MEX3C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MEX3C
Entrez Gene ID	51320
Full Name	mex-3 RNA binding family member C
Synonyms	BM-013,MEX-3C,RKHD2,RNF194
General protein information	Preferred Names mex-3 RNA binding family member C Names RNA-binding E3 ubiquitin-protein ligase MEX3C MEX3C variant 1 MEX3C variant 2 RING finger and KH domain-containing protein 2 RING finger protein 194 RING-type E3 ubiquitin transferase MEX3C RNA-binding protein MEX3C ring finger and KH domain containing 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q21.2
Summary	This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009].
Disorder MIM:	611005

mRNA and Protein(s)

mRNA	Protein	Name
NM_016626.4	NP_057710.3	RNA-binding E3 ubiquitin-protein ligase MEX3C
NM_016626.5	NP_057710.3	RNA-binding E3 ubiquitin-protein ligase MEX3C

Pathways from BioSystems

Homologies

Homo sapiens (human)	MEX3C	NP_057710.3
Canis lupus familiaris (dog)	MEX3C	XP_005615738.1
Mus musculus (house mouse)	Mex3c	NP_001034303.3
Xenopus tropicalis (tropical clawed frog)	mex3c	NP_001017067.1
Bos taurus (cattle)	MEX3C	XP_002697870.3
Rattus norvegicus (Norway rat)	Mex3c	NP_001100847.1
Pan troglodytes (chimpanzee)	MEX3C	XP_001155789.1
	MEX3C	XP_001096989.2

Gene Ontology
Bibliography

Related articles in PubMed

The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity.
Yang L, Wang C, Li F, Zhang J, Nayab A, Wu J, Shi Y, Gong Q
The Journal of biological chemistry292(39)16221-16234(2017 09)

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.
Cano F, Rapiteanu R, Sebastiaan Winkler G, Lehner PJ
Nature communications68670(2015 Oct)

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.
Cano F, Bye H, Duncan LM, Buchet-Poyau K, Billaud M, Wills MR, Lehner PJ
The EMBO journal31(17)3596-606(2012 Aug)

A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
Pajewski NM, Shrestha S, Quinn CP, Parker SD, Wiener H, Aissani B, McKinney BA, Poland GA, Edberg JC, Kimberly RP, Tang J, Kaslow RA
Vaccine30(32)4778-84(2012 Jul)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that KH1 and HK2 domains of MEX3C bind with high affinity to MRE10, a 10-mer RNA (5prime-CAGAGUUUAG-3prime) containing an eight-nucleotide MEX3C recognition element motif (AGAGUUUA); 3prime-untranslated region of HLA-A2 mRNA contains such a high affinity binding site for KH domains of MEX3C. (MEX3C = mex-3 RNA binding family member C; HLA-A2 = HLA class I histocompatibility antigen, A-2 alpha chain)
Title: The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity.

associates with cytoplasmic deadenylation complexes and ubiquitinates CNOT7
Title: A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation
Title: The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

In combination sibling-pair linkage analysis and case-control association studies of chromosome 18, RKHD2 is found to contribute to the genetic susceptibility of essential hypertension.
Title: Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene.

The following MEX3C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MEX3C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22457	NM_016626.5 Latest version!	Homo sapiens mex-3 RNA binding family member C (MEX3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu22457	NM_016626.4	Homo sapiens mex-3 RNA binding family member C (MEX3C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MEX3C ( NM_016626.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057710.3 Homo sapiens mex-3 RNA binding family member C (MEX3C), mRNA.

