Tlr11 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tlr11
Entrez Gene ID	239081
Full Name	toll-like receptor 11
Synonyms	Gm287
General protein information	Preferred Names toll-like receptor 11 Names toll-like receptor 11
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_205819.3	NP_991388.2	toll-like receptor 11

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tlr11	NP_991388.2
Rattus norvegicus (Norway rat)	Tlr11	NP_001138251.2

Gene Ontology
Bibliography

Related articles in PubMed

TLR11 or TLR12 silencing reduces Leishmania major infection.
Shukla D, Chandel HS, Srivastava S, Chauhan P, Pandey SP, Patidar A, Banerjee R, Chattopadhyay D, Saha B
Cytokine(2017 Oct)

Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
Hatai H, Lepelley A, Zeng W, Hayden MS, Ghosh S
PloS one11(2)e0148987(2016)

Astrocytes, microglia/macrophages, and neurons expressing Toll-like receptor 11 contribute to innate immunity against encephalitic Toxoplasma gondii infection.
Atmaca HT, Kul O, Karaku? E, Terzi OS, Canpolat S, Anteplio?lu T
Neuroscience269184-91(2014 Jun)

Toll-like receptor 11-initiated innate immune response in male mouse germ cells.
Chen Q, Zhu W, Liu Z, Yan K, Zhao S, Han D
Biology of reproduction90(2)38(2014 Feb)

Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.
Raetz M, Kibardin A, Sturge CR, Pifer R, Li H, Burstein E, Ozato K, Larin S, Yarovinsky F
Journal of immunology (Baltimore, Md. : 1950)191(9)4818-27(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mechanisms of interaction with flagellin and profilin
Title: Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.

Data show that TLR11 expression is induced in astrocytes, neurons, and microglia in the immune response to T. gondii infection
Title: Astrocytes, microglia/macrophages, and neurons expressing Toll-like receptor 11 contribute to innate immunity against encephalitic Toxoplasma gondii infection.

TLR11 mediates innate immune function of male germ cells in response to T. gondii profilin and uropathogenic escherichia coli stimulations.
Title: Toll-like receptor 11-initiated innate immune response in male mouse germ cells.

Biochemical experiments revealed that TLR11 and TLR12 directly bind to Toxoplasma gondii profilin and are capable of forming a heterodimer complex.
Title: Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.

Selective elimination of neutrophils in TLR11-deficient mice infected with Toxoplasma gondii results in acute susceptibility similar to that observed in IFN-gamma-deficient mice.
Title: TLR-independent neutrophil-derived IFN-? is important for host resistance to intracellular pathogens.

The following Tlr11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tlr11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17417	NM_205819.3 Latest version!	Mus musculus toll-like receptor 11 (Tlr11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tlr11 ( NM_205819.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_991388.2 Mus musculus toll-like receptor 11 (Tlr11), mRNA.

