SMYD2 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	SMYD2
Entrez Gene ID	226830
Full Name	SET and MYND domain containing 2
Synonyms	1110020E07Rik,4930402C15,KMT3C,Zmynd14
General protein information	Preferred Names SET and MYND domain containing 2 Names N-lysine methyltransferase SMYD2 SET and MYND domain-containing protein 2 histone methyltransferase SMYD2
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 1 Map Location: 1\|1 H6

mRNA and Protein(s)

mRNA	Protein	Name
XM_006497146.4	XP_006497209.1	N-lysine methyltransferase SMYD2 isoform X1
XM_006497146.3	XP_006497209.1	N-lysine methyltransferase SMYD2 isoform X1
XM_006497147.3	XP_006497210.1	N-lysine methyltransferase SMYD2 isoform X2
XM_006497147.4	XP_006497210.1	N-lysine methyltransferase SMYD2 isoform X2
NM_026796.2	NP_081072.1	N-lysine methyltransferase SMYD2
XM_017320186.1	XP_017175675.1	N-lysine methyltransferase SMYD2 isoform X3
NM_026796.1	NP_081072.1	N-lysine methyltransferase SMYD2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SMYD2	XP_537149.3
Xenopus tropicalis (tropical clawed frog)	LOC100495522	XP_002934751.2
Homo sapiens (human)	SMYD2	NP_064582.2
Rattus norvegicus (Norway rat)	Smyd2	NP_996733.1
Danio rerio (zebrafish)	smyd2a	NP_001013568.1
Pan troglodytes (chimpanzee)	SMYD2	XP_003308794.1
	SMYD2	XP_001106482.2
Bos taurus (cattle)	SMYD2	NP_001069832.1
Mus musculus (house mouse)	Smyd2	NP_081072.1
Gallus gallus (chicken)	SMYD2	NP_001264500.1

Gene Ontology
Bibliography

Related articles in PubMed

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.
Li LX, Fan LX, Zhou JX, Grantham JJ, Calvet JP, Sage J, Li X
The Journal of clinical investigation127(7)2751-2764(2017 Jun)

Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
Bagislar S, Sab? A, Kress TR, Doni M, Nicoli P, Campaner S, Amati B
Oncotarget7(41)66398-66415(2016 Oct)

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.
Reynoird N, Mazur PK, Stellfeld T, Flores NM, Lofgren SM, Carlson SM, Brambilla E, Hainaut P, Kaznowska EB, Arrowsmith CH, Khatri P, Stresemann C, Gozani O, Sage J
Genes & development30(7)772-85(2016 Apr)

The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor ? (TNF-?) production.
Xu G, Liu G, Xiong S, Liu H, Chen X, Zheng B
The Journal of biological chemistry290(9)5414-23(2015 Feb)

Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis.
Sajjad A, Novoyatleva T, Vergarajauregui S, Troidl C, Schermuly RT, Tucker HO, Engel FB
Biochimica et biophysica acta1843(11)2556-62(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

two positive feedback loops that integrate epigenetic regulation and renal inflammation in cyst development: SMYD2/IL-6/STAT3/SMYD2 and SMYD2/TNF-alpha/NF-kappaB/SMYD2.
Title: Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.

a pivotal role for SMYD2 in promoting pancreatic cancer.
Title: Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.

Data show that histone methyltransferase Smyd2 inhibits macrophage interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. production.
Title: The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor ? (TNF-?) production.

Smyd2 is a lysine methyltransferase which has, next to its nuclear activity, specific regulatory functions in the cytoplasm of heart and skeletal muscle cells.
Title: Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function.

Smyd2, similar to Smyd3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ
Title: Cardiac deletion of Smyd2 is dispensable for mouse heart development.

