Mex3c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mex3c
Entrez Gene ID	240396
Full Name	mex3 RNA binding family member C
Synonyms	A130001D14Rik,BC035207,BM-013,Rkhd2
General protein information	Preferred Names mex3 RNA binding family member C Names RNA-binding E3 ubiquitin-protein ligase MEX3C MEX3C variant 1 MEX3C variant 10 MEX3C variant 11 MEX3C variant 2 MEX3C variant 3 MEX3C variant 4 MEX3C variant 5 MEX3C variant 6 MEX3C variant 9 RING finger and KH domain-containing protein 2 RING-type E3 ubiquitin transferase MEX3C RNA-binding protein MEX3C mex3 homolog C ring finger and KH domain containing 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 E2

mRNA and Protein(s)

mRNA	Protein	Name
XM_011246932.3	XP_011245234.1	RNA-binding E3 ubiquitin-protein ligase MEX3C isoform X1
NM_001039214.4	NP_001034303.3	RNA-binding E3 ubiquitin-protein ligase MEX3C
XM_011246932.2	XP_011245234.1	RNA-binding E3 ubiquitin-protein ligase MEX3C isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	MEX3C	NP_057710.3
Canis lupus familiaris (dog)	MEX3C	XP_005615738.1
Mus musculus (house mouse)	Mex3c	NP_001034303.3
Xenopus tropicalis (tropical clawed frog)	mex3c	NP_001017067.1
Bos taurus (cattle)	MEX3C	XP_002697870.3
Rattus norvegicus (Norway rat)	Mex3c	NP_001100847.1
Pan troglodytes (chimpanzee)	MEX3C	XP_001155789.1
	MEX3C	XP_001096989.2

Gene Ontology
Bibliography

Related articles in PubMed

MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting.
Lu P, Li H, Li N, Singh RN, Bishop CE, Chen X, Lu B
PloS one12(10)e0185992(2017)

Oocyte-Specific Expression of Mouse MEX3C652AA in the Ovary and Its Potential Role in Regulating Maternal Fos mRNA.
Li X, Li Y, Liu C, Jin M, Lu B
Biology of reproduction94(5)115(2016 05)

Mex3c mutation reduces adiposity partially through increasing physical activity.
Han C, Jiao Y, Zhao Q, Lu B
The Journal of endocrinology221(3)457-68(2014 Jun)

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, Iwasaki H, Akira S, Kawai T
Proceedings of the National Academy of Sciences of the United States of America111(15)5646-51(2014 Apr)

Mex3c mutation reduces adiposity and increases energy expenditure.
Jiao Y, George SK, Zhao Q, Hulver MW, Hutson SM, Bishop CE, Lu B
Molecular and cellular biology32(21)4350-62(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MEX3C associates with the endolysosomal compartment through an endocytosis-like process. siRNA-mediated inhibition of the MEX3C or AP-2 complex substantially decreased exosomal but not cellular microRNA miR-451a expression
Title: MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting.

The specific expression of this long MEX3C isoform in oocytes and its ability to enhance FOS mRNA nuclear export and stability all suggest that MEX3C(659AA) is an RNA-binding protein that preserves maternal FOS mRNA in oocytes.
Title: Oocyte-Specific Expression of Mouse MEX3C652AA in the Ovary and Its Potential Role in Regulating Maternal Fos mRNA.

Data indicate that Mex3c mutation significantly increases physical activity.
Title: Mex3c mutation reduces adiposity partially through increasing physical activity.

MEX3C is required for cytokine production after infection with RNA viruses that are detected by RIG-I.
Title: Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.

Mex3c mutation caused leanness in both heterozygous and homozygous transgenic mice, as well as a more beneficial blood glucose and lipid profile in homozygous transgenic mice, in both sexes; data show Mex3c is involved in energy balance regulation
Title: Mex3c mutation reduces adiposity and increases energy expenditure.

