Slc30a8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc30a8
Entrez Gene ID	299903
Full Name	solute carrier family 30 member 8
Synonyms	ZnT-8
General protein information	Preferred Names solute carrier family 30 member 8 Names zinc transporter 8 solute carrier family 30 (zinc transporter), member 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001130538.1	NP_001124010.1	zinc transporter 8
XM_008765500.2	XP_008763722.1	zinc transporter 8 isoform X1
XM_006241645.3	XP_006241707.1	zinc transporter 8 isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC30A8	XP_519918.2
Gallus gallus (chicken)	SLC30A8	XP_418398.4
Xenopus tropicalis (tropical clawed frog)	slc30a8	NP_001011041.1
Mus musculus (house mouse)	Slc30a8	NP_766404.1
Rattus norvegicus (Norway rat)	Slc30a8	NP_001124010.1
	SLC30A8	XP_001095488.1
Homo sapiens (human)	SLC30A8	NP_776250.2
Canis lupus familiaris (dog)	SLC30A8	XP_539143.2
Danio rerio (zebrafish)	LOC560642	XP_689129.4

Gene Ontology
Bibliography

Related articles in PubMed

Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1? Expression.
Xu G, Kang D, Zhang C, Lou H, Sun C, Yang Q, Lu L, Xu GT, Zhang J, Wang F
Investigative ophthalmology & visual science56(13)8166-78(2015 Dec)

Moderate-intensity exercise training elevates serum and pancreatic zinc levels and pancreatic ZnT8 expression in streptozotocin-induced diabetic rats.
Somboonwong J, Traisaeng S, Saguanrungsirikul S
Life sciences13946-51(2015 Oct)

Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy.
Deniro M, Al-Mohanna FA
PloS one7(11)e50360(2012)

siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells.
Petersen AB, Smidt K, Magnusson NE, Moore F, Egefjord L, Rungby J
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica119(2)93-102(2011 Feb)

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.
Fu Y, Tian W, Pratt EB, Dirling LB, Shyng SL, Meshul CK, Cohen DM
PloS one4(5)e5679(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In diabetic retinas, EPO maintains zinc homeostasis through activating the ERK pathway and downregulating HIF-1alpha, and thus upregulating ZnT8 expression.
Title: Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1? Expression.

Diabetes caused reductions in the serum and pancreatic zinc levels and pancreatic ZnT8 expression. Following moderate exercise training, there was a significant increase in all of these parameters.
Title: Moderate-intensity exercise training elevates serum and pancreatic zinc levels and pancreatic ZnT8 expression in streptozotocin-induced diabetic rats.

ischemic retinopathy maybe mediated by aberrant Zn(++) homeostasis caused by ZnT8 downregulation, whereas YC-1 plays a neuroprotective role against ischemic insult
Title: Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy.

Both ZnT3 and ZnT8 seem to play a role in beta-cell survival and the ability of these cells to react appropriately to surrounding glucose concentrations.
Title: siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells.

These data indicate that reduced ZnT8 expression in cultured pancreatic beta cells gives rise to a reduced insulin response to hyperglycemia.
Title: Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.

The following Slc30a8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc30a8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa30367	XM_006241645.3 Latest version!	Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa42782	NM_001130538.1 Latest version!	Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa45645	XM_008765500.2 Latest version!	Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc30a8 ( XM_006241645.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006241707.1 Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa30367
Clone ID Related Accession (Same CDS sequence)	XM_006241645.3
Accession Version	XM_006241645.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter 8 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006241645.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTTTC TTGAGAGGAC TTACCTTGTG AATGATCAAG CCACCAAGAT GTATGCCTTC 
ACTTCAGACA GAGAACGTGG ACAGAAGCCT GTGAATAAAG ATCAGTGTCC TGGAGACGGG 
CCAGAGCGTC CGGAGGCAGG AGCCATCTAT CACTGCCACA ACAGCTTCAA GGCCACAGGG 
AACAGGTCGA GCAAGCAAGT GCATGCCAAG TGGAGACTCT GTGCTGCTTC AGCAATATGC 
TTCTTCTTTA TGGTGGCAGA GGTGGTGGGT GGACATGTTG CTGGGAGTCT GGCGGTCCTC 
ACTGATGCTG CTCATCTCTT AATTGACCTG ACTAGTTTCC TGCTCAGTCT CTTTTCTTTG 
TGGTTATCTT CAAGGCCCCC TTCCAAGCGG CTGACATTTG GGTGGTATCG AGCAGAGATC 
CTCGGTGCCC TGCTGTCTGT CCTTTGCATC TGGGTGGTGA CTGGTGTGCT GGTGTACCTT 
GCCTGTGAGC GCCTCTTGTA TCCTGATTAC CAGATCCAAG CAGGCATCAT GATCACTGTT 
TCAGGCTGTG CAGTGGCAGC CAACATTGTA CTAACTCTGA TTTTGCACCA ACGGCATCTT 
GGCCACAACC ACAAGGATGC ACAAGCTAAT GCCAGCGTTC GAGCGGCCTT TGTGCATGCC 
CTGGGGGATG TGTTTCAGAG CACCAGTGTG CTAATTAGTG CTCTCATTAT CTACTTTAAG 
CCCGACTACA AAATGGCTGA TCCAGTGTGC ACATTTATCT CTTCCGTCTT GGCTTTGGCC 
AGCACCGTCA TGATCTTAAA AGACTTCTCC ATCTTACTCA TGGAAGGTGT TCCAAAGGGC 
CTGAGTTACA ACAGTGTGAA AGAACTCCTC CTCACAGTCG ATGGCGTGAT CTCCGTGCAC 
AATCTACACA TCTGGTCGCT GACAGTGAAC CAAGTGATTC TCTCTGTTCA TGTTGCTACA 
GCTGCGAGCC AGGACAGCCA GTCTGTGCGG ACAGGAATTG CTTGCGCTCT CAGCAGTAGC 
TTTGATCTGC ACTCTCTTAC CATTCAGATC GAATCTGCGG CAGATCAGGA CCCCAGCTGC 
CTTCTCTGTG AAGACCCACA GGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006241707.1
CDS	310..1416
Translation	MEFLERTYLVNDQATKMYAFTSDRERGQKPVNKDQCPGDGPERPEAGAIYHCHNSFKATGNRSSKQVHAKWRLCAASAICFFFMVAEVVGGHVAGSLAVLTDAAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWYRAEILGALLSVLCIWVVTGVLVYLACERLLYPDYQIQAGIMITVSGCAVAANIVLTLILHQRHLGHNHKDAQANASVRAAFVHALGDVFQSTSVLISALIIYFKPDYKMADPVCTFISSVLALASTVMILKDFSILLMEGVPKGLSYNSVKELLLTVDGVISVHNLHIWSLTVNQVILSVHVATAASQDSQSVRTGIACALSSSFDLHSLTIQIESAADQDPSCLLCEDPQD

Target ORF information:

RefSeq Version	XM_006241645.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006241645.3

ORF Insert Sequence:

ATGGAGTTTC TTGAGAGGAC TTACCTTGTG AATGATCAAG CCACCAAGAT GTATGCCTTC 
ACTTCAGACA GAGAACGTGG ACAGAAGCCT GTGAATAAAG ATCAGTGTCC TGGAGACGGG 
CCAGAGCGTC CGGAGGCAGG AGCCATCTAT CACTGCCACA ACAGCTTCAA GGCCACAGGG 
AACAGGTCGA GCAAGCAAGT GCATGCCAAG TGGAGACTCT GTGCTGCTTC AGCAATATGC 
TTCTTCTTTA TGGTGGCAGA GGTGGTGGGT GGACATGTTG CTGGGAGTCT GGCGGTCCTC 
ACTGATGCTG CTCATCTCTT AATTGACCTG ACTAGTTTCC TGCTCAGTCT CTTTTCTTTG 
TGGTTATCTT CAAGGCCCCC TTCCAAGCGG CTGACATTTG GGTGGTATCG AGCAGAGATC 
CTCGGTGCCC TGCTGTCTGT CCTTTGCATC TGGGTGGTGA CTGGTGTGCT GGTGTACCTT 
GCCTGTGAGC GCCTCTTGTA TCCTGATTAC CAGATCCAAG CAGGCATCAT GATCACTGTT 
TCAGGCTGTG CAGTGGCAGC CAACATTGTA CTAACTCTGA TTTTGCACCA ACGGCATCTT 
GGCCACAACC ACAAGGATGC ACAAGCTAAT GCCAGCGTTC GAGCGGCCTT TGTGCATGCC 
CTGGGGGATG TGTTTCAGAG CACCAGTGTG CTAATTAGTG CTCTCATTAT CTACTTTAAG 
CCCGACTACA AAATGGCTGA TCCAGTGTGC ACATTTATCT CTTCCGTCTT GGCTTTGGCC 
AGCACCGTCA TGATCTTAAA AGACTTCTCC ATCTTACTCA TGGAAGGTGT TCCAAAGGGC 
CTGAGTTACA ACAGTGTGAA AGAACTCCTC CTCACAGTCG ATGGCGTGAT CTCCGTGCAC 
AATCTACACA TCTGGTCGCT GACAGTGAAC CAAGTGATTC TCTCTGTTCA TGTTGCTACA 
GCTGCGAGCC AGGACAGCCA GTCTGTGCGG ACAGGAATTG CTTGCGCTCT CAGCAGTAGC 
TTTGATCTGC ACTCTCTTAC CATTCAGATC GAATCTGCGG CAGATCAGGA CCCCAGCTGC 
CTTCTCTGTG AAGACCCACA GGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc30a8 ( NM_001130538.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001124010.1 Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), mRNA.