Price & Availability↑

CloneID	OHu22457
Clone ID Related Accession (Same CDS sequence)	NM_016626.4 , NM_016626.5
Accession Version	NM_016626.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1980bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Homo sapiens(human)
Product	RNA-binding E3 ubiquitin-protein ligase MEX3C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC090330.22, AY950679.1 and BC063244.1. This sequence is a reference standard in the RefSeqGene project. On Oct 3, 2009 this sequence version replaced NM_016626.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK096190.1, SRR1660809.169000.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGCG GCAGCTCCGC GGCCCTGGCC CTGGCGGCGG CCCCGGCCCC CCTGCCGCAG 
CCGCCCCCGC CGCCGCCGCC GCCACCGCCG CCTCTGCCGC CGCCCTCGGG CGGCCCGGAG 
CTCGAGGGGG ACGGGCTCCT GCTGAGGGAG CGCTTGGCCG CGCTAGGCCT CGACGACCCC 
AGCCCGGCGG AGCCCGGCGC CCCGGCGCTT CGGGCCCCGG CAGCGGCGGC GCAGGGCCAG 
GCCCGGCGGG CGGCGGAGCT GTCTCCAGAG GAGCGGGCTC CGCCCGGCCG GCCCGGGGCC 
CCGGAGGCGG CCGAGCTGGA GCTGGAAGAG GACGAGGAGG AGGGGGAGGA AGCGGAGCTG 
GACGGAGACC TGCTGGAGGA GGAGGAGCTG GAGGAAGCAG AGGAGGAGGA CCGGTCGTCG 
CTGCTGCTGC TGTCGCCGCC CGCGGCCACC GCCTCTCAGA CCCAGCAGAT CCCGGGCGGG 
TCCCTGGGGT CTGTGCTGCT GCCAGCCGCC AGGTTCGATG CCCGGGAGGC GGCGGCCGCG 
GCGGCGGCGG CGGGGGTGCT GTACGGAGGG GACGATGCCC AGGGCATGAT GGCGGCGATG 
CTGTCCCACG CCTACGGCCC CGGCGGTTGT GGGGCGGCGG CGGCCGCCCT GAACGGGGAG 
CAGGCGGCCC TGCTCCGGAG AAAGAGCGTC AACACCACCG AGTGCGTCCC GGTGCCCAGC 
TCCGAGCACG TCGCCGAGAT CGTCGGCCGC CAGGGTTGTA AAATTAAAGC ACTGAGAGCC 
AAGACAAACA CGTATATCAA GACTCCTGTT CGTGGTGAAG AGCCCATTTT TGTTGTCACT 
GGAAGGAAAG AAGATGTTGC CATGGCCAAA AGAGAGATCC TCTCAGCTGC AGAGCACTTC 
TCCATGATTC GTGCATCTCG AAACAAAAAT GGGCCTGCCC TGGGAGGATT ATCATGTAGT 
CCTAATCTGC CCGGTCAAAC CACCGTCCAA GTCAGGGTCC CTTATCGTGT GGTAGGATTA 
GTGGTTGGAC CCAAAGGAGC AACTATTAAA AGAATTCAGC AGCAGACCCA CACCTACATA 
GTAACTCCGA GCAGAGATAA GGAACCTGTC TTTGAAGTGA CAGGGATGCC TGAAAATGTT 
GACCGAGCAC GGGAAGAAAT AGAAATGCAT ATTGCCATGC GTACAGGAAA CTATATAGAG 
CTCAATGAAG AGAATGATTT CCATTACAAT GGTACCGATG TAAGCTTTGA AGGTGGCACT 
CTTGGCTCTG CGTGGCTCTC CTCCAATCCT GTTCCTCCTA GCCGCGCAAG AATGATATCC 
AATTATCGAA ATGATAGTTC CAGTTCTCTA GGAAGTGGCT CTACAGATTC CTACTTTGGA 
AGCAATAGGC TGGCTGACTT TAGTCCAACA AGCCCATTTA GCACAGGAAA CTTCTGGTTT 
GGAGATACAC TACCATCTGT AGGCTCAGAA GACCTAGCAG TTGACTCTCC TGCCTTTGAC 
TCTTTACCAA CATCTGCTCA AACTATCTGG ACTCCATTTG AACCAGTTAA CCCACTCTCT 
GGCTTTGGGA GTGATCCTTC TGGTAACATG AAGACTCAGC GCAGAGGAAG TCAGCCATCT 
ACTCCTCGTC TGTCTCCTAC ATTTCCTGAG AGCATAGAAC ATCCACTTGC TCGGAGGGTT 
AGGAGCGACC CACCTAGTAC AGGCAACCAT GTTGGCCTTC CAATATATAT CCCTGCTTTT 
TCTAATGGTA CCAATAGTTA CTCCTCTTCC AATGGTGGTT CCACCTCTAG CTCACCTCCA 
GAATCAAGAC GAAAGCACGA CTGTGTGATT TGCTTTGAGA ATGAGGTTAT TGCTGCCCTA 
GTTCCATGTG GCCACAACCT CTTCTGCATG GAATGTGCCA ACAAGATCTG TGAAAAGAGA 
ACGCCATCAT GTCCAGTTTG CCAGACAGCT GTTACTCAGG CAATCCAAAT TCACTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057710.3
CDS	362..2341
Translation	MPSGSSAALALAAAPAPLPQPPPPPPPPPPPLPPPSGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAPAAAAQGQARRAAELSPEERAPPGRPGAPEAAELELEEDEEEGEEAELDGDLLEEEELEEAEEEDRSSLLLLSPPAATASQTQQIPGGSLGSVLLPAARFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS

Target ORF information:

RefSeq Version	NM_016626.4
Organism	Homo sapiens(human)
Definition	Homo sapiens mex-3 RNA binding family member C (MEX3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016626.4

ORF Insert Sequence:

ATGCCCAGCG GCAGCTCCGC GGCCCTGGCC CTGGCGGCGG CCCCGGCCCC CCTGCCGCAG 
CCGCCCCCGC CGCCGCCGCC GCCACCGCCG CCTCTGCCGC CGCCCTCGGG CGGCCCGGAG 
CTCGAGGGGG ACGGGCTCCT GCTGAGGGAG CGCTTGGCCG CGCTAGGCCT CGACGACCCC 
AGCCCGGCGG AGCCCGGCGC CCCGGCGCTT CGGGCCCCGG CAGCGGCGGC GCAGGGCCAG 
GCCCGGCGGG CGGCGGAGCT GTCTCCAGAG GAGCGGGCTC CGCCCGGCCG GCCCGGGGCC 
CCGGAGGCGG CCGAGCTGGA GCTGGAAGAG GACGAGGAGG AGGGGGAGGA AGCGGAGCTG 
GACGGAGACC TGCTGGAGGA GGAGGAGCTG GAGGAAGCAG AGGAGGAGGA CCGGTCGTCG 
CTGCTGCTGC TGTCGCCGCC CGCGGCCACC GCCTCTCAGA CCCAGCAGAT CCCGGGCGGG 
TCCCTGGGGT CTGTGCTGCT GCCAGCCGCC AGGTTCGATG CCCGGGAGGC GGCGGCCGCG 
GCGGCGGCGG CGGGGGTGCT GTACGGAGGG GACGATGCCC AGGGCATGAT GGCGGCGATG 
CTGTCCCACG CCTACGGCCC CGGCGGTTGT GGGGCGGCGG CGGCCGCCCT GAACGGGGAG 
CAGGCGGCCC TGCTCCGGAG AAAGAGCGTC AACACCACCG AGTGCGTCCC GGTGCCCAGC 
TCCGAGCACG TCGCCGAGAT CGTCGGCCGC CAGGGTTGTA AAATTAAAGC ACTGAGAGCC 
AAGACAAACA CGTATATCAA GACTCCTGTT CGTGGTGAAG AGCCCATTTT TGTTGTCACT 
GGAAGGAAAG AAGATGTTGC CATGGCCAAA AGAGAGATCC TCTCAGCTGC AGAGCACTTC 
TCCATGATTC GTGCATCTCG AAACAAAAAT GGGCCTGCCC TGGGAGGATT ATCATGTAGT 
CCTAATCTGC CCGGTCAAAC CACCGTCCAA GTCAGGGTCC CTTATCGTGT GGTAGGATTA 
GTGGTTGGAC CCAAAGGAGC AACTATTAAA AGAATTCAGC AGCAGACCCA CACCTACATA 
GTAACTCCGA GCAGAGATAA GGAACCTGTC TTTGAAGTGA CAGGGATGCC TGAAAATGTT 
GACCGAGCAC GGGAAGAAAT AGAAATGCAT ATTGCCATGC GTACAGGAAA CTATATAGAG 
CTCAATGAAG AGAATGATTT CCATTACAAT GGTACCGATG TAAGCTTTGA AGGTGGCACT 
CTTGGCTCTG CGTGGCTCTC CTCCAATCCT GTTCCTCCTA GCCGCGCAAG AATGATATCC 
AATTATCGAA ATGATAGTTC CAGTTCTCTA GGAAGTGGCT CTACAGATTC CTACTTTGGA 
AGCAATAGGC TGGCTGACTT TAGTCCAACA AGCCCATTTA GCACAGGAAA CTTCTGGTTT 
GGAGATACAC TACCATCTGT AGGCTCAGAA GACCTAGCAG TTGACTCTCC TGCCTTTGAC 
TCTTTACCAA CATCTGCTCA AACTATCTGG ACTCCATTTG AACCAGTTAA CCCACTCTCT 
GGCTTTGGGA GTGATCCTTC TGGTAACATG AAGACTCAGC GCAGAGGAAG TCAGCCATCT 
ACTCCTCGTC TGTCTCCTAC ATTTCCTGAG AGCATAGAAC ATCCACTTGC TCGGAGGGTT 
AGGAGCGACC CACCTAGTAC AGGCAACCAT GTTGGCCTTC CAATATATAT CCCTGCTTTT 
TCTAATGGTA CCAATAGTTA CTCCTCTTCC AATGGTGGTT CCACCTCTAG CTCACCTCCA 
GAATCAAGAC GAAAGCACGA CTGTGTGATT TGCTTTGAGA ATGAGGTTAT TGCTGCCCTA 
GTTCCATGTG GCCACAACCT CTTCTGCATG GAATGTGCCA ACAAGATCTG TGAAAAGAGA 
ACGCCATCAT GTCCAGTTTG CCAGACAGCT GTTACTCAGG CAATCCAAAT TCACTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MEX3C ( NM_016626.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057710.3 Homo sapiens mex-3 RNA binding family member C (MEX3C), mRNA.

