Slc30a8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc30a8
Entrez Gene ID	239436
Full Name	solute carrier family 30 (zinc transporter), member 8
Synonyms	C820002P14Rik,ZnT-8,ZnT8
General protein information	Preferred Names solute carrier family 30 (zinc transporter), member 8 Names zinc transporter 8 solute carrier family 30 member 8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_172816.3	NP_766404.1	zinc transporter 8
NM_172816.4	NP_766404.1	zinc transporter 8

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC30A8	XP_519918.2
Gallus gallus (chicken)	SLC30A8	XP_418398.4
Xenopus tropicalis (tropical clawed frog)	slc30a8	NP_001011041.1
Mus musculus (house mouse)	Slc30a8	NP_766404.1
Rattus norvegicus (Norway rat)	Slc30a8	NP_001124010.1
	SLC30A8	XP_001095488.1
Homo sapiens (human)	SLC30A8	NP_776250.2
Canis lupus familiaris (dog)	SLC30A8	XP_539143.2
Danio rerio (zebrafish)	LOC560642	XP_689129.4

Gene Ontology
Bibliography

Related articles in PubMed

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM
Development (Cambridge, England)144(13)2402-2414(2017 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data demonstrate that the function of ZnT8 in islets can be unmasked by removal of ZnT7 and imply that ZnT8 may affect T2D susceptibility through actions in other tissues where it is expressed at low levels rather than through effects on pancreatic islet function.
Title: Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion.

Our findings demonstrate that glucose homeostasis in the mouse improves as beta-cell ZnT8 activity increases, and remarkably, these changes track Zn(2+) rather than insulin release in vitro.
Title: Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.

Deletion of ZnT8 in a limited subset ( approximately 15%) of alpha-pancreatic cells is sufficient to increase glucagon secretion at low glucose concentrations in vitro and in vivo and to improve the response to hypoglycemia.
Title: The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic ?-Cells for Hypoglycemia-induced Glucagon Secretion.

Data suggest that, despite a marked reduction in islet zinc content, the absence of ZnT-8 does not have a substantial impact on mouse physiology.
Title: The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background.

ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 plays a neuroprotective role against ischemic insult
Title: Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy.

The following Slc30a8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc30a8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19625	NM_172816.4 Latest version!	Mus musculus solute carrier family 30 (zinc transporter), member 8 (Slc30a8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu19625	NM_172816.3	Mus musculus solute carrier family 30 (zinc transporter), member 8 (Slc30a8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc30a8 ( NM_172816.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766404.1 Mus musculus solute carrier family 30 (zinc transporter), member 8 (Slc30a8), mRNA.

Price & Availability↑

CloneID	OMu19625
Clone ID Related Accession (Same CDS sequence)	NM_172816.3 , NM_172816.4
Accession Version	NM_172816.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Mus musculus(house mouse)
Product	zinc transporter 8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC127562.3. On May 2, 2007 this sequence version replaced NM_172816.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK050494.1, AK050482.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164139 [ECO:0000350] ##Evidence-Data-END##

