Svs2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Svs2
Entrez Gene ID	53878
Full Name	seminal vesicle secretory protein 2
Synonyms	BB115391,Semg1,SvsII
General protein information	Preferred Names seminal vesicle secretory protein 2 Names semenogelin I semenoclotin seminal vesicle protein, secretion 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 H3\|2 84.82 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_017390.4	NP_059086.3	semenogelin I precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Svs2	NP_059086.3
Rattus norvegicus (Norway rat)	Semg1	NP_036842.2

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Seminal vesicle secretion 2 acts as a protectant of sperm sterols and prevents ectopic sperm capacitation in mice.
Araki N, Trencs?nyi G, Krasznai ZT, Nizsal?czki E, Sakamoto A, Kawano N, Miyado K, Yoshida K, Yoshida M
Biology of reproduction92(1)8(2015 Jan)

Seminal vesicle protein SVS2 is required for sperm survival in the uterus.
Kawano N, Araki N, Yoshida K, Hibino T, Ohnami N, Makino M, Kanai S, Hasuwa H, Yoshida M, Miyado K, Umezawa A
Proceedings of the National Academy of Sciences of the United States of America111(11)4145-50(2014 Mar)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Ganglioside GM1 mediates decapacitation effects of SVS2 on murine spermatozoa.
Kawano N, Yoshida K, Iwamoto T, Yoshida M
Biology of reproduction79(6)1153-9(2008 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SVS2 keeps sterols on the sperm plasma membrane and plays a key role in unlocking sperm capacitation in vivo.
Title: Seminal vesicle secretion 2 acts as a protectant of sperm sterols and prevents ectopic sperm capacitation in mice.

Seminal vesicle protein SVS2 is required for sperm survival in the uterus.
Title: Seminal vesicle protein SVS2 is required for sperm survival in the uterus.

the fertility of ejaculated sperm is associated with SVS2 distribution in the female reproductive tract, SVS2 functions as a decapacitation factor for mouse sperm.
Title: Semen-coagulating protein, SVS2, in mouse seminal plasma controls sperm fertility.

The following Svs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Svs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10735	NM_017390.4 Latest version!	Mus musculus seminal vesicle secretory protein 2 (Svs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Svs2 ( NM_017390.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_059086.3 Mus musculus seminal vesicle secretory protein 2 (Svs2), mRNA.

Price & Availability↑

CloneID	OMu10735
Clone ID Related Accession (Same CDS sequence)	NM_017390.4
Accession Version	NM_017390.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-28
Organism	Mus musculus(house mouse)
Product	semenogelin I precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV056729.1, BB871464.1, AK144285.1 and AK035204.1. On Sep 3, 2009 this sequence version replaced NM_017390.3. ##Evidence-Data-START## Transcript exon combination :: AK035204.1, AK144285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCCT CTGTCTTCGT CCTTTCTCTG CTCCTCATTC TGGAAAGACA GTCAGCTGTG 
GTTGGACAAT ATGGGGCTAC AAAAGGCCAC TTCCAGAGCA GCTCCTCAGA GGGATTTATG 
CTTGGTCAGA AAGGCCGTCT CAGTTTCGGG ATCAAAGGAG GAAGTGACGA AGCAGCTGAA 
GAAAGCCTTT TCATGCAATC ACAACGCCGG GTGTATGGCC AGGGTGGTGG TGACATGACC 
CAGACACGTG TTTCACAAGA GCATACAAGT GTCAAAGGGG CCGCACTTTG TCGTAATGGA 
CAAGTATCCC AACTGAAATC CCAAGAATCC CAAATAAAAT CCTATGGCCA AGTGAAATCC 
AGTGGACAGC TGAAATCTGG AGGATCAGCC TTTGGACAAG TGAAGTCCAG TGTGTCCCAA 
ATAAAATCCT ATGGACAGCT GAAATCCGGT GGTCAGTTGA AATCTGGAGG ACCAGCCTTT 
GGACAAGTGA AATCCCAAGA ATCCCAAATA AAATCTTATG GACAATTGAA ATCCAGTGGA 
CAACTGAAAT CTGGAGGATC GGCCTTTGGA CAAGTGAAGT CCAGTGTGTC CCAAATAAAA 
TCCTATGGAC AGCTGAAATC CGGTGGATCC CAAGTAAAAT CCTATGGTCA AACAAAATCC 
TATGGTGAAG AAGGTCAACT GAACTCTTTC AGCCAACTAA AATCCCAAGG TGCCCAACTA 
AAATCCTATG GTCAACAAAA ATCTCAACAA CAGTCCTCCT TTAGCCAAGT AAAATCTCAA 
AGTTCCCAAC TAAAGTCCTA TGGCCAACAA AAATCCCTCA AAGGTTTTTC TCAACAAACT 
CAGCATAAAG GATTTGCCAT GGATGAAGGT ATGTCACAAG TGCGGAAACA ATTTAGTGAC 
GATGACCTCT CAGTACAACA GAAGTCTACC CAACAGATGA AAACAGAGGA AGACTTATCC 
CAATTCGGAC AACAGCGGCA ATATGGACAA GAGCGCTCAC AATCCTATAA AGGATATCTT 
GAGCAATACA GAAAGAAAGT ACAAGAACAA CAACGAAAAA ATTTTAATCC CGGTAACTAT 
TTTACAAAGG GAGGAGCAGA CCTCTATCAA GCTCAGCTTA AGGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059086.3
CDS	99..1226
Translation	MKSSVFVLSLLLILERQSAVVGQYGATKGHFQSSSSEGFMLGQKGRLSFGIKGGSDEAAEESLFMQSQRRVYGQGGGDMTQTRVSQEHTSVKGAALCRNGQVSQLKSQESQIKSYGQVKSSGQLKSGGSAFGQVKSSVSQIKSYGQLKSGGQLKSGGPAFGQVKSQESQIKSYGQLKSSGQLKSGGSAFGQVKSSVSQIKSYGQLKSGGSQVKSYGQTKSYGEEGQLNSFSQLKSQGAQLKSYGQQKSQQQSSFSQVKSQSSQLKSYGQQKSLKGFSQQTQHKGFAMDEGMSQVRKQFSDDDLSVQQKSTQQMKTEEDLSQFGQQRQYGQERSQSYKGYLEQYRKKVQEQQRKNFNPGNYFTKGGADLYQAQLKG

Target ORF information:

RefSeq Version	NM_017390.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus seminal vesicle secretory protein 2 (Svs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017390.4

ORF Insert Sequence:

ATGAAGTCCT CTGTCTTCGT CCTTTCTCTG CTCCTCATTC TGGAAAGACA GTCAGCTGTG 
GTTGGACAAT ATGGGGCTAC AAAAGGCCAC TTCCAGAGCA GCTCCTCAGA GGGATTTATG 
CTTGGTCAGA AAGGCCGTCT CAGTTTCGGG ATCAAAGGAG GAAGTGACGA AGCAGCTGAA 
GAAAGCCTTT TCATGCAATC ACAACGCCGG GTGTATGGCC AGGGTGGTGG TGACATGACC 
CAGACACGTG TTTCACAAGA GCATACAAGT GTCAAAGGGG CCGCACTTTG TCGTAATGGA 
CAAGTATCCC AACTGAAATC CCAAGAATCC CAAATAAAAT CCTATGGCCA AGTGAAATCC 
AGTGGACAGC TGAAATCTGG AGGATCAGCC TTTGGACAAG TGAAGTCCAG TGTGTCCCAA 
ATAAAATCCT ATGGACAGCT GAAATCCGGT GGTCAGTTGA AATCTGGAGG ACCAGCCTTT 
GGACAAGTGA AATCCCAAGA ATCCCAAATA AAATCTTATG GACAATTGAA ATCCAGTGGA 
CAACTGAAAT CTGGAGGATC GGCCTTTGGA CAAGTGAAGT CCAGTGTGTC CCAAATAAAA 
TCCTATGGAC AGCTGAAATC CGGTGGATCC CAAGTAAAAT CCTATGGTCA AACAAAATCC 
TATGGTGAAG AAGGTCAACT GAACTCTTTC AGCCAACTAA AATCCCAAGG TGCCCAACTA 
AAATCCTATG GTCAACAAAA ATCTCAACAA CAGTCCTCCT TTAGCCAAGT AAAATCTCAA 
AGTTCCCAAC TAAAGTCCTA TGGCCAACAA AAATCCCTCA AAGGTTTTTC TCAACAAACT 
CAGCATAAAG GATTTGCCAT GGATGAAGGT ATGTCACAAG TGCGGAAACA ATTTAGTGAC 
GATGACCTCT CAGTACAACA GAAGTCTACC CAACAGATGA AAACAGAGGA AGACTTATCC 
CAATTCGGAC AACAGCGGCA ATATGGACAA GAGCGCTCAC AATCCTATAA AGGATATCTT 
GAGCAATACA GAAAGAAAGT ACAAGAACAA CAACGAAAAA ATTTTAATCC CGGTAACTAT 
TTTACAAAGG GAGGAGCAGA CCTCTATCAA GCTCAGCTTA AGGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Seminal vesicle secretion 2 acts as a protectant of sperm sterols and prevents ectopic sperm capacitation in mice.
Biology of reproduction92(1)8(2015 Jan)
Araki N,Trencs?nyi G,Krasznai ZT,Nizsal?czki E,Sakamoto A,Kawano N,Miyado K,Yoshida K,Yoshida M

Seminal vesicle protein SVS2 is required for sperm survival in the uterus.
Proceedings of the National Academy of Sciences of the United States of America111(11)4145-50(2014 Mar)
Kawano N,Araki N,Yoshida K,Hibino T,Ohnami N,Makino M,Kanai S,Hasuwa H,Yoshida M,Miyado K,Umezawa A

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Ganglioside GM1 mediates decapacitation effects of SVS2 on murine spermatozoa.
Biology of reproduction79(6)1153-9(2008 Dec)
Kawano N,Yoshida K,Iwamoto T,Yoshida M

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Svs2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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