FAM3B cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	FAM3B
Entrez Gene ID	52793
Full Name	family with sequence similarity 3, member B
Synonyms	2-21,9030624C24Rik,D16Jhu19e,ORF9,Pander
General protein information	Preferred Names family with sequence similarity 3, member B Names protein FAM3B cytokine-like protein 2-21 pancreatic-derived factor
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 16 Map Location: 16 C4\|16 57.47 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_020622.3	NP_065647.1	protein FAM3B precursor
NM_020622.2	NP_065647.1	protein FAM3B precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FAM3B	XP_514906.2
Bos taurus (cattle)	FAM3B	XP_002685160.1
Mus musculus (house mouse)	Fam3b	NP_065647.1
Xenopus tropicalis (tropical clawed frog)	fam3b	NP_001015990.1
	LOC722516	XP_001118654.2
Gallus gallus (chicken)	FAM3B	XP_416736.2
Canis lupus familiaris (dog)	FAM3B	XP_535596.3
Rattus norvegicus (Norway rat)	Fam3b	NP_001100572.1
Homo sapiens (human)	FAM3B	NP_478066.3

Gene Ontology
Bibliography

Related articles in PubMed

Pancreatic-derived factor impaired glucagon-like Peptide-1 production from GLUTag enterendorine L-cell line and intestines.
Lai F, Chen Y, Lin H, Wang X, Zhu X, Li Y, Xiao H, Cao X
Molecular and cellular endocrinology452110-119(2017 Sep)

Quantitative proteomic profiling reveals hepatic lipogenesis and liver X receptor activation in the PANDER transgenic model.
Athanason MG, Ratliff WA, Chaput D, MarElia CB, Kuehl MN, Stevens SM Jr, Burkhardt BR
Molecular and cellular endocrinology43641-9(2016 Nov)

Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter.
Ratliff WA, Athanason MG, Chechele AC, Kuehl MN, Fernandez AM, MarElia CB, Burkhardt BR
Molecular and cellular endocrinology413101-12(2015 Sep)

F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression.
Mo X, Yang C, Wang X, Burkhardt BR, Li Y, Xia H, Cao X
PloS one10(2)e0117156(2015)

Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice.
Moak SL, Dougan GC, MarElia CB, Danse WA, Fernandez AM, Kuehl MN, Athanason MG, Burkhardt BR
Disease models & mechanisms7(11)1307-15(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway.
Title: Quantitative proteomic profiling reveals hepatic lipogenesis and liver X receptor activation in the PANDER transgenic model.

in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP.
Title: Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter.

F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression
Title: F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression.

X-ray crystal structure of the mouse FAM3B protein.
Title: FAM3B PANDER and FAM3C ILEI represent a distinct class of signaling molecules with a non-cytokine-like fold.

these results demonstrated that the JNK-mediated signaling mechanism of palmitic acid -induced beta-cell apoptosis involves up-regulated expression of PANDER and activation of caspase-3.
Title: Effect of PANDER in ?TC6-cell lipoapoptosis and the protective role of exendin-4.

The following FAM3B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FAM3B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu12087	NM_020622.3 Latest version!	Mus musculus family with sequence similarity 3, member B (Fam3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OMu12087	NM_020622.2	Mus musculus family with sequence similarity 3, member B (Fam3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FAM3B ( NM_020622.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_065647.1 Mus musculus family with sequence similarity 3, member B (Fam3b), mRNA.

