Brip1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Brip1
Entrez Gene ID	237911
Full Name	BRCA1 interacting protein C-terminal helicase 1
Synonyms	3110009N10Rik,8030460J03Rik,Bach1,FACJ,Fancj,OF
General protein information	Preferred Names BRCA1 interacting protein C-terminal helicase 1 Names Fanconi anemia group J protein homolog ATP-dependent RNA helicase BRIP1 BRCA1-associated C-terminal helicase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 C
Summary	This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011].

mRNA and Protein(s)

mRNA	Protein	Name
NM_178309.2	NP_840094.1	Fanconi anemia group J protein homolog
XM_006533239.2	XP_006533302.1	Fanconi anemia group J protein homolog isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BRIP1	XP_002695655.2
Gallus gallus (chicken)	BRIP1	NP_001028230.1
Danio rerio (zebrafish)	brip1	NP_001103766.1
Homo sapiens (human)	BRIP1	NP_114432.2
Pan troglodytes (chimpanzee)	BRIP1	XP_511607.2
	LOC712408	XP_002808171.1
Xenopus tropicalis (tropical clawed frog)	brip1	XP_002933884.1
Canis lupus familiaris (dog)	BRIP1	XP_852649.2
Mus musculus (house mouse)	Brip1	NP_840094.1
Rattus norvegicus (Norway rat)	Brip1	XP_006247125.1

Gene Ontology
Bibliography

Related articles in PubMed

FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Sun X, Brie?o-Enr?quez MA, Cornelius A, Modzelewski AJ, Maley TT, Campbell-Peterson KM, Holloway JK, Cohen PE
Chromosoma125(2)237-52(2016 Jun)

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Matsuzaki K, Borel V, Adelman CA, Schindler D, Boulton SJ
Genes & development29(24)2532-46(2015 Dec)

Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.
Peng M, Xie J, Ucher A, Stavnezer J, Cantor SB
The EMBO journal33(15)1698-712(2014 Aug)

FANCJ: solving problems in DNA replication.
Hiom K
DNA repair9(3)250-6(2010 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

FANCJ play roles in spermatogenesis at two stages: firstly in the proliferative activity that gives rise to the full complement of testicular spermatogonia and secondly in the establishment of appropriate crossovers numbers during prophase I.
Title: FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.

Review of the functions and disease associations of human FANCJ.
Title: FANCJ: solving problems in DNA replication.

Compares the human homolog to other members of the RecQ helicase family
Title: SUVi and BACH1: a new subfamily of mammalian helicases?

The following Brip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Brip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07189	NM_178309.2 Latest version!	Mus musculus BRCA1 interacting protein C-terminal helicase 1 (Brip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$643.30 $919.00
OMu07189	XM_006533239.2 Latest version!	Mus musculus BRCA1 interacting protein C-terminal helicase 1 (Brip1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$643.30 $919.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Brip1 ( NM_178309.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_840094.1 Mus musculus BRCA1 interacting protein C-terminal helicase 1 (Brip1), mRNA.