ATGGAGTTTC TTGAGAGAAC TTATCTTGTG AATGATCAAG CCACCAAGAT GTACGCCTTC 
CCTCTAGACA GAGAACTTCG ACAGAAGCCT GTGAATAAAG ATCAGTGTCC TGGAGACAGG 
CCAGAGCATC CAGAGGCAGG AGGCATCTAT CACTGCCACA ACAGCGCCAA GGCCACAGGG 
AACAGGTCGA GCAAGCAAGC GCATGCCAAG TGGAGACTCT GTGCTGCTTC AGCAATATGC 
TTCATCTTTA TGGTGGCAGA GGTGGTGGGT GGACACGTTG CTGGGAGTCT GGCTATCCTC 
ACTGATGCGG CTCATCTCTT AATTGACCTG ACTAGTTTCC TGCTCAGTCT CTTTTCTTTG 
TGGTTGTCAT CGAGGCCCCC TTCCAAGCGG CTGACATTTG GGTGGTATCG AGCAGAGATC 
CTCGGTGCCC TGCTGTCTGT CCTTTGCATC TGGGTGGTGA CTGGTGTGCT GCTGTACCTT 
GCCTGTGAGC GCCTTTTGTA TCCTGATTAC CAGATCCAAG CAGGTATCAT GATCACTGTT 
TCAGGCTGTG CAGTGGCAGC CAACATTGTA CTAACTATGA TTTTGCACCA ACGGAACTTT 
GGCTACAACC ACAAGGATGT ACAAGCTAAT GCCAGTGTCC GAGCAGCCTT TGTGCATGCC 
CTGGGGGATG TATTTCAGAG CATCAGTGTG CTAATTAGTG CTCTCATTAT CTACTTTAAG 
CCTGACTACA AAATTGCTGA TCCAGTGTGC ACATTTATCT TTTCCATCCT GGTTTTGGCC 
AGCACCGTCA TGATCTTAAA AGACTTCTCC ATCTTACTCA TGGAAGGTGT TCCAAAGGGC 
CTGAGTTACA ACAGTGTGAA AGAGATCATC CTCGCAGTTG ATGGCGTGAT CTCCGTGCAC 
AGTCTACACA TCTGGTCACT GACTGTGAAC CAAGTGATTC TCTCTGTTCA TGTTGCTACA 
GCTGCCAGCC AGGACAGCCA GTCTGTGCGG ACAGGAATTG CTCAAGCCCT CAGCAGCTTT 
GATCTTCACT CTCTTACCAT TCAGATAGAA TCTGCAGCAG ACCAGGACCC CAGCTGCCTT 
CTCTGCGAAG ACCCTCAGGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766404.1
CDS	334..1437
Translation	MEFLERTYLVNDQATKMYAFPLDRELRQKPVNKDQCPGDRPEHPEAGGIYHCHNSAKATGNRSSKQAHAKWRLCAASAICFIFMVAEVVGGHVAGSLAILTDAAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWYRAEILGALLSVLCIWVVTGVLLYLACERLLYPDYQIQAGIMITVSGCAVAANIVLTMILHQRNFGYNHKDVQANASVRAAFVHALGDVFQSISVLISALIIYFKPDYKIADPVCTFIFSILVLASTVMILKDFSILLMEGVPKGLSYNSVKEIILAVDGVISVHSLHIWSLTVNQVILSVHVATAASQDSQSVRTGIAQALSSFDLHSLTIQIESAADQDPSCLLCEDPQD

Target ORF information:

RefSeq Version	NM_172816.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 30 (zinc transporter), member 8 (Slc30a8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172816.3

ORF Insert Sequence:

ATGGAGTTTC TTGAGAGAAC TTATCTTGTG AATGATCAAG CCACCAAGAT GTACGCCTTC 
CCTCTAGACA GAGAACTTCG ACAGAAGCCT GTGAATAAAG ATCAGTGTCC TGGAGACAGG 
CCAGAGCATC CAGAGGCAGG AGGCATCTAT CACTGCCACA ACAGCGCCAA GGCCACAGGG 
AACAGGTCGA GCAAGCAAGC GCATGCCAAG TGGAGACTCT GTGCTGCTTC AGCAATATGC 
TTCATCTTTA TGGTGGCAGA GGTGGTGGGT GGACACGTTG CTGGGAGTCT GGCTATCCTC 
ACTGATGCGG CTCATCTCTT AATTGACCTG ACTAGTTTCC TGCTCAGTCT CTTTTCTTTG 
TGGTTGTCAT CGAGGCCCCC TTCCAAGCGG CTGACATTTG GGTGGTATCG AGCAGAGATC 
CTCGGTGCCC TGCTGTCTGT CCTTTGCATC TGGGTGGTGA CTGGTGTGCT GCTGTACCTT 
GCCTGTGAGC GCCTTTTGTA TCCTGATTAC CAGATCCAAG CAGGTATCAT GATCACTGTT 
TCAGGCTGTG CAGTGGCAGC CAACATTGTA CTAACTATGA TTTTGCACCA ACGGAACTTT 
GGCTACAACC ACAAGGATGT ACAAGCTAAT GCCAGTGTCC GAGCAGCCTT TGTGCATGCC 
CTGGGGGATG TATTTCAGAG CATCAGTGTG CTAATTAGTG CTCTCATTAT CTACTTTAAG 
CCTGACTACA AAATTGCTGA TCCAGTGTGC ACATTTATCT TTTCCATCCT GGTTTTGGCC 
AGCACCGTCA TGATCTTAAA AGACTTCTCC ATCTTACTCA TGGAAGGTGT TCCAAAGGGC 
CTGAGTTACA ACAGTGTGAA AGAGATCATC CTCGCAGTTG ATGGCGTGAT CTCCGTGCAC 
AGTCTACACA TCTGGTCACT GACTGTGAAC CAAGTGATTC TCTCTGTTCA TGTTGCTACA 
GCTGCCAGCC AGGACAGCCA GTCTGTGCGG ACAGGAATTG CTCAAGCCCT CAGCAGCTTT 
GATCTTCACT CTCTTACCAT TCAGATAGAA TCTGCAGCAG ACCAGGACCC CAGCTGCCTT 
CTCTGCGAAG ACCCTCAGGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc30a8 ( NM_172816.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766404.1 Mus musculus solute carrier family 30 (zinc transporter), member 8 (Slc30a8), mRNA.