Price & Availability↑

CloneID	OMu12087
Clone ID Related Accession (Same CDS sequence)	NM_020622.3 , NM_020622.2
Accession Version	NM_020622.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	protein FAM3B precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF360358.1 and AF494380.1. On Jan 24, 2017 this sequence version replaced NM_020622.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF494380.1, AF360358.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGTCCAG TTGCTACAGG CATCTTCAAG GCACTAGTGT TTATTTTCTC CTCCCTGTGC 
GCCTGGTATT CTGGGTACCT GCTCGCGGAG CTCATTCCTG ACGTGCCCCT GTCCAGCACT 
CTCTACAACA TCCGAAGCAT TGGAGAGAGA CCTGTTCTCA AAGCCCCAGC CCCCAAAAGA 
CAAAAATGTG ACCATTGGTC CCCATGTCCT CCTGACACCT ATGCCTACCG GCTGCTCAGT 
GGTGGTGGCC GCGACAAGTA TGCCAAGATC TGCTTTGAGG ATGAAGTGCT AATAGGAGAG 
AAGACGGGGA ATGTGGCAAG AGGGATAAAC ATTGCTGTCG TCAACTATGA GACAGGAAAA 
GTGATAGCGA CAAAGTACTT TGATATGTAT GAAGGTGATA ACTCCGGGCC AATGGCCAAG 
TTCATTCAGA GCACTCCTTC AAAATCCCTG CTGTTCATGG TGACTCATGA TGATGGAAGT 
TCCAAACTGA AGGCTCAAGC AAAGGATGCC ATAGAAGCCC TTGGAAGCAA AGAAATCAAG 
AACATGAAGT TCAGATCAAG CTGGGTGTTT GTTGCAGCAA AGGGCTTTGA GCTCCCTTCA 
GAAATCGAGA GAGAAAAAAT CAACCACTCA GATCAATCCA GGAACAGATA TGCAGGCTGG 
CCAGCGGAGA TCCAGATCGA AGGATGCATA CCCAAAGGGC TGAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065647.1
CDS	96..803
Translation	MRPVATGIFKALVFIFSSLCAWYSGYLLAELIPDVPLSSTLYNIRSIGERPVLKAPAPKRQKCDHWSPCPPDTYAYRLLSGGGRDKYAKICFEDEVLIGEKTGNVARGINIAVVNYETGKVIATKYFDMYEGDNSGPMAKFIQSTPSKSLLFMVTHDDGSSKLKAQAKDAIEALGSKEIKNMKFRSSWVFVAAKGFELPSEIEREKINHSDQSRNRYAGWPAEIQIEGCIPKGLR

Target ORF information:

RefSeq Version	NM_020622.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus family with sequence similarity 3, member B (Fam3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020622.3

ORF Insert Sequence:

ATGCGTCCAG TTGCTACAGG CATCTTCAAG GCACTAGTGT TTATTTTCTC CTCCCTGTGC 
GCCTGGTATT CTGGGTACCT GCTCGCGGAG CTCATTCCTG ACGTGCCCCT GTCCAGCACT 
CTCTACAACA TCCGAAGCAT TGGAGAGAGA CCTGTTCTCA AAGCCCCAGC CCCCAAAAGA 
CAAAAATGTG ACCATTGGTC CCCATGTCCT CCTGACACCT ATGCCTACCG GCTGCTCAGT 
GGTGGTGGCC GCGACAAGTA TGCCAAGATC TGCTTTGAGG ATGAAGTGCT AATAGGAGAG 
AAGACGGGGA ATGTGGCAAG AGGGATAAAC ATTGCTGTCG TCAACTATGA GACAGGAAAA 
GTGATAGCGA CAAAGTACTT TGATATGTAT GAAGGTGATA ACTCCGGGCC AATGGCCAAG 
TTCATTCAGA GCACTCCTTC AAAATCCCTG CTGTTCATGG TGACTCATGA TGATGGAAGT 
TCCAAACTGA AGGCTCAAGC AAAGGATGCC ATAGAAGCCC TTGGAAGCAA AGAAATCAAG 
AACATGAAGT TCAGATCAAG CTGGGTGTTT GTTGCAGCAA AGGGCTTTGA GCTCCCTTCA 
GAAATCGAGA GAGAAAAAAT CAACCACTCA GATCAATCCA GGAACAGATA TGCAGGCTGG 
CCAGCGGAGA TCCAGATCGA AGGATGCATA CCCAAAGGGC TGAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAM3B ( NM_020622.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_065647.1 Mus musculus family with sequence similarity 3, member B (Fam3b), mRNA.

Price & Availability↑

CloneID	OMu12087
Clone ID Related Accession (Same CDS sequence)	NM_020622.3 , NM_020622.2
Accession Version	NM_020622.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	protein FAM3B precursor
Comment