Price & Availability↑

CloneID	ORa42782
Clone ID Related Accession (Same CDS sequence)	NM_001130538.1
Accession Version	NM_001130538.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter 8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473950.2. On or before Jul 28, 2008 this sequence version replaced XM_235269.4, XM_001065623.1.

ATGGAGTTTC TTGAGAGGAC TTACCTTGTG AATGATCAAG CCACCAAGAT GTATGCCTTC 
ACTTCAGACA GAGAACGTGG ACAGAAGCCT GTGAATAAAG ATCAGTGTCC TGGAGACGGG 
CCAGAGCGTC CGGAGGCAGG AGCCATCTAT CACTGCCACA ACAGCTTCAA GGCCACAGGG 
AACAGGTCGA GCAAGCAAGT GCATGCCAAG TGGAGACTCT GTGCTGCTTC AGCAATATGC 
TTCTTCTTTA TGGTGGCAGA GGTGGTGGGT GGACATGTTG CTGGGAGTCT GGCGGTCCTC 
ACTGATGCTG CTCATCTCTT AATTGACCTG ACTAGTTTCC TGCTCAGTCT CTTTTCTTTG 
TGGTTATCTT CAAGGCCCCC TTCCAAGCGG CTGACATTTG GGTGGTATCG AGCAGAGATC 
CTCGGTGCCC TGCTGTCTGT CCTTTGCATC TGGGTGGTGA CTGGTGTGCT GGTGTACCTT 
GCCTGTGAGC GCCTCTTGTA TCCTGATTAC CAGATCCAAG CAGGCATCAT GATCACTGTT 
TCAGGCTGTG CAGTGGCAGC CAACATTGTA CTAACTCTGA TTTTGCACCA ACGGCATCTT 
GGCCACAACC ACAAGGATGC ACAAGCTAAT GCCAGCGTTC GAGCGGCCTT TGTGCATGCC 
CTGGGGGATG TGTTTCAGAG CACCAGTGTG CTAATTAGTG CTCTCATTAT CTACTTTAAG 
CCCGACTACA AAATGGCTGA TCCAGTGTGC ACATTTATCT CTTCCGTCTT GGCTTTGGCC 
AGCACCGTCA TGATCTTAAA AGACTTCTCC ATCTTACTCA TGGAAGGTGT TCCAAAGGGC 
CTGAGTTACA ACAGTGTGAA AGAACTCCTC CTCACAGTCG ATGGCGTGAT CTCCGTGCAC 
AATCTACACA TCTGGTCGCT GACAGTGAAC CAAGTGATTC TCTCTGTTCA TGTTGCTACA 
GGTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124010.1
CDS	310..1278
Translation	MEFLERTYLVNDQATKMYAFTSDRERGQKPVNKDQCPGDGPERPEAGAIYHCHNSFKATGNRSSKQVHAKWRLCAASAICFFFMVAEVVGGHVAGSLAVLTDAAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWYRAEILGALLSVLCIWVVTGVLVYLACERLLYPDYQIQAGIMITVSGCAVAANIVLTLILHQRHLGHNHKDAQANASVRAAFVHALGDVFQSTSVLISALIIYFKPDYKMADPVCTFISSVLALASTVMILKDFSILLMEGVPKGLSYNSVKELLLTVDGVISVHNLHIWSLTVNQVILSVHVATGQ

Target ORF information:

RefSeq Version	NM_001130538.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130538.1

ORF Insert Sequence:

ATGGAGTTTC TTGAGAGGAC TTACCTTGTG AATGATCAAG CCACCAAGAT GTATGCCTTC 
ACTTCAGACA GAGAACGTGG ACAGAAGCCT GTGAATAAAG ATCAGTGTCC TGGAGACGGG 
CCAGAGCGTC CGGAGGCAGG AGCCATCTAT CACTGCCACA ACAGCTTCAA GGCCACAGGG 
AACAGGTCGA GCAAGCAAGT GCATGCCAAG TGGAGACTCT GTGCTGCTTC AGCAATATGC 
TTCTTCTTTA TGGTGGCAGA GGTGGTGGGT GGACATGTTG CTGGGAGTCT GGCGGTCCTC 
ACTGATGCTG CTCATCTCTT AATTGACCTG ACTAGTTTCC TGCTCAGTCT CTTTTCTTTG 
TGGTTATCTT CAAGGCCCCC TTCCAAGCGG CTGACATTTG GGTGGTATCG AGCAGAGATC 
CTCGGTGCCC TGCTGTCTGT CCTTTGCATC TGGGTGGTGA CTGGTGTGCT GGTGTACCTT 
GCCTGTGAGC GCCTCTTGTA TCCTGATTAC CAGATCCAAG CAGGCATCAT GATCACTGTT 
TCAGGCTGTG CAGTGGCAGC CAACATTGTA CTAACTCTGA TTTTGCACCA ACGGCATCTT 
GGCCACAACC ACAAGGATGC ACAAGCTAAT GCCAGCGTTC GAGCGGCCTT TGTGCATGCC 
CTGGGGGATG TGTTTCAGAG CACCAGTGTG CTAATTAGTG CTCTCATTAT CTACTTTAAG 
CCCGACTACA AAATGGCTGA TCCAGTGTGC ACATTTATCT CTTCCGTCTT GGCTTTGGCC 
AGCACCGTCA TGATCTTAAA AGACTTCTCC ATCTTACTCA TGGAAGGTGT TCCAAAGGGC 
CTGAGTTACA ACAGTGTGAA AGAACTCCTC CTCACAGTCG ATGGCGTGAT CTCCGTGCAC 
AATCTACACA TCTGGTCGCT GACAGTGAAC CAAGTGATTC TCTCTGTTCA TGTTGCTACA 
GGTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc30a8 ( XM_008765500.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008763722.1 Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa45645
Clone ID Related Accession (Same CDS sequence)	XM_008765500.2
Accession Version	XM_008765500.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1110bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008765500.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTTTC TTGAGAGGAC TTACCTTGTG AATGATCAAG CCACCAAGAT GTATGCCTTC 
ACTTCAGACA GCAGAGAACG TGGACAGAAG CCTGTGAATA AAGATCAGTG TCCTGGAGAC 
GGGCCAGAGC GTCCGGAGGC AGGAGCCATC TATCACTGCC ACAACAGCTT CAAGGCCACA 
GGGAACAGGT CGAGCAAGCA AGTGCATGCC AAGTGGAGAC TCTGTGCTGC TTCAGCAATA 
TGCTTCTTCT TTATGGTGGC AGAGGTGGTG GGTGGACATG TTGCTGGGAG TCTGGCGGTC 
CTCACTGATG CTGCTCATCT CTTAATTGAC CTGACTAGTT TCCTGCTCAG TCTCTTTTCT 
TTGTGGTTAT CTTCAAGGCC CCCTTCCAAG CGGCTGACAT TTGGGTGGTA TCGAGCAGAG 
ATCCTCGGTG CCCTGCTGTC TGTCCTTTGC ATCTGGGTGG TGACTGGTGT GCTGGTGTAC 
CTTGCCTGTG AGCGCCTCTT GTATCCTGAT TACCAGATCC AAGCAGGCAT CATGATCACT 
GTTTCAGGCT GTGCAGTGGC AGCCAACATT GTACTAACTC TGATTTTGCA CCAACGGCAT 
CTTGGCCACA ACCACAAGGA TGCACAAGCT AATGCCAGCG TTCGAGCGGC CTTTGTGCAT 
GCCCTGGGGG ATGTGTTTCA GAGCACCAGT GTGCTAATTA GTGCTCTCAT TATCTACTTT 
AAGCCCGACT ACAAAATGGC TGATCCAGTG TGCACATTTA TCTCTTCCGT CTTGGCTTTG 
GCCAGCACCG TCATGATCTT AAAAGACTTC TCCATCTTAC TCATGGAAGG TGTTCCAAAG 
GGCCTGAGTT ACAACAGTGT GAAAGAACTC CTCCTCACAG TCGATGGCGT GATCTCCGTG 
CACAATCTAC ACATCTGGTC GCTGACAGTG AACCAAGTGA TTCTCTCTGT TCATGTTGCT 
ACAGCTGCGA GCCAGGACAG CCAGTCTGTG CGGACAGGAA TTGCTTGCGC TCTCAGCAGT 
AGCTTTGATC TGCACTCTCT TACCATTCAG ATCGAATCTG CGGCAGATCA GGACCCCAGC 
TGCCTTCTCT GTGAAGACCC ACAGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008763722.1
CDS	73..1182
Translation	MEFLERTYLVNDQATKMYAFTSDSRERGQKPVNKDQCPGDGPERPEAGAIYHCHNSFKATGNRSSKQVHAKWRLCAASAICFFFMVAEVVGGHVAGSLAVLTDAAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWYRAEILGALLSVLCIWVVTGVLVYLACERLLYPDYQIQAGIMITVSGCAVAANIVLTLILHQRHLGHNHKDAQANASVRAAFVHALGDVFQSTSVLISALIIYFKPDYKMADPVCTFISSVLALASTVMILKDFSILLMEGVPKGLSYNSVKELLLTVDGVISVHNLHIWSLTVNQVILSVHVATAASQDSQSVRTGIACALSSSFDLHSLTIQIESAADQDPSCLLCEDPQD

Target ORF information:

RefSeq Version	XM_008765500.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 30 member 8 (Slc30a8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008765500.2

ORF Insert Sequence:

ATGGAGTTTC TTGAGAGGAC TTACCTTGTG AATGATCAAG CCACCAAGAT GTATGCCTTC 
ACTTCAGACA GCAGAGAACG TGGACAGAAG CCTGTGAATA AAGATCAGTG TCCTGGAGAC 
GGGCCAGAGC GTCCGGAGGC AGGAGCCATC TATCACTGCC ACAACAGCTT CAAGGCCACA 
GGGAACAGGT CGAGCAAGCA AGTGCATGCC AAGTGGAGAC TCTGTGCTGC TTCAGCAATA 
TGCTTCTTCT TTATGGTGGC AGAGGTGGTG GGTGGACATG TTGCTGGGAG TCTGGCGGTC 
CTCACTGATG CTGCTCATCT CTTAATTGAC CTGACTAGTT TCCTGCTCAG TCTCTTTTCT 
TTGTGGTTAT CTTCAAGGCC CCCTTCCAAG CGGCTGACAT TTGGGTGGTA TCGAGCAGAG 
ATCCTCGGTG CCCTGCTGTC TGTCCTTTGC ATCTGGGTGG TGACTGGTGT GCTGGTGTAC 
CTTGCCTGTG AGCGCCTCTT GTATCCTGAT TACCAGATCC AAGCAGGCAT CATGATCACT 
GTTTCAGGCT GTGCAGTGGC AGCCAACATT GTACTAACTC TGATTTTGCA CCAACGGCAT 
CTTGGCCACA ACCACAAGGA TGCACAAGCT AATGCCAGCG TTCGAGCGGC CTTTGTGCAT 
GCCCTGGGGG ATGTGTTTCA GAGCACCAGT GTGCTAATTA GTGCTCTCAT TATCTACTTT 
AAGCCCGACT ACAAAATGGC TGATCCAGTG TGCACATTTA TCTCTTCCGT CTTGGCTTTG 
GCCAGCACCG TCATGATCTT AAAAGACTTC TCCATCTTAC TCATGGAAGG TGTTCCAAAG 
GGCCTGAGTT ACAACAGTGT GAAAGAACTC CTCCTCACAG TCGATGGCGT GATCTCCGTG 
CACAATCTAC ACATCTGGTC GCTGACAGTG AACCAAGTGA TTCTCTCTGT TCATGTTGCT 
ACAGCTGCGA GCCAGGACAG CCAGTCTGTG CGGACAGGAA TTGCTTGCGC TCTCAGCAGT 
AGCTTTGATC TGCACTCTCT TACCATTCAG ATCGAATCTG CGGCAGATCA GGACCCCAGC 
TGCCTTCTCT GTGAAGACCC ACAGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1? Expression.
Investigative ophthalmology & visual science56(13)8166-78(2015 Dec)
Xu G,Kang D,Zhang C,Lou H,Sun C,Yang Q,Lu L,Xu GT,Zhang J,Wang F

Moderate-intensity exercise training elevates serum and pancreatic zinc levels and pancreatic ZnT8 expression in streptozotocin-induced diabetic rats.
Life sciences13946-51(2015 Oct)
Somboonwong J,Traisaeng S,Saguanrungsirikul S

Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy.
PloS one7(11)e50360(2012)
Deniro M,Al-Mohanna FA

siRNA-mediated knock-down of ZnT3 and ZnT8 affects production and secretion of insulin and apoptosis in INS-1E cells.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica119(2)93-102(2011 Feb)
Petersen AB,Smidt K,Magnusson NE,Moore F,Egefjord L,Rungby J

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.
PloS one4(5)e5679(2009 May)
Fu Y,Tian W,Pratt EB,Dirling LB,Shyng SL,Meshul CK,Cohen DM

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Slc30a8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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