Price & Availability↑

CloneID	OMu19625
Clone ID Related Accession (Same CDS sequence)	NM_172816.3 , NM_172816.4
Accession Version	NM_172816.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Mus musculus(house mouse)
Product	zinc transporter 8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127562.3. On Jul 12, 2018 this sequence version replaced NM_172816.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK050494.1, BC117544.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01164139 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTTTC TTGAGAGAAC TTATCTTGTG AATGATCAAG CCACCAAGAT GTACGCCTTC 
CCTCTAGACA GAGAACTTCG ACAGAAGCCT GTGAATAAAG ATCAGTGTCC TGGAGACAGG 
CCAGAGCATC CAGAGGCAGG AGGCATCTAT CACTGCCACA ACAGCGCCAA GGCCACAGGG 
AACAGGTCGA GCAAGCAAGC GCATGCCAAG TGGAGACTCT GTGCTGCTTC AGCAATATGC 
TTCATCTTTA TGGTGGCAGA GGTGGTGGGT GGACACGTTG CTGGGAGTCT GGCTATCCTC 
ACTGATGCGG CTCATCTCTT AATTGACCTG ACTAGTTTCC TGCTCAGTCT CTTTTCTTTG 
TGGTTGTCAT CGAGGCCCCC TTCCAAGCGG CTGACATTTG GGTGGTATCG AGCAGAGATC 
CTCGGTGCCC TGCTGTCTGT CCTTTGCATC TGGGTGGTGA CTGGTGTGCT GCTGTACCTT 
GCCTGTGAGC GCCTTTTGTA TCCTGATTAC CAGATCCAAG CAGGTATCAT GATCACTGTT 
TCAGGCTGTG CAGTGGCAGC CAACATTGTA CTAACTATGA TTTTGCACCA ACGGAACTTT 
GGCTACAACC ACAAGGATGT ACAAGCTAAT GCCAGTGTCC GAGCAGCCTT TGTGCATGCC 
CTGGGGGATG TATTTCAGAG CATCAGTGTG CTAATTAGTG CTCTCATTAT CTACTTTAAG 
CCTGACTACA AAATTGCTGA TCCAGTGTGC ACATTTATCT TTTCCATCCT GGTTTTGGCC 
AGCACCGTCA TGATCTTAAA AGACTTCTCC ATCTTACTCA TGGAAGGTGT TCCAAAGGGC 
CTGAGTTACA ACAGTGTGAA AGAGATCATC CTCGCAGTTG ATGGCGTGAT CTCCGTGCAC 
AGTCTACACA TCTGGTCACT GACTGTGAAC CAAGTGATTC TCTCTGTTCA TGTTGCTACA 
GCTGCCAGCC AGGACAGCCA GTCTGTGCGG ACAGGAATTG CTCAAGCCCT CAGCAGCTTT 
GATCTTCACT CTCTTACCAT TCAGATAGAA TCTGCAGCAG ACCAGGACCC CAGCTGCCTT 
CTCTGCGAAG ACCCTCAGGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766404.1
CDS	334..1437
Translation	MEFLERTYLVNDQATKMYAFPLDRELRQKPVNKDQCPGDRPEHPEAGGIYHCHNSAKATGNRSSKQAHAKWRLCAASAICFIFMVAEVVGGHVAGSLAILTDAAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWYRAEILGALLSVLCIWVVTGVLLYLACERLLYPDYQIQAGIMITVSGCAVAANIVLTMILHQRNFGYNHKDVQANASVRAAFVHALGDVFQSISVLISALIIYFKPDYKIADPVCTFIFSILVLASTVMILKDFSILLMEGVPKGLSYNSVKEIILAVDGVISVHSLHIWSLTVNQVILSVHVATAASQDSQSVRTGIAQALSSFDLHSLTIQIESAADQDPSCLLCEDPQD

