C1qtnf12 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	C1qtnf12
Entrez Gene ID	67389
Full Name	C1q and tumor necrosis factor related 12
Synonyms	1110035L05Rik,C1qdc2,CTRP12,Fam132a,alipolin
General protein information	Preferred Names C1q and tumor necrosis factor related 12 Names adipolin C1q domain containing 2 adipose-derived insulin-sensitizing factor complement C1q tumor necrosis factor-related protein 12 family with sequence similarity 132, member A protein FAM132A
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 E2\|4 87.66 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_026125.3	NP_080401.1	adipolin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	FAM132A	NP_001014980.1
Canis lupus familiaris (dog)	FAM132A	XP_005620430.1
Rattus norvegicus (Norway rat)	Fam132a	NP_001101470.1
Gallus gallus (chicken)	FAM132A	XP_004947479.1
Mus musculus (house mouse)	Fam132a	NP_080401.1
Xenopus tropicalis (tropical clawed frog)	fam132a	NP_001016365.2
Bos taurus (cattle)	FAM132A	XP_002694178.1
Danio rerio (zebrafish)	fam132a	NP_001073547.1

Gene Ontology
Bibliography

Related articles in PubMed

Myc cooperates with ?-catenin to drive gene expression in nephron progenitor cells.
Pan X, Karner CM, Carroll TJ
Development (Cambridge, England)144(22)4173-4182(2017 Nov)

Partial deficiency of CTRP12 alters hepatic lipid metabolism.
Tan SY, Little HC, Lei X, Li S, Rodriguez S, Wong GW
Physiological genomics48(12)936-949(2016 Dec)

?-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S
PloS one11(2)e0150010(2016)

Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Kr?ppel-like factor 15.
Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Miyabe M, Matsuo K, Joki Y, Hayakawa S, Hiramatsu-Ito M, Ito M, Murohara T, Ouchi N
PloS one8(12)e83183(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mRNA expression of Fam132a, which encodes a newly identified insulin-sensitizing adipokine, adipolin, is significantly upregulated in the absence of KLF3.
Title: Loss of Kr?ppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).

Adipolin is transcriptionally regulated by KLF15 in adipocytes.
Title: Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Kr?ppel-like factor 15.

The aim of this study was to demonstrate adipolin expression in human and murine chondrocytes and to elucidate the intracellular mechanism involved in adipolin basal expression
Title: Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line.

These data suggest that obesity states facilitate the cleavage of adipolin presumably through upregulation of furin in adipose tissue.
Title: Regulation of adipolin/CTRP12 cleavage by obesity.

Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity.
Title: Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity.

The following C1qtnf12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C1qtnf12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16331	NM_026125.3 Latest version!	Mus musculus C1q and tumor necrosis factor related 12 (C1qtnf12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C1qtnf12 ( NM_026125.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080401.1 Mus musculus C1q and tumor necrosis factor related 12 (C1qtnf12), mRNA.

Price & Availability↑

CloneID	OMu16331
Clone ID Related Accession (Same CDS sequence)	NM_026125.3
Accession Version	NM_026125.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	adipolin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL627204.7, AK004116.1 and CO043709.1. On Oct 4, 2011 this sequence version replaced NM_026125.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004116.1, AK002876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGGCCT GGGGCTGGGC CGCTGCAGCG CTCCTCTGGC TACAGACTGC AGGAGCCGGG 
GCCCGGCAGG AGCTCAAGAA GTCTCGGCAG CTGTTTGCGC GTGTGGATTC CCCCAATATT 
ACCACGTCCA ACCGTGAGGG ATTCCCAGGC TCCGTCAAGC CCCCGGAAGC CTCTGGACCT 
GAGCTCTCAG ATGCCCACAT GACGTGGTTG AACTTTGTCC GACGGCCAGA TGATGGGTCC 
TCTAGAAAAC GGTGTCGTGG CCGGGACAAG AAGTCGCGAG GCCTCTCAGG TCTCCCAGGG 
CCCCCAGGAC CTCCTGGCCC TCCTGGTCCC CCTGGCTCCC CTGGTGTGGG CGTTACCCCA 
GAGGCCTTAC TGCAGGAATT TCAGGAGATA CTGAAAGAGG CCACAGAACT TCGATTCTCA 
GGGCTACCAG ACACATTGTT ACCCCAGGAA CCCAGCCAAC GGCTGGTGGT TGAGGCCTTC 
TACTGCCGTT TGAAAGGCCC TGTGCTGGTG GACAAGAAGA CTCTGGTGGA ACTGCAAGGA 
TTCCAAGCTC CTACTACTCA GGGCGCCTTC CTGCGGGGAT CTGGCCTGAG CCTGTCCTTG 
GGCCGATTCA CAGCCCCAGT CTCTGCCATC TTCCAGTTTT CTGCCAGCCT GCACGTGGAC 
CACAGTGAAC TGCAGGGCAG AGGCCGGTTG CGTACCCGGG ATATGGTCCG TGTTCTCATC 
TGTATTGAGT CCTTGTGTCA TCGTCATACG TCCCTGGAGG CTGTATCAGG TCTGGAGAGC 
AACAGCAGGG TCTTCACAGT GCAGGTTCAG GGGCTGCTGC ATCTACAGTC TGGACAGTAT 
GTCTCTGTGT TCGTGGACAA CAGTTCTGGG GCAGTCCTCA CCATCCAGAA CACTTCCAGC 
TTCTCGGGAA TGCTTTTGGG TACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080401.1
CDS	268..1194
Translation	MWAWGWAAAALLWLQTAGAGARQELKKSRQLFARVDSPNITTSNREGFPGSVKPPEASGPELSDAHMTWLNFVRRPDDGSSRKRCRGRDKKSRGLSGLPGPPGPPGPPGPPGSPGVGVTPEALLQEFQEILKEATELRFSGLPDTLLPQEPSQRLVVEAFYCRLKGPVLVDKKTLVELQGFQAPTTQGAFLRGSGLSLSLGRFTAPVSAIFQFSASLHVDHSELQGRGRLRTRDMVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLHLQSGQYVSVFVDNSSGAVLTIQNTSSFSGMLLGT

Target ORF information:

RefSeq Version	NM_026125.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus C1q and tumor necrosis factor related 12 (C1qtnf12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026125.3

ORF Insert Sequence:

ATGTGGGCCT GGGGCTGGGC CGCTGCAGCG CTCCTCTGGC TACAGACTGC AGGAGCCGGG 
GCCCGGCAGG AGCTCAAGAA GTCTCGGCAG CTGTTTGCGC GTGTGGATTC CCCCAATATT 
ACCACGTCCA ACCGTGAGGG ATTCCCAGGC TCCGTCAAGC CCCCGGAAGC CTCTGGACCT 
GAGCTCTCAG ATGCCCACAT GACGTGGTTG AACTTTGTCC GACGGCCAGA TGATGGGTCC 
TCTAGAAAAC GGTGTCGTGG CCGGGACAAG AAGTCGCGAG GCCTCTCAGG TCTCCCAGGG 
CCCCCAGGAC CTCCTGGCCC TCCTGGTCCC CCTGGCTCCC CTGGTGTGGG CGTTACCCCA 
GAGGCCTTAC TGCAGGAATT TCAGGAGATA CTGAAAGAGG CCACAGAACT TCGATTCTCA 
GGGCTACCAG ACACATTGTT ACCCCAGGAA CCCAGCCAAC GGCTGGTGGT TGAGGCCTTC 
TACTGCCGTT TGAAAGGCCC TGTGCTGGTG GACAAGAAGA CTCTGGTGGA ACTGCAAGGA 
TTCCAAGCTC CTACTACTCA GGGCGCCTTC CTGCGGGGAT CTGGCCTGAG CCTGTCCTTG 
GGCCGATTCA CAGCCCCAGT CTCTGCCATC TTCCAGTTTT CTGCCAGCCT GCACGTGGAC 
CACAGTGAAC TGCAGGGCAG AGGCCGGTTG CGTACCCGGG ATATGGTCCG TGTTCTCATC 
TGTATTGAGT CCTTGTGTCA TCGTCATACG TCCCTGGAGG CTGTATCAGG TCTGGAGAGC 
AACAGCAGGG TCTTCACAGT GCAGGTTCAG GGGCTGCTGC ATCTACAGTC TGGACAGTAT 
GTCTCTGTGT TCGTGGACAA CAGTTCTGGG GCAGTCCTCA CCATCCAGAA CACTTCCAGC 
TTCTCGGGAA TGCTTTTGGG TACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myc cooperates with ?-catenin to drive gene expression in nephron progenitor cells.
Development (Cambridge, England)144(22)4173-4182(2017 Nov)
Pan X,Karner CM,Carroll TJ

Partial deficiency of CTRP12 alters hepatic lipid metabolism.
Physiological genomics48(12)936-949(2016 Dec)
Tan SY,Little HC,Lei X,Li S,Rodriguez S,Wong GW

?-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
PloS one11(2)e0150010(2016)
Abdellatif AM,Oishi H,Itagaki T,Jung Y,Shawki HH,Okita Y,Hasegawa Y,Suzuki H,El-Morsy SE,El-Sayed MA,Shoaib MB,Sugiyama F,Takahashi S

Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Kr?ppel-like factor 15.
PloS one8(12)e83183(2013)
Enomoto T,Ohashi K,Shibata R,Kambara T,Uemura Y,Yuasa D,Kataoka Y,Miyabe M,Matsuo K,Joki Y,Hayakawa S,Hiramatsu-Ito M,Ito M,Murohara T,Ouchi N

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C1qtnf12 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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