Lrwd1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrwd1
Entrez Gene ID	71735
Full Name	leucine-rich repeats and WD repeat domain containing 1
Synonyms	1200011O22Rik,AU042569,AW548074,Orca
General protein information	Preferred Names leucine-rich repeats and WD repeat domain containing 1 Names leucine-rich repeat and WD repeat-containing protein 1 ORC-associated protein origin recognition complex-associated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G2

mRNA and Protein(s)

mRNA	Protein	Name
NM_027891.4	NP_082167.2	leucine-rich repeat and WD repeat-containing protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LRWD1	XP_519556.3
	LRWD1	XP_001108941.1
Bos taurus (cattle)	LRWD1	NP_001178398.1
Gallus gallus (chicken)	LRWD1	XP_415759.2
Homo sapiens (human)	LRWD1	NP_690852.1
Mus musculus (house mouse)	Lrwd1	NP_082167.2
Canis lupus familiaris (dog)	LRWD1	XP_536851.3
Danio rerio (zebrafish)	lrwd1	XP_683313.4
Xenopus tropicalis (tropical clawed frog)	lrwd1	NP_001120130.1

Gene Ontology
Bibliography

Related articles in PubMed

Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.
Chan KM, Zhang Z
The Journal of biological chemistry287(18)15024-33(2012 Apr)

Expression of lrwd1 in mouse testis and its centrosomal localization.
Teng YN, Liao MH, Lin YB, Kuo PL, Kuo TY
International journal of andrology33(6)832-40(2010 Dec)

A WD-repeat protein stabilizes ORC binding to chromatin.
Shen Z, Sathyan KM, Geng Y, Zheng R, Chakraborty A, Freeman B, Wang F, Prasanth KV, Prasanth SG
Molecular cell40(1)99-111(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing
Title: Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.

immunostaining and immunoprecipitation showed colocalization and interaction between lrwd1 and gamma-tubulin respectively, implicating lrwd1 as a candidate centrosomal protein. These results suggest that lrwd1 may play an important role in spermatogenesis.
Title: Expression of lrwd1 in mouse testis and its centrosomal localization.

The following Lrwd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrwd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04731	NM_027891.4 Latest version!	Mus musculus leucine-rich repeats and WD repeat domain containing 1 (Lrwd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$384.30 $549.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrwd1 ( NM_027891.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082167.2 Mus musculus leucine-rich repeats and WD repeat domain containing 1 (Lrwd1), mRNA.