Target ORF information:

RefSeq Version	NM_172816.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 30 (zinc transporter), member 8 (Slc30a8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172816.4

ORF Insert Sequence:

ATGGAGTTTC TTGAGAGAAC TTATCTTGTG AATGATCAAG CCACCAAGAT GTACGCCTTC 
CCTCTAGACA GAGAACTTCG ACAGAAGCCT GTGAATAAAG ATCAGTGTCC TGGAGACAGG 
CCAGAGCATC CAGAGGCAGG AGGCATCTAT CACTGCCACA ACAGCGCCAA GGCCACAGGG 
AACAGGTCGA GCAAGCAAGC GCATGCCAAG TGGAGACTCT GTGCTGCTTC AGCAATATGC 
TTCATCTTTA TGGTGGCAGA GGTGGTGGGT GGACACGTTG CTGGGAGTCT GGCTATCCTC 
ACTGATGCGG CTCATCTCTT AATTGACCTG ACTAGTTTCC TGCTCAGTCT CTTTTCTTTG 
TGGTTGTCAT CGAGGCCCCC TTCCAAGCGG CTGACATTTG GGTGGTATCG AGCAGAGATC 
CTCGGTGCCC TGCTGTCTGT CCTTTGCATC TGGGTGGTGA CTGGTGTGCT GCTGTACCTT 
GCCTGTGAGC GCCTTTTGTA TCCTGATTAC CAGATCCAAG CAGGTATCAT GATCACTGTT 
TCAGGCTGTG CAGTGGCAGC CAACATTGTA CTAACTATGA TTTTGCACCA ACGGAACTTT 
GGCTACAACC ACAAGGATGT ACAAGCTAAT GCCAGTGTCC GAGCAGCCTT TGTGCATGCC 
CTGGGGGATG TATTTCAGAG CATCAGTGTG CTAATTAGTG CTCTCATTAT CTACTTTAAG 
CCTGACTACA AAATTGCTGA TCCAGTGTGC ACATTTATCT TTTCCATCCT GGTTTTGGCC 
AGCACCGTCA TGATCTTAAA AGACTTCTCC ATCTTACTCA TGGAAGGTGT TCCAAAGGGC 
CTGAGTTACA ACAGTGTGAA AGAGATCATC CTCGCAGTTG ATGGCGTGAT CTCCGTGCAC 
AGTCTACACA TCTGGTCACT GACTGTGAAC CAAGTGATTC TCTCTGTTCA TGTTGCTACA 
GCTGCCAGCC AGGACAGCCA GTCTGTGCGG ACAGGAATTG CTCAAGCCCT CAGCAGCTTT 
GATCTTCACT CTCTTACCAT TCAGATAGAA TCTGCAGCAG ACCAGGACCC CAGCTGCCTT 
CTCTGCGAAG ACCCTCAGGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Development (Cambridge, England)144(13)2402-2414(2017 07)
Sinagoga KL,Stone WJ,Schiesser JV,Schweitzer JI,Sampson L,Zheng Y,Wells JM

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Slc30a8 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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