The following SMYD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMYD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu73312	XM_017320186.1 Latest version!	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu03046	NM_026796.2 Latest version!	Mus musculus SET and MYND domain containing 2 (Smyd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu28949	XM_006497146.4 Latest version!	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu28950	XM_006497147.4 Latest version!	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu28949	XM_006497146.3	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu28950	XM_006497147.3	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu03046	NM_026796.1	Mus musculus SET and MYND domain containing 2 (Smyd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SMYD2 ( XM_017320186.1 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_017175675.1 Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu73312
Clone ID Related Accession (Same CDS sequence)	XM_017320186.1
Accession Version	XM_017320186.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	N-lysine methyltransferase SMYD2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATCACA GCTGCTGCCC GAATGTCATT GTGACCTACA AAGGGACCCT GGCAGAAGTC 
AGAGCTGTAC AGGAGATCCA CCCAGGAGAC GAGGTGTTCA CCAGCTACAT CGACCTGCTA 
TATCCAACAG AAGACAGGAA CGACCGGCTA AGAGACTCCT ATTTCTTTAC CTGTGAGTGC 
CGGGAGTGTA CAACCAAGGA TAAGGACAAA GCCAAGGTGG AAGTCCGAAA GCTCAGCAGC 
CCGCCACAGG CAGAAGCCAT CCGAGACATG GTCAGATACG CACGCAATGT CATCGAGGAG 
TTCCGGAGGG CCAAACACTA CAAATCCCCT AGTGAGCTGC TGGAGATCTG CGAGCTTAGC 
CAGGAGAAGA TGAGCTCCGT GTTTGAGGAC AGCAATGTGT ACATGCTGCA CATGATGTAC 
CAGGCCATGG GCGTCTGCCT GTACATGCAG GACTGGGAGG GAGCCCTGAA ATACGGGCAG 
AAGATCATTA AGCCGTACAG TAAGCACTAC CCCGTGTACT CCCTCAACGT GGCTTCCATG 
TGGCTGAAGC TGGGAAGACT GTACATGGGT CTGGAAAACA AAGCGGCCGG CGAGAAGGCC 
CTGAAGAAGG CCATTGCCAT CATGGAGGTA GCTCACGGCA AGGACCATCC GTACATCTCT 
GAAATCAAGC AGGAGATTGA GAGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017175675.1
CDS	483..1172
Translation	MNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEVRKLSSPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

Target ORF information:

RefSeq Version	XM_017320186.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017320186.1

ORF Insert Sequence:

ATGAATCACA GCTGCTGCCC GAATGTCATT GTGACCTACA AAGGGACCCT GGCAGAAGTC 
AGAGCTGTAC AGGAGATCCA CCCAGGAGAC GAGGTGTTCA CCAGCTACAT CGACCTGCTA 
TATCCAACAG AAGACAGGAA CGACCGGCTA AGAGACTCCT ATTTCTTTAC CTGTGAGTGC 
CGGGAGTGTA CAACCAAGGA TAAGGACAAA GCCAAGGTGG AAGTCCGAAA GCTCAGCAGC 
CCGCCACAGG CAGAAGCCAT CCGAGACATG GTCAGATACG CACGCAATGT CATCGAGGAG 
TTCCGGAGGG CCAAACACTA CAAATCCCCT AGTGAGCTGC TGGAGATCTG CGAGCTTAGC 
CAGGAGAAGA TGAGCTCCGT GTTTGAGGAC AGCAATGTGT ACATGCTGCA CATGATGTAC 
CAGGCCATGG GCGTCTGCCT GTACATGCAG GACTGGGAGG GAGCCCTGAA ATACGGGCAG 
AAGATCATTA AGCCGTACAG TAAGCACTAC CCCGTGTACT CCCTCAACGT GGCTTCCATG 
TGGCTGAAGC TGGGAAGACT GTACATGGGT CTGGAAAACA AAGCGGCCGG CGAGAAGGCC 
CTGAAGAAGG CCATTGCCAT CATGGAGGTA GCTCACGGCA AGGACCATCC GTACATCTCT 
GAAATCAAGC AGGAGATTGA GAGCCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMYD2 ( XM_006497146.3 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006497209.1 Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu28949
Clone ID Related Accession (Same CDS sequence)	XM_006497146.4 , XM_006497146.3
Accession Version	XM_006497146.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	N-lysine methyltransferase SMYD2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006497146.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAA 
ATCCACCCAG AGAGGACACC TTCAGAGAAA TTGTTGGCTG TGAGGGAGTT TGAGTCACAT 
CTGGACAAGC TAGACAACGA GAAGAAAGAT CTCATCCAGA GTGACATCGC CGCTCTCCAC 
CAGTTCTACT CCAAGTACCT GGAATTCCCT GACCACAGCA GTCTCGTGGT GCTCTTCGCC 
CAGGTGAACT GTAATGGCTT CACTATTGAA GATGAAGAGC TCTCCCATTT GGGATCGGCG 
ATATTCCCTG ATGTTGCATT GATGAATCAC AGCTGCTGCC CGAATGTCAT TGTGACCTAC 
AAAGGGACCC TGGCAGAAGT CAGAGCTGTA CAGGAGATCC ACCCAGGAGA CGAGGTGTTC 
ACCAGCTACA TCGACCTGCT ATATCCAACA GAAGACAGGA ACGACCGGCT AAGAGACTCC 
TATTTCTTTA CCTGTGAGTG CCGGGAGTGT ACAACCAAGG ATAAGGACAA AGCCAAGGTG 
GAAGTCCGAA AGCTCAGCAG CCCGCCACAG GCAGAAGCCA TCCGAGACAT GGTCAGATAC 
GCACGCAATG TCATCGAGGA GTTCCGGAGG GCCAAACACT ACAAATCCCC TAGTGAGCTG 
CTGGAGATCT GCGAGCTTAG CCAGGAGAAG ATGAGCTCCG TGTTTGAGGA CAGCAATGTG 
TACATGCTGC ACATGATGTA CCAGGCCATG GGCGTCTGCC TGTACATGCA GGACTGGGAG 
GGAGCCCTGA AATACGGGCA GAAGATCATT AAGCCGTACA GTAAGCACTA CCCCGTGTAC 
TCCCTCAACG TGGCTTCCAT GTGGCTGAAG CTGGGAAGAC TGTACATGGG TCTGGAAAAC 
AAAGCGGCCG GCGAGAAGGC CCTGAAGAAG GCCATTGCCA TCATGGAGGT AGCTCACGGC 
AAGGACCATC CGTACATCTC TGAAATCAAG CAGGAGATTG AGAGCCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497209.1
CDS	97..1287
Translation	MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEVRKLSSPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

Target ORF information:

RefSeq Version	XM_006497146.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497146.3

ORF Insert Sequence:

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAA 
ATCCACCCAG AGAGGACACC TTCAGAGAAA TTGTTGGCTG TGAGGGAGTT TGAGTCACAT 
CTGGACAAGC TAGACAACGA GAAGAAAGAT CTCATCCAGA GTGACATCGC CGCTCTCCAC 
CAGTTCTACT CCAAGTACCT GGAATTCCCT GACCACAGCA GTCTCGTGGT GCTCTTCGCC 
CAGGTGAACT GTAATGGCTT CACTATTGAA GATGAAGAGC TCTCCCATTT GGGATCGGCG 
ATATTCCCTG ATGTTGCATT GATGAATCAC AGCTGCTGCC CGAATGTCAT TGTGACCTAC 
AAAGGGACCC TGGCAGAAGT CAGAGCTGTA CAGGAGATCC ACCCAGGAGA CGAGGTGTTC 
ACCAGCTACA TCGACCTGCT ATATCCAACA GAAGACAGGA ACGACCGGCT AAGAGACTCC 
TATTTCTTTA CCTGTGAGTG CCGGGAGTGT ACAACCAAGG ATAAGGACAA AGCCAAGGTG 
GAAGTCCGAA AGCTCAGCAG CCCGCCACAG GCAGAAGCCA TCCGAGACAT GGTCAGATAC 
GCACGCAATG TCATCGAGGA GTTCCGGAGG GCCAAACACT ACAAATCCCC TAGTGAGCTG 
CTGGAGATCT GCGAGCTTAG CCAGGAGAAG ATGAGCTCCG TGTTTGAGGA CAGCAATGTG 
TACATGCTGC ACATGATGTA CCAGGCCATG GGCGTCTGCC TGTACATGCA GGACTGGGAG 
GGAGCCCTGA AATACGGGCA GAAGATCATT AAGCCGTACA GTAAGCACTA CCCCGTGTAC 
TCCCTCAACG TGGCTTCCAT GTGGCTGAAG CTGGGAAGAC TGTACATGGG TCTGGAAAAC 
AAAGCGGCCG GCGAGAAGGC CCTGAAGAAG GCCATTGCCA TCATGGAGGT AGCTCACGGC 
AAGGACCATC CGTACATCTC TGAAATCAAG CAGGAGATTG AGAGCCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMYD2 ( XM_006497147.3 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006497210.1 Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu28950
Clone ID Related Accession (Same CDS sequence)	XM_006497147.3 , XM_006497147.4
Accession Version	XM_006497147.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	N-lysine methyltransferase SMYD2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006497147.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAG 
GAAGACTGGC CCCTGCACAA GCTGGAATGC TCCTCCATGG TTGTTTTGGG GGAGAACTGG 
AATCCTTCGG AGACTGTGCG GCTCACAGCA AGAATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGGACAC CTTCAGAGAA ATTGTTGGCT GTGAGGGAGT TTGAGTCACA TCTGGACAAG 
CTAGACAACG AGAAGAAAGA TCTCATCCAG AGTGACATCG CCGCTCTCCA CCAGTTCTAC 
TCCAAGTACC TGGAATTCCC TGACCACAGC AGTCTCGTGG TGCTCTTCGC CCAGTGTTGC 
ATTGATGAAT CACAGCTGCT GCCCGAATGT CATTGTGACC TACAAAGGGA CCCTGGCAGA 
AGTCAGAGCT GTACAGGAGA TCCACCCAGG AGACGAGGTG TTCACCAGCT ACATCGACCT 
GCTATATCCA ACAGAAGACA GGAACGACCG GCTAAGAGAC TCCTATTTCT TTACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497210.1
CDS	98..817
Translation	MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVLGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQCCIDESQLLPECHCDLQRDPGRSQSCTGDPPRRRGVHQLHRPAISNRRQERPAKRLLFLYL

Target ORF information:

RefSeq Version	XM_006497147.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497147.3

ORF Insert Sequence:

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAG 
GAAGACTGGC CCCTGCACAA GCTGGAATGC TCCTCCATGG TTGTTTTGGG GGAGAACTGG 
AATCCTTCGG AGACTGTGCG GCTCACAGCA AGAATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGGACAC CTTCAGAGAA ATTGTTGGCT GTGAGGGAGT TTGAGTCACA TCTGGACAAG 
CTAGACAACG AGAAGAAAGA TCTCATCCAG AGTGACATCG CCGCTCTCCA CCAGTTCTAC 
TCCAAGTACC TGGAATTCCC TGACCACAGC AGTCTCGTGG TGCTCTTCGC CCAGTGTTGC 
ATTGATGAAT CACAGCTGCT GCCCGAATGT CATTGTGACC TACAAAGGGA CCCTGGCAGA 
AGTCAGAGCT GTACAGGAGA TCCACCCAGG AGACGAGGTG TTCACCAGCT ACATCGACCT 
GCTATATCCA ACAGAAGACA GGAACGACCG GCTAAGAGAC TCCTATTTCT TTACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMYD2 ( NM_026796.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_081072.1 Mus musculus SET and MYND domain containing 2 (Smyd2), mRNA.

