Tmbim1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tmbim1
Entrez Gene ID	69660
Full Name	transmembrane BAX inhibitor motif containing 1
Synonyms	2310061B02Rik,AA960455,AU024746,C78899,RECS1,Tmbib1,mKIAA4161
General protein information	Preferred Names transmembrane BAX inhibitor motif containing 1 Names protein lifeguard 3 responsive to centrifugal force and shear stress gene 1 protein transmembrane BAX inhibitor motif-containing protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_027154.5	NP_081430.3	protein lifeguard 3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TMBIM1	XP_005640784.1
Bos taurus (cattle)	TMBIM1	NP_991367.1
Pan troglodytes (chimpanzee)	TMBIM1	XP_001144519.2
	TMBIM1	XP_001089836.1
Rattus norvegicus (Norway rat)	Tmbim1	NP_001007714.1
Danio rerio (zebrafish)	tmbim1	NP_001005992.1
Xenopus tropicalis (tropical clawed frog)	tmbim1	NP_001025668.1
Homo sapiens (human)	TMBIM1	NP_071435.2
Gallus gallus (chicken)	TMBIM1	XP_422067.3
Mus musculus (house mouse)	Tmbim1	NP_081430.3

Gene Ontology
Bibliography

Related articles in PubMed

Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.
Zhao GN, Zhang P, Gong J, Zhang XJ, Wang PX, Yin M, Jiang Z, Shen LJ, Ji YX, Tong J, Wang Y, Wei QF, Wang Y, Zhu XY, Zhang X, Fang J, Xie Q, She ZG, Wang Z, Huang Z, Li H
Nature medicine23(6)742-752(2017 Jun)

RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation.
Zhao H, Ito A, Sakai N, Matsuzawa Y, Yamashita S, Nojima H
Circulation journal : official journal of the Japanese Circulation Society70(5)615-24(2006 May)

RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.
Zhao H, Ito A, Kimura SH, Yabuta N, Sakai N, Ikawa M, Okabe M, Matsuzawa Y, Yamashita S, Nojima H
Genes & genetic systems81(1)41-50(2006 Feb)

Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library.
Yoshisue H, Suzuki K, Kawabata A, Ohya T, Zhao H, Sakurada K, Taba Y, Sasaguri T, Sakai N, Yamashita S, Matsuzawa Y, Nojima H
Atherosclerosis162(2)323-34(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TMBIM1 is an effective suppressor of steatohepatitis and a previously unknown regulator of the multivesicular body (MVB)-lysosomal pathway. Tmbim1 expression in hepatocytes substantially inhibited high-fat diet-induced insulin resistance, hepatic steatosis and inflammation in mice. Overexpression of Tmbim1 in the liver effectively inhibited a severe form of NAFLD in mice.
Title: Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.

RECS1 negatively regulates aortic MMP-9 production and knocking out RECS1 induces susceptibility to aortic dilation as well as cystic medial degeneration in the aged mice.
Title: RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation.

An endosomal/lysosomal membrane protein which plays protective roles in vascular remodeling
Title: RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.

The following Tmbim1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tmbim1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03731	NM_027154.5 Latest version!	Mus musculus transmembrane BAX inhibitor motif containing 1 (Tmbim1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tmbim1 ( NM_027154.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081430.3 Mus musculus transmembrane BAX inhibitor motif containing 1 (Tmbim1), mRNA.

Price & Availability↑

CloneID	OMu03731
Clone ID Related Accession (Same CDS sequence)	NM_027154.5
Accession Version	NM_027154.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	protein lifeguard 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY312755.1, AK152864.1 and BQ031095.1. On May 7, 2009 this sequence version replaced NM_027154.4. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.45386.1, SRR1660813.139961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCAATC CCAGTGCCCC ACCTCCCTAT GAGGACCACA ACCCCCTGTA CCCTGGCTCT 
CCACCTCCTG GTGGCTACGG GCAGCCATCT GTCCTGCCAG GTGGTTATCC CGCCTACCCT 
GCCTACCCTC AACCTGGTTA CGGTCATCCT GCTGGCTACC CACAGCCGGT TCCTCCCGTC 
CATCCAATGC CCATGAACTA CGGCCATGAC TATAATGAAG AGGAGAGAGC AGGAAGTGAC 
AGCTTTCGTC CTGGAGAATG GGATGACCGG AAAGTTCGAC ATTCCTTCAT CCAAAAGGTG 
TATTGCATCA TTTCTGTCCA GCTGCTCATC ACTGTGGCCA TCATTGCAAT CTTCACCTTT 
GTGGAACCAG TCGGCAAATA CGTGAGGAAC AATGTGGCTG TGTACTACGT GTCCTATGCT 
GTCTTCCTTG TCACCTACCT GACCCTTGCC TGCTGCCAGG GACCCAGGCG CCGATTCCCA 
TGGAACATCA TCTTGCTCAC CATCTTTACT TTGGCTTTGG GCTTTGTGAC AGGCACTATT 
TCCAGTATGT ATGAAACCAA AGCTGTCATC ATAGCAATGA TCATCACCGC TGTGGTATCC 
ATCTCTGTCA CCATCTTCTG CTTTCAGACT AAGGTGGACT TCACCTCGTG TACAGGCCTC 
TTCTGTGTGC TGGGAATAGT GCTGATGGTG ACCGGAATTG TCACAAGCAT AGTGCTGATC 
TTTAAATATA TTTACTGGCT CCACATGGTC TATGCAGCTC TGGGGGCCAT CTGTTTCACC 
CTGTTCCTGG CTTATGACAC ACAGCTGGTC CTGGGGAACC GGAAGCACAC CATCAGCCCG 
GAGGACTACA TCACAGGCGC CCTACAGATC TACACAGATA TAGTCTATAT CTTCACGTTC 
GTGCTCCAGC TCGTAGGAAG TAGAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081430.3
CDS	255..1184
Translation	MSNPSAPPPYEDHNPLYPGSPPPGGYGQPSVLPGGYPAYPAYPQPGYGHPAGYPQPVPPVHPMPMNYGHDYNEEERAGSDSFRPGEWDDRKVRHSFIQKVYCIISVQLLITVAIIAIFTFVEPVGKYVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFPWNIILLTIFTLALGFVTGTISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLMVTGIVTSIVLIFKYIYWLHMVYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGSRD

Target ORF information:

RefSeq Version	NM_027154.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane BAX inhibitor motif containing 1 (Tmbim1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027154.5

ORF Insert Sequence:

ATGTCCAATC CCAGTGCCCC ACCTCCCTAT GAGGACCACA ACCCCCTGTA CCCTGGCTCT 
CCACCTCCTG GTGGCTACGG GCAGCCATCT GTCCTGCCAG GTGGTTATCC CGCCTACCCT 
GCCTACCCTC AACCTGGTTA CGGTCATCCT GCTGGCTACC CACAGCCGGT TCCTCCCGTC 
CATCCAATGC CCATGAACTA CGGCCATGAC TATAATGAAG AGGAGAGAGC AGGAAGTGAC 
AGCTTTCGTC CTGGAGAATG GGATGACCGG AAAGTTCGAC ATTCCTTCAT CCAAAAGGTG 
TATTGCATCA TTTCTGTCCA GCTGCTCATC ACTGTGGCCA TCATTGCAAT CTTCACCTTT 
GTGGAACCAG TCGGCAAATA CGTGAGGAAC AATGTGGCTG TGTACTACGT GTCCTATGCT 
GTCTTCCTTG TCACCTACCT GACCCTTGCC TGCTGCCAGG GACCCAGGCG CCGATTCCCA 
TGGAACATCA TCTTGCTCAC CATCTTTACT TTGGCTTTGG GCTTTGTGAC AGGCACTATT 
TCCAGTATGT ATGAAACCAA AGCTGTCATC ATAGCAATGA TCATCACCGC TGTGGTATCC 
ATCTCTGTCA CCATCTTCTG CTTTCAGACT AAGGTGGACT TCACCTCGTG TACAGGCCTC 
TTCTGTGTGC TGGGAATAGT GCTGATGGTG ACCGGAATTG TCACAAGCAT AGTGCTGATC 
TTTAAATATA TTTACTGGCT CCACATGGTC TATGCAGCTC TGGGGGCCAT CTGTTTCACC 
CTGTTCCTGG CTTATGACAC ACAGCTGGTC CTGGGGAACC GGAAGCACAC CATCAGCCCG 
GAGGACTACA TCACAGGCGC CCTACAGATC TACACAGATA TAGTCTATAT CTTCACGTTC 
GTGCTCCAGC TCGTAGGAAG TAGAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4.
Nature medicine23(6)742-752(2017 Jun)
Zhao GN,Zhang P,Gong J,Zhang XJ,Wang PX,Yin M,Jiang Z,Shen LJ,Ji YX,Tong J,Wang Y,Wei QF,Wang Y,Zhu XY,Zhang X,Fang J,Xie Q,She ZG,Wang Z,Huang Z,Li H

RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation.
Circulation journal : official journal of the Japanese Circulation Society70(5)615-24(2006 May)
Zhao H,Ito A,Sakai N,Matsuzawa Y,Yamashita S,Nojima H

RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.
Genes & genetic systems81(1)41-50(2006 Feb)
Zhao H,Ito A,Kimura SH,Yabuta N,Sakai N,Ikawa M,Okabe M,Matsuzawa Y,Yamashita S,Nojima H

Large scale isolation of non-uniform shear stress-responsive genes from cultured human endothelial cells through the preparation of a subtracted cDNA library.
Atherosclerosis162(2)323-34(2002 Jun)
Yoshisue H,Suzuki K,Kawabata A,Ohya T,Zhao H,Sakurada K,Taba Y,Sasaguri T,Sakai N,Yamashita S,Matsuzawa Y,Nojima H

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Tmbim1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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