Fscn2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fscn2
Entrez Gene ID	238021
Full Name	fascin actin-bundling protein 2
Synonyms	A930022G03,Ahl8,C630046B20Rik
General protein information	Preferred Names fascin actin-bundling protein 2 Names fascin-2 fascin homolog 2, actin-bundling protein, retinal retinal fascin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 E2

mRNA and Protein(s)

mRNA	Protein	Name
XM_006533259.3	XP_006533322.1	fascin-2 isoform X1
NM_172802.4	NP_766390.2	fascin-2
XM_006533259.4	XP_006533322.1	fascin-2 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FSCN2	XP_003435223.1
Rattus norvegicus (Norway rat)	Fscn2	NP_001100542.1
Drosophila melanogaster (fruit fly)	sn	NP_001162696.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012991	XP_003437121.1
Pan troglodytes (chimpanzee)	FSCN2	XP_003953273.1
Gallus gallus (chicken)	FSCN2	NP_001171209.1
Danio rerio (zebrafish)	fscn2a	NP_001116988.1
Homo sapiens (human)	FSCN2	NP_001070650.1
	FSCN2	XP_001110926.2
Mus musculus (house mouse)	Fscn2	NP_766390.2
Danio rerio (zebrafish)	fscn2b	NP_957064.2
Xenopus tropicalis (tropical clawed frog)	fscn2	NP_001093724.1
Bos taurus (cattle)	FSCN2	NP_788806.1

Gene Ontology
Bibliography

Related articles in PubMed

Otoprotective effects of mouse nerve growth factor in DBA/2J mice with early-onset progressive hearing loss.
Wang Q, Zhao H, Zheng T, Wang W, Zhang X, Wang A, Li B, Wang Y, Zheng Q
Journal of neuroscience research95(10)1937-1950(2017 Oct)

CD40-CD40L cross-talk drives fascin expression in dendritic cells for efficient antigen presentation to CD4+ T cells.
Elizondo DM, Andargie TE, Kubhar DS, Gugssa A, Lipscomb MW
International immunology29(3)121-131(2017 03)

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.
Krey JF, Krystofiak ES, Dumont RA, Vijayakumar S, Choi D, Rivero F, Kachar B, Jones SM, Barr-Gillespie PG
The Journal of cell biology215(4)467-482(2016 Nov)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

?-Actin and fascin-2 cooperate to maintain stereocilia length.
Perrin BJ, Strandjord DM, Narayanan P, Henderson DM, Johnson KR, Ervasti JM
The Journal of neuroscience : the official journal of the Society for Neuroscience33(19)8114-21(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results show that cross-talk through CD40-CD40L signaling drives elevated fascin expression in DCs to support acquisition of full T-cell responses.
Title: CD40-CD40L cross-talk drives fascin expression in dendritic cells for efficient antigen presentation to CD4+ T cells.

A quantitative trait locus on chromosome 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J mice.
Title: A QTL on Chr 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J mice.

Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles.
Title: The formin Daam1 and fascin directly collaborate to promote filopodia formation.

The results of this study demonistrated that fascin-2 crosslinks function to slow actin depolymerization at stereocilia tips to maintain stereocilia length.
Title: ?-Actin and fascin-2 cooperate to maintain stereocilia length.

Mutation in the Fscn2 gene underlies the early onset progressive hearing loss of DBA/2J mice attributed to the ahl8 locus.
Title: The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice.