Price & Availability↑

CloneID	OMu03046
Clone ID Related Accession (Same CDS sequence)	NM_026796.2 , NM_026796.1
Accession Version	NM_026796.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-26
Organism	Mus musculus(house mouse)
Product	N-lysine methyltransferase SMYD2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC140250.3, AK150857.1, AK003853.1 and W76826.1. On Sep 8, 2017 this sequence version replaced NM_026796.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023119.1, AK150857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAG 
GAAGACTGGC CCCTGCACAA GCTGGAATGC TCCTCCATGG TTGTTTTGGG GGAGAACTGG 
AATCCTTCGG AGACTGTGCG GCTCACAGCA AGAATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGGACAC CTTCAGAGAA ATTGTTGGCT GTGAGGGAGT TTGAGTCACA TCTGGACAAG 
CTAGACAACG AGAAGAAAGA TCTCATCCAG AGTGACATCG CCGCTCTCCA CCAGTTCTAC 
TCCAAGTACC TGGAATTCCC TGACCACAGC AGTCTCGTGG TGCTCTTCGC CCAGGTGAAC 
TGTAATGGCT TCACTATTGA AGATGAAGAG CTCTCCCATT TGGGATCGGC GATATTCCCT 
GATGTTGCAT TGATGAATCA CAGCTGCTGC CCGAATGTCA TTGTGACCTA CAAAGGGACC 
CTGGCAGAAG TCAGAGCTGT ACAGGAGATC CACCCAGGAG ACGAGGTGTT CACCAGCTAC 
ATCGACCTGC TATATCCAAC AGAAGACAGG AACGACCGGC TAAGAGACTC CTATTTCTTT 
ACCTGTGAGT GCCGGGAGTG TACAACCAAG GATAAGGACA AAGCCAAGGT GGAAGTCCGA 
AAGCTCAGCA GCCCGCCACA GGCAGAAGCC ATCCGAGACA TGGTCAGATA CGCACGCAAT 
GTCATCGAGG AGTTCCGGAG GGCCAAACAC TACAAATCCC CTAGTGAGCT GCTGGAGATC 
TGCGAGCTTA GCCAGGAGAA GATGAGCTCC GTGTTTGAGG ACAGCAATGT GTACATGCTG 
CACATGATGT ACCAGGCCAT GGGCGTCTGC CTGTACATGC AGGACTGGGA GGGAGCCCTG 
AAATACGGGC AGAAGATCAT TAAGCCGTAC AGTAAGCACT ACCCCGTGTA CTCCCTCAAC 
GTGGCTTCCA TGTGGCTGAA GCTGGGAAGA CTGTACATGG GTCTGGAAAA CAAAGCGGCC 
GGCGAGAAGG CCCTGAAGAA GGCCATTGCC ATCATGGAGG TAGCTCACGG CAAGGACCAT 
CCGTACATCT CTGAAATCAA GCAGGAGATT GAGAGCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081072.1
CDS	13..1314
Translation	MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVLGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEVRKLSSPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

Target ORF information:

RefSeq Version	NM_026796.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET and MYND domain containing 2 (Smyd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026796.2

ORF Insert Sequence:

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAG 
GAAGACTGGC CCCTGCACAA GCTGGAATGC TCCTCCATGG TTGTTTTGGG GGAGAACTGG 
AATCCTTCGG AGACTGTGCG GCTCACAGCA AGAATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGGACAC CTTCAGAGAA ATTGTTGGCT GTGAGGGAGT TTGAGTCACA TCTGGACAAG 
CTAGACAACG AGAAGAAAGA TCTCATCCAG AGTGACATCG CCGCTCTCCA CCAGTTCTAC 
TCCAAGTACC TGGAATTCCC TGACCACAGC AGTCTCGTGG TGCTCTTCGC CCAGGTGAAC 
TGTAATGGCT TCACTATTGA AGATGAAGAG CTCTCCCATT TGGGATCGGC GATATTCCCT 
GATGTTGCAT TGATGAATCA CAGCTGCTGC CCGAATGTCA TTGTGACCTA CAAAGGGACC 
CTGGCAGAAG TCAGAGCTGT ACAGGAGATC CACCCAGGAG ACGAGGTGTT CACCAGCTAC 
ATCGACCTGC TATATCCAAC AGAAGACAGG AACGACCGGC TAAGAGACTC CTATTTCTTT 
ACCTGTGAGT GCCGGGAGTG TACAACCAAG GATAAGGACA AAGCCAAGGT GGAAGTCCGA 
AAGCTCAGCA GCCCGCCACA GGCAGAAGCC ATCCGAGACA TGGTCAGATA CGCACGCAAT 
GTCATCGAGG AGTTCCGGAG GGCCAAACAC TACAAATCCC CTAGTGAGCT GCTGGAGATC 
TGCGAGCTTA GCCAGGAGAA GATGAGCTCC GTGTTTGAGG ACAGCAATGT GTACATGCTG 
CACATGATGT ACCAGGCCAT GGGCGTCTGC CTGTACATGC AGGACTGGGA GGGAGCCCTG 
AAATACGGGC AGAAGATCAT TAAGCCGTAC AGTAAGCACT ACCCCGTGTA CTCCCTCAAC 
GTGGCTTCCA TGTGGCTGAA GCTGGGAAGA CTGTACATGG GTCTGGAAAA CAAAGCGGCC 
GGCGAGAAGG CCCTGAAGAA GGCCATTGCC ATCATGGAGG TAGCTCACGG CAAGGACCAT 
CCGTACATCT CTGAAATCAA GCAGGAGATT GAGAGCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMYD2 ( NM_026796.1 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_081072.1 Mus musculus SET and MYND domain containing 2 (Smyd2), mRNA.

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CloneID	OMu03046
Clone ID Related Accession (Same CDS sequence)	NM_026796.2 , NM_026796.1
Accession Version	NM_026796.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-05-05
Organism	Mus musculus(House mouse)
Product	N-lysine methyltransferase SMYD2
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC023119.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023119.1, AK150857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAG 
GAAGACTGGC CCCTGCACAA GCTGGAATGC TCCTCCATGG TTGTTTTGGG GGAGAACTGG 
AATCCTTCGG AGACTGTGCG GCTCACAGCA AGAATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGGACAC CTTCAGAGAA ATTGTTGGCT GTGAGGGAGT TTGAGTCACA TCTGGACAAG 
CTAGACAACG AGAAGAAAGA TCTCATCCAG AGTGACATCG CCGCTCTCCA CCAGTTCTAC 
TCCAAGTACC TGGAATTCCC TGACCACAGC AGTCTCGTGG TGCTCTTCGC CCAGGTGAAC 
TGTAATGGCT TCACTATTGA AGATGAAGAG CTCTCCCATT TGGGATCGGC GATATTCCCT 
GATGTTGCAT TGATGAATCA CAGCTGCTGC CCGAATGTCA TTGTGACCTA CAAAGGGACC 
CTGGCAGAAG TCAGAGCTGT ACAGGAGATC CACCCAGGAG ACGAGGTGTT CACCAGCTAC 
ATCGACCTGC TATATCCAAC AGAAGACAGG AACGACCGGC TAAGAGACTC CTATTTCTTT 
ACCTGTGAGT GCCGGGAGTG TACAACCAAG GATAAGGACA AAGCCAAGGT GGAAGTCCGA 
AAGCTCAGCA GCCCGCCACA GGCAGAAGCC ATCCGAGACA TGGTCAGATA CGCACGCAAT 
GTCATCGAGG AGTTCCGGAG GGCCAAACAC TACAAATCCC CTAGTGAGCT GCTGGAGATC 
TGCGAGCTTA GCCAGGAGAA GATGAGCTCC GTGTTTGAGG ACAGCAATGT GTACATGCTG 
CACATGATGT ACCAGGCCAT GGGCGTCTGC CTGTACATGC AGGACTGGGA GGGAGCCCTG 
AAATACGGGC AGAAGATCAT TAAGCCGTAC AGTAAGCACT ACCCCGTGTA CTCCCTCAAC 
GTGGCTTCCA TGTGGCTGAA GCTGGGAAGA CTGTACATGG GTCTGGAAAA CAAAGCGGCC 
GGCGAGAAGG CCCTGAAGAA GGCCATTGCC ATCATGGAGG TAGCTCACGG CAAGGACCAT 
CCGTACATCT CTGAAATCAA GCAGGAGATT GAGAGCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081072.1
CDS	10..1311
Translation	MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVLGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEVRKLSSPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

