Dclk3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dclk3
Entrez Gene ID	245038
Full Name	doublecortin-like kinase 3
Synonyms	BC056929,C730036H08,Dcamkl3
General protein information	Preferred Names doublecortin-like kinase 3 Names serine/threonine-protein kinase DCLK3 CLICK-I and II-related CLr Click-I, -II related doublecortin and CaM kinase-like 3 doublecortin-like and CAM kinase-like 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 F3
Summary	This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_172928.5	NP_766516.2	serine/threonine-protein kinase DCLK3

Pathways from BioSystems

Homologies

Homo sapiens (human)	DCLK3	NP_208382.1
Pan troglodytes (chimpanzee)	DCLK3	XP_003309741.1
Canis lupus familiaris (dog)	DCLK3	XP_542700.3
Mus musculus (house mouse)	Dclk3	NP_766516.2
Bos taurus (cattle)	DCLK3	XP_003587668.2
Rattus norvegicus (Norway rat)	Dclk3	NP_001178729.1
Gallus gallus (chicken)	DCLK3	XP_001236017.3
Caenorhabditis elegans (roundworm)	F32D8.1	NP_505770.3
	DCLK3	XP_001088118.2

Gene Ontology
Bibliography

Related articles in PubMed

DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.
Molyneaux BJ, Goff LA, Brettler AC, Chen HH, Hrvatin S, Rinn JL, Arlotta P
Neuron85(2)275-288(2015 Jan)

The doublecortin gene family and disorders of neuronal structure.
Dijkmans TF, van Hooijdonk LW, Fitzsimons CP, Vreugdenhil E
Central nervous system agents in medicinal chemistry10(1)32-46(2010 Mar)

The evolving doublecortin (DCX) superfamily.
Reiner O, Coquelle FM, Peter B, Levy T, Kaplan A, Sapir T, Orr I, Barkai N, Eichele G, Bergmann S
BMC genomics7188(2006 Jul)

Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.
Ohmae S, Takemoto-Kimura S, Okamura M, Adachi-Morishima A, Nonaka M, Fuse T, Kida S, Tanji M, Furuyashiki T, Arakawa Y, Narumiya S, Okuno H, Bito H
The Journal of biological chemistry281(29)20427-39(2006 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dclk3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dclk3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04316	NM_172928.5 Latest version!	Mus musculus doublecortin-like kinase 3 (Dclk3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dclk3 ( NM_172928.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766516.2 Mus musculus doublecortin-like kinase 3 (Dclk3), mRNA.