Price & Availability↑

CloneID	OMu17417
Clone ID Related Accession (Same CDS sequence)	NM_205819.3
Accession Version	NM_205819.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2796bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-06
Organism	Mus musculus(house mouse)
Product	toll-like receptor 11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC135188.2, AY510704.1 and AI646605.1. On Oct 11, 2012 this sequence version replaced NM_205819.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BB666029.1, BB637372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCAAAG AATCGATGCC AAGGATGGAA AGACATCAGT TCTGCTCTGT TCTCCTCATT 
CTGATACTAT TGACTCTGGT GAGCCTTACC TTGACTGGCT GGGCATGGAC CATCCCTGAT 
TGCATCATAG CAGACAGTTT GTTATTTCCT AACCTTTCCT ACTACATCCC ATTCTGTACC 
TCGGCCCCAG GACTGCACCT TTTGGCATCT TGCTCTAATG TTAAAAACTT AAATCAGACC 
CTAAAAAGAG TGCCCAGAAA TACAGAGGTA CTCTGCCTCC AGGGCATGGT TCCTACTCTG 
CCAGCTAAGG CCTTTATTCG CTTCCACTCC CTACAGCTTC TAAGGCTGCA ATTGCGTACA 
ACCAGTGTCA CATCTAGGAC TTTTCAAGGA CTGGACCAGC TACAATACCT TTTTTTTGAT 
CATCATGCTC CCTGTTGCCT AAGTTTGTTC CTCTCTCCAA ATTGTTTTGA GTCTCTTAGA 
TCCCTTAGTA GTCTTTCCTT TCAAGGATAT TGCCTGACTT ATAGCCAAAG CATCTACTTG 
CCAACTAGTC TTAGGCATCT AACTCTGAGG AATAGCTGTC TAACAAAGTT TCAGGACCTT 
CAAAGGCTCT TCCCAGACCT TCTGCTGAGT ACCTCCTCTA CACCCAATAT CAAACCAGGG 
GCACCCTTTT TAGAGACGCT GGATTTATCT TACAACCTTC AGCTGAAACA GGCAGGTGTC 
AGAGACTTGT ATGGCCTCAC ACTCCATTCC CTAATATTGG ATGGTACCCC ACTAAAAGCA 
CTTGATCTCA CAGACTCAGG ACTGCTCCAC TTGCATTTCC TCTCCCTTGT GGGAACAGGA 
ATAGAAAAAG TGCCTGCAAG TTTGACTGGC TACTCTGAGC TTCGTGCACT TGACCTTGGG 
AAAAACCAAA TCCAAAACAT CTTGGAAAAT GGAGAAATCC CAGGTTATAA AGCCCTGGAA 
TTCCTTAGCC TTCATGATAA CCATCTGCAA ACACTTCCTA CCAGGTTTCT ACATACTCTA 
CCCCAGCTTC AGAAGCTCAA CCTATCTATG AATAAGCTTG GCCCAATCTT GGAGCTTCCA 
GAAGGACTCT TTAGCACAAA CTTAAAAGTG CTAGATCTAT CCTATAATCA ACTCTGTGAT 
GTACCCCATG GGGCTTTATC CCTTTTGTCA CAGCTCCAGG AGCTCTGGTT GAGTGGCAAT 
AACATCTCTA GTTTATCCAA TGAAAGCCTG CAGGGACTGA GGCAGCTGAG GACACTAGAC 
TTAAGTTGGA ATCAAATTAA AGTACTCAAA CCAGGCTGGC TCTCTCATCT TCCTGCTCTG 
ACTACCTTGA ACCTTCTGGG CACCTACTTA GAATATATCT TAGGCATACA ACTTCAGGGT 
CCCAAGATGC TAAGGCATTT ACAACTGGGT TCTTATCCAA TACTGGACAT ATATCCTCCC 
TGGCCCCCAA CACTCCTTAG CTTAGAAATA CAAGCAGAAT CATGTATTCA GTTTATGATT 
CACAGTGGAC AGCCATTCTT ATTCTTGGAG AACCTTACCT TAGAGACTTC CATTCTATTA 
CTAAAACCAG ACAACATCAC AATTCATTTT CCCTCCCTGC GTCGCCTCAC CTTGCGTGGC 
TACAGCTTCA TCTTCTCAAC CAGTCAACTT CAGAGATTCT TCCCACAACA GCTTCCTCTT 
CTGGAGCACT TCTTTATCTG GTGTGAAAAC AGCTATGCAG TAGACCTCTA TCTATTTGGG 
ATGCCCAGGC TACGTGTGCT AGAGCTGGGG TACCTTAACT TTTTCTATGA GTCAAGTACT 
ATGAAGCTAG AGATGCTATT GAAGGAGGTA CCTCAGTTAC AGGTACTGGC ATTGAGCCAC 
CTGAATCTCA GGAACCTCTC TGTGTCCAGC TTTAAGAGCT TGCAGGACCT CAAACTGCTG 
CTCTTCAACT CTGAAAGGGC GCTGGAGATG AACAGCAACC TCCAGGAGTT TATTCCTCAG 
ATGCCTCAGT ACGTTTACTT CTCTGATGTC ACCTTTACTT GCCAGTGTGA AGCTTCCTGG 
CTGGAGTCTT GGGCTACACG GGCCCCAAAC ACATTTGTTT ATGGGCTGGA AAAATCCATT 
TGCATAGCTA ATGCCTCAGA CTACTCCAAA ACTCTACTAT TCTCTTTCCT TGCTACTAAT 
TGTCCACACG GTACTGAGTT TTGGGGCTTT CTCACCAGTT TCATTCTGCT GCTTCTGTTG 
ATTATCCTTC CTCTGATTAG CTGTCCTAAA TGGTCCTGGC TTCATCACCT CTGGACACTC 
TTTCATACTT GTTGGTGGAA ATTATGTGGA CATAGACTCA GAGGCCAATT CAACTATGAT 
GTCTTTATAT CCTATTGTGA GGAGGATCAA GCTTGGGTGC TGGAAGAACT GGTTCCAGTT 
CTGGAGAAAG CCCCTCCTGA AGGTGAAGGC TTGAGGTTGT GCCTGCCTGC CAGGGACTTT 
GGGATTGGAA ATGACAGGAT GGAATCCATG ATTGCCAGCA TGGGCAAAAG CAGAGCCACC 
CTCTGTGTGC TCACAGGACA GGCCTTAGCA AGTCCCTGGT GCAATCTAGA GTTACGACTG 
GCCACTTACC ACTTGGTAGC CAGGCCTGGG ACCACTCATC TCCTGCTGTT GTTTCTGGAG 
CCCCTTGATA GGCAGAGGCT CCATAGTTAC CATCGCCTAT CCCGTTGGCT CCAGAAGGAG 
GACTATTTTG ATTTGTCCCA AGGGAAAGTG GAGTGGAACT CTTTCTGTGA GCAACTGAAG 
AGACGGCTCA GCAAAGCTGG ACAAGAAAGA GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_991388.2
CDS	103..2898
Translation	MLKESMPRMERHQFCSVLLILILLTLVSLTLTGWAWTIPDCIIADSLLFPNLSYYIPFCTSAPGLHLLASCSNVKNLNQTLKRVPRNTEVLCLQGMVPTLPAKAFIRFHSLQLLRLQLRTTSVTSRTFQGLDQLQYLFFDHHAPCCLSLFLSPNCFESLRSLSSLSFQGYCLTYSQSIYLPTSLRHLTLRNSCLTKFQDLQRLFPDLLLSTSSTPNIKPGAPFLETLDLSYNLQLKQAGVRDLYGLTLHSLILDGTPLKALDLTDSGLLHLHFLSLVGTGIEKVPASLTGYSELRALDLGKNQIQNILENGEIPGYKALEFLSLHDNHLQTLPTRFLHTLPQLQKLNLSMNKLGPILELPEGLFSTNLKVLDLSYNQLCDVPHGALSLLSQLQELWLSGNNISSLSNESLQGLRQLRTLDLSWNQIKVLKPGWLSHLPALTTLNLLGTYLEYILGIQLQGPKMLRHLQLGSYPILDIYPPWPPTLLSLEIQAESCIQFMIHSGQPFLFLENLTLETSILLLKPDNITIHFPSLRRLTLRGYSFIFSTSQLQRFFPQQLPLLEHFFIWCENSYAVDLYLFGMPRLRVLELGYLNFFYESSTMKLEMLLKEVPQLQVLALSHLNLRNLSVSSFKSLQDLKLLLFNSERALEMNSNLQEFIPQMPQYVYFSDVTFTCQCEASWLESWATRAPNTFVYGLEKSICIANASDYSKTLLFSFLATNCPHGTEFWGFLTSFILLLLLIILPLISCPKWSWLHHLWTLFHTCWWKLCGHRLRGQFNYDVFISYCEEDQAWVLEELVPVLEKAPPEGEGLRLCLPARDFGIGNDRMESMIASMGKSRATLCVLTGQALASPWCNLELRLATYHLVARPGTTHLLLLFLEPLDRQRLHSYHRLSRWLQKEDYFDLSQGKVEWNSFCEQLKRRLSKAGQERD

Target ORF information:

RefSeq Version	NM_205819.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus toll-like receptor 11 (Tlr11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_205819.3

ORF Insert Sequence:

ATGCTCAAAG AATCGATGCC AAGGATGGAA AGACATCAGT TCTGCTCTGT TCTCCTCATT 
CTGATACTAT TGACTCTGGT GAGCCTTACC TTGACTGGCT GGGCATGGAC CATCCCTGAT 
TGCATCATAG CAGACAGTTT GTTATTTCCT AACCTTTCCT ACTACATCCC ATTCTGTACC 
TCGGCCCCAG GACTGCACCT TTTGGCATCT TGCTCTAATG TTAAAAACTT AAATCAGACC 
CTAAAAAGAG TGCCCAGAAA TACAGAGGTA CTCTGCCTCC AGGGCATGGT TCCTACTCTG 
CCAGCTAAGG CCTTTATTCG CTTCCACTCC CTACAGCTTC TAAGGCTGCA ATTGCGTACA 
ACCAGTGTCA CATCTAGGAC TTTTCAAGGA CTGGACCAGC TACAATACCT TTTTTTTGAT 
CATCATGCTC CCTGTTGCCT AAGTTTGTTC CTCTCTCCAA ATTGTTTTGA GTCTCTTAGA 
TCCCTTAGTA GTCTTTCCTT TCAAGGATAT TGCCTGACTT ATAGCCAAAG CATCTACTTG 
CCAACTAGTC TTAGGCATCT AACTCTGAGG AATAGCTGTC TAACAAAGTT TCAGGACCTT 
CAAAGGCTCT TCCCAGACCT TCTGCTGAGT ACCTCCTCTA CACCCAATAT CAAACCAGGG 
GCACCCTTTT TAGAGACGCT GGATTTATCT TACAACCTTC AGCTGAAACA GGCAGGTGTC 
AGAGACTTGT ATGGCCTCAC ACTCCATTCC CTAATATTGG ATGGTACCCC ACTAAAAGCA 
CTTGATCTCA CAGACTCAGG ACTGCTCCAC TTGCATTTCC TCTCCCTTGT GGGAACAGGA 
ATAGAAAAAG TGCCTGCAAG TTTGACTGGC TACTCTGAGC TTCGTGCACT TGACCTTGGG 
AAAAACCAAA TCCAAAACAT CTTGGAAAAT GGAGAAATCC CAGGTTATAA AGCCCTGGAA 
TTCCTTAGCC TTCATGATAA CCATCTGCAA ACACTTCCTA CCAGGTTTCT ACATACTCTA 
CCCCAGCTTC AGAAGCTCAA CCTATCTATG AATAAGCTTG GCCCAATCTT GGAGCTTCCA 
GAAGGACTCT TTAGCACAAA CTTAAAAGTG CTAGATCTAT CCTATAATCA ACTCTGTGAT 
GTACCCCATG GGGCTTTATC CCTTTTGTCA CAGCTCCAGG AGCTCTGGTT GAGTGGCAAT 
AACATCTCTA GTTTATCCAA TGAAAGCCTG CAGGGACTGA GGCAGCTGAG GACACTAGAC 
TTAAGTTGGA ATCAAATTAA AGTACTCAAA CCAGGCTGGC TCTCTCATCT TCCTGCTCTG 
ACTACCTTGA ACCTTCTGGG CACCTACTTA GAATATATCT TAGGCATACA ACTTCAGGGT 
CCCAAGATGC TAAGGCATTT ACAACTGGGT TCTTATCCAA TACTGGACAT ATATCCTCCC 
TGGCCCCCAA CACTCCTTAG CTTAGAAATA CAAGCAGAAT CATGTATTCA GTTTATGATT 
CACAGTGGAC AGCCATTCTT ATTCTTGGAG AACCTTACCT TAGAGACTTC CATTCTATTA 
CTAAAACCAG ACAACATCAC AATTCATTTT CCCTCCCTGC GTCGCCTCAC CTTGCGTGGC 
TACAGCTTCA TCTTCTCAAC CAGTCAACTT CAGAGATTCT TCCCACAACA GCTTCCTCTT 
CTGGAGCACT TCTTTATCTG GTGTGAAAAC AGCTATGCAG TAGACCTCTA TCTATTTGGG 
ATGCCCAGGC TACGTGTGCT AGAGCTGGGG TACCTTAACT TTTTCTATGA GTCAAGTACT 
ATGAAGCTAG AGATGCTATT GAAGGAGGTA CCTCAGTTAC AGGTACTGGC ATTGAGCCAC 
CTGAATCTCA GGAACCTCTC TGTGTCCAGC TTTAAGAGCT TGCAGGACCT CAAACTGCTG 
CTCTTCAACT CTGAAAGGGC GCTGGAGATG AACAGCAACC TCCAGGAGTT TATTCCTCAG 
ATGCCTCAGT ACGTTTACTT CTCTGATGTC ACCTTTACTT GCCAGTGTGA AGCTTCCTGG 
CTGGAGTCTT GGGCTACACG GGCCCCAAAC ACATTTGTTT ATGGGCTGGA AAAATCCATT 
TGCATAGCTA ATGCCTCAGA CTACTCCAAA ACTCTACTAT TCTCTTTCCT TGCTACTAAT 
TGTCCACACG GTACTGAGTT TTGGGGCTTT CTCACCAGTT TCATTCTGCT GCTTCTGTTG 
ATTATCCTTC CTCTGATTAG CTGTCCTAAA TGGTCCTGGC TTCATCACCT CTGGACACTC 
TTTCATACTT GTTGGTGGAA ATTATGTGGA CATAGACTCA GAGGCCAATT CAACTATGAT 
GTCTTTATAT CCTATTGTGA GGAGGATCAA GCTTGGGTGC TGGAAGAACT GGTTCCAGTT 
CTGGAGAAAG CCCCTCCTGA AGGTGAAGGC TTGAGGTTGT GCCTGCCTGC CAGGGACTTT 
GGGATTGGAA ATGACAGGAT GGAATCCATG ATTGCCAGCA TGGGCAAAAG CAGAGCCACC 
CTCTGTGTGC TCACAGGACA GGCCTTAGCA AGTCCCTGGT GCAATCTAGA GTTACGACTG 
GCCACTTACC ACTTGGTAGC CAGGCCTGGG ACCACTCATC TCCTGCTGTT GTTTCTGGAG 
CCCCTTGATA GGCAGAGGCT CCATAGTTAC CATCGCCTAT CCCGTTGGCT CCAGAAGGAG 
GACTATTTTG ATTTGTCCCA AGGGAAAGTG GAGTGGAACT CTTTCTGTGA GCAACTGAAG 
AGACGGCTCA GCAAAGCTGG ACAAGAAAGA GATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TLR11 or TLR12 silencing reduces Leishmania major infection.
Cytokine(2017 Oct)
Shukla D,Chandel HS,Srivastava S,Chauhan P,Pandey SP,Patidar A,Banerjee R,Chattopadhyay D,Saha B

Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
PloS one11(2)e0148987(2016)
Hatai H,Lepelley A,Zeng W,Hayden MS,Ghosh S

Astrocytes, microglia/macrophages, and neurons expressing Toll-like receptor 11 contribute to innate immunity against encephalitic Toxoplasma gondii infection.
Neuroscience269184-91(2014 Jun)
Atmaca HT,Kul O,Karaku? E,Terzi OS,Canpolat S,Anteplio?lu T

Toll-like receptor 11-initiated innate immune response in male mouse germ cells.
Biology of reproduction90(2)38(2014 Feb)
Chen Q,Zhu W,Liu Z,Yan K,Zhao S,Han D

Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.
Journal of immunology (Baltimore, Md. : 1950)191(9)4818-27(2013 Nov)
Raetz M,Kibardin A,Sturge CR,Pifer R,Li H,Burstein E,Ozato K,Larin S,Yarovinsky F

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Tlr11 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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