Target ORF information:

RefSeq Version	NM_026796.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus SET and MYND domain containing 2 (Smyd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026796.1

ORF Insert Sequence:

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAG 
GAAGACTGGC CCCTGCACAA GCTGGAATGC TCCTCCATGG TTGTTTTGGG GGAGAACTGG 
AATCCTTCGG AGACTGTGCG GCTCACAGCA AGAATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGGACAC CTTCAGAGAA ATTGTTGGCT GTGAGGGAGT TTGAGTCACA TCTGGACAAG 
CTAGACAACG AGAAGAAAGA TCTCATCCAG AGTGACATCG CCGCTCTCCA CCAGTTCTAC 
TCCAAGTACC TGGAATTCCC TGACCACAGC AGTCTCGTGG TGCTCTTCGC CCAGGTGAAC 
TGTAATGGCT TCACTATTGA AGATGAAGAG CTCTCCCATT TGGGATCGGC GATATTCCCT 
GATGTTGCAT TGATGAATCA CAGCTGCTGC CCGAATGTCA TTGTGACCTA CAAAGGGACC 
CTGGCAGAAG TCAGAGCTGT ACAGGAGATC CACCCAGGAG ACGAGGTGTT CACCAGCTAC 
ATCGACCTGC TATATCCAAC AGAAGACAGG AACGACCGGC TAAGAGACTC CTATTTCTTT 
ACCTGTGAGT GCCGGGAGTG TACAACCAAG GATAAGGACA AAGCCAAGGT GGAAGTCCGA 
AAGCTCAGCA GCCCGCCACA GGCAGAAGCC ATCCGAGACA TGGTCAGATA CGCACGCAAT 
GTCATCGAGG AGTTCCGGAG GGCCAAACAC TACAAATCCC CTAGTGAGCT GCTGGAGATC 
TGCGAGCTTA GCCAGGAGAA GATGAGCTCC GTGTTTGAGG ACAGCAATGT GTACATGCTG 
CACATGATGT ACCAGGCCAT GGGCGTCTGC CTGTACATGC AGGACTGGGA GGGAGCCCTG 
AAATACGGGC AGAAGATCAT TAAGCCGTAC AGTAAGCACT ACCCCGTGTA CTCCCTCAAC 
GTGGCTTCCA TGTGGCTGAA GCTGGGAAGA CTGTACATGG GTCTGGAAAA CAAAGCGGCC 
GGCGAGAAGG CCCTGAAGAA GGCCATTGCC ATCATGGAGG TAGCTCACGG CAAGGACCAT 
CCGTACATCT CTGAAATCAA GCAGGAGATT GAGAGCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMYD2 ( XM_006497146.4 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006497209.1 Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X1, mRNA.

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CloneID	OMu28949
Clone ID Related Accession (Same CDS sequence)	XM_006497146.4 , XM_006497146.3
Accession Version	XM_006497146.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	N-lysine methyltransferase SMYD2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006497146.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAA 
ATCCACCCAG AGAGGACACC TTCAGAGAAA TTGTTGGCTG TGAGGGAGTT TGAGTCACAT 
CTGGACAAGC TAGACAACGA GAAGAAAGAT CTCATCCAGA GTGACATCGC CGCTCTCCAC 
CAGTTCTACT CCAAGTACCT GGAATTCCCT GACCACAGCA GTCTCGTGGT GCTCTTCGCC 
CAGGTGAACT GTAATGGCTT CACTATTGAA GATGAAGAGC TCTCCCATTT GGGATCGGCG 
ATATTCCCTG ATGTTGCATT GATGAATCAC AGCTGCTGCC CGAATGTCAT TGTGACCTAC 
AAAGGGACCC TGGCAGAAGT CAGAGCTGTA CAGGAGATCC ACCCAGGAGA CGAGGTGTTC 
ACCAGCTACA TCGACCTGCT ATATCCAACA GAAGACAGGA ACGACCGGCT AAGAGACTCC 
TATTTCTTTA CCTGTGAGTG CCGGGAGTGT ACAACCAAGG ATAAGGACAA AGCCAAGGTG 
GAAGTCCGAA AGCTCAGCAG CCCGCCACAG GCAGAAGCCA TCCGAGACAT GGTCAGATAC 
GCACGCAATG TCATCGAGGA GTTCCGGAGG GCCAAACACT ACAAATCCCC TAGTGAGCTG 
CTGGAGATCT GCGAGCTTAG CCAGGAGAAG ATGAGCTCCG TGTTTGAGGA CAGCAATGTG 
TACATGCTGC ACATGATGTA CCAGGCCATG GGCGTCTGCC TGTACATGCA GGACTGGGAG 
GGAGCCCTGA AATACGGGCA GAAGATCATT AAGCCGTACA GTAAGCACTA CCCCGTGTAC 
TCCCTCAACG TGGCTTCCAT GTGGCTGAAG CTGGGAAGAC TGTACATGGG TCTGGAAAAC 
AAAGCGGCCG GCGAGAAGGC CCTGAAGAAG GCCATTGCCA TCATGGAGGT AGCTCACGGC 
AAGGACCATC CGTACATCTC TGAAATCAAG CAGGAGATTG AGAGCCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497209.1
CDS	193..1383
Translation	MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEVRKLSSPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

Target ORF information:

RefSeq Version	XM_006497146.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497146.4

ORF Insert Sequence:

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAA 
ATCCACCCAG AGAGGACACC TTCAGAGAAA TTGTTGGCTG TGAGGGAGTT TGAGTCACAT 
CTGGACAAGC TAGACAACGA GAAGAAAGAT CTCATCCAGA GTGACATCGC CGCTCTCCAC 
CAGTTCTACT CCAAGTACCT GGAATTCCCT GACCACAGCA GTCTCGTGGT GCTCTTCGCC 
CAGGTGAACT GTAATGGCTT CACTATTGAA GATGAAGAGC TCTCCCATTT GGGATCGGCG 
ATATTCCCTG ATGTTGCATT GATGAATCAC AGCTGCTGCC CGAATGTCAT TGTGACCTAC 
AAAGGGACCC TGGCAGAAGT CAGAGCTGTA CAGGAGATCC ACCCAGGAGA CGAGGTGTTC 
ACCAGCTACA TCGACCTGCT ATATCCAACA GAAGACAGGA ACGACCGGCT AAGAGACTCC 
TATTTCTTTA CCTGTGAGTG CCGGGAGTGT ACAACCAAGG ATAAGGACAA AGCCAAGGTG 
GAAGTCCGAA AGCTCAGCAG CCCGCCACAG GCAGAAGCCA TCCGAGACAT GGTCAGATAC 
GCACGCAATG TCATCGAGGA GTTCCGGAGG GCCAAACACT ACAAATCCCC TAGTGAGCTG 
CTGGAGATCT GCGAGCTTAG CCAGGAGAAG ