IFITM5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFITM5
Entrez Gene ID	387733
Full Name	interferon induced transmembrane protein 5
Synonyms	BRIL,DSPA1,Hrmp1,OI5,fragilis4
General protein information	Preferred Names interferon induced transmembrane protein 5 Names interferon-induced transmembrane protein 5 bone-restricted ifitm-like protein bone-restricted interferon-induced transmembrane protein-like protein dispanin subfamily A member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.5
Summary	This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012].
Disorder MIM:	614757
Disorder Html:	Osteogenesis imperfecta, type V, 610967 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025295.2	NP_001020466.1	interferon-induced transmembrane protein 5
NM_001025295.3	NP_001020466.1	interferon-induced transmembrane protein 5

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IFITM5	NP_001075193.1
Xenopus tropicalis (tropical clawed frog)	LOC100498002	XP_002937679.1
Homo sapiens (human)	IFITM5	NP_001020466.1
Rattus norvegicus (Norway rat)	Ifitm5	XP_002728878.1
Gallus gallus (chicken)	IFITM5	NP_001186427.1
Pan troglodytes (chimpanzee)	IFITM5	NP_001185698.1
	IFITM5	XP_001085215.1
Mus musculus (house mouse)	Ifitm5	NP_444318.1

Gene Ontology
Bibliography

Related articles in PubMed

A nonclassical IFITM5 mutation located in the coding region causes severe osteogenesis imperfecta with prenatal onset.
Hoyer-Kuhn H, Semler O, Garbes L, Zimmermann K, Becker J, Wollnik B, Schoenau E, Netzer C
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(6)1387-91(2014 Jun)

A novel IFITM5 mutation in severe atypical osteogenesis imperfecta type VI impairs osteoblast production of pigment epithelium-derived factor.
Farber CR, Reich A, Barnes AM, Becerra P, Rauch F, Cabral WA, Bae A, Quinlan A, Glorieux FH, Clemens TL, Marini JC
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(6)1402-11(2014 Jun)

Two mutations in IFITM5 causing distinct forms of osteogenesis imperfecta.
Guill?n-Navarro E, Ballesta-Mart?nez MJ, Valencia M, Bueno AM, Martinez-Glez V, L?pez-Gonz?lez V, Burnyte B, Utkus A, Lapunzina P, Ruiz-Perez VL
American journal of medical genetics. Part A164A(5)1136-42(2014 May)

The IFITM5 mutation c.-14C > T results in an elongated transcript expressed in human bone; and causes varying phenotypic severity of osteogenesis imperfecta type V.
Lazarus S, McInerney-Leo AM, McKenzie FA, Baynam G, Broley S, Cavan BV, Munns CF, Pruijs JE, Sillence D, Terhal PA, Pryce K, Brown MA, Zankl A, Thomas G, Duncan EL
BMC musculoskeletal disorders15107(2014 Mar)

Phenotype and genotype analysis of Chinese patients with osteogenesis imperfecta type V.
Zhang Z, Li M, He JW, Fu WZ, Zhang CQ, Zhang ZL
PloS one8(8)e72337(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two mutations in IFITM5 causing distinct forms of osteogenesis imperfect.
Title: Two mutations in IFITM5 causing distinct forms of osteogenesis imperfecta.

The IFITM5 5' UTR was sequenced in 9 heterozygous subjects with osteogenesis imperfecta type V. Both wild-type and mutant IFITM5 mRNA transcripts were present in bone. Identical mutations have variable phenotypic expression, even within the same family.
Title: The IFITM5 mutation c.-14C > T results in an elongated transcript expressed in human bone; and causes varying phenotypic severity of osteogenesis imperfecta type V.

IFITM5 mutation is associated with Osteogenesis imperfecta type V.
Title: Osteogenesis imperfecta type V: clinical and radiographic manifestations in mutation confirmed patients.

Recurrent mutation in the 5'-UTR of IFITM5 causes osteogenesis imperfecta type V.
Title: A recurrent mutation in the 5'-UTR of IFITM5 causes osteogenesis imperfecta type V.