Price & Availability↑

CloneID	OMu04316
Clone ID Related Accession (Same CDS sequence)	NM_172928.5
Accession Version	NM_172928.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2373bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase DCLK3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BB617821.1, DQ286388.1 and AV341123.2. On Jun 2, 2009 this sequence version replaced NM_172928.4. CCDS Note: The coding region has been updated to extend the N-terminus to one that is supported by available conservation data. This would result in a protein that is 171 aa longer at the N-terminal. ##Evidence-Data-START## Transcript exon combination :: AK135010.1, DQ286388.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCAGCCG CGCCGGTCCT GCGCCCGCCG CCGCCGCCAG CGACCCCCGC CCCGCCGGCA 
CCCAGTCGCC CTGCGCCTCC CATTCCGGGC CACCGAGGCC CATGTGACCA TTCTCTGAAA 
TGCTTAAGCT CGAAGATCTC TGAGAGAAAG CTGCCAGGCC CCTGGTTACC TGCGGGACGA 
GGACCTCTGG AGAAGCCAGT TCTGGGGCCA CGTGGTGCCG TCATGCCGCT GTTCAGCCCT 
CAGAGCAGCC TCCACTCAGT CCGCGCAGAG CACAGCCCAC TGAAGCCCAG GGTGGTGACG 
GTGGTGAAGC TGGGTGGGCA GCCCCTCCGT AAGGCCACCC TGCTCCTCAA CCGGCGCTCA 
GTGCAGACCT TTGAGCAGCT CCTATCAGAC ATCTCCGAAG CCTTGGGCTT CCCACGCTGG 
AAGAACGACC GTGTGCGGAA GCTGTTCACC CTCAAGGGCA GGGAGGTGAA GAGTGTGTCT 
GACTTCTTCC GGGAGGGTGA TGCTTTCATA GCTATGGGCA AAGAGCCGCT GACATTGAAG 
AGTATCCAGT TGGCCATGGA GGAGCTGTAT CCTAAGAACC GGGCTCTTGC CCTGGCCCCT 
CACAGTAGAG TCCCCTCCCC AAGGCTGAGA AGCAGACTTC CCAGCAAGCT TCTGAAAGGA 
AGTCACCGCT GTGGGGAGGC AGGAAGCTAT AGCGCGGAAA TGGAGAGTAA GGCAGTCTCT 
AGGCATCAGG GCAAGACTTC CACAGTGCTG GCCCCAGAAG ACAAGGCGAG GGCCCAGAAG 
TGGGTAAGAG GGAAACAGGA GTCAGAACCT GGTGGCCCGC CTTCACCCGG GGCAGCCACT 
CAGGAGGAGA CTCATGCAAG TGGAGAGAAA CATCTGGGGG TGGAGATCGA AAAGACCTCC 
GGGGAGATTG TCAGATGTGA GAAGTGTAAG AGAGAAAGAG AGCTGCAGTT GGGCCTGCAG 
AGGGAGCCGT GCCCGCTGGG AACCAGTGAG CTGGACCTGG GGAGAGCTCA GAAGAGGGAT 
TCCGAGAAGT TGGTGAGGAC CAAGAGCTGC AGGAGGCCTT CTGAGGCAAA ATCTACAGAT 
GGAGAGGAAG GGTGGAAGGG TGACAGCCAT CGGGGCAGTC CCAGGGACCC CCCTCAGGAA 
CTGAGGAGGC CCAACAGCAA CTCAGACAAG AAAGAGATCA GAGGCTCAGA AAGTCAGGAC 