Price & Availability↑

CloneID	OMu04731
Clone ID Related Accession (Same CDS sequence)	NM_027891.4
Accession Version	NM_027891.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1947bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat and WD repeat-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY142519.1, AK084948.1 and AA620153.1. On Feb 5, 2008 this sequence version replaced NM_027891.3. ##Evidence-Data-START## Transcript exon combination :: BC048397.1, AK084948.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCTCCTC TCACGCCGCA ACTGCTCCTG CAACGTGGGC GACCCAAGAC GGATAAGCTG 
GGGAAGATTC AGAGTTTGAA TCTGTCGGGG CTGCAGCTGC TCTCAGAGCA CTTGGATCCC 
AATCTCCTGG GGCGCCTGAA GAAGCTGAGG GAACTTGACC TCTCTAACAA CTTGCTGGAG 
ACGCTGCCTG CTAACCTGGG CCTGTCCCAT CTGCGCATCC TTCGCTGTAC CAACAACCAG 
CTCGGGGATG TCACTGCCTT GCACCAGTTC CCAGAACTTG AGGAGCTCAA TCTGGAAGGC 
AACCCCTTCC TGACGGTCAG TGACAACCTC AAAGTCTCCT TTCTCCTGCC CAAGCTTCGT 
AAGGTGAATG GCAAGGACAC GGCCTCCACC TGCTCACAGG TGGAGAATCT AGATCGGGAG 
CTGATGGACA GGGTCACAGC TCACTGGCAG AAGTTCATAG CCACTGTGAG CCCTGAGGAG 
GAAACTGACA AGGTGCGGGC TGATTTCATG AGGTCTGCAG TCAGGGATGT GTGTTACGGC 
CCTGAGTCGC TCATCGAGTT CACGCAGTGG CGGGTGCGGA TGATCGCCGA GGAACTGGTG 
GCCTCAGGTG GGGCCCAGGT GCAAGACGCT AAGGTCCCCG TGGAGCATCC CCAGGCTGCA 
GGTGCCTCCA AGTTCAGGGC CAGAGAGGTG GCTTCAAAAC GGCCAGGTAA AGACCCAGTC 
ACCCTTCCTC CCAGCAAGCG AGTGCGTGCT CTCCCACCTG CTCAGGCTGA GGGCAGTCCT 
ATGGGTGCTG ATGGAGGGCA GGCTGCCCTA CACCTGGAAC CCCTGCACTT CCTGCAGTGT 
CATAGCAGAA ACAACAGCCC AAAGGACCTG GAGACCCAGC TGTGGGCCTG TGCCTTTGAG 
CCGGCCCGGG AGGAGGGGCA CTCGAGGGCC ACATCCCAGA CCGTGGCCAC ATGTGGTGGA 
GAGGCTGTTT GCGTGATAGA CTGCCAGACA GGCCTCGTAC TCCATAAGTA CAAGGTACCA 
GGCGAGGAGT TCTTCTCAGT GGCCTGGACA GCCCTCACGG TGGTCACCCA GGCAGGCCAC 
AAGAAGCGCT GGAACATGCT AGCAGCTGCA GGCCTCCGCG GCATGGTCCG GCTGCTGCAT 
GTTCGCGCAG GCTTCTGCTG CAGCGTCATC CGGGCCCATA AGAAGGCCAT TGCCACCCTC 
TGCTTCAGCC CCAGCCATGA GACTCACCTC TTCACTGCCT CCTACGACAA ACGGATCATC 
CTCTGGGACA TTGGGGTGCC CAACCAGGAT TACAAGTTCC AGGCTAGCCA GCTCCTCACG 
CTCAACTGTG GTTCTGTCCC CTTGCGCCTC TGTCCTGTTG CCACCTGCCC AGATGACTTC 
CTGCTGGCTG GCTGTGAGGG TGGCTGCTAC TGCTGGGACG TGCGGCTAGA CCAGCCCCAG 
AAGCAAAGGG TGTGTGAGGT GAACTTCATC TTCTCTGAGG ACTCCAAGGT GTCAGGACAA 
AGAGTCGATG GGCTGGCATT TGTGAATGAA GATGTGGTGG CCTCCAAAGG GAGTGGACAG 
GGCACCATCT ACCTGTGGAG CTGGAGCCAG ACATGGGCAG GCCGGGGCAG ACAGTCTGTG 
TTGCCCGTAG TCATCCTGGT CCGGCTGCAG TGGTCACCCA CCAACCTGGC CTACTTTTCA 
CTCAGCACCT GTCCCGGCAA AAACCTCGTG CTGTGTGGGG ACGAGGAAGG CAGTGTGTGG 
ATCTATGATG TTGAACACCT CCTGAAAGAG CCTCCACAGG CAACAACTCT GCAGCCCCCA 
ACACAGATCC TGAAGTGGCC TCAGCCAACA GCATTGGGCC AACCAGTGAC CAAGACCATG 
ATAAACACAG TCGTGGCCAA TGCAGCCTTC ACCTACCTCA CTGCCCTGAC AGACTCCAAC 
ATCGTGTCCA TCTGGAGGAG ATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082167.2
CDS	124..2070
Translation	MAPLTPQLLLQRGRPKTDKLGKIQSLNLSGLQLLSEHLDPNLLGRLKKLRELDLSNNLLETLPANLGLSHLRILRCTNNQLGDVTALHQFPELEELNLEGNPFLTVSDNLKVSFLLPKLRKVNGKDTASTCSQVENLDRELMDRVTAHWQKFIATVSPEEETDKVRADFMRSAVRDVCYGPESLIEFTQWRVRMIAEELVASGGAQVQDAKVPVEHPQAAGASKFRAREVASKRPGKDPVTLPPSKRVRALPPAQAEGSPMGADGGQAALHLEPLHFLQCHSRNNSPKDLETQLWACAFEPAREEGHSRATSQTVATCGGEAVCVIDCQTGLVLHKYKVPGEEFFSVAWTALTVVTQAGHKKRWNMLAAAGLRGMVRLLHVRAGFCCSVIRAHKKAIATLCFSPSHETHLFTASYDKRIILWDIGVPNQDYKFQASQLLTLNCGSVPLRLCPVATCPDDFLLAGCEGGCYCWDVRLDQPQKQRVCEVNFIFSEDSKVSGQRVDGLAFVNEDVVASKGSGQGTIYLWSWSQTWAGRGRQSVLPVVILVRLQWSPTNLAYFSLSTCPGKNLVLCGDEEGSVWIYDVEHLLKEPPQATTLQPPTQILKWPQPTALGQPVTKTMINTVVANAAFTYLTALTDSNIVSIWRRC

Target ORF information:

RefSeq Version	NM_027891.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine-rich repeats and WD repeat domain containing 1 (Lrwd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027891.4

ORF Insert Sequence:

ATGGCTCCTC TCACGCCGCA ACTGCTCCTG CAACGTGGGC GACCCAAGAC GGATAAGCTG 
GGGAAGATTC AGAGTTTGAA TCTGTCGGGG CTGCAGCTGC TCTCAGAGCA CTTGGATCCC 
AATCTCCTGG GGCGCCTGAA GAAGCTGAGG GAACTTGACC TCTCTAACAA CTTGCTGGAG 
ACGCTGCCTG CTAACCTGGG CCTGTCCCAT CTGCGCATCC TTCGCTGTAC CAACAACCAG 
CTCGGGGATG TCACTGCCTT GCACCAGTTC CCAGAACTTG AGGAGCTCAA TCTGGAAGGC 
AACCCCTTCC TGACGGTCAG TGACAACCTC AAAGTCTCCT TTCTCCTGCC CAAGCTTCGT 
AAGGTGAATG GCAAGGACAC GGCCTCCACC TGCTCACAGG TGGAGAATCT AGATCGGGAG 
CTGATGGACA GGGTCACAGC TCACTGGCAG AAGTTCATAG CCACTGTGAG CCCTGAGGAG 
GAAACTGACA AGGTGCGGGC TGATTTCATG AGGTCTGCAG TCAGGGATGT GTGTTACGGC 
CCTGAGTCGC TCATCGAGTT CACGCAGTGG CGGGTGCGGA TGATCGCCGA GGAACTGGTG 
GCCTCAGGTG GGGCCCAGGT GCAAGACGCT AAGGTCCCCG TGGAGCATCC CCAGGCTGCA 
GGTGCCTCCA AGTTCAGGGC CAGAGAGGTG GCTTCAAAAC GGCCAGGTAA AGACCCAGTC 
ACCCTTCCTC CCAGCAAGCG AGTGCGTGCT CTCCCACCTG CTCAGGCTGA GGGCAGTCCT 
ATGGGTGCTG ATGGAGGGCA GGCTGCCCTA CACCTGGAAC CCCTGCACTT CCTGCAGTGT 
CATAGCAGAA ACAACAGCCC AAAGGACCTG GAGACCCAGC TGTGGGCCTG TGCCTTTGAG 
CCGGCCCGGG AGGAGGGGCA CTCGAGGGCC ACATCCCAGA CCGTGGCCAC ATGTGGTGGA 
GAGGCTGTTT GCGTGATAGA CTGCCAGACA GGCCTCGTAC TCCATAAGTA CAAGGTACCA 
GGCGAGGAGT TCTTCTCAGT GGCCTGGACA GCCCTCACGG TGGTCACCCA GGCAGGCCAC 
AAGAAGCGCT GGAACATGCT AGCAGCTGCA GGCCTCCGCG GCATGGTCCG GCTGCTGCAT 
GTTCGCGCAG GCTTCTGCTG CAGCGTCATC CGGGCCCATA AGAAGGCCAT TGCCACCCTC 
TGCTTCAGCC CCAGCCATGA GACTCACCTC TTCACTGCCT CCTACGACAA ACGGATCATC 
CTCTGGGACA TTGGGGTGCC CAACCAGGAT TACAAGTTCC AGGCTAGCCA GCTCCTCACG 
CTCAACTGTG GTTCTGTCCC CTTGCGCCTC TGTCCTGTTG CCACCTGCCC AGATGACTTC 
CTGCTGGCTG GCTGTGAGGG TGGCTGCTAC TGCTGGGACG TGCGGCTAGA CCAGCCCCAG 
AAGCAAAGGG TGTGTGAGGT GAACTTCATC TTCTCTGAGG ACTCCAAGGT GTCAGGACAA 
AGAGTCGATG GGCTGGCATT TGTGAATGAA GATGTGGTGG CCTCCAAAGG GAGTGGACAG 
GGCACCATCT ACCTGTGGAG CTGGAGCCAG ACATGGGCAG GCCGGGGCAG ACAGTCTGTG 
TTGCCCGTAG TCATCCTGGT CCGGCTGCAG TGGTCACCCA CCAACCTGGC CTACTTTTCA 
CTCAGCACCT GTCCCGGCAA AAACCTCGTG CTGTGTGGGG ACGAGGAAGG CAGTGTGTGG 
ATCTATGATG TTGAACACCT CCTGAAAGAG CCTCCACAGG CAACAACTCT GCAGCCCCCA 
ACACAGATCC TGAAGTGGCC TCAGCCAACA GCATTGGGCC AACCAGTGAC CAAGACCATG 
ATAAACACAG TCGTGGCCAA TGCAGCCTTC ACCTACCTCA CTGCCCTGAC AGACTCCAAC 
ATCGTGTCCA TCTGGAGGAG ATGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.
The Journal of biological chemistry287(18)15024-33(2012 Apr)
Chan KM,Zhang Z

Expression of lrwd1 in mouse testis and its centrosomal localization.
International journal of andrology33(6)832-40(2010 Dec)
Teng YN,Liao MH,Lin YB,Kuo PL,Kuo TY

A WD-repeat protein stabilizes ORC binding to chromatin.
Molecular cell40(1)99-111(2010 Oct)
Shen Z,Sathyan KM,Geng Y,Zheng R,Chakraborty A,Freeman B,Wang F,Prasanth KV,Prasanth SG

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Lrwd1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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