The following Mex3c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mex3c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu74002	XM_011246932.3 Latest version!	Mus musculus mex3 RNA binding family member C (Mex3c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu00546	NM_001039214.4 Latest version!	Mus musculus mex3 RNA binding family member C (Mex3c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OMu74002	XM_011246932.2	Mus musculus mex3 RNA binding family member C (Mex3c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mex3c ( XM_011246932.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011245234.1 Mus musculus mex3 RNA binding family member C (Mex3c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu74002
Clone ID Related Accession (Same CDS sequence)	XM_011246932.3 , XM_011246932.2
Accession Version	XM_011246932.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	RNA-binding E3 ubiquitin-protein ligase MEX3C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011246932.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAAGCG GCAGCTCCGC GGCCCTGGCC CTGGCCCTGG CGGCGGCCCC GGCCCCCCTG 
CCGCAGCCGC CTCCGCTGCC GCCGCCGCCG CCCGCGGGAG GCCCAGAGCT CGAAGGGGAC 
GGGCTGCTGC TGAGGGAGCG CCTGGCCGCG CTAGGCCTCG ACGACCCCAG CCCGGCGGAG 
CCCGGCGCCC CGGCGCTCAG GGCCGCGGCG GTGGCGGCGG CGGCGGCGGC GCAGTGCCAG 
GCCCGGCGGG CGACCGGGCT GGCTCCGGAG GAGCCTGGCC GCCTCGCGAC CTCCGAGACG 
GCGGAGCTGG AGCTGGAGGT GGACGAAGAG GAGGGGGAGG AAGCGGAGCT GGACGGAGAA 
CTGCTGGAGG AGGAGGAGCT GGAGGAGGCA GAGGAGGAGG ACCGGCCGTC GCTGCTGCTG 
TTGTCGCCGC CCGCGGCCAC CGCCTCCCAG ACTCAGCCGA TCCCGGGCGG GCCCCTGGGG 
TCGGTGCTGC TGCCGGCCGC GGGCTTCGAT GCCCGGGAGG CCGCGGCGGC AGGGGTGCTG 
TACGGAGGGG ACGATGCCCA GGGCATGATG GCGGCGATGC TGTCCCACGC CTACGGCCCC 
GGCGGCGGCG GGGCCGCCGC TGCCGCCCTG AACGGAGAGC AAGCGGCCCT GCTGAGAAGG 
AAGAGCGTCA ACACCACCGA GTGCGTCCCC GTGCCCAGTT CCGAGCATGT CGCTGAGATT 
GTCGGACGCC AGGGTGCCTG CAGAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011245234.1
CDS	408..1157
Translation	MPSGSSAALALALAAAPAPLPQPPPLPPPPPAGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAAAVAAAAAAQCQARRATGLAPEEPGRLATSETAELELEVDEEEGEEAELDGELLEEEELEEAEEEDRPSLLLLSPPAATASQTQPIPGGPLGSVLLPAAGFDAREAAAAGVLYGGDDAQGMMAAMLSHAYGPGGGGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGACRD

Target ORF information:

RefSeq Version	XM_011246932.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mex3 RNA binding family member C (Mex3c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011246932.3

ORF Insert Sequence:

ATGCCAAGCG GCAGCTCCGC GGCCCTGGCC CTGGCCCTGG CGGCGGCCCC GGCCCCCCTG 
CCGCAGCCGC CTCCGCTGCC GCCGCCGCCG CCCGCGGGAG GCCCAGAGCT CGAAGGGGAC 
GGGCTGCTGC TGAGGGAGCG CCTGGCCGCG CTAGGCCTCG ACGACCCCAG CCCGGCGGAG 
CCCGGCGCCC CGGCGCTCAG GGCCGCGGCG GTGGCGGCGG CGGCGGCGGC GCAGTGCCAG 
GCCCGGCGGG CGACCGGGCT GGCTCCGGAG GAGCCTGGCC GCCTCGCGAC CTCCGAGACG 
GCGGAGCTGG AGCTGGAGGT GGACGAAGAG GAGGGGGAGG AAGCGGAGCT GGACGGAGAA 
CTGCTGGAGG AGGAGGAGCT GGAGGAGGCA GAGGAGGAGG ACCGGCCGTC GCTGCTGCTG 
TTGTCGCCGC CCGCGGCCAC CGCCTCCCAG ACTCAGCCGA TCCCGGGCGG GCCCCTGGGG 
TCGGTGCTGC TGCCGGCCGC GGGCTTCGAT GCCCGGGAGG CCGCGGCGGC AGGGGTGCTG 
TACGGAGGGG ACGATGCCCA GGGCATGATG GCGGCGATGC TGTCCCACGC CTACGGCCCC 
GGCGGCGGCG GGGCCGCCGC TGCCGCCCTG AACGGAGAGC AAGCGGCCCT GCTGAGAAGG 
AAGAGCGTCA ACACCACCGA GTGCGTCCCC GTGCCCAGTT CCGAGCATGT CGCTGAGATT 
GTCGGACGCC AGGGTGCCTG CAGAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mex3c ( NM_001039214.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001034303.3 Mus musculus mex3 RNA binding family member C (Mex3c), mRNA.