Price & Availability↑

CloneID	OHu22457
Clone ID Related Accession (Same CDS sequence)	NM_016626.4 , NM_016626.5
Accession Version	NM_016626.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1980bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	RNA-binding E3 ubiquitin-protein ligase MEX3C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC090330.22, AY950679.1 and BC063244.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_016626.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK096190.1, SRR1660809.169000.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000406189.4/ ENSP00000385610.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCCAGCG GCAGCTCCGC GGCCCTGGCC CTGGCGGCGG CCCCGGCCCC CCTGCCGCAG 
CCGCCCCCGC CGCCGCCGCC GCCACCGCCG CCTCTGCCGC CGCCCTCGGG CGGCCCGGAG 
CTCGAGGGGG ACGGGCTCCT GCTGAGGGAG CGCTTGGCCG CGCTAGGCCT CGACGACCCC 
AGCCCGGCGG AGCCCGGCGC CCCGGCGCTT CGGGCCCCGG CAGCGGCGGC GCAGGGCCAG 
GCCCGGCGGG CGGCGGAGCT GTCTCCAGAG GAGCGGGCTC CGCCCGGCCG GCCCGGGGCC 
CCGGAGGCGG CCGAGCTGGA GCTGGAAGAG GACGAGGAGG AGGGGGAGGA AGCGGAGCTG 
GACGGAGACC TGCTGGAGGA GGAGGAGCTG GAGGAAGCAG AGGAGGAGGA CCGGTCGTCG 
CTGCTGCTGC TGTCGCCGCC CGCGGCCACC GCCTCTCAGA CCCAGCAGAT CCCGGGCGGG 
TCCCTGGGGT CTGTGCTGCT GCCAGCCGCC AGGTTCGATG CCCGGGAGGC GGCGGCCGCG 
GCGGCGGCGG CGGGGGTGCT GTACGGAGGG GACGATGCCC AGGGCATGAT GGCGGCGATG 
CTGTCCCACG CCTACGGCCC CGGCGGTTGT GGGGCGGCGG CGGCCGCCCT GAACGGGGAG 
CAGGCGGCCC TGCTCCGGAG AAAGAGCGTC AACACCACCG AGTGCGTCCC GGTGCCCAGC 
TCCGAGCACG TCGCCGAGAT CGTCGGCCGC CAGGGTTGTA AAATTAAAGC ACTGAGAGCC 
AAGACAAACA CGTATATCAA GACTCCTGTT CGTGGTGAAG AGCCCATTTT TGTTGTCACT 
GGAAGGAAAG AAGATGTTGC CATGGCCAAA AGAGAGATCC TCTCAGCTGC AGAGCACTTC 
TCCATGATTC GTGCATCTCG AAACAAAAAT GGGCCTGCCC TGGGAGGATT ATCATGTAGT 
CCTAATCTGC CCGGTCAAAC CACCGTCCAA GTCAGGGTCC CTTATCGTGT GGTAGGATTA 
GTGGTTGGAC CCAAAGGAGC AACTATTAAA AGAATTCAGC AGCAGACCCA CACCTACATA 
GTAACTCCGA GCAGAGATAA GGAACCTGTC TTTGAAGTGA CAGGGATGCC TGAAAATGTT 
GACCGAGCAC GGGAAGAAAT AGAAATGCAT ATTGCCATGC GTACAGGAAA CTATATAGAG 
CTCAATGAAG AGAATGATTT CCATTACAAT GGTACCGATG TAAGCTTTGA AGGTGGCACT 
CTTGGCTCTG CGTGGCTCTC CTCCAATCCT GTTCCTCCTA GCCGCGCAAG AATGATATCC 
AATTATCGAA ATGATAGTTC CAGTTCTCTA GGAAGTGGCT CTACAGATTC CTACTTTGGA 
AGCAATAGGC TGGCTGACTT TAGTCCAACA AGCCCATTTA GCACAGGAAA CTTCTGGTTT 
GGAGATACAC TACCATCTGT AGGCTCAGAA GACCTAGCAG TTGACTCTCC TGCCTTTGAC 
TCTTTACCAA CATCTGCTCA AACTATCTGG ACTCCATTTG AACCAGTTAA CCCACTCTCT 
GGCTTTGGGA GTGATCCTTC TGGTAACATG AAGACTCAGC GCAGAGGAAG TCAGCCATCT 
ACTCCTCGTC TGTCTCCTAC ATTTCCTGAG AGCATAGAAC ATCCACTTGC TCGGAGGGTT 
AGGAGCGACC CACCTAGTAC AGGCAACCAT GTTGGCCTTC CAATATATAT CCCTGCTTTT 
TCTAATGGTA CCAATAGTTA CTCCTCTTCC AATGGTGGTT CCACCTCTAG CTCACCTCCA 
GAATCAAGAC GAAAGCACGA CTGTGTGATT TGCTTTGAGA ATGAGGTTAT TGCTGCCCTA 
GTTCCATGTG GCCACAACCT CTTCTGCATG GAATGTGCCA ACAAGATCTG TGAAAAGAGA 
ACGCCATCAT GTCCAGTTTG CCAGACAGCT GTTACTCAGG CAATCCAAAT TCACTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057710.3
CDS	362..2341
Translation	MPSGSSAALALAAAPAPLPQPPPPPPPPPPPLPPPSGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAPAAAAQGQARRAAELSPEERAPPGRPGAPEAAELELEEDEEEGEEAELDGDLLEEEELEEAEEEDRSSLLLLSPPAATASQTQQIPGGSLGSVLLPAARFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS

Target ORF information:

RefSeq Version	NM_016626.5
Organism	Homo sapiens(human)
Definition	Homo sapiens mex-3 RNA binding family member C (MEX3C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016626.5

ORF Insert Sequence:

ATGCCCAGCG GCAGCTCCGC GGCCCTGGCC CTGGCGGCGG CCCCGGCCCC CCTGCCGCAG 
CCGCCCCCGC CGCCGCCGCC GCCACCGCCG CCTCTGCCGC CGCCCTCGGG CGGCCCGGAG 
CTCGAGGGGG ACGGGCTCCT GCTGAGGGAG CGCTTGGCCG CGCTAGGCCT CGACGACCCC 
AGCCCGGCGG AGCCCGGCGC CCCGGCGCTT CGGGCCCCGG CAGCGGCGGC GCAGGGCCAG 
GCCCGGCGGG CGGCGGAGCT GTCTCCAGAG GAGCGGGCTC CGCCCGGCCG GCCCGGGGCC 
CCGGAGGCGG CCGAGCTGGA GCTGGAAGAG GACGAGGAGG AGGGGGAGGA AGCGGAGCTG 
GACGGAGACC TGCTGGAGGA GGAGGAGCTG GAGGAAGCAG AGGAGGAGGA CCGGTCGTCG 
CTGCTGCTGC TGTCGCCGCC CGCGGCCACC GCCTCTCAGA CCCAGCAGAT CCCGGGCGGG 
TCCCTGGGGT CTGTGCTGCT GCCAGCCGCC AGGTTCGATG CCCGGGAGGC GGCGGCCGCG 
GCGGCGGCGG CGGGGGTGCT GTACGGAGGG GACGATGCCC AGGGCATGAT GGCGGCGATG 
CTGTCCCACG CCTACGGCCC CGGCGGTTGT GGGGCGGCGG CGGCCGCCCT GAACGGGGAG 
CAGGCGGCCC TGCTCCGGAG AAAGAGCGTC AACACCACCG AGTGCGTCCC GGTGCCCAGC 
TCCGAGCACG TCGCCGAGAT CGTCGGCCGC CAGGGTTGTA AAATTAAAGC ACTGAGAGCC 
AAGACAAACA CGTATATCAA GACTCCTGTT CGTGGTGAAG AGCCCATTTT TGTTGTCACT 
GGAAGGAAAG AAGATGTTGC CATGGCCAAA AGAGAGATCC TCTCAGCTGC AGAGCACTTC 
TCCATGATTC GTGCATCTCG AAACAAAAAT GGGCCTGCCC TGGGAGGATT ATCATGTAGT 
CCTAATCTGC CCGGTCAAAC CACCGTCCAA GTCAGGGTCC CTTATCGTGT GGTAGGATTA 
GTGGTTGGAC CCAAAGGAGC AACTATTAAA AGAATTCAGC AGCAGACCCA CACCTACATA 
GTAACTCCGA GCAGAGATAA GGAACCTGTC TTTGAAGTGA CAGGGATGCC TGAAAATGTT 
GACCGAGCAC GGGAAGAAAT AGAAATGCAT ATTGCCATGC GTACAGGAAA CTATATAGAG 
CTCAATGAAG AGAATGATTT CCATTACAAT GGTACCGATG TAAGCTTTGA AGGTGGCACT 
CTTGGCTCTG CGTGGCTCTC CTCCAATCCT GTTCCTCCTA GCCGCGCAAG AATGATATCC 