Price & Availability↑

CloneID	OMu07189
Clone ID Related Accession (Same CDS sequence)	NM_178309.2 , XM_006533239.2
Accession Version	NM_178309.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-22
Organism	Mus musculus(house mouse)
Product	Fanconi anemia group J protein homolog
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK051878.1, BC094252.1, AK080771.1 and CJ240209.1. On Feb 10, 2011 this sequence version replaced NM_178309.1. ##Evidence-Data-START## Transcript exon combination :: BC094252.1, AK033205.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGTCCTCAG TGTTGTCTGA CTACACCATC GGTGGGGTGA AGATCCACTT TCCCTGTAGA 
GCGTATCCAG CACAGCTTGC GATGATGAAT TCTATTGTCA GAGGACTAAA CAGCAGCCAA 
CACTGTTTGC TGGAGAGTCC CACAGGAAGT GGAAAAAGTT TAGCCTTACT TTGTTCTGCA 
TTAGCATGGC AGCAATCTCT TAGTGAGAAG CCAGTGGATG AGGGCCTGAA TAAAAAGCCT 
GAGGCACCAC CTTCATGTTC TTGTGCATGC CATTCAAAGA ATTTTACCTA CAGCGACACA 
AACCTGGACA CTTCACCTCA TTTCAATAGT CCAAGCAAAC CATCTTCTGG AAGAAATGGA 
GTCTCAACTC CCTGTCAAGA CTCTCCTGAA AAAAATACTC TGGCTGCAAA GTTATCTGCC 
AAGAAACAGG CATCTATACA CAGAGACGAA GATGATGATT TTCAGGTAGA GAAGAAAAGA 
ATCCGACCCT TAGAAACTAC ACAGCAGATA AGAAAACGTC ATTGTTTGGA AAAGGACGTC 
CACCATGTAG ATGCACGACT AGCTTCGGAA AAGAGAGTAA AGCCTGAGTC TCCGATAGGA 
AAGTCTTTCT CCGACAGGAA AGACTCTTTT CAAAATGTGG ATGGCCTTTG TTCCAGGTGC 
TGCTGTTCTG CTAAACAAGG AAACAACCAA GAGCCTGCAA ATACTGTTAA GAAAGATCAC 
GGGGGACAAT GCAAGAGACC TAAAATTTAT TTTGGGACGC GGACACACAA GCAGATTGCT 
CAGATTACCA GGGAGCTCCG TAAGACAGCT TACTCAGGGG TCCCGATGAC TATTCTTTCC 
AGCAGGGACC ACAGCTGTGT CCATCCTGAA GTGGTGGGGA ATTTCAACAG AAAGGAGAAG 
TGCATGGAGC TGCTGGATGG CAAGCACGGG AAGTCCTGCT ATTTCTATCA TGGTGTTCAT 
AAAATTAGTA ATCAGCAGAC ACTGCAGCAC CTTCAGGGCA TGTCCAGAGC CTGGGACATA 
GAAGAACTAG TCAGCCTCGG GAGGAAACTG AAAGCTTGTC CCTACTATAC AGCTCGAGAA 
CTGATAGAGG ATGCTGACAT AGTGTTTTGT CCCTACAACT ACCTTTTAGA CTCACAAATA 
AGGGAAACTA TGGATATAAA GCTGAAAGGA CAAGTTGTCA TTTTAGATGA AGCTCACAAC 
ATTGAAGACT GTGCTCGGGA ATCAGCAAGC TACAGTGTAA CCGAAGTTCA GCTTAGGTTT 
GCTCGGGATG AGCTAGATAG TTTGATCAAC GGTAACATAA GGAAGAAAAG CCACGAGCCC 
CTACGAGATG TGTGCTATAA CCTCATCAAT TGGTTAGAAA CAAATTCTAA GCATCTTGTA 
GAAAGGGGTT ATGAGTCGTC TTGTAAAATA TGGAGTGGAA ATGAGATGCT CTTAAACTTA 
TACAGGATGG GCATCACCAC GGCTACTTTT CCAGTTTTGC AGAGGCATCT CTCAGCTGTT 
CTTCAAAAAG AAGAGAAAGT CACACCAATC CATGGTAAAG AGGAGGCAAT ACAAATCCCT 
ATTATCAGTG CATCAACTCA AGTCGTGCTC AAAGGACTCT TTATGGTGCT TGACTATCTC 
TTTAGAGAAA ATAGCAGATT TGCAGATGAT TATAAAGTTG CTATTCAACA GACTTACTCC 
TGGACAAATC AGATTGCTAT TTTTGATAAA ACTGGAGTCT TGGCTGTACC AAAAAATAAG 
AAACATTCAC GACAGAAAAT TGGAGTTAAT GCGCTAAACT TTTGGTGTTT AAATCCAGCT 
GTGGCCTTTT CAGATATTAA TGACAAAGTA CGGACCATTG TTCTAACATC AGGAACACTC 
TCACCCCTGA AATCCTTTTC ATCTGAGCTT GGTGTCACAT TTAGCATCCA ACTGGAGGCT 
AACCATGTCA TCAGTAACTC ACAGGTTTGG GTTGGTACTG TTGGCTCAGG CCCTAAGGGT 
CGGAATCTCT GCGCTACCTT TCAGCATACT GAAACATTTG AGTTCCAGGA TGAAGTGGGA 