Price & Availability↑

CloneID	OMu00546
Clone ID Related Accession (Same CDS sequence)	NM_001039214.4
Accession Version	NM_001039214.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1959bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Mus musculus(house mouse)
Product	RNA-binding E3 ubiquitin-protein ligase MEX3C
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ071688.1, BB618103.1, CJ067036.1, BC125427.1, BC108422.1 and BY595095.1. On Oct 19, 2007 this sequence version replaced NM_001039214.3. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.147669.1, BC035207.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCAAGCG GCAGCTCCGC GGCCCTGGCC CTGGCCCTGG CGGCGGCCCC GGCCCCCCTG 
CCGCAGCCGC CTCCGCTGCC GCCGCCGCCG CCCGCGGGAG GCCCAGAGCT CGAAGGGGAC 
GGGCTGCTGC TGAGGGAGCG CCTGGCCGCG CTAGGCCTCG ACGACCCCAG CCCGGCGGAG 
CCCGGCGCCC CGGCGCTCAG GGCCGCGGCG GTGGCGGCGG CGGCGGCGGC GCAGTGCCAG 
GCCCGGCGGG CGACCGGGCT GGCTCCGGAG GAGCCTGGCC GCCTCGCGAC CTCCGAGACG 
GCGGAGCTGG AGCTGGAGGT GGACGAAGAG GAGGGGGAGG AAGCGGAGCT GGACGGAGAA 
CTGCTGGAGG AGGAGGAGCT GGAGGAGGCA GAGGAGGAGG ACCGGCCGTC GCTGCTGCTG 
TTGTCGCCGC CCGCGGCCAC CGCCTCCCAG ACTCAGCCGA TCCCGGGCGG GCCCCTGGGG 
TCGGTGCTGC TGCCGGCCGC GGGCTTCGAT GCCCGGGAGG CCGCGGCGGC AGGGGTGCTG 
TACGGAGGGG ACGATGCCCA GGGCATGATG GCGGCGATGC TGTCCCACGC CTACGGCCCC 
GGCGGCGGCG GGGCCGCCGC TGCCGCCCTG AACGGAGAGC AAGCGGCCCT GCTGAGAAGG 
AAGAGCGTCA ACACCACCGA GTGCGTCCCC GTGCCCAGTT CCGAGCATGT CGCTGAGATT 
GTCGGACGCC AGGGTTGTAA AATTAAAGCA CTGAGAGCCA AGACAAACAC GTATATCAAG 
ACACCTGTTC GTGGTGAAGA ACCCATTTTT GTTGTCACTG GACGGAAAGA AGATGTTGCC 
ATGGCCAAAA GAGAAATCCT CTCGGCTGCA GAGCACTTTT CTATGATTCG TGCATCTCGA 
AACAAAAATG GTCCTGCACT AGGAGGGTTA TCGTGTAGTC CTAATCTGCC TGGTCAAACC 
ACAGTCCAAG TCAGGGTCCC CTATCGTGTG GTAGGGCTAG TGGTTGGACC AAAAGGAGCA 
ACAATTAAGA GAATTCAGCA ACAGACCCAC ACGTACATAG TTACTCCGAG CAGAGATAAG 
GAGCCAGTCT TTGAAGTCAC AGGGATGCCC GAAAATGTTG ATCGAGCACG AGAAGAGATA 
GAAATGCATA TCGCCATGCG TACCGGAAAC TACATAGAGC TCAATGAAGA AAATGATTTC 
CATTATAACG GTACCGATGT GAGCTTTGAA GGTGGCACTC TTGGCTCTGC ATGGCTCTCT 
TCCAATCCAG TTCCTCCAAG CCGAGCAAGA ATGATGTCTA ACTATCGCAA TGATAGTTCT 
AGCTCTCTAG GAAGTGGCTC CACTGATTCC TATTTTGGGA GCAATAGGCT AGCTGACTTT 
AGTCCAACAA GCCCATTTAG CACAGGGAAC TTTTGGTTTG GAGATACACT ACCATCTGTA 
GGCTCAGAAG ATCTTACAGT AGACTCTCCT GCCTTTGACT CTTTACCAAC ATCTGCTCAA 
ACTATCTGGA CTCCATTTGA ACCAGTTAAC CCACTCTCTG GCTTTGGGAG TGATCCTTCT 
GGTAACATGA AGACTCAGCG TAGAGGAAGT CAGCCATCAA CTCCTCGTCT GTCTCCTACA 
TTTCCTGAGA GCATAGAACA CCCACTTGCT CGAAGGGTGA GGAGTGACCC ACCTAGTACA 
GGCAACCATG TTGGCCTTCC AATATACATC CCTGCTTTTT CTAATGGTAC CAATAGTTAC 
TCCTCTTCCA ATGGTGGTTC CACCTCTAGC TCACCTCCAG AATCAAGAAG AAAGCACGAC 
TGTGTGATTT GCTTTGAGAA TGAAGTTATT GCTGCCCTAG TTCCATGTGG CCACAACCTC 
TTCTGCATGG AATGTGCCAA CAAGATCTGT GAAAAGAGAA CGCCGTCATG TCCAGTTTGC 
CAGACAGCTG TTACTCAGGC AATCCAAATT CACTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034303.3
CDS	340..2298
Translation	MPSGSSAALALALAAAPAPLPQPPPLPPPPPAGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAAAVAAAAAAQCQARRATGLAPEEPGRLATSETAELELEVDEEEGEEAELDGELLEEEELEEAEEEDRPSLLLLSPPAATASQTQPIPGGPLGSVLLPAAGFDAREAAAAGVLYGGDDAQGMMAAMLSHAYGPGGGGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMMSNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLTVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS

Target ORF information:

RefSeq Version	NM_001039214.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus mex3 RNA binding family member C (Mex3c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039214.4

ORF Insert Sequence:

ATGCCAAGCG GCAGCTCCGC GGCCCTGGCC CTGGCCCTGG CGGCGGCCCC GGCCCCCCTG 
CCGCAGCCGC CTCCGCTGCC GCCGCCGCCG CCCGCGGGAG GCCCAGAGCT CGAAGGGGAC 
GGGCTGCTGC TGAGGGAGCG CCTGGCCGCG CTAGGCCTCG ACGACCCCAG CCCGGCGGAG 
CCCGGCGCCC CGGCGCTCAG GGCCGCGGCG GTGGCGGCGG CGGCGGCGGC GCAGTGCCAG 
GCCCGGCGGG CGACCGGGCT GGCTCCGGAG GAGCCTGGCC GCCTCGCGAC CTCCGAGACG 
GCGGAGCTGG AGCTGGAGGT GGACGAAGAG GAGGGGGAGG AAGCGGAGCT GGACGGAGAA 
CTGCTGGAGG AGGAGGAGCT GGAGGAGGCA GAGGAGGAGG ACCGGCCGTC GCTGCTGCTG 
TTGTCGCCGC CCGCGGCCAC CGCCTCCCAG ACTCAGCCGA TCCCGGGCGG GCCCCTGGGG 
TCGGTGCTGC TGCCGGCCGC GGGCTTCGAT GCCCGGGAGG CCGCGGCGGC AGGGGTGCTG 
TACGGAGGGG ACGATGCCCA GGGCATGATG GCGGCGATGC TGTCCCACGC CTACGGCCCC 
GGCGGCGGCG GGGCCGCCGC TGCCGCCCTG AACGGAGAGC AAGCGGCCCT GCTGAGAAGG 
AAGAGCGTCA ACACCACCGA GTGCGTCCCC GTGCCCAGTT CCGAGCATGT CGCTGAGATT 
GTCGGACGCC AGGGTTGTAA AATTAAAGCA CTGAGAGCCA AGACAAACAC GTATATCAAG 
ACACCTGTTC GTGGTGAAGA ACCCATTTTT GTTGTCACTG GACGGAAAGA AGATGTTGCC 
ATGGCCAAAA GAGAAATCCT CTCGGCTGCA GAGCACTTTT CTATGATTCG TGCATCTCGA 
AACAAAAATG GTCCTGCACT AGGAGGGTTA TCGTGTAGTC CTAATCTGCC TGGTCAAACC 
ACAGTCCAAG TCAGGGTCCC CTATCGTGTG GTAGGGCTAG TGGTTGGACC AAAAGGAGCA 
ACAATTAAGA GAATTCAGCA ACAGACCCAC ACGTACATAG TTACTCCGAG CAGAGATAAG 
GAGCCAGTCT TTGAAGTCAC AGGGATGCCC GAAAATGTTG ATCGAGCACG AGAAGAGATA 
GAAATGCATA TCGCCATGCG TACCGGAAAC TACATAGAGC TCAATGAAGA AAATGATTTC 
CATTATAACG GTACCGATGT GAGCTTTGAA GGTGGCACTC TTGGCTCTGC ATGGCTCTCT 
TCCAATCCAG TTCCTCCAAG CCGAGCAAGA ATGATGTCTA ACTATCGCAA TGATAGTTCT 
AGCTCTCTAG GAAGTGGCTC CACTGATTCC TATTTTGGGA GCAATAGGCT AGCTGACTTT 
AGTCCAACAA GCCCATTTAG CACAGGGAAC TTTTGGTTTG GAGATACACT ACCATCTGTA 
GGCTCAGAAG ATCTTACAGT AGACTCTCCT GCCTTTGACT CTTTACCAAC ATCTGCTCAA 
ACTATCTGGA CTCCATTTGA ACCAGTTAAC CCACTCTCTG GCTTTGGGAG TGATCCTTCT 
GGTAACATGA AGACTCAGCG TAGAGGAAGT CAGCCATCAA CTCCTCGTCT GTCTCCTACA 
TTTCCTGAGA GCATAGAACA CCCACTTGCT CGAAGGGTGA GGAGTGACCC ACCTAGTACA 