AGTCATCCTC AGGGGGCACC CAAGGCCCAG AAGGACCTCG TGGAAGGGCC ACCAGCTGTA 
GAGGAGGGGC CGATAGACAT GAGGAGAGAG GACCGGCACA CATGCAGGAG CAAGCATGCC 
GCCTGGCTCC GGAGAGAGCA GCAGGCCGAA CCCCCACAGC TCCCCAGAAC CCGAGGGGAG 
GAGAAGCAAG CAGAGCACGA GAAGAAGCCA GGCGGCTTAG GAGAGAGGAG GGCGCCAGAG 
AAGGAGTCTA AGAGGAAGCT AGAAGAGAAG AGGCCAGAAC GACCCAGTGG CCGGAAGCCG 
AGGCCCAAGG GCATCATCTC AGCGGATGTG GAGAAGCACT ATGACATAGG TGGGGTCATT 
GGGGATGGCA ACTTTGCCAC CGTGAAGGAA TGCAGGCACC GAGAGACCAA GCAGGCTTAC 
GCCATGAAGA TGATTGACAA GTCCCAGCTG AAGGGTAAGG AGGACATTGT CGACAGTGAG 
ATTTTAATCA TCCAGAGTCT CTCTCATCCC AACATTGTGA AACTGCACGA GGTCTACGAG 
ACGGAGGCGG AGATCTACCT GATCATGGAG TATGTGCAGG GAGGGGACCT TTTTGATGCC 
ATCGTTGAAA ATGTGAAGTT TCCAGAGCCC GAGGCTGCAG TTATGATCAC AGACTTGTGT 
AAGGCCCTCG TCCACATGCA CGACAAGAAT ATCGTCCACC GGGACGTGAA ACCAGAAAAC 
CTCCTGGTTC AGCGAAATGA AGACAAGTCT ATCACCTTGA AGCTGGCTGA TTTTGGCTTG 
GCCAAATATG TGGTGAGGCC TATATTTACT GTGTGTGGGA CGCCAACATA TGTAGCTCCT 
GAAATTCTTT CTGAGAAAGG TTACGGCCTG GAGGTGGACA TGTGGGCGGC AGGTGTGATC 
CTATACATCC TCTTGTGTGG CTTCCCCCCT TTCCGAAGTC CTGAGAGGGA CCAAGACGAG 
CTCTTCAACA TCATCCAAGT GGGCCAGTTT GAGTTCCTCT CTCCTTACTG GGACAACATT 
TCTGATGCTG CCAAAGATCT GGTGAGAAAT TTGCTGGAGG TGGACCCTAA GAAGCGGTAC 
ACGGCCGAAC AGGTCCTACA GCATCCCTGG ATTGAGATGG TTGGGCATAC CAACACAGGG 
AACTCACAGA AGGAGGAGTC CCCCAACAGT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766516.2
CDS	185..2557
Translation	MPAAPVLRPPPPPATPAPPAPSRPAPPIPGHRGPCDHSLKCLSSKISERKLPGPWLPAGRGPLEKPVLGPRGAVMPLFSPQSSLHSVRAEHSPLKPRVVTVVKLGGQPLRKATLLLNRRSVQTFEQLLSDISEALGFPRWKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMGKEPLTLKSIQLAMEELYPKNRALALAPHSRVPSPRLRSRLPSKLLKGSHRCGEAGSYSAEMESKAVSRHQGKTSTVLAPEDKARAQKWVRGKQESEPGGPPSPGAATQEETHASGEKHLGVEIEKTSGEIVRCEKCKRERELQLGLQREPCPLGTSELDLGRAQKRDSEKLVRTKSCRRPSEAKSTDGEEGWKGDSHRGSPRDPPQELRRPNSNSDKKEIRGSESQDSHPQGAPKAQKDLVEGPPAVEEGPIDMRREDRHTCRSKHAAWLRREQQAEPPQLPRTRGEEKQAEHEKKPGGLGERRAPEKESKRKLEEKRPERPSGRKPRPKGIISADVEKHYDIGGVIGDGNFATVKECRHRETKQAYAMKMIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLVQRNEDKSITLKLADFGLAKYVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRYTAEQVLQHPWIEMVGHTNTGNSQKEESPNS

Target ORF information:

RefSeq Version	NM_172928.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus doublecortin-like kinase 3 (Dclk3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172928.5

ORF Insert Sequence:

ATGCCAGCCG CGCCGGTCCT GCGCCCGCCG CCGCCGCCAG CGACCCCCGC CCCGCCGGCA 
CCCAGTCGCC CTGCGCCTCC CATTCCGGGC CACCGAGGCC CATGTGACCA TTCTCTGAAA 
TGCTTAAGCT CGAAGATCTC TGAGAGAAAG CTGCCAGGCC CCTGGTTACC TGCGGGACGA 
GGACCTCTGG AGAAGCCAGT TCTGGGGCCA CGTGGTGCCG TCATGCCGCT GTTCAGCCCT 
CAGAGCAGCC TCCACTCAGT CCGCGCAGAG CACAGCCCAC TGAAGCCCAG GGTGGTGACG 
GTGGTGAAGC TGGGTGGGCA GCCCCTCCGT AAGGCCACCC TGCTCCTCAA CCGGCGCTCA 
GTGCAGACCT TTGAGCAGCT CCTATCAGAC ATCTCCGAAG CCTTGGGCTT CCCACGCTGG 
AAGAACGACC GTGTGCGGAA GCTGTTCACC CTCAAGGGCA GGGAGGTGAA GAGTGTGTCT 
GACTTCTTCC GGGAGGGTGA TGCTTTCATA GCTATGGGCA AAGAGCCGCT GACATTGAAG 
AGTATCCAGT TGGCCATGGA GGAGCTGTAT CCTAAGAACC GGGCTCTTGC CCTGGCCCCT 
CACAGTAGAG TCCCCTCCCC AAGGCTGAGA AGCAGACTTC CCAGCAAGCT TCTGAAAGGA 
AGTCACCGCT GTGGGGAGGC AGGAAGCTAT AGCGCGGAAA TGGAGAGTAA GGCAGTCTCT 
AGGCATCAGG GCAAGACTTC CACAGTGCTG GCCCCAGAAG ACAAGGCGAG GGCCCAGAAG 
TGGGTAAGAG GGAAACAGGA GTCAGAACCT GGTGGCCCGC CTTCACCCGG GGCAGCCACT 
CAGGAGGAGA CTCATGCAAG TGGAGAGAAA CATCTGGGGG TGGAGATCGA AAAGACCTCC 
GGGGAGATTG TCAGATGTGA GAAGTGTAAG AGAGAAAGAG AGCTGCAGTT GGGCCTGCAG 
AGGGAGCCGT GCCCGCTGGG AACCAGTGAG CTGGACCTGG GGAGAGCTCA GAAGAGGGAT 
TCCGAGAAGT TGGTGAGGAC CAAGAGCTGC AGGAGGCCTT CTGAGGCAAA ATCTACAGAT 
GGAGAGGAAG GGTGGAAGGG TGACAGCCAT CGGGGCAGTC CCAGGGACCC CCCTCAGGAA 
CTGAGGAGGC CCAACAGCAA CTCAGACAAG AAAGAGATCA GAGGCTCAGA AAGTCAGGAC 
AGTCATCCTC AGGGGGCACC CAAGGCCCAG AAGGACCTCG TGGAAGGGCC ACCAGCTGTA 
GAGGAGGGGC CGATAGACAT GAGGAGAGAG GACCGGCACA CATGCAGGAG CAAGCATGCC 
GCCTGGCTCC GGAGAGAGCA GCAGGCCGAA CCCCCACAGC TCCCCAGAAC CCGAGGGGAG 
GAGAAGCAAG CAGAGCACGA GAAGAAGCCA GGCGGCTTAG GAGAGAGGAG GGCGCCAGAG 
AAGGAGTCTA AGAGGAAGCT AGAAGAGAAG AGGCCAGAAC GACCCAGTGG CCGGAAGCCG 
AGGCCCAAGG GCATCATCTC AGCGGATGTG GAGAAGCACT ATGACATAGG TGGGGTCATT 
GGGGATGGCA ACTTTGCCAC CGTGAAGGAA TGCAGGCACC GAGAGACCAA GCAGGCTTAC 
GCCATGAAGA TGATTGACAA GTCCCAGCTG AAGGGTAAGG AGGACATTGT CGACAGTGAG 
ATTTTAATCA TCCAGAGTCT CTCTCATCCC AACATTGTGA AACTGCACGA GGTCTACGAG 
ACGGAGGCGG AGATCTACCT GATCATGGAG TATGTGCAGG GAGGGGACCT TTTTGATGCC 
ATCGTTGAAA ATGTGAAGTT TCCAGAGCCC GAGGCTGCAG TTATGATCAC AGACTTGTGT 
AAGGCCCTCG TCCACATGCA CGACAAGAAT ATCGTCCACC GGGACGTGAA ACCAGAAAAC 
CTCCTGGTTC AGCGAAATGA AGACAAGTCT ATCACCTTGA AGCTGGCTGA TTTTGGCTTG 
GCCAAATATG TGGTGAGGCC TATATTTACT GTGTGTGGGA CGCCAACATA TGTAGCTCCT 
GAAATTCTTT CTGAGAAAGG TTACGGCCTG GAGGTGGACA TGTGGGCGGC AGGTGTGATC 
CTATACATCC TCTTGTGTGG CTTCCCCCCT TTCCGAAGTC CTGAGAGGGA CCAAGACGAG 
CTCTTCAACA TCATCCAAGT GGGCCAGTTT GAGTTCCTCT CTCCTTACTG GGACAACATT 
TCTGATGCTG CCAAAGATCT GGTGAGAAAT TTGCTGGAGG TGGACCCTAA GAAGCGGTAC 
ACGGCCGAAC AGGTCCTACA GCATCCCTGG ATTGAGATGG TTGGGCATAC CAACACAGGG 
AACTCACAGA AGGAGGAGTC CCCCAACAGT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.
Neuron85(2)275-288(2015 Jan)
Molyneaux BJ,Goff LA,Brettler AC,Chen HH,Hrvatin S,Rinn JL,Arlotta P

The doublecortin gene family and disorders of neuronal structure.
Central nervous system agents in medicinal chemistry10(1)32-46(2010 Mar)
Dijkmans TF,van Hooijdonk LW,Fitzsimons CP,Vreugdenhil E

The evolving doublecortin (DCX) superfamily.
BMC genomics7188(2006 Jul)
Reiner O,Coquelle FM,Peter B,Levy T,Kaplan A,Sapir T,Orr I,Barkai N,Eichele G,Bergmann S

Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV.
The Journal of biological chemistry281(29)20427-39(2006 Jul)
Ohmae S,Takemoto-Kimura S,Okamura M,Adachi-Morishima A,Nonaka M,Fuse T,Kida S,Tanji M,Furuyashiki T,Arakawa Y,Narumiya S,Okuno H,Bito H

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Dclk3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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