm5), mRNA.

Price & Availability↑

CloneID	OMu21743
Clone ID Related Accession (Same CDS sequence)	NM_053088.2 , NM_053088.3
Accession Version	NM_053088.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-09
Organism	Mus musculus(house mouse)
Product	interferon-induced transmembrane protein 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC103790.1. On Jul 23, 2006 this sequence version replaced NM_053088.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC103790.1, FJ200451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGACACTT CATATCCCCG TGAGGACCCC CGGGCTCCAT CATCCCGCAA GGCTGATGCT 
GCAGCCCACA CAGCCCTCTC CATGGGAACA CCTGGCCCTA CACCACGAGA TCACATGCTC 
TGGTCTGTCT TCAGCACGAT GTACCTGAAT CTGTGCTGCC TTGGATTCCT GGCGCTGGTC 
CACTCTGTCA AGGCCCGAGA CCAGAAGATG GCTGGGAACT TGGAGGCTGC AAGGCAGTAT 
GGCTCCAAAG CCAAGTGCTA CAACATCCTG GCTGCAATGT GGACATTGGT GCCCCCATTG 
CTGCTCCTGG GACTGGTGGT GACTGGCGCC TTGCACCTGT CCAAGTTAGC CAAAGACTCT 
GCGGCTTTCT TCAGCACCAA GTTTGATGAG GAGGACTATA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444318.1
CDS	31..435
Translation	MDTSYPREDPRAPSSRKADAAAHTALSMGTPGPTPRDHMLWSVFSTMYLNLCCLGFLALVHSVKARDQKMAGNLEAARQYGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLSKLAKDSAAFFSTKFDEEDYN

Target ORF information:

RefSeq Version	NM_053088.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon induced transmembrane protein 5 (Ifitm5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053088.2

ORF Insert Sequence:

ATGGACACTT CATATCCCCG TGAGGACCCC CGGGCTCCAT CATCCCGCAA GGCTGATGCT 
GCAGCCCACA CAGCCCTCTC CATGGGAACA CCTGGCCCTA CACCACGAGA TCACATGCTC 
TGGTCTGTCT TCAGCACGAT GTACCTGAAT CTGTGCTGCC TTGGATTCCT GGCGCTGGTC 
CACTCTGTCA AGGCCCGAGA CCAGAAGATG GCTGGGAACT TGGAGGCTGC AAGGCAGTAT 
GGCTCCAAAG CCAAGTGCTA CAACATCCTG GCTGCAATGT GGACATTGGT GCCCCCATTG 
CTGCTCCTGG GACTGGTGGT GACTGGCGCC TTGCACCTGT CCAAGTTAGC CAAAGACTCT 
GCGGCTTTCT TCAGCACCAA GTTTGATGAG GAGGACTATA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ifitm5 ( NM_053088.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444318.1 Mus musculus interferon induced transmembrane protein 5 (Ifitm5), mRNA.

Price & Availability↑

CloneID	OMu21743
Clone ID Related Accession (Same CDS sequence)	NM_053088.2 , NM_053088.3
Accession Version	NM_053088.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	interferon-induced transmembrane protein 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY703620.1, BC103790.1 and FJ200451.1. On Jun 5, 2018 this sequence version replaced NM_053088.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ200451.1, BC103790.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACACTT CATATCCCCG TGAGGACCCC CGGGCTCCAT CATCCCGCAA GGCTGATGCT 
GCAGCCCACA CAGCCCTCTC CATGGGAACA CCTGGCCCTA CACCACGAGA TCACATGCTC 
TGGTCTGTCT TCAGCACGAT GTACCTGAAT CTGTGCTGCC TTGGATTCCT GGCGCTGGTC 
CACTCTGTCA AGGCCCGAGA CCAGAAGATG GCTGGGAACT TGGAGGCTGC AAGGCAGTAT 
GGCTCCAAAG CCAAGTGCTA CAACATCCTG GCTGCAATGT GGACATTGGT GCCCCCATTG 
CTGCTCCTGG GACTGGTGGT GACTGGCGCC TTGCACCTGT CCAAGTTAGC CAAAGACTCT 
GCGGCTTTCT TCAGCACCAA GTTTGATGAG GAGGACTATA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444318.1
CDS	35..439
Translation	MDTSYPREDPRAPSSRKADAAAHTALSMGTPGPTPRDHMLWSVFSTMYLNLCCLGFLALVHSVKARDQKMAGNLEAARQYGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLSKLAKDSAAFFSTKFDEEDYN

Target ORF information:

RefSeq Version	NM_053088.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus interferon induced transmembrane protein 5 (Ifitm5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053088.3

ORF Insert Sequence:

ATGGACACTT CATATCCCCG TGAGGACCCC CGGGCTCCAT CATCCCGCAA GGCTGATGCT 
GCAGCCCACA CAGCCCTCTC CATGGGAACA CCTGGCCCTA CACCACGAGA TCACATGCTC 
TGGTCTGTCT TCAGCACGAT GTACCTGAAT CTGTGCTGCC TTGGATTCCT GGCGCTGGTC 
CACTCTGTCA AGGCCCGAGA CCAGAAGATG GCTGGGAACT TGGAGGCTGC AAGGCAGTAT 
GGCTCCAAAG CCAAGTGCTA CAACATCCTG GCTGCAATGT GGACATTGGT GCCCCCATTG 
CTGCTCCTGG GACTGGTGGT GACTGGCGCC TTGCACCTGT CCAAGTTAGC CAAAGACTCT 
GCGGCTTTCT TCAGCACCAA GTTTGATGAG GAGGACTATA ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Bone107131-142(2018 Feb)
Rauch F,Geng Y,Lamplugh L,Hekmatnejad B,Gaumond MH,Penney J,Yamanaka Y,Moffatt P

The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice.
PloS one12(9)e0184568(2017)
Patoine A,Husseini A,Kasaai B,Gaumond MH,Moffatt P

A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research30(3)489-98(2015 Mar)
Lietman CD,Marom R,Munivez E,Bertin TK,Jiang MM,Chen Y,Dawson B,Weis MA,Eyre D,Lee B

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Ifitm5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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