Angptl3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Angptl3
Entrez Gene ID	30924
Full Name	angiopoietin-like 3
Synonyms	hypl
General protein information	Preferred Names angiopoietin-like 3 Names angiopoietin-related protein 3 angiopoietin-like protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 C6\|4 45.6 cM
Summary	This gene encodes a member of the angiopoietin-like family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may inhibit triglyceride metabolism. Homozygous knockout mice for this gene exhibit reduced plasma lipid concentrations, including reduced plasma triglyceride concentrations, and enhanced activity of enzymes involved in triglyceride metabolism. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013913.4	NP_038941.1	angiopoietin-related protein 3 preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ANGPTL3	NP_001073814.1
Gallus gallus (chicken)	ANGPTL3	NP_001128594.1
Danio rerio (zebrafish)	angptl3	NP_571893.1
Mus musculus (house mouse)	Angptl3	NP_038941.1
Pan troglodytes (chimpanzee)	ANGPTL3	XP_001159650.1
	ANGPTL3	XP_001086114.1
Canis lupus familiaris (dog)	ANGPTL3	XP_005620276.1
Homo sapiens (human)	ANGPTL3	NP_055310.1
Rattus norvegicus (Norway rat)	Angptl3	NP_001020236.1
Xenopus tropicalis (tropical clawed frog)	LOC496885	NP_001011408.1

Gene Ontology
Bibliography

Related articles in PubMed

New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases.
Su X, Peng DQ
Lipids in health and disease17(1)12(2018 Jan)

Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.
Xu YX, Redon V, Yu H, Querbes W, Pirruccello J, Liebow A, Deik A, Trindade K, Wang X, Musunuru K, Clish CB, Cowan C, Fizgerald K, Rader D, Kathiresan S
Atherosclerosis268196-206(2018 Jan)

ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.
Xiao HB, Wang JY, Sun ZL
Experimental and molecular pathology103(3)242-248(2017 12)

Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.
Kang DY, S P N, Darvin P, Joung YH, Byun HJ, Do CH, Park KD, Park MN, Cho KH, Yang YM
Animal biotechnology28(3)189-197(2017 Jul)

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.
Haller JF, Mintah IJ, Shihanian LM, Stevis P, Buckler D, Alexa-Braun CA, Kleiner S, Banfi S, Cohen JC, Hobbs HH, Yancopoulos GD, Murphy AJ, Gusarova V, Gromada J
Journal of lipid research58(6)1166-1173(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data suggests that ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.
Title: ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.

Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b.
Title: Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.

ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3
Title: ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.

This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 at different nutritional statuses.
Title: A lipasin/Angptl8 monoclonal antibody lowers mouse serum triglycerides involving increased postprandial activity of the cardiac lipoprotein lipase.

ANGPTL3 has a role in regulating white adipose tissue energy homeostasis but not in liver
Title: Hepatic ANGPTL3 regulates adipose tissue energy homeostasis.

The following Angptl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Angptl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10151	NM_013913.4 Latest version!	Mus musculus angiopoietin-like 3 (Angptl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$272.30 $389.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Angptl3 ( NM_013913.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038941.1 Mus musculus angiopoietin-like 3 (Angptl3), mRNA.

Price & Availability↑

CloneID	OMu10151
Clone ID Related Accession (Same CDS sequence)	NM_013913.4
Accession Version	NM_013913.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1368bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-03
Organism	Mus musculus(house mouse)
Product	angiopoietin-related protein 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY137245.1, AK149450.1 and AL935325.14. On Aug 20, 2015 this sequence version replaced NM_013913.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149450.1, AK149555.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACACAA TTAAATTATT CCTTTTTGTT GTTCCTTTAG TAATTGCATC CAGAGTGGAT 
CCAGACCTTT CATCATTTGA TTCTGCACCT TCAGAGCCAA AATCAAGATT TGCTATGTTG 
GATGATGTCA AAATTTTAGC GAATGGCCTC CTGCAGCTGG GTCATGGACT TAAAGATTTT 
GTCCATAAGA CTAAGGGACA AATTAACGAC ATATTTCAGA AGCTCAACAT ATTTGATCAG 
TCTTTTTATG ACCTATCACT TCGAACCAAT GAAATCAAAG AAGAGGAAAA GGAGCTAAGA 
AGAACTACAT CTACACTACA AGTTAAAAAC GAGGAGGTGA AGAACATGTC AGTAGAACTG 
AACTCAAAGC TTGAGAGTCT GCTGGAAGAG AAGACAGCCC TTCAACACAA GGTCAGGGCT 
TTGGAGGAGC AGCTAACCAA CTTAATTCTA AGCCCAGCTG GGGCTCAGGA GCACCCAGAA 
GTAACATCAC TCAAAAGTTT TGTAGAACAG CAAGACAACA GCATAAGAGA ACTCCTCCAG 
AGTGTGGAAG AACAGTATAA ACAATTAAGT CAACAGCACA TGCAGATAAA AGAAATAGAA 
AAGCAGCTCA GAAAGACTGG TATTCAAGAA CCCTCAGAAA ATTCTCTTTC TTCTAAATCA 
AGAGCACCAA GAACTACTCC CCCTCTTCAA CTGAACGAAA CAGAAAATAC AGAACAAGAT 
GACCTTCCTG CCGACTGCTC TGCCGTTTAT AACAGAGGCG AACATACAAG TGGCGTGTAC 
ACTATTAAAC CAAGAAACTC CCAAGGGTTT AATGTCTACT GTGATACCCA ATCAGGCAGT 
CCATGGACAT TAATTCAACA CCGGAAAGAT GGCTCACAGG ACTTCAACGA AACATGGGAA 
AACTACGAAA AGGGCTTTGG GAGGCTCGAT GGAGAATTTT GGTTGGGCCT AGAGAAGATC 
TATGCTATAG TCCAACAGTC TAACTACATT TTACGACTCG AGCTACAAGA CTGGAAAGAC 
AGCAAGCACT ACGTTGAATA CTCCTTTCAC CTGGGCAGTC ACGAAACCAA CTACACGCTA 
CATGTGGCTG AGATTGCTGG CAATATCCCT GGGGCCCTCC CAGAGCACAC AGACCTGATG 
TTTTCTACAT GGAATCACAG AGCAAAGGGA CAGCTCTACT GTCCAGAAAG TTACTCAGGT 
GGCTGGTGGT GGAATGACAT ATGTGGAGAA AACAACCTAA ATGGAAAATA CAACAAACCC 
AGAACCAAAT CCAGACCAGA GAGAAGAAGA GGGATCTACT GGAGACCTCA GAGCAGAAAG 
CTCTATGCTA TCAAATCATC CAAAATGATG CTCCAGCCCA CCACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038941.1
CDS	52..1419
Translation	MHTIKLFLFVVPLVIASRVDPDLSSFDSAPSEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLRTNEIKEEEKELRRTTSTLQVKNEEVKNMSVELNSKLESLLEEKTALQHKVRALEEQLTNLILSPAGAQEHPEVTSLKSFVEQQDNSIRELLQSVEEQYKQLSQQHMQIKEIEKQLRKTGIQEPSENSLSSKSRAPRTTPPLQLNETENTEQDDLPADCSAVYNRGEHTSGVYTIKPRNSQGFNVYCDTQSGSPWTLIQHRKDGSQDFNETWENYEKGFGRLDGEFWLGLEKIYAIVQQSNYILRLELQDWKDSKHYVEYSFHLGSHETNYTLHVAEIAGNIPGALPEHTDLMFSTWNHRAKGQLYCPESYSGGWWWNDICGENNLNGKYNKPRTKSRPERRRGIYWRPQSRKLYAIKSSKMMLQPTT

Target ORF information:

RefSeq Version	NM_013913.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus angiopoietin-like 3 (Angptl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013913.4

ORF Insert Sequence:

ATGCACACAA TTAAATTATT CCTTTTTGTT GTTCCTTTAG TAATTGCATC CAGAGTGGAT 
CCAGACCTTT CATCATTTGA TTCTGCACCT TCAGAGCCAA AATCAAGATT TGCTATGTTG 
GATGATGTCA AAATTTTAGC GAATGGCCTC CTGCAGCTGG GTCATGGACT TAAAGATTTT 
GTCCATAAGA CTAAGGGACA AATTAACGAC ATATTTCAGA AGCTCAACAT ATTTGATCAG 
TCTTTTTATG ACCTATCACT TCGAACCAAT GAAATCAAAG AAGAGGAAAA GGAGCTAAGA 
AGAACTACAT CTACACTACA AGTTAAAAAC GAGGAGGTGA AGAACATGTC AGTAGAACTG 
AACTCAAAGC TTGAGAGTCT GCTGGAAGAG AAGACAGCCC TTCAACACAA GGTCAGGGCT 
TTGGAGGAGC AGCTAACCAA CTTAATTCTA AGCCCAGCTG GGGCTCAGGA GCACCCAGAA 
GTAACATCAC TCAAAAGTTT TGTAGAACAG CAAGACAACA GCATAAGAGA ACTCCTCCAG 
AGTGTGGAAG AACAGTATAA ACAATTAAGT CAACAGCACA TGCAGATAAA AGAAATAGAA 
AAGCAGCTCA GAAAGACTGG TATTCAAGAA CCCTCAGAAA ATTCTCTTTC TTCTAAATCA 
AGAGCACCAA GAACTACTCC CCCTCTTCAA CTGAACGAAA CAGAAAATAC AGAACAAGAT 
GACCTTCCTG CCGACTGCTC TGCCGTTTAT AACAGAGGCG AACATACAAG TGGCGTGTAC 
ACTATTAAAC CAAGAAACTC CCAAGGGTTT AATGTCTACT GTGATACCCA ATCAGGCAGT 
CCATGGACAT TAATTCAACA CCGGAAAGAT GGCTCACAGG ACTTCAACGA AACATGGGAA 
AACTACGAAA AGGGCTTTGG GAGGCTCGAT GGAGAATTTT GGTTGGGCCT AGAGAAGATC 
TATGCTATAG TCCAACAGTC TAACTACATT TTACGACTCG AGCTACAAGA CTGGAAAGAC 
AGCAAGCACT ACGTTGAATA CTCCTTTCAC CTGGGCAGTC ACGAAACCAA CTACACGCTA 
CATGTGGCTG AGATTGCTGG CAATATCCCT GGGGCCCTCC CAGAGCACAC AGACCTGATG 
TTTTCTACAT GGAATCACAG AGCAAAGGGA CAGCTCTACT GTCCAGAAAG TTACTCAGGT 
GGCTGGTGGT GGAATGACAT ATGTGGAGAA AACAACCTAA ATGGAAAATA CAACAAACCC 
AGAACCAAAT CCAGACCAGA GAGAAGAAGA GGGATCTACT GGAGACCTCA GAGCAGAAAG 
CTCTATGCTA TCAAATCATC CAAAATGATG CTCCAGCCCA CCACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New insights into ANGPLT3 in controlling lipoprotein metabolism and risk of cardiovascular diseases.
Lipids in health and disease17(1)12(2018 Jan)
Su X,Peng DQ

Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.
Atherosclerosis268196-206(2018 Jan)
Xu YX,Redon V,Yu H,Querbes W,Pirruccello J,Liebow A,Deik A,Trindade K,Wang X,Musunuru K,Clish CB,Cowan C,Fizgerald K,Rader D,Kathiresan S

ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice.
Experimental and molecular pathology103(3)242-248(2017 12)
Xiao HB,Wang JY,Sun ZL

Momilactone B Inhibits Ketosis In Vitro by Regulating the ANGPTL3-LPL Pathway and Inhibiting HMGCS2.
Animal biotechnology28(3)189-197(2017 Jul)
Kang DY,S P N,Darvin P,Joung YH,Byun HJ,Do CH,Park KD,Park MN,Cho KH,Yang YM

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.
Journal of lipid research58(6)1166-1173(2017 Jun)
Haller JF,Mintah IJ,Shihanian LM,Stevis P,Buckler D,Alexa-Braun CA,Kleiner S,Banfi S,Cohen JC,Hobbs HH,Yancopoulos GD,Murphy AJ,Gusarova V,Gromada J

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Angptl3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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