Mob1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mob1b
Entrez Gene ID	68473
Full Name	MOB kinase activator 1B
Synonyms	1110003E08Rik,AU015450,B230364F10,Mobkl1a
General protein information	Preferred Names MOB kinase activator 1B Names MOB kinase activator 1B MOB1, Mps One Binder kinase activator-like 1A mob1 homolog 1A mps one binder kinase activator-like 1A
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_026735.2	NP_081011.1	MOB kinase activator 1B

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	mats	NP_001262835.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002066	XP_320981.3
Homo sapiens (human)	MOB1B	NP_001231695.1
Bos taurus (cattle)	MOB1B	NP_001179341.1
Rattus norvegicus (Norway rat)	Mob1b	NP_001101827.1
Danio rerio (zebrafish)	mob1ba	NP_956494.1
Arabidopsis thaliana (thale cress)	AT4G19045	NP_001154253.1
	LOC707984	XP_001107567.1
Canis lupus familiaris (dog)	MOB1B	XP_539306.4
Arabidopsis thaliana (thale cress)	AT5G45550	NP_199368.1
Pan troglodytes (chimpanzee)	MOBKL1A	XP_001159136.1
Mus musculus (house mouse)	Mob1b	NP_081011.1
Gallus gallus (chicken)	MOBKL1A	XP_420601.2
Oryza sativa (rice)	Os03g0577200	NP_001050541.1
Xenopus tropicalis (tropical clawed frog)	mob1b	NP_001072572.1

Gene Ontology
Bibliography

Related articles in PubMed

MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation.
Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, Sasaki T, Maehama T, Nishina H, Mimori K, Nakano T, Shimizu H, Mak TW, Nakao K, Nakanishi Y, Suzuki A
Oncogene36(29)4201-4211(2017 Jul)

YAP determines the cell fate of injured mouse hepatocytes in vivo.
Miyamura N, Hata S, Itoh T, Tanaka M, Nishio M, Itoh M, Ogawa Y, Terai S, Sakaida I, Suzuki A, Miyajima A, Nishina H
Nature communications816017(2017 Jul)

Dysregulated YAP1/TAZ and TGF-? signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.
Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, Takano Y, Hikasa H, Itoh T, Suzuki SO, Kurihara H, Aishima S, Leask A, Sasaki T, Nakano T, Nishina H, Nishikawa Y, Sekido Y, Nakao K, Shin-Ya K, Mimori K, Suzuki A
Proceedings of the National Academy of Sciences of the United States of America113(1)E71-80(2016 Jan)

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.
Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, Snitow M, Morley M, Li D, Petrenko N, Zhou S, Lu M, Gao E, Koch WJ, Stewart KM, Morrisey EE
Science translational medicine7(279)279ra38(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.
Title: Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.

Mst1/2-catalyzed MOBKL1A/B phosphorylation slows proliferation and is therefore a likely contributor to the anti-proliferative action of Mst1 in naive T cells
Title: The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of na?ve T cells.

MOBKL1A/MOBKL1B phosphorylation, by MST1 and MST2, is sufficient to inhibit proliferation through actions at several points in the cell cycle.
Title: MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.

The following Mob1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mob1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu20757	NM_026735.2 Latest version!	Mus musculus MOB kinase activator 1B (Mob1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mob1b ( NM_026735.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081011.1 Mus musculus MOB kinase activator 1B (Mob1b), mRNA.