AATTATCGAA ATGATAGTTC CAGTTCTCTA GGAAGTGGCT CTACAGATTC CTACTTTGGA 
AGCAATAGGC TGGCTGACTT TAGTCCAACA AGCCCATTTA GCACAGGAAA CTTCTGGTTT 
GGAGATACAC TACCATCTGT AGGCTCAGAA GACCTAGCAG TTGACTCTCC TGCCTTTGAC 
TCTTTACCAA CATCTGCTCA AACTATCTGG ACTCCATTTG AACCAGTTAA CCCACTCTCT 
GGCTTTGGGA GTGATCCTTC TGGTAACATG AAGACTCAGC GCAGAGGAAG TCAGCCATCT 
ACTCCTCGTC TGTCTCCTAC ATTTCCTGAG AGCATAGAAC ATCCACTTGC TCGGAGGGTT 
AGGAGCGACC CACCTAGTAC AGGCAACCAT GTTGGCCTTC CAATATATAT CCCTGCTTTT 
TCTAATGGTA CCAATAGTTA CTCCTCTTCC AATGGTGGTT CCACCTCTAG CTCACCTCCA 
GAATCAAGAC GAAAGCACGA CTGTGTGATT TGCTTTGAGA ATGAGGTTAT TGCTGCCCTA 
GTTCCATGTG GCCACAACCT CTTCTGCATG GAATGTGCCA ACAAGATCTG TGAAAAGAGA 
ACGCCATCAT GTCCAGTTTG CCAGACAGCT GTTACTCAGG CAATCCAAAT TCACTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity.
The Journal of biological chemistry292(39)16221-16234(2017 09)
Yang L,Wang C,Li F,Zhang J,Nayab A,Wu J,Shi Y,Gong Q

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.
Nature communications68670(2015 Oct)
Cano F,Rapiteanu R,Sebastiaan Winkler G,Lehner PJ

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation.
The EMBO journal31(17)3596-606(2012 Aug)
Cano F,Bye H,Duncan LM,Buchet-Poyau K,Billaud M,Wills MR,Lehner PJ

A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
Vaccine30(32)4778-84(2012 Jul)
Pajewski NM,Shrestha S,Quinn CP,Parker SD,Wiener H,Aissani B,McKinney BA,Poland GA,Edberg JC,Kimberly RP,Tang J,Kaslow RA

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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MEX3C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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