ATGCTTCTGT TATCTGTGTG CCAGACTGTG AGCCAAGGAA TTCTGTGCTT TTTGCCATCT 
TACAAGCTAT TAGAGAAATT AAGAGAACGT TGGATTTTCA CTGGCCTATG GCATAGTTTG 
GAGTCAGTGA AGACAGTCAT TGCAGAACCC CAAGGAGGAG AAAAAACTGA TTTTGATGAA 
TTGCTGCAAG TGTACTATGA CGCCATCAAG TTCAAAGGAG AAAAGGATGG AGCCCTTCTC 
ATAGCAGTCT GTCGTGGCAA GGTGAGCGAG GGTCTGGATT TCTCAGATGA TAACGCCCGT 
GCTGTCATAA CCGTAGGGAT TCCTTTCCCA AATGTGAAGG ATCTTCAGGT GGAGCTAAAA 
CGACAATACA ATGACCACCA CTCAAAATCG AGAGGTCTTC TGCCTGGCCG TCAGTGGTAT 
GAAATTCAAG CATACCGAGC CTTGAATCAG GCTCTAGGCA GATGTATTCG GCACAAAAAT 
GATTGGGGAG CTCTTATTCT AGTGGACGAT CGCTTCAATA ACAATCCAAA CCGCTATATA 
TCAGGACTTT CTAAATGGGT GAGGCAGCAG ATTCAGCACC ACTCAAGCTT TGCAAGTGCC 
CTGGAGTCGC TGACCGAGTT CTCCAGAAGA CACCAGAAAG TTACTAATAG ATCCAAAAAA 
GACGAAAAAT GTACAAAAGA CAATGAGCCT ACTCTGGAAG TGGCCTGTTT GGAGGATAGC 
ACTTTTACAA GTGTGTCAGA ATCAAGTCAT CAGTCACCAG AAAACTCGAC AGAAGAAGCA 
GAAGTGTGTG TCCAGGAGCT TCAGTGTCCC CAGGTGGCTA CTAAAAGCCC CTCAGTAGCA 
AGCCACGGTG TTTCCAGAAG GAAGAAAAGT GATCCAGGAC TAAGAGGAGA GTCTCTTCAG 
ACAATGAAAA CAGAAAAAAA TGAGATTTCC CGATCTTCAA GCCCAACTTT TGGAAAGCAA 
ACAGAGCCAG TCAACTGGCC TATCTTTAAT TCTCTAAGAC GGCATTTCAA TAGTAAAGTA 
AAAAATTGCA CACCAGTACT CAAGTCATCA AAGAACCGTG CCCCTGGTTC TTCCACTTTC 
AATAAAACTG CTTTGCCACT CACAGGTAAC TGTGTGCCCT CAAACGAAAC AGCAGACACA 
TCACTGGGAC CTTGCCTTCA GTCAGAAGTC ATAATTTCAC CAGTGAAGAT TGAAGCTACT 
CCTGCTACGA ATTATTCCAA ACAGGTGTTC TGCTGTGAGA AAGACCTACT CCCGGATACT 
GAATTGTCGC CAGGAACTGA AGAAGCCAAG TGTCCCAGCT CAAACAAAGC TGCTGAAACA 
GAAGTGGATG ATGACTCTGA GTGTTTTACA CCTGAACTTT TTGATCCTGT CGATACCAAC 
GAAGAAAACG GTGAACTGGT TGAAACTGAT AGATCAAGTC ATAGTTCAGA TTGTTTTTCA 
GCGGAAGAGC TTTTTGAAAC TGCAACTGGA TTTGGGCAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_840094.1
CDS	116..3640
Translation	MSSVLSDYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLSEKPVDEGLNKKPEAPPSCSCACHSKNFTYSDTNLDTSPHFNSPSKPSSGRNGVSTPCQDSPEKNTLAAKLSAKKQASIHRDEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHVDARLASEKRVKPESPIGKSFSDRKDSFQNVDGLCSRCCCSAKQGNNQEPANTVKKDHGGQCKRPKIYFGTRTHKQIAQITRELRKTAYSGVPMTILSSRDHSCVHPEVVGNFNRKEKCMELLDGKHGKSCYFYHGVHKISNQQTLQHLQGMSRAWDIEELVSLGRKLKACPYYTARELIEDADIVFCPYNYLLDSQIRETMDIKLKGQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSLINGNIRKKSHEPLRDVCYNLINWLETNSKHLVERGYESSCKIWSGNEMLLNLYRMGITTATFPVLQRHLSAVLQKEEKVTPIHGKEEAIQIPIISASTQVVLKGLFMVLDYLFRENSRFADDYKVAIQQTYSWTNQIAIFDKTGVLAVPKNKKHSRQKIGVNALNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFSIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITVGIPFPNVKDLQVELKRQYNDHHSKSRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPNRYISGLSKWVRQQIQHHSSFASALESLTEFSRRHQKVTNRSKKDEKCTKDNEPTLEVACLEDSTFTSVSESSHQSPENSTEEAEVCVQELQCPQVATKSPSVASHGVSRRKKSDPGLRGESLQTMKTEKNEISRSSSPTFGKQTEPVNWPIFNSLRRHFNSKVKNCTPVLKSSKNRAPGSSTFNKTALPLTGNCVPSNETADTSLGPCLQSEVIISPVKIEATPATNYSKQVFCCEKDLLPDTELSPGTEEAKCPSSNKAAETEVDDDSECFTPELFDPVDTNEENGELVETDRSSHSSDCFSAEELFETATGFGQK

Target ORF information:

RefSeq Version	NM_178309.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus BRCA1 interacting protein C-terminal helicase 1 (Brip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178309.2

ORF Insert Sequence:

ATGTCCTCAG TGTTGTCTGA CTACACCATC GGTGGGGTGA AGATCCACTT TCCCTGTAGA 
GCGTATCCAG CACAGCTTGC GATGATGAAT TCTATTGTCA GAGGACTAAA CAGCAGCCAA 
CACTGTTTGC TGGAGAGTCC CACAGGAAGT GGAAAAAGTT TAGCCTTACT TTGTTCTGCA 
TTAGCATGGC AGCAATCTCT TAGTGAGAAG CCAGTGGATG AGGGCCTGAA TAAAAAGCCT 
GAGGCACCAC CTTCATGTTC TTGTGCATGC CATTCAAAGA ATTTTACCTA CAGCGACACA 
AACCTGGACA CTTCACCTCA TTTCAATAGT CCAAGCAAAC CATCTTCTGG AAGAAATGGA 
GTCTCAACTC CCTGTCAAGA CTCTCCTGAA AAAAATACTC TGGCTGCAAA GTTATCTGCC 
AAGAAACAGG CATCTATACA CAGAGACGAA GATGATGATT TTCAGGTAGA GAAGAAAAGA 
ATCCGACCCT TAGAAACTAC ACAGCAGATA AGAAAACGTC ATTGTTTGGA AAAGGACGTC 
CACCATGTAG ATGCACGACT AGCTTCGGAA AAGAGAGTAA AGCCTGAGTC TCCGATAGGA 
AAGTCTTTCT CCGACAGGAA AGACTCTTTT CAAAATGTGG ATGGCCTTTG TTCCAGGTGC 
TGCTGTTCTG CTAAACAAGG AAACAACCAA GAGCCTGCAA ATACTGTTAA GAAAGATCAC 
GGGGGACAAT GCAAGAGACC TAAAATTTAT TTTGGGACGC GGACACACAA GCAGATTGCT 
CAGATTACCA GGGAGCTCCG TAAGACAGCT TACTCAGGGG TCCCGATGAC TATTCTTTCC 
AGCAGGGACC ACAGCTGTGT CCATCCTGAA GTGGTGGGGA ATTTCAACAG AAAGGAGAAG 
TGCATGGAGC TGCTGGATGG CAAGCACGGG AAGTCCTGCT ATTTCTATCA TGGTGTTCAT 
AAAATTAGTA ATCAGCAGAC ACTGCAGCAC CTTCAGGGCA TGTCCAGAGC CTGGGACATA 
GAAGAACTAG TCAGCCTCGG GAGGAAACTG AAAGCTTGTC CCTACTATAC AGCTCGAGAA 
CTGATAGAGG ATGCTGACAT AGTGTTTTGT CCCTACAACT ACCTTTTAGA CTCACAAATA 
AGGGAAACTA TGGATATAAA GCTGAAAGGA CAAGTTGTCA TTTTAGATGA AGCTCACAAC 
ATTGAAGACT GTGCTCGGGA ATCAGCAAGC TACAGTGTAA CCGAAGTTCA GCTTAGGTTT 
GCTCGGGATG AGCTAGATAG TTTGATCAAC GGTAACATAA GGAAGAAAAG CCACGAGCCC 
CTACGAGATG TGTGCTATAA CCTCATCAAT TGGTTAGAAA CAAATTCTAA GCATCTTGTA 
GAAAGGGGTT ATGAGTCGTC TTGTAAAATA TGGAGTGGAA ATGAGATGCT CTTAAACTTA 
TACAGGATGG GCATCACCAC GGCTACTTTT CCAGTTTTGC AGAGGCATCT CTCAGCTGTT 
CTTCAAAAAG AAGAGAAAGT CACACCAATC CATGGTAAAG AGGAGGCAAT ACAAATCCCT 
ATTATCAGTG CATCAACTCA AGTCGTGCTC AAAGGACTCT TTATGGTGCT TGACTATCTC 
TTTAGAGAAA ATAGCAGATT TGCAGATGAT TATAAAGTTG CTATTCAACA GACTTACTCC 
TGGACAAATC AGATTGCTAT TTTTGATAAA ACTGGAGTCT TGGCTGTACC AAAAAATAAG 
AAACATTCAC GACAGAAAAT TGGAGTTAAT GCGCTAAACT TTTGGTGTTT AAATCCAGCT 
GTGGCCTTTT CAGATATTAA TGACAAAGTA CGGACCATTG TTCTAACATC AGGAACACTC 
TCACCCCTGA AATCCTTTTC ATCTGAGCTT GGTGTCACAT TTAGCATCCA ACTGGAGGCT 
AACCATGTCA TCAGTAACTC ACAGGTTTGG GTTGGTACTG TTGGCTCAGG CCCTAAGGGT 
CGGAATCTCT GCGCTACCTT TCAGCATACT GAAACATTTG AGTTCCAGGA TGAAGTGGGA 
ATGCTTCTGT TATCTGTGTG CCAGACTGTG AGCCAAGGAA TTCTGTGCTT TTTGCCATCT 
TACAAGCTAT TAGAGAAATT AAGAGAACGT TGGATTTTCA CTGGCCTATG GCATAGTTTG 
GAGTCAGTGA AGACAGTCAT TGCAGAACCC CAAGGAGGAG AAAAAACTGA TTTTGATGAA 
TTGCTGCAAG TGTACTATGA CGCCATCAAG TTCAAAGGAG AAAAGGATGG AGCCCTTCTC 
ATAGCAGTCT GTCGTGGCAA GGTGAGCGAG GGTCTGGATT TCTCAGATGA TAACGCCCGT 
GCTGTCATAA CCGTAGGGAT TCCTTTCCCA AATGTGAAGG ATCTTCAGGT GGAGCTAAAA 
CGACAATACA ATGACCACCA CTCAAAATCG AGAGGTCTTC TGCCTGGCCG TCAGTGGTAT 
GAAATTCAAG CATACCGAGC CTTGAATCAG GCTCTAGGCA GATGTATTCG GCACAAAAAT 
GATTGGGGAG CTCTTATTCT AGTGGACGAT CGCTTCAATA ACAATCCAAA CCGCTATATA 
TCAGGACTTT CTAAATGGGT GAGGCAGCAG ATTCAGCACC ACTCAAGCTT TGCAAGTGCC 
CTGGAGTCGC TGACCGAGTT CTCCAGAAGA CACCAGAAAG TTACTAATAG ATCCAAAAAA 
GACGAAAAAT GTACAAAAGA CAATGAGCCT ACTCTGGAAG TGGCCTGTTT GGAGGATAGC 
ACTTTTACAA GTGTGTCAGA ATCAAGTCAT CAGTCACCAG AAAACTCGAC AGAAGAAGCA 
GAAGTGTGTG TCCAGGAGCT TCAGTGTCCC CAGGTGGCTA CTAAAAGCCC CTCAGTAGCA 
AGCCACGGTG TTTCCAGAAG GAAGAAAAGT GATCCAGGAC TAAGAGGAGA GTCTCTTCAG 
ACAATGAAAA CAGAAAAAAA TGAGATTTCC CGATCTTCAA GCCCAACTTT TGGAAAGCAA 
ACAGAGCCAG TCAACTGGCC TATCTTTAAT TCTCTAAGAC GGCATTTCAA TAGTAAAGTA 
AAAAATTGCA CACCAGTACT CAAGTCATCA AAGAACCGTG CCCCTGGTTC TTCCACTTTC 
AATAAAACTG CTTTGCCACT CACAGGTAAC TGTGTGCCCT CAAACGAAAC AGCAGACACA 
TCACTGGGAC CTTGCCTTCA GTCAGAAGTC ATAATTTCAC CAGTGAAGAT TGAAGCTACT 
CCTGCTACGA ATTATTCCAA ACAGGTGTTC TGCTGTGAGA AAGACCTACT CCCGGATACT 
GAATTGTCGC CAGGAACTGA AGAAGCCAAG TGTCCCAGCT CAAACAAAGC TGCTGAAACA 
GAAGTGGATG ATGACTCTGA GTGTTTTACA CCTGAACTTT TTGATCCTGT CGATACCAAC 
GAAGAAAACG GTGAACTGGT TGAAACTGAT AGATCAAGTC ATAGTTCAGA TTGTTTTTCA 
GCGGAAGAGC TTTTTGAAAC TGCAACTGGA TTTGGGCAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Brip1 ( XM_006533239.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006533302.1 Mus musculus BRCA1 interacting protein C-terminal helicase 1 (Brip1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu07189
Clone ID Related Accession (Same CDS sequence)	NM_178309.2 , XM_006533239.2
Accession Version	XM_006533239.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	Fanconi anemia group J protein homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006533239.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCTCAG TGTTGTCTGA CTACACCATC GGTGGGGTGA AGATCCACTT TCCCTGTAGA 
GCGTATCCAG CACAGCTTGC GATGATGAAT TCTATTGTCA GAGGACTAAA CAGCAGCCAA 
CACTGTTTGC TGGAGAGTCC CACAGGAAGT GGAAAAAGTT TAGCCTTACT TTGTTCTGCA 
TTAGCATGGC AGCAATCTCT TAGTGAGAAG CCAGTGGATG AGGGCCTGAA TAAAAAGCCT 
GAGGCACCAC CTTCATGTTC TTGTGCATGC CATTCAAAGA ATTTTACCTA CAGCGACACA 
AACCTGGACA CTTCACCTCA TTTCAATAGT CCAAGCAAAC CATCTTCTGG AAGAAATGGA 
GTCTCAACTC CCTGTCAAGA CTCTCCTGAA AAAAATACTC TGGCTGCAAA GTTATCTGCC 
AAGAAACAGG CATCTATACA CAGAGACGAA GATGATGATT TTCAGGTAGA GAAGAAAAGA 
ATCCGACCCT TAGAAACTAC ACAGCAGATA AGAAAACGTC ATTGTTTGGA AAAGGACGTC 
CACCATGTAG ATGCACGACT AGCTTCGGAA AAGAGAGTAA AGCCTGAGTC TCCGATAGGA 
AAGTCTTTCT CCGACAGGAA AGACTCTTTT CAAAATGTGG ATGGCCTTTG TTCCAGGTGC 
TGCTGTTCTG CTAAACAAGG AAACAACCAA GAGCCTGCAA ATACTGTTAA GAAAGATCAC 
GGGGGACAAT GCAAGAGACC TAAAATTTAT TTTGGGACGC GGACACACAA GCAGATTGCT 
CAGATTACCA GGGAGCTCCG TAAGACAGCT TACTCAGGGG TCCCGATGAC TATTCTTTCC 
AGCAGGGACC ACAGCTGTGT CCATCCTGAA GTGGTGGGGA ATTTCAACAG AAAGGAGAAG 
TGCATGGAGC TGCTGGATGG CAAGCACGGG AAGTCCTGCT ATTTCTATCA TGGTGTTCAT 
AAAATTAGTA ATCAGCAGAC ACTGCAGCAC CTTCAGGGCA TGTCCAGAGC CTGGGACATA 
GAAGAACTAG TCAGCCTCGG GAGGAAACTG AAAGCTTGTC CCTACTATAC AGCTCGAGAA 
CTGATAGAGG ATGCTGACAT AGTGTTTTGT CCCTACAACT ACCTTTTAGA CTCACAAATA 
AGGGAAACTA TGGATATAAA GCTGAAAGGA CAAGTTGTCA TTTTAGATGA AGCTCACAAC 
ATTGAAGACT GTGCTCGGGA ATCAGCAAGC TACAGTGTAA CCGAAGTTCA GCTTAGGTTT 
GCTCGGGATG AGCTAGATAG TTTGATCAAC GGTAACATAA GGAAGAAAAG CCACGAGCCC 
CTACGAGATG TGTGCTATAA CCTCATCAAT TGGTTAGAAA CAAATTCTAA GCATCTTGTA 
GAAAGGGGTT ATGAGTCGTC TTGTAAAATA TGGAGTGGAA ATGAGATGCT CTTAAACTTA 
TACAGGATGG GCATCACCAC GGCTACTTTT CCAGTTTTGC AGAGGCATCT CTCAGCTGTT 
CTTCAAAAAG AAGAGAAAGT CACACCAATC CATGGTAAAG AGGAGGCAAT ACAAATCCCT 
ATTATCAGTG CATCAACTCA AGTCGTGCTC AAAGGACTCT TTATGGTGCT TGACTATCTC 
TTTAGAGAAA ATAGCAGATT TGCAGATGAT TATAAAGTTG CTATTCAACA GACTTACTCC 
TGGACAAATC AGATTGCTAT TTTTGATAAA ACTGGAGTCT TGGCTGTACC AAAAAATAAG 
AAACATTCAC GACAGAAAAT TGGAGTTAAT GCGCTAAACT TTTGGTGTTT AAATCCAGCT 
GTGGCCTTTT CAGATATTAA TGACAAAGTA CGGACCATTG TTCTAACATC AGGAACACTC 
TCACCCCTGA AATCCTTTTC ATCTGAGCTT GGTGTCACAT TTAGCATCCA ACTGGAGGCT 
AACCATGTCA TCAGTAACTC ACAGGTTTGG GTTGGTACTG TTGGCTCAGG CCCTAAGGGT 
CGGAATCTCT GCGCTACCTT TCAGCATACT GAAACATTTG AGTTCCAGGA TGAAGTGGGA 
ATGCTTCTGT TATCTGTGTG CCAGACTGTG AGCCAAGGAA TTCTGTGCTT TTTGCCATCT 
TACAAGCTAT TAGAGAAATT AAGAGAACGT TGGATTTTCA CTGGCCTATG GCATAGTTTG 
GAGTCAGTGA AGACAGTCAT TGCAGAACCC CAAGGAGGAG AAAAAACTGA TTTTGATGAA 
TTGCTGCAAG TGTACTATGA CGCCATCAAG TTCAAAGGAG AAAAGGATGG AGCCCTTCTC 
ATAGCAGTCT GTCGTGGCAA GGTGAGCGAG GGTCTGGATT TCTCAGATGA TAACGCCCGT 
GCTGTCATAA CCGTAGGGAT TCCTTTCCCA AATGTGAAGG ATCTTCAGGT GGAGCTAAAA 
CGACAATACA ATGACCACCA CTCAAAATCG AGAGGTCTTC TGCCTGGCCG TCAGTGGTAT 
GAAATTCAAG CATACCGAGC CTTGAATCAG GCTCTAGGCA GATGTATTCG GCACAAAAAT 
GATTGGGGAG CTCTTATTCT AGTGGACGAT CGCTTCAATA ACAATCCAAA CCGCTATATA 
TCAGGACTTT CTAAATGGGT GAGGCAGCAG ATTCAGCACC ACTCAAGCTT TGCAAGTGCC 
CTGGAGTCGC TGACCGAGTT CTCCAGAAGA CACCAGAAAG TTACTAATAG ATCCAAAAAA 
GACGAAAAAT GTACAAAAGA CAATGAGCCT ACTCTGGAAG TGGCCTGTTT GGAGGATAGC 
ACTTTTACAA GTGTGTCAGA ATCAAGTCAT CAGTCACCAG AAAACTCGAC AGAAGAAGCA 
GAAGTGTGTG TCCAGGAGCT TCAGTGTCCC CAGGTGGCTA CTAAAAGCCC CTCAGTAGCA 
AGCCACGGTG TTTCCAGAAG GAAGAAAAGT GATCCAGGAC TAAGAGGAGA GTCTCTTCAG 
ACAATGAAAA CAGAAAAAAA TGAGATTTCC CGATCTTCAA GCCCAACTTT TGGAAAGCAA 
ACAGAGCCAG TCAACTGGCC TATCTTTAAT TCTCTAAGAC GGCATTTCAA TAGTAAAGTA 
AAAAATTGCA CACCAGTACT CAAGTCATCA AAGAACCGTG CCCCTGGTTC TTCCACTTTC 
AATAAAACTG CTTTGCCACT CACAGGTAAC TGTGTGCCCT CAAACGAAAC AGCAGACACA 
TCACTGGGAC CTTGCCTTCA GTCAGAAGTC ATAATTTCAC CAGTGAAGAT TGAAGCTACT 
CCTGCTACGA ATTATTCCAA ACAGGTGTTC TGCTGTGAGA AAGACCTACT CCCGGATACT 
GAATTGTCGC CAGGAACTGA AGAAGCCAAG TGTCCCAGCT CAAACAAAGC TGCTGAAACA 
GAAGTGGATG ATGACTCTGA GTGTTTTACA CCTGAACTTT TTGATCCTGT CGATACCAAC 
GAAGAAAACG GTGAACTGGT TGAAACTGAT AGATCAAGTC ATAGTTCAGA TTGTTTTTCA 
GCGGAAGAGC TTTTTGAAAC TGCAACTGGA TTTGGGCAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006533302.1
CDS	225..3749
Translation	MSSVLSDYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLSEKPVDEGLNKKPEAPPSCSCACHSKNFTYSDTNLDTSPHFNSPSKPSSGRNGVSTPCQDSPEKNTLAAKLSAKKQASIHRDEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHVDARLASEKRVKPESPIGKSFSDRKDSFQNVDGLCSRCCCSAKQGNNQEPANTVKKDHGGQCKRPKIYFGTRTHKQIAQITRELRKTAYSGVPMTILSSRDHSCVHPEVVGNFNRKEKCMELLDGKHGKSCYFYHGVHKISNQQTLQHLQGMSRAWDIEELVSLGRKLKACPYYTARELIEDADIVFCPYNYLLDSQIRETMDIKLKGQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSLINGNIRKKSHEPLRDVCYNLINWLETNSKHLVERGYESSCKIWSGNEMLLNLYRMGITTATFPVLQRHLSAVLQKEEKVTPIHGKEEAIQIPIISASTQVVLKGLFMVLDYLFRENSRFADDYKVAIQQTYSWTNQIAIFDKTGVLAVPKNKKHSRQKIGVNALNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFSIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITVGIPFPNVKDLQVELKRQYNDHHSKSRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPNRYISGLSKWVRQQIQHHSSFASALESLTEFSRRHQKVTNRSKKDEKCTKDNEPTLEVACLEDSTFTSVSESSHQSPENSTEEAEVCVQELQCPQVATKSPSVASHGVSRRKKSDPGLRGESLQTMKTEKNEISRSSSPTFGKQTEPVNWPIFNSLRRHFNSKVKNCTPVLKSSKNRAPGSSTFNKTALPLTGNCVPSNETADTSLGPCLQSEVIISPVKIEATPATNYSKQVFCCEKDLLPDTELSPGTEEAKCPSSNKAAETEVDDDSECFTPELFDPVDTNEENGELVETDRSSHSSDCFSAEELFETATGFGQK

Target ORF information:

RefSeq Version	XM_006533239.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus BRCA1 interacting protein C-terminal helicase 1 (Brip1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006533239.2

ORF Insert Sequence:

ATGTCCTCAG TGTTGTCTGA CTACACCATC GGTGGGGTGA AGATCCACTT TCCCTGTAGA 
GCGTATCCAG CACAGCTTGC GATGATGAAT TCTATTGTCA GAGGACTAAA CAGCAGCCAA 
CACTGTTTGC TGGAGAGTCC CACAGGAAGT GGAAAAAGTT TAGCCTTACT TTGTTCTGCA 
TTAGCATGGC AGCAATCTCT TAGTGAGAAG CCAGTGGATG AGGGCCTGAA TAAAAAGCCT 
GAGGCACCAC CTTCATGTTC TTGTGCATGC CATTCAAAGA ATTTTACCTA CAGCGACACA 
AACCTGGACA CTTCACCTCA TTTCAATAGT CCAAGCAAAC CATCTTCTGG AAGAAATGGA 
GTCTCAACTC CCTGTCAAGA CTCTCCTGAA AAAAATACTC TGGCTGCAAA GTTATCTGCC 
AAGAAACAGG CATCTATACA CAGAGACGAA GATGATGATT TTCAGGTAGA GAAGAAAAGA 
ATCCGACCCT TAGAAACTAC ACAGCAGATA AGAAAACGTC ATTGTTTGGA AAAGGACGTC 
CACCATGTAG ATGCACGACT AGCTTCGGAA AAGAGAGTAA AGCCTGAGTC TCCGATAGGA 
AAGTCTTTCT CCGACAGGAA AGACTCTTTT CAAAATGTGG ATGGCCTTTG TTCCAGGTGC 
TGCTGTTCTG CTAAACAAGG AAACAACCAA GAGCCTGCAA ATACTGTTAA GAAAGATCAC 
GGGGGACAAT GCAAGAGACC TAAAATTTAT TTTGGGACGC GGACACACAA GCAGATTGCT 
CAGATTACCA GGGAGCTCCG TAAGACAGCT TACTCAGGGG TCCCGATGAC TATTCTTTCC 
AGCAGGGACC ACAGCTGTGT CCATCCTGAA GTGGTGGGGA ATTTCAACAG AAAGGAGAAG 
TGCATGGAGC TGCTGGATGG CAAGCACGGG AAGTCCTGCT ATTTCTATCA TGGTGTTCAT 
AAAATTAGTA ATCAGCAGAC ACTGCAGCAC CTTCAGGGCA TGTCCAGAGC CTGGGACATA 
GAAGAACTAG TCAGCCTCGG GAGGAAACTG AAAGCTTGTC CCTACTATAC AGCTCGAGAA 
CTGATAGAGG ATGCTGACAT AGTGTTTTGT CCCTACAACT ACCTTTTAGA CTCACAAATA 
AGGGAAACTA TGGATATAAA GCTGAAAGGA CAAGTTGTCA TTTTAGATGA AGCTCACAAC 
ATTGAAGACT GTGCTCGGGA ATCAGCAAGC TACAGTGTAA CCGAAGTTCA GCTTAGGTTT 
GCTCGGGATG AGCTAGATAG TTTGATCAAC GGTAACATAA GGAAGAAAAG CCACGAGCCC 
CTACGAGATG TGTGCTATAA CCTCATCAAT TGGTTAGAAA CAAATTCTAA GCATCTTGTA 
GAAAGGGGTT ATGAGTCGTC TTGTAAAATA TGGAGTGGAA ATGAGATGCT CTTAAACTTA 
TACAGGATGG GCATCACCAC GGCTACTTTT CCAGTTTTGC AGAGGCATCT CTCAGCTGTT 
CTTCAAAAAG AAGAGAAAGT CACACCAATC CATGGTAAAG AGGAGGCAAT ACAAATCCCT 
ATTATCAGTG CATCAACTCA AGTCGTGCTC AAAGGACTCT TTATGGTGCT TGACTATCTC 
TTTAGAGAAA ATAGCAGATT TGCAGATGAT TATAAAGTTG CTATTCAACA GACTTACTCC 
TGGACAAATC AGATTGCTAT TTTTGATAAA ACTGGAGTCT TGGCTGTACC AAAAAATAAG 
AAACATTCAC GACAGAAAAT TGGAGTTAAT GCGCTAAACT TTTGGTGTTT AAATCCAGCT 
GTGGCCTTTT CAGATATTAA TGACAAAGTA CGGACCATTG TTCTAACATC AGGAACACTC 
TCACCCCTGA AATCCTTTTC ATCTGAGCTT GGTGTCACAT TTAGCATCCA ACTGGAGGCT 
AACCATGTCA TCAGTAACTC ACAGGTTTGG GTTGGTACTG TTGGCTCAGG CCCTAAGGGT 
CGGAATCTCT GCGCTACCTT TCAGCATACT GAAACATTTG AGTTCCAGGA TGAAGTGGGA 
ATGCTTCTGT TATCTGTGTG CCAGACTGTG AGCCAAGGAA TTCTGTGCTT TTTGCCATCT 
TACAAGCTAT TAGAGAAATT AAGAGAACGT TGGATTTTCA CTGGCCTATG GCATAGTTTG 
GAGTCAGTGA AGACAGTCAT TGCAGAACCC CAAGGAGGAG AAAAAACTGA TTTTGATGAA 
TTGCTGCAAG TGTACTATGA CGCCATCAAG TTCAAAGGAG AAAAGGATGG AGCCCTTCTC 
ATAGCAGTCT GTCGTGGCAA GGTGAGCGAG GGTCTGGATT TCTCAGATGA TAACGCCCGT 
GCTGTCATAA CCGTAGGGAT TCCTTTCCCA AATGTGAAGG ATCTTCAGGT GGAGCTAAAA 
CGACAATACA ATGACCACCA CTCAAAATCG AGAGGTCTTC TGCCTGGCCG TCAGTGGTAT 
GAAATTCAAG CATACCGAGC CTTGAATCAG GCTCTAGGCA GATGTATTCG GCACAAAAAT 
GATTGGGGAG CTCTTATTCT AGTGGACGAT CGCTTCAATA ACAATCCAAA CCGCTATATA 
TCAGGACTTT CTAAATGGGT GAGGCAGCAG ATTCAGCACC ACTCAAGCTT TGCAAGTGCC 
CTGGAGTCGC TGACCGAGTT CTCCAGAAGA CACCAGAAAG TTACTAATAG ATCCAAAAAA 
GACGAAAAAT GTACAAAAGA CAATGAGCCT ACTCTGGAAG TGGCCTGTTT GGAGGATAGC 
ACTTTTACAA GTGTGTCAGA ATCAAGTCAT CAGTCACCAG AAAACTCGAC AGAAGAAGCA 
GAAGTGTGTG TCCAGGAGCT TCAGTGTCCC CAGGTGGCTA CTAAAAGCCC CTCAGTAGCA 
AGCCACGGTG TTTCCAGAAG GAAGAAAAGT GATCCAGGAC TAAGAGGAGA GTCTCTTCAG 
ACAATGAAAA CAGAAAAAAA TGAGATTTCC CGATCTTCAA GCCCAACTTT TGGAAAGCAA 
ACAGAGCCAG TCAACTGGCC TATCTTTAAT TCTCTAAGAC GGCATTTCAA TAGTAAAGTA 
AAAAATTGCA CACCAGTACT CAAGTCATCA AAGAACCGTG CCCCTGGTTC TTCCACTTTC 
AATAAAACTG CTTTGCCACT CACAGGTAAC TGTGTGCCCT CAAACGAAAC AGCAGACACA 
TCACTGGGAC CTTGCCTTCA GTCAGAAGTC ATAATTTCAC CAGTGAAGAT TGAAGCTACT 
CCTGCTACGA ATTATTCCAA ACAGGTGTTC TGCTGTGAGA AAGACCTACT CCCGGATACT 
GAATTGTCGC CAGGAACTGA AGAAGCCAAG TGTCCCAGCT CAAACAAAGC TGCTGAAACA 
GAAGTGGATG ATGACTCTGA GTGTTTTACA CCTGAACTTT TTGATCCTGT CGATACCAAC 
GAAGAAAACG GTGAACTGGT TGAAACTGAT AGATCAAGTC ATAGTTCAGA TTGTTTTTCA 
GCGGAAGAGC TTTTTGAAAC TGCAACTGGA TTTGGGCAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Chromosoma125(2)237-52(2016 Jun)
Sun X,Brie?o-Enr?quez MA,Cornelius A,Modzelewski AJ,Maley TT,Campbell-Peterson KM,Holloway JK,Cohen PE

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Genes & development29(24)2532-46(2015 Dec)
Matsuzaki K,Borel V,Adelman CA,Schindler D,Boulton SJ

Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.
The EMBO journal33(15)1698-712(2014 Aug)
Peng M,Xie J,Ucher A,Stavnezer J,Cantor SB

FANCJ: solving problems in DNA replication.
DNA repair9(3)250-6(2010 Mar)
Hiom K

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Brip1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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