Price & Availability↑

CloneID	OMu20757
Clone ID Related Accession (Same CDS sequence)	NM_026735.2
Accession Version	NM_026735.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	MOB kinase activator 1B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK162120.1, AK077320.1 and AK042552.1. On Dec 2, 2006 this sequence version replaced NM_026735.1. ##Evidence-Data-START## Transcript exon combination :: AK162120.1, SRR1660811.6317.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAGCTTCT TGTTTGGTAG TCGCTCTTCT AAAACTTTTA AACCAAAGAA GAACATACCA 
GAGGGGTCTC ACCAGTATGA ACTCTTAAAG CATGCGGAAG CCACACTGGG CAGCGGCAAC 
CTACGGATGG CTGTCATGCT TCCCGAGGGA GAGGATCTGA ATGAGTGGGT TGCAGTTAAC 
ACTGTGGATT TTTTCAATCA AATCAATATG CTTTATGGAA CCATCACAGA CTTCTGTACA 
GAGGAGAGCT GTCCGGTGAT GTCAGCTGGA CCAAAATATG AATATCACTG GGCAGATGGA 
ACAAACATAA AAAAGCCTAT TAAGTGTTCT GCACCAAAGT ATATTGATTA CTTGATGACT 
TGGGTTCAGG ACCAGCTGGA TGATGAGACA TTATTTCCAT CAAAAATTGG TGTTCCATTC 
CCGAAGAATT TCATGTCAGT GGCAAAAACA ATACTCAAAC GACTCTTTAG AGTTTATGCT 
CATATTTATC ACCAACATTT TGACCCTGTG ATCCAGCTTC AGGAGGAAGC ACATCTCAAT 
ACATCTTTCA AGCACTTTAT TTTTTTCGTT CAGGAGTTCA ACCTTATTGA CAGACGAGAG 
TTGGCACCAC TGCAAGAGCT GATTGAAAAA CTCACCTCAA AGGACAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081011.1
CDS	238..888
Translation	MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR

Target ORF information:

RefSeq Version	NM_026735.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus MOB kinase activator 1B (Mob1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026735.2

ORF Insert Sequence:

ATGAGCTTCT TGTTTGGTAG TCGCTCTTCT AAAACTTTTA AACCAAAGAA GAACATACCA 
GAGGGGTCTC ACCAGTATGA ACTCTTAAAG CATGCGGAAG CCACACTGGG CAGCGGCAAC 
CTACGGATGG CTGTCATGCT TCCCGAGGGA GAGGATCTGA ATGAGTGGGT TGCAGTTAAC 
ACTGTGGATT TTTTCAATCA AATCAATATG CTTTATGGAA CCATCACAGA CTTCTGTACA 
GAGGAGAGCT GTCCGGTGAT GTCAGCTGGA CCAAAATATG AATATCACTG GGCAGATGGA 
ACAAACATAA AAAAGCCTAT TAAGTGTTCT GCACCAAAGT ATATTGATTA CTTGATGACT 
TGGGTTCAGG ACCAGCTGGA TGATGAGACA TTATTTCCAT CAAAAATTGG TGTTCCATTC 
CCGAAGAATT TCATGTCAGT GGCAAAAACA ATACTCAAAC GACTCTTTAG AGTTTATGCT 
CATATTTATC ACCAACATTT TGACCCTGTG ATCCAGCTTC AGGAGGAAGC ACATCTCAAT 
ACATCTTTCA AGCACTTTAT TTTTTTCGTT CAGGAGTTCA ACCTTATTGA CAGACGAGAG 
TTGGCACCAC TGCAAGAGCT GATTGAAAAA CTCACCTCAA AGGACAGATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation.
Oncogene36(29)4201-4211(2017 Jul)
Otsubo K,Goto H,Nishio M,Kawamura K,Yanagi S,Nishie W,Sasaki T,Maehama T,Nishina H,Mimori K,Nakano T,Shimizu H,Mak TW,Nakao K,Nakanishi Y,Suzuki A

YAP determines the cell fate of injured mouse hepatocytes in vivo.
Nature communications816017(2017 Jul)
Miyamura N,Hata S,Itoh T,Tanaka M,Nishio M,Itoh M,Ogawa Y,Terai S,Sakaida I,Suzuki A,Miyajima A,Nishina H

Dysregulated YAP1/TAZ and TGF-? signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America113(1)E71-80(2016 Jan)
Nishio M,Sugimachi K,Goto H,Wang J,Morikawa T,Miyachi Y,Takano Y,Hikasa H,Itoh T,Suzuki SO,Kurihara H,Aishima S,Leask A,Sasaki T,Nakano T,Nishina H,Nishikawa Y,Sekido Y,Nakao K,Shin-Ya K,Mimori K,Suzuki A

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.
Science translational medicine7(279)279ra38(2015 Mar)
Tian Y,Liu Y,Wang T,Zhou N,Kong J,Chen L,Snitow M,Morley M,Li D,Petrenko N,Zhou S,Lu M,Gao E,Koch WJ,Stewart KM,Morrisey EE

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Mob1b cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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