The following Fscn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fscn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18209	NM_172802.4 Latest version!	Mus musculus fascin actin-bundling protein 2 (Fscn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$286.30 $409.00
OMu46270	XM_006533259.4 Latest version!	Mus musculus fascin actin-bundling protein 2 (Fscn2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu46270	XM_006533259.3	Mus musculus fascin actin-bundling protein 2 (Fscn2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fscn2 ( XM_006533259.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006533322.1 Mus musculus fascin actin-bundling protein 2 (Fscn2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu46270
Clone ID Related Accession (Same CDS sequence)	XM_006533259.3 , XM_006533259.4
Accession Version	XM_006533259.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	fascin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006533259.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAACCA ACGGTCTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT TAACGATGCC 
GACCGCTACC TGACTGCAGA GAGCTTTGGC TTCAAGGTCA ACGCCTCCGC AGCCAGCCTC 
AAGAGGAAGC AGATCTGGGT CCTGGAGCCT GACCCGGGGC AGGGCACTGC CGTGCTGTTC 
CGAAGCAGTC ACCTAGGCCG CTACCTGTCA GCAGAAGAAG ATGGACGTGT GGCCTGTGAG 
ATGGATCAGC CGGGCCGTGA CTGCCGCTTC CTGGTCTTGC CGCAGCCTGA TGGGCGCTGG 
GTGCTGCAGT CAGAGCCACA CGGCCGCTTC TTCGGTGGCA TTGAGGACCG ACTGTCCTGC 
TTTGCCACGG CCATTTCCCC GGCAGAGCTG TGGACTGTGC ACCTGGCCAT CCACCCACAG 
GCTCATTTGC TGAGTGTGAG CCGTCGGCGC TACGTGCACC TGTGCCTTCA GGAAGATGAG 
ATGGCAGCAG ACGGTGACAT GCCATGGGGT GTGGACGCAC TAGTCACCCT CATTTTCCAG 
AGCAGGCGGT ACTGCCTCAA GTCTTATGAC AGCCGCTACC TTCGCAGCGA TGGCCGCCTT 
GTCTGGGAAC CTGAAGCCCA TGCCTGCTAC ACGCTGGAGT TCAAGGCAGG CAAGCTGGCC 
TTCAAGGACT GTGACGGCCG GTACCTGGCA CCTGTGGGGC CTGCTGGCAC ACTCAAGGCT 
GGTCGCAACA CGAGGCCCAG CAAGGATGAA CTCTTCGACC TGGAGCAAAG TCACCCACAG 
GTGGTGCTGG TAGCTGCCAA CCGGCGCTAC ATCTCTGTGA GGCAAGGAAT CAATGTCTCA 
GCCAATCAGG ATGAAGAACT GGGTCATGAG ACATTCCTGA TGCAAATCGA CCAGGAGACA 
AAGAAGTGTA CTTTCTATTC CAGCACTGGG GGCTACTGGA CCTTGGTCAC CCATGGGGGC 
ATTCAGGCCA CAGCCACACA AGTCTCTGCC AACACCATGT TTGAAATAGA ATGGCATGGC 
CGGCGGGTGG CACTTAAAGC CAGCAACGGG CGTTTTGTGT GCATGAAGAA AAACGGGCAG 
CTGGCCGCCA TCAGCGACTT TGTGGGTGAG CATTCCCTGC CTTCCACGGC CTGGAAAGAA 
CAGATGGGGG TGGGGAGTGG TCAGTCCACA TCACCCTCTC CTGCAGGCGA GGACGAGCTA 
TTTACCCTCA AGCTCATCAA TCGACCCCTC CTGGTGCTGC GTGGCCTGGA TGGCTTTGTG 
TGCCACCGCC GGGGCTCCAA CCAGCTGGAC ACCAACCGTT CCACTTACGA CGTCTTCCAC 
TTGAGCTTCA GGGATGGCGC CTATCAGATT AGAGGCCGTG GAGGTGGGTT CTGGTACACA 
GGCAGCCATG GAAGCGTGTG CAGCGACGGT GACTTGGCGG AAGATTTCCT CTTTGAGTTC 
CGAGAGCGTG GCCGTCTGGC CATCCGAGCC CTCAGCGGCA AGTACCTGCG TGGAGGAGCC 
TCAGGGCTCC TGCGTGCTGA TGCAGACCTG CCTGTGGGGG AAGCTCTCTG GGAATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006533322.1
CDS	3344..4903
Translation	MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQIWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDQPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGIEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDEMAADGDMPWGVDALVTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGKLAFKDCDGRYLAPVGPAGTLKAGRNTRPSKDELFDLEQSHPQVVLVAANRRYISVRQGINVSANQDEELGHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMFEIEWHGRRVALKASNGRFVCMKKNGQLAAISDFVGEHSLPSTAWKEQMGVGSGQSTSPSPAGEDELFTLKLINRPLLVLRGLDGFVCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFLFEFRERGRLAIRALSGKYLRGGASGLLRADADLPVGEALWEY

Target ORF information:

RefSeq Version	XM_006533259.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus fascin actin-bundling protein 2 (Fscn2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006533259.3

ORF Insert Sequence:

ATGCCAACCA ACGGTCTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT TAACGATGCC 
GACCGCTACC TGACTGCAGA GAGCTTTGGC TTCAAGGTCA ACGCCTCCGC AGCCAGCCTC 
AAGAGGAAGC AGATCTGGGT CCTGGAGCCT GACCCGGGGC AGGGCACTGC CGTGCTGTTC 
CGAAGCAGTC ACCTAGGCCG CTACCTGTCA GCAGAAGAAG ATGGACGTGT GGCCTGTGAG 
ATGGATCAGC CGGGCCGTGA CTGCCGCTTC CTGGTCTTGC CGCAGCCTGA TGGGCGCTGG 
GTGCTGCAGT CAGAGCCACA CGGCCGCTTC TTCGGTGGCA TTGAGGACCG ACTGTCCTGC 
TTTGCCACGG CCATTTCCCC GGCAGAGCTG TGGACTGTGC ACCTGGCCAT CCACCCACAG 
GCTCATTTGC TGAGTGTGAG CCGTCGGCGC TACGTGCACC TGTGCCTTCA GGAAGATGAG 
ATGGCAGCAG ACGGTGACAT GCCATGGGGT GTGGACGCAC TAGTCACCCT CATTTTCCAG 
AGCAGGCGGT ACTGCCTCAA GTCTTATGAC AGCCGCTACC TTCGCAGCGA TGGCCGCCTT 
GTCTGGGAAC CTGAAGCCCA TGCCTGCTAC ACGCTGGAGT TCAAGGCAGG CAAGCTGGCC 
TTCAAGGACT GTGACGGCCG GTACCTGGCA CCTGTGGGGC CTGCTGGCAC ACTCAAGGCT 
GGTCGCAACA CGAGGCCCAG CAAGGATGAA CTCTTCGACC TGGAGCAAAG TCACCCACAG 
GTGGTGCTGG TAGCTGCCAA CCGGCGCTAC ATCTCTGTGA GGCAAGGAAT CAATGTCTCA 
GCCAATCAGG ATGAAGAACT GGGTCATGAG ACATTCCTGA TGCAAATCGA CCAGGAGACA 
AAGAAGTGTA CTTTCTATTC CAGCACTGGG GGCTACTGGA CCTTGGTCAC CCATGGGGGC 
ATTCAGGCCA CAGCCACACA AGTCTCTGCC AACACCATGT TTGAAATAGA ATGGCATGGC 
CGGCGGGTGG CACTTAAAGC CAGCAACGGG CGTTTTGTGT GCATGAAGAA AAACGGGCAG 
CTGGCCGCCA TCAGCGACTT TGTGGGTGAG CATTCCCTGC CTTCCACGGC CTGGAAAGAA 
CAGATGGGGG TGGGGAGTGG TCAGTCCACA TCACCCTCTC CTGCAGGCGA GGACGAGCTA 
TTTACCCTCA AGCTCATCAA TCGACCCCTC CTGGTGCTGC GTGGCCTGGA TGGCTTTGTG 
TGCCACCGCC GGGGCTCCAA CCAGCTGGAC ACCAACCGTT CCACTTACGA CGTCTTCCAC 
TTGAGCTTCA GGGATGGCGC CTATCAGATT AGAGGCCGTG GAGGTGGGTT CTGGTACACA 
GGCAGCCATG GAAGCGTGTG CAGCGACGGT GACTTGGCGG AAGATTTCCT CTTTGAGTTC 
CGAGAGCGTG GCCGTCTGGC CATCCGAGCC CTCAGCGGCA AGTACCTGCG TGGAGGAGCC 
TCAGGGCTCC TGCGTGCTGA TGCAGACCTG CCTGTGGGGG AAGCTCTCTG GGAATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fscn2 ( NM_172802.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766390.2 Mus musculus fascin actin-bundling protein 2 (Fscn2), mRNA.