GGCAACCATG TTGGCCTTCC AATATACATC CCTGCTTTTT CTAATGGTAC CAATAGTTAC 
TCCTCTTCCA ATGGTGGTTC CACCTCTAGC TCACCTCCAG AATCAAGAAG AAAGCACGAC 
TGTGTGATTT GCTTTGAGAA TGAAGTTATT GCTGCCCTAG TTCCATGTGG CCACAACCTC 
TTCTGCATGG AATGTGCCAA CAAGATCTGT GAAAAGAGAA CGCCGTCATG TCCAGTTTGC 
CAGACAGCTG TTACTCAGGC AATCCAAATT CACTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mex3c ( XM_011246932.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011245234.1 Mus musculus mex3 RNA binding family member C (Mex3c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu74002
Clone ID Related Accession (Same CDS sequence)	XM_011246932.3 , XM_011246932.2
Accession Version	XM_011246932.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	RNA-binding E3 ubiquitin-protein ligase MEX3C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011246932.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAAGCG GCAGCTCCGC GGCCCTGGCC CTGGCCCTGG CGGCGGCCCC GGCCCCCCTG 
CCGCAGCCGC CTCCGCTGCC GCCGCCGCCG CCCGCGGGAG GCCCAGAGCT CGAAGGGGAC 
GGGCTGCTGC TGAGGGAGCG CCTGGCCGCG CTAGGCCTCG ACGACCCCAG CCCGGCGGAG 
CCCGGCGCCC CGGCGCTCAG GGCCGCGGCG GTGGCGGCGG CGGCGGCGGC GCAGTGCCAG 
GCCCGGCGGG CGACCGGGCT GGCTCCGGAG GAGCCTGGCC GCCTCGCGAC CTCCGAGACG 
GCGGAGCTGG AGCTGGAGGT GGACGAAGAG GAGGGGGAGG AAGCGGAGCT GGACGGAGAA 
CTGCTGGAGG AGGAGGAGCT GGAGGAGGCA GAGGAGGAGG ACCGGCCGTC GCTGCTGCTG 
TTGTCGCCGC CCGCGGCCAC CGCCTCCCAG ACTCAGCCGA TCCCGGGCGG GCCCCTGGGG 
TCGGTGCTGC TGCCGGCCGC GGGCTTCGAT GCCCGGGAGG CCGCGGCGGC AGGGGTGCTG 
TACGGAGGGG ACGATGCCCA GGGCATGATG GCGGCGATGC TGTCCCACGC CTACGGCCCC 
GGCGGCGGCG GGGCCGCCGC TGCCGCCCTG AACGGAGAGC AAGCGGCCCT GCTGAGAAGG 
AAGAGCGTCA ACACCACCGA GTGCGTCCCC GTGCCCAGTT CCGAGCATGT CGCTGAGATT 
GTCGGACGCC AGGGTGCCTG CAGAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011245234.1
CDS	453..1202
Translation	MPSGSSAALALALAAAPAPLPQPPPLPPPPPAGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAAAVAAAAAAQCQARRATGLAPEEPGRLATSETAELELEVDEEEGEEAELDGELLEEEELEEAEEEDRPSLLLLSPPAATASQTQPIPGGPLGSVLLPAAGFDAREAAAAGVLYGGDDAQGMMAAMLSHAYGPGGGGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGACRD

Target ORF information:

RefSeq Version	XM_011246932.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus mex3 RNA binding family member C (Mex3c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011246932.2

ORF Insert Sequence:

ATGCCAAGCG GCAGCTCCGC GGCCCTGGCC CTGGCCCTGG CGGCGGCCCC GGCCCCCCTG 
CCGCAGCCGC CTCCGCTGCC GCCGCCGCCG CCCGCGGGAG GCCCAGAGCT CGAAGGGGAC 
GGGCTGCTGC TGAGGGAGCG CCTGGCCGCG CTAGGCCTCG ACGACCCCAG CCCGGCGGAG 
CCCGGCGCCC CGGCGCTCAG GGCCGCGGCG GTGGCGGCGG CGGCGGCGGC GCAGTGCCAG 
GCCCGGCGGG CGACCGGGCT GGCTCCGGAG GAGCCTGGCC GCCTCGCGAC CTCCGAGACG 
GCGGAGCTGG AGCTGGAGGT GGACGAAGAG GAGGGGGAGG AAGCGGAGCT GGACGGAGAA 
CTGCTGGAGG AGGAGGAGCT GGAGGAGGCA GAGGAGGAGG ACCGGCCGTC GCTGCTGCTG 
TTGTCGCCGC CCGCGGCCAC CGCCTCCCAG ACTCAGCCGA TCCCGGGCGG GCCCCTGGGG 
TCGGTGCTGC TGCCGGCCGC GGGCTTCGAT GCCCGGGAGG CCGCGGCGGC AGGGGTGCTG 
TACGGAGGGG ACGATGCCCA GGGCATGATG GCGGCGATGC TGTCCCACGC CTACGGCCCC 
GGCGGCGGCG GGGCCGCCGC TGCCGCCCTG AACGGAGAGC AAGCGGCCCT GCTGAGAAGG 
AAGAGCGTCA ACACCACCGA GTGCGTCCCC GTGCCCAGTT CCGAGCATGT CGCTGAGATT 
GTCGGACGCC AGGGTGCCTG CAGAGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting.
PloS one12(10)e0185992(2017)
Lu P,Li H,Li N,Singh RN,Bishop CE,Chen X,Lu B

Oocyte-Specific Expression of Mouse MEX3C652AA in the Ovary and Its Potential Role in Regulating Maternal Fos mRNA.
Biology of reproduction94(5)115(2016 05)
Li X,Li Y,Liu C,Jin M,Lu B

Mex3c mutation reduces adiposity partially through increasing physical activity.
The Journal of endocrinology221(3)457-68(2014 Jun)
Han C,Jiao Y,Zhao Q,Lu B

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Proceedings of the National Academy of Sciences of the United States of America111(15)5646-51(2014 Apr)
Kuniyoshi K,Takeuchi O,Pandey S,Satoh T,Iwasaki H,Akira S,Kawai T

Mex3c mutation reduces adiposity and increases energy expenditure.
Molecular and cellular biology32(21)4350-62(2012 Nov)
Jiao Y,George SK,Zhao Q,Hulver MW,Hutson SM,Bishop CE,Lu B

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Mex3c cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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