The point mutation, c.-14C>T in the 5'-untranslated region of IFITM5, is responsible for osteogenesis imperfecta type V in Chinese patients.
Title: Phenotype and genotype analysis of Chinese patients with osteogenesis imperfecta type V.

The following IFITM5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFITM5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27672	NM_001025295.3 Latest version!	Homo sapiens interferon induced transmembrane protein 5 (IFITM5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu27672	NM_001025295.2	Homo sapiens interferon induced transmembrane protein 5 (IFITM5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFITM5 ( NM_001025295.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001020466.1 Homo sapiens interferon induced transmembrane protein 5 (IFITM5), mRNA.

Price & Availability↑

CloneID	OHu27672
Clone ID Related Accession (Same CDS sequence)	NM_001025295.2 , NM_001025295.3
Accession Version	NM_001025295.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	interferon-induced transmembrane protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CR747200.1, BC150562.1, BQ574249.1 and AA460254.1. This sequence is a reference standard in the RefSeqGene project. On Aug 16, 2012 this sequence version replaced NM_001025295.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC150562.1, CR747200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156099 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACACGG CGTATCCCCG CGAGGACACC CGGGCCCCCA CGCCCAGCAA GGCCGGTGCC 
CACACAGCCC TCACACTGGG GGCCCCGCAC CCCCCGCCTC GAGACCACTT GATCTGGTCG 
GTGTTCAGCA CCCTCTACCT GAATCTGTGT TGCCTCGGCT TCCTGGCGCT GGCCTACTCC 
ATCAAGGCCC GAGATCAGAA GGTGGTTGGT GACCTGGAAG CGGCCCGGCG TTTTGGCTCC 
AAAGCCAAGT GCTACAACAT CCTGGCCGCG ATGTGGACGC TGGTGCCGCC ACTGCTGCTC 
CTGGGGCTGG TGGTGACTGG TGCCCTGCAC CTGGCCCGGC TGGCCAAGGA CTCTGCCGCC 
TTCTTCAGCA CCAAGTTTGA TGACGCGGAC TATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020466.1
CDS	37..435
Translation	MDTAYPREDTRAPTPSKAGAHTALTLGAPHPPPRDHLIWSVFSTLYLNLCCLGFLALAYSIKARDQKVVGDLEAARRFGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLARLAKDSAAFFSTKFDDADYD

Target ORF information:

RefSeq Version	NM_001025295.2
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon induced transmembrane protein 5 (IFITM5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025295.2

ORF Insert Sequence:

ATGGACACGG CGTATCCCCG CGAGGACACC CGGGCCCCCA CGCCCAGCAA GGCCGGTGCC 
CACACAGCCC TCACACTGGG GGCCCCGCAC CCCCCGCCTC GAGACCACTT GATCTGGTCG 
GTGTTCAGCA CCCTCTACCT GAATCTGTGT TGCCTCGGCT TCCTGGCGCT GGCCTACTCC 
ATCAAGGCCC GAGATCAGAA GGTGGTTGGT GACCTGGAAG CGGCCCGGCG TTTTGGCTCC 
AAAGCCAAGT GCTACAACAT CCTGGCCGCG ATGTGGACGC TGGTGCCGCC ACTGCTGCTC 
CTGGGGCTGG TGGTGACTGG TGCCCTGCAC CTGGCCCGGC TGGCCAAGGA CTCTGCCGCC 
TTCTTCAGCA CCAAGTTTGA TGACGCGGAC TATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IFITM5 ( NM_001025295.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001020466.1 Homo sapiens interferon induced transmembrane protein 5 (IFITM5), mRNA.

Price & Availability↑

CloneID	OHu27672
Clone ID Related Accession (Same CDS sequence)	NM_001025295.2 , NM_001025295.3
Accession Version	NM_001025295.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	interferon-induced transmembrane protein 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CR747200.1, BC150562.1, BQ574249.1 and AA460254.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001025295.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CR747200.1, AA463818.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156099 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382614.2/ ENSP00000372059.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACACGG CGTATCCCCG CGAGGACACC CGGGCCCCCA CGCCCAGCAA GGCCGGTGCC 
CACACAGCCC TCACACTGGG GGCCCCGCAC CCCCCGCCTC GAGACCACTT GATCTGGTCG 
GTGTTCAGCA CCCTCTACCT GAATCTGTGT TGCCTCGGCT TCCTGGCGCT GGCCTACTCC 
ATCAAGGCCC GAGATCAGAA GGTGGTTGGT GACCTGGAAG CGGCCCGGCG TTTTGGCTCC 
AAAGCCAAGT GCTACAACAT CCTGGCCGCG ATGTGGACGC TGGTGCCGCC ACTGCTGCTC 
CTGGGGCTGG TGGTGACTGG TGCCCTGCAC CTGGCCCGGC TGGCCAAGGA CTCTGCCGCC 
TTCTTCAGCA CCAAGTTTGA TGACGCGGAC TATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020466.1
CDS	37..435
Translation	MDTAYPREDTRAPTPSKAGAHTALTLGAPHPPPRDHLIWSVFSTLYLNLCCLGFLALAYSIKARDQKVVGDLEAARRFGSKAKCYNILAAMWTLVPPLLLLGLVVTGALHLARLAKDSAAFFSTKFDDADYD

Target ORF information:

RefSeq Version	NM_001025295.3
Organism	Homo sapiens(human)
Definition	Homo sapiens interferon induced transmembrane protein 5 (IFITM5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025295.3

ORF Insert Sequence:

ATGGACACGG CGTATCCCCG CGAGGACACC CGGGCCCCCA CGCCCAGCAA GGCCGGTGCC 
CACACAGCCC TCACACTGGG GGCCCCGCAC CCCCCGCCTC GAGACCACTT GATCTGGTCG 
GTGTTCAGCA CCCTCTACCT GAATCTGTGT TGCCTCGGCT TCCTGGCGCT GGCCTACTCC 
ATCAAGGCCC GAGATCAGAA GGTGGTTGGT GACCTGGAAG CGGCCCGGCG TTTTGGCTCC 
AAAGCCAAGT GCTACAACAT CCTGGCCGCG ATGTGGACGC TGGTGCCGCC ACTGCTGCTC 
CTGGGGCTGG TGGTGACTGG TGCCCTGCAC CTGGCCCGGC TGGCCAAGGA CTCTGCCGCC 
TTCTTCAGCA CCAAGTTTGA TGACGCGGAC TATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A nonclassical IFITM5 mutation located in the coding region causes severe osteogenesis imperfecta with prenatal onset.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(6)1387-91(2014 Jun)
Hoyer-Kuhn H,Semler O,Garbes L,Zimmermann K,Becker J,Wollnik B,Schoenau E,Netzer C

A novel IFITM5 mutation in severe atypical osteogenesis imperfecta type VI impairs osteoblast production of pigment epithelium-derived factor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research29(6)1402-11(2014 Jun)
Farber CR,Reich A,Barnes AM,Becerra P,Rauch F,Cabral WA,Bae A,Quinlan A,Glorieux FH,Clemens TL,Marini JC

Two mutations in IFITM5 causing distinct forms of osteogenesis imperfecta.
American journal of medical genetics. Part A164A(5)1136-42(2014 May)
Guill?n-Navarro E,Ballesta-Mart?nez MJ,Valencia M,Bueno AM,Martinez-Glez V,L?pez-Gonz?lez V,Burnyte B,Utkus A,Lapunzina P,Ruiz-Perez VL

The IFITM5 mutation c.-14C > T results in an elongated transcript expressed in human bone; and causes varying phenotypic severity of osteogenesis imperfecta type V.
BMC musculoskeletal disorders15107(2014 Mar)
Lazarus S,McInerney-Leo AM,McKenzie FA,Baynam G,Broley S,Cavan BV,Munns CF,Pruijs JE,Sillence D,Terhal PA,Pryce K,Brown MA,Zankl A,Thomas G,Duncan EL

Phenotype and genotype analysis of Chinese patients with osteogenesis imperfecta type V.
PloS one8(8)e72337(2013)
Zhang Z,Li M,He JW,Fu WZ,Zhang CQ,Zhang ZL

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IFITM5 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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