Price & Availability↑

CloneID	OMu18209
Clone ID Related Accession (Same CDS sequence)	NM_172802.4
Accession Version	NM_172802.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	fascin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK050002.1, BC109356.1 and BB279997.2. On Nov 11, 2009 this sequence version replaced NM_172802.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK050002.1, BC109356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGCCAACCA ACGGTCTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT TAACGATGCC 
GACCGCTACC TGACTGCAGA GAGCTTTGGC TTCAAGGTCA ACGCCTCCGC AGCCAGCCTC 
AAGAGGAAGC AGATCTGGGT CCTGGAGCCT GACCCGGGGC AGGGCACTGC CGTGCTGTTC 
CGAAGCAGTC ACCTAGGCCG CTACCTGTCA GCAGAAGAAG ATGGACGTGT GGCCTGTGAG 
ATGGATCAGC CGGGCCGTGA CTGCCGCTTC CTGGTCTTGC CGCAGCCTGA TGGGCGCTGG 
GTGCTGCAGT CAGAGCCACA CGGCCGCTTC TTCGGTGGCA TTGAGGACCG ACTGTCCTGC 
TTTGCCACGG CCATTTCCCC GGCAGAGCTG TGGACTGTGC ACCTGGCCAT CCACCCACAG 
GCTCATTTGC TGAGTGTGAG CCGTCGGCGC TACGTGCACC TGTGCCTTCA GGAAGATGAG 
ATGGCAGCAG ACGGTGACAT GCCATGGGGT GTGGACGCAC TAGTCACCCT CATTTTCCAG 
AGCAGGCGGT ACTGCCTCAA GTCTTATGAC AGCCGCTACC TTCGCAGCGA TGGCCGCCTT 
GTCTGGGAAC CTGAAGCCCA TGCCTGCTAC ACGCTGGAGT TCAAGGCAGG CAAGCTGGCC 
TTCAAGGACT GTGACGGCCG GTACCTGGCA CCTGTGGGGC CTGCTGGCAC ACTCAAGGCT 
GGTCGCAACA CGAGGCCCAG CAAGGATGAA CTCTTCGACC TGGAGCAAAG TCACCCACAG 
GTGGTGCTGG TAGCTGCCAA CCGGCGCTAC ATCTCTGTGA GGCAAGGAAT CAATGTCTCA 
GCCAATCAGG ATGAAGAACT GGGTCATGAG ACATTCCTGA TGCAAATCGA CCAGGAGACA 
AAGAAGTGTA CTTTCTATTC CAGCACTGGG GGCTACTGGA CCTTGGTCAC CCATGGGGGC 
ATTCAGGCCA CAGCCACACA AGTCTCTGCC AACACCATGT TTGAAATAGA ATGGCATGGC 
CGGCGGGTGG CACTTAAAGC CAGCAACGGG CGTTTTGTGT GCATGAAGAA AAACGGGCAG 
CTGGCCGCCA TCAGCGACTT TGTGGGCGAG GACGAGCTAT TTACCCTCAA GCTCATCAAT 
CGACCCCTCC TGGTGCTGCG TGGCCTGGAT GGCTTTGTGT GCCACCGCCG GGGCTCCAAC 
CAGCTGGACA CCAACCGTTC CACTTACGAC GTCTTCCACT TGAGCTTCAG GGATGGCGCC 
TATCAGATTA GAGGCCGTGG AGGTGGGTTC TGGTACACAG GCAGCCATGG AAGCGTGTGC 
AGCGACGGTG ACTTGGCGGA AGATTTCCTC TTTGAGTTCC GAGAGCGTGG CCGTCTGGCC 
ATCCGAGCCC TCAGCGGCAA GTACCTGCGT GGAGGAGCCT CAGGGCTCCT GCGTGCTGAT 
GCAGACCTGC CTGTGGGGGA AGCTCTCTGG GAATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766390.2
CDS	176..1654
Translation	MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQIWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDQPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGIEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDEMAADGDMPWGVDALVTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGKLAFKDCDGRYLAPVGPAGTLKAGRNTRPSKDELFDLEQSHPQVVLVAANRRYISVRQGINVSANQDEELGHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMFEIEWHGRRVALKASNGRFVCMKKNGQLAAISDFVGEDELFTLKLINRPLLVLRGLDGFVCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFLFEFRERGRLAIRALSGKYLRGGASGLLRADADLPVGEALWEY

Target ORF information:

RefSeq Version	NM_172802.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus fascin actin-bundling protein 2 (Fscn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172802.4

ORF Insert Sequence:

ATGCCAACCA ACGGTCTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT TAACGATGCC 
GACCGCTACC TGACTGCAGA GAGCTTTGGC TTCAAGGTCA ACGCCTCCGC AGCCAGCCTC 
AAGAGGAAGC AGATCTGGGT CCTGGAGCCT GACCCGGGGC AGGGCACTGC CGTGCTGTTC 
CGAAGCAGTC ACCTAGGCCG CTACCTGTCA GCAGAAGAAG ATGGACGTGT GGCCTGTGAG 
ATGGATCAGC CGGGCCGTGA CTGCCGCTTC CTGGTCTTGC CGCAGCCTGA TGGGCGCTGG 
GTGCTGCAGT CAGAGCCACA CGGCCGCTTC TTCGGTGGCA TTGAGGACCG ACTGTCCTGC 
TTTGCCACGG CCATTTCCCC GGCAGAGCTG TGGACTGTGC ACCTGGCCAT CCACCCACAG 
GCTCATTTGC TGAGTGTGAG CCGTCGGCGC TACGTGCACC TGTGCCTTCA GGAAGATGAG 
ATGGCAGCAG ACGGTGACAT GCCATGGGGT GTGGACGCAC TAGTCACCCT CATTTTCCAG 
AGCAGGCGGT ACTGCCTCAA GTCTTATGAC AGCCGCTACC TTCGCAGCGA TGGCCGCCTT 
GTCTGGGAAC CTGAAGCCCA TGCCTGCTAC ACGCTGGAGT TCAAGGCAGG CAAGCTGGCC 
TTCAAGGACT GTGACGGCCG GTACCTGGCA CCTGTGGGGC CTGCTGGCAC ACTCAAGGCT 
GGTCGCAACA CGAGGCCCAG CAAGGATGAA CTCTTCGACC TGGAGCAAAG TCACCCACAG 
GTGGTGCTGG TAGCTGCCAA CCGGCGCTAC ATCTCTGTGA GGCAAGGAAT CAATGTCTCA 
GCCAATCAGG ATGAAGAACT GGGTCATGAG ACATTCCTGA TGCAAATCGA CCAGGAGACA 
AAGAAGTGTA CTTTCTATTC CAGCACTGGG GGCTACTGGA CCTTGGTCAC CCATGGGGGC 
ATTCAGGCCA CAGCCACACA AGTCTCTGCC AACACCATGT TTGAAATAGA ATGGCATGGC 
CGGCGGGTGG CACTTAAAGC CAGCAACGGG CGTTTTGTGT GCATGAAGAA AAACGGGCAG 
CTGGCCGCCA TCAGCGACTT TGTGGGCGAG GACGAGCTAT TTACCCTCAA GCTCATCAAT 
CGACCCCTCC TGGTGCTGCG TGGCCTGGAT GGCTTTGTGT GCCACCGCCG GGGCTCCAAC 
CAGCTGGACA CCAACCGTTC CACTTACGAC GTCTTCCACT TGAGCTTCAG GGATGGCGCC 
TATCAGATTA GAGGCCGTGG AGGTGGGTTC TGGTACACAG GCAGCCATGG AAGCGTGTGC 
AGCGACGGTG ACTTGGCGGA AGATTTCCTC TTTGAGTTCC GAGAGCGTGG CCGTCTGGCC 
ATCCGAGCCC TCAGCGGCAA GTACCTGCGT GGAGGAGCCT CAGGGCTCCT GCGTGCTGAT 
GCAGACCTGC CTGTGGGGGA AGCTCTCTGG GAATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fscn2 ( XM_006533259.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006533322.1 Mus musculus fascin actin-bundling protein 2 (Fscn2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu46270
Clone ID Related Accession (Same CDS sequence)	XM_006533259.3 , XM_006533259.4
Accession Version	XM_006533259.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	fascin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006533259.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAACCA ACGGTCTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT TAACGATGCC 
GACCGCTACC TGACTGCAGA GAGCTTTGGC TTCAAGGTCA ACGCCTCCGC AGCCAGCCTC 
AAGAGGAAGC AGATCTGGGT CCTGGAGCCT GACCCGGGGC AGGGCACTGC CGTGCTGTTC 
CGAAGCAGTC ACCTAGGCCG CTACCTGTCA GCAGAAGAAG ATGGACGTGT GGCCTGTGAG 
ATGGATCAGC CGGGCCGTGA CTGCCGCTTC CTGGTCTTGC CGCAGCCTGA TGGGCGCTGG 
GTGCTGCAGT CAGAGCCACA CGGCCGCTTC TTCGGTGGCA TTGAGGACCG ACTGTCCTGC 
TTTGCCACGG CCATTTCCCC GGCAGAGCTG TGGACTGTGC ACCTGGCCAT CCACCCACAG 
GCTCATTTGC TGAGTGTGAG CCGTCGGCGC TACGTGCACC TGTGCCTTCA GGAAGATGAG 
ATGGCAGCAG ACGGTGACAT GCCATGGGGT GTGGACGCAC TAGTCACCCT CATTTTCCAG 
AGCAGGCGGT ACTGCCTCAA GTCTTATGAC AGCCGCTACC TTCGCAGCGA TGGCCGCCTT 
GTCTGGGAAC CTGAAGCCCA TGCCTGCTAC ACGCTGGAGT TCAAGGCAGG CAAGCTGGCC 
TTCAAGGACT GTGACGGCCG GTACCTGGCA CCTGTGGGGC CTGCTGGCAC ACTCAAGGCT 
GGTCGCAACA CGAGGCCCAG CAAGGATGAA CTCTTCGACC TGGAGCAAAG TCACCCACAG 
GTGGTGCTGG TAGCTGCCAA CCGGCGCTAC ATCTCTGTGA GGCAAGGAAT CAATGTCTCA 
GCCAATCAGG ATGAAGAACT GGGTCATGAG ACATTCCTGA TGCAAATCGA CCAGGAGACA 
AAGAAGTGTA CTTTCTATTC CAGCACTGGG GGCTACTGGA CCTTGGTCAC CCATGGGGGC 
ATTCAGGCCA CAGCCACACA AGTCTCTGCC AACACCATGT TTGAAATAGA ATGGCATGGC 
CGGCGGGTGG CACTTAAAGC CAGCAACGGG CGTTTTGTGT GCATGAAGAA AAACGGGCAG 
CTGGCCGCCA TCAGCGACTT TGTGGGTGAG CATTCCCTGC CTTCCACGGC CTGGAAAGAA 
CAGATGGGGG TGGGGAGTGG TCAGTCCACA TCACCCTCTC CTGCAGGCGA GGACGAGCTA 
TTTACCCTCA AGCTCATCAA TCGACCCCTC CTGGTGCTGC GTGGCCTGGA TGGCTTTGTG 
TGCCACCGCC GGGGCTCCAA CCAGCTGGAC ACCAACCGTT CCACTTACGA CGTCTTCCAC 
TTGAGCTTCA GGGATGGCGC CTATCAGATT AGAGGCCGTG GAGGTGGGTT CTGGTACACA 
GGCAGCCATG GAAGCGTGTG CAGCGACGGT GACTTGGCGG AAGATTTCCT CTTTGAGTTC 
CGAGAGCGTG GCCGTCTGGC CATCCGAGCC CTCAGCGGCA AGTACCTGCG TGGAGGAGCC 
TCAGGGCTCC TGCGTGCTGA TGCAGACCTG CCTGTGGGGG AAGCTCTCTG GGAATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006533322.1
CDS	1545..3104
Translation	MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQIWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDQPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGIEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDEMAADGDMPWGVDALVTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGKLAFKDCDGRYLAPVGPAGTLKAGRNTRPSKDELFDLEQSHPQVVLVAANRRYISVRQGINVSANQDEELGHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMFEIEWHGRRVALKASNGRFVCMKKNGQLAAISDFVGEHSLPSTAWKEQMGVGSGQSTSPSPAGEDELFTLKLINRPLLVLRGLDGFVCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFLFEFRERGRLAIRALSGKYLRGGASGLLRADADLPVGEALWEY

Target ORF information:

RefSeq Version	XM_006533259.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus fascin actin-bundling protein 2 (Fscn2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006533259.4

ORF Insert Sequence:

ATGCCAACCA ACGGTCTGCA CCAGGTGCTG AAGATCCAGT TTGGCCTTGT TAACGATGCC 
GACCGCTACC TGACTGCAGA GAGCTTTGGC TTCAAGGTCA ACGCCTCCGC AGCCAGCCTC 
AAGAGGAAGC AGATCTGGGT CCTGGAGCCT GACCCGGGGC AGGGCACTGC CGTGCTGTTC 
CGAAGCAGTC ACCTAGGCCG CTACCTGTCA GCAGAAGAAG ATGGACGTGT GGCCTGTGAG 
ATGGATCAGC CGGGCCGTGA CTGCCGCTTC CTGGTCTTGC CGCAGCCTGA TGGGCGCTGG 
GTGCTGCAGT CAGAGCCACA CGGCCGCTTC TTCGGTGGCA TTGAGGACCG ACTGTCCTGC 
TTTGCCACGG CCATTTCCCC GGCAGAGCTG TGGACTGTGC ACCTGGCCAT CCACCCACAG 
GCTCATTTGC TGAGTGTGAG CCGTCGGCGC TACGTGCACC TGTGCCTTCA GGAAGATGAG 
ATGGCAGCAG ACGGTGACAT GCCATGGGGT GTGGACGCAC TAGTCACCCT CATTTTCCAG 
AGCAGGCGGT ACTGCCTCAA GTCTTATGAC AGCCGCTACC TTCGCAGCGA TGGCCGCCTT 
GTCTGGGAAC CTGAAGCCCA TGCCTGCTAC ACGCTGGAGT TCAAGGCAGG CAAGCTGGCC 
TTCAAGGACT GTGACGGCCG GTACCTGGCA CCTGTGGGGC CTGCTGGCAC ACTCAAGGCT 
GGTCGCAACA CGAGGCCCAG CAAGGATGAA CTCTTCGACC TGGAGCAAAG TCACCCACAG 
GTGGTGCTGG TAGCTGCCAA CCGGCGCTAC ATCTCTGTGA GGCAAGGAAT CAATGTCTCA 
GCCAATCAGG ATGAAGAACT GGGTCATGAG ACATTCCTGA TGCAAATCGA CCAGGAGACA 
AAGAAGTGTA CTTTCTATTC CAGCACTGGG GGCTACTGGA CCTTGGTCAC CCATGGGGGC 
ATTCAGGCCA CAGCCACACA AGTCTCTGCC AACACCATGT TTGAAATAGA ATGGCATGGC 
CGGCGGGTGG CACTTAAAGC CAGCAACGGG CGTTTTGTGT GCATGAAGAA AAACGGGCAG 
CTGGCCGCCA TCAGCGACTT TGTGGGTGAG CATTCCCTGC CTTCCACGGC CTGGAAAGAA 
CAGATGGGGG TGGGGAGTGG TCAGTCCACA TCACCCTCTC CTGCAGGCGA GGACGAGCTA 
TTTACCCTCA AGCTCATCAA TCGACCCCTC CTGGTGCTGC GTGGCCTGGA TGGCTTTGTG 
TGCCACCGCC GGGGCTCCAA CCAGCTGGAC ACCAACCGTT CCACTTACGA CGTCTTCCAC 
TTGAGCTTCA GGGATGGCGC CTATCAGATT AGAGGCCGTG GAGGTGGGTT CTGGTACACA 
GGCAGCCATG GAAGCGTGTG CAGCGACGGT GACTTGGCGG AAGATTTCCT CTTTGAGTTC 
CGAGAGCGTG GCCGTCTGGC CATCCGAGCC CTCAGCGGCA AGTACCTGCG TGGAGGAGCC 
TCAGGGCTCC TGCGTGCTGA TGCAGACCTG CCTGTGGGGG AAGCTCTCTG GGAATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Otoprotective effects of mouse nerve growth factor in DBA/2J mice with early-onset progressive hearing loss.
Journal of neuroscience research95(10)1937-1950(2017 Oct)
Wang Q,Zhao H,Zheng T,Wang W,Zhang X,Wang A,Li B,Wang Y,Zheng Q

CD40-CD40L cross-talk drives fascin expression in dendritic cells for efficient antigen presentation to CD4+ T cells.
International immunology29(3)121-131(2017 03)
Elizondo DM,Andargie TE,Kubhar DS,Gugssa A,Lipscomb MW

Plastin 1 widens stereocilia by transforming actin filament packing from hexagonal to liquid.
The Journal of cell biology215(4)467-482(2016 Nov)
Krey JF,Krystofiak ES,Dumont RA,Vijayakumar S,Choi D,Rivero F,Kachar B,Jones SM,Barr-Gillespie PG

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

?-Actin and fascin-2 cooperate to maintain stereocilia length.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(19)8114-21(2013 May)
Perrin BJ,Strandjord DM,Narayanan P,Henderson DM,Johnson KR,Ervasti JM

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Fscn2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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