ATGCGTCCAG TTGCTACAGG CATCTTCAAG GCACTAGTGT TTATTTTCTC CTCCCTGTGC 
GCCTGGTATT CTGGGTACCT GCTCGCGGAG CTCATTCCTG ACGTGCCCCT GTCCAGCACT 
CTCTACAACA TCCGAAGCAT TGGAGAGAGA CCTGTTCTCA AAGCCCCAGC CCCCAAAAGA 
CAAAAATGTG ACCATTGGTC CCCATGTCCT CCTGACACCT ATGCCTACCG GCTGCTCAGT 
GGTGGTGGCC GCGACAAGTA TGCCAAGATC TGCTTTGAGG ATGAAGTGCT AATAGGAGAG 
AAGACGGGGA ATGTGGCAAG AGGGATAAAC ATTGCTGTCG TCAACTATGA GACAGGAAAA 
GTGATAGCGA CAAAGTACTT TGATATGTAT GAAGGTGATA ACTCCGGGCC AATGGCCAAG 
TTCATTCAGA GCACTCCTTC AAAATCCCTG CTGTTCATGG TGACTCATGA TGATGGAAGT 
TCCAAACTGA AGGCTCAAGC AAAGGATGCC ATAGAAGCCC TTGGAAGCAA AGAAATCAAG 
AACATGAAGT TCAGATCAAG CTGGGTGTTT GTTGCAGCAA AGGGCTTTGA GCTCCCTTCA 
GAAATCGAGA GAGAAAAAAT CAACCACTCA GATCAATCCA GGAACAGATA TGCAGGCTGG 
CCAGCGGAGA TCCAGATCGA AGGATGCATA CCCAAAGGGC TGAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065647.1
Translation	MRPVATGIFKALVFIFSSLCAWYSGYLLAELIPDVPLSSTLYNIRSIGERPVLKAPAPKRQKCDHWSPCPPDTYAYRLLSGGGRDKYAKICFEDEVLIGEKTGNVARGINIAVVNYETGKVIATKYFDMYEGDNSGPMAKFIQSTPSKSLLFMVTHDDGSSKLKAQAKDAIEALGSKEIKNMKFRSSWVFVAAKGFELPSEIEREKINHSDQSRNRYAGWPAEIQIEGCIPKGLR

Target ORF information:

RefSeq Version	NM_020622.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus family with sequence similarity 3, member B (Fam3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020622.2

ORF Insert Sequence:

ATGCGTCCAG TTGCTACAGG CATCTTCAAG GCACTAGTGT TTATTTTCTC CTCCCTGTGC 
GCCTGGTATT CTGGGTACCT GCTCGCGGAG CTCATTCCTG ACGTGCCCCT GTCCAGCACT 
CTCTACAACA TCCGAAGCAT TGGAGAGAGA CCTGTTCTCA AAGCCCCAGC CCCCAAAAGA 
CAAAAATGTG ACCATTGGTC CCCATGTCCT CCTGACACCT ATGCCTACCG GCTGCTCAGT 
GGTGGTGGCC GCGACAAGTA TGCCAAGATC TGCTTTGAGG ATGAAGTGCT AATAGGAGAG 
AAGACGGGGA ATGTGGCAAG AGGGATAAAC ATTGCTGTCG TCAACTATGA GACAGGAAAA 
GTGATAGCGA CAAAGTACTT TGATATGTAT GAAGGTGATA ACTCCGGGCC AATGGCCAAG 
TTCATTCAGA GCACTCCTTC AAAATCCCTG CTGTTCATGG TGACTCATGA TGATGGAAGT 
TCCAAACTGA AGGCTCAAGC AAAGGATGCC ATAGAAGCCC TTGGAAGCAA AGAAATCAAG 
AACATGAAGT TCAGATCAAG CTGGGTGTTT GTTGCAGCAA AGGGCTTTGA GCTCCCTTCA 
GAAATCGAGA GAGAAAAAAT CAACCACTCA GATCAATCCA GGAACAGATA TGCAGGCTGG 
CCAGCGGAGA TCCAGATCGA AGGATGCATA CCCAAAGGGC TGAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pancreatic-derived factor impaired glucagon-like Peptide-1 production from GLUTag enterendorine L-cell line and intestines.
Molecular and cellular endocrinology452110-119(2017 Sep)
Lai F,Chen Y,Lin H,Wang X,Zhu X,Li Y,Xiao H,Cao X

Quantitative proteomic profiling reveals hepatic lipogenesis and liver X receptor activation in the PANDER transgenic model.
Molecular and cellular endocrinology43641-9(2016 Nov)
Athanason MG,Ratliff WA,Chaput D,MarElia CB,Kuehl MN,Stevens SM Jr,Burkhardt BR

Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter.
Molecular and cellular endocrinology413101-12(2015 Sep)
Ratliff WA,Athanason MG,Chechele AC,Kuehl MN,Fernandez AM,MarElia CB,Burkhardt BR

F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression.
PloS one10(2)e0117156(2015)
Mo X,Yang C,Wang X,Burkhardt BR,Li Y,Xia H,Cao X

Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice.
Disease models & mechanisms7(11)1307-15(2014 Nov)
Moak SL,Dougan GC,MarElia CB,Danse WA,Fernandez AM,Kuehl MN,Athanason MG,Burkhardt BR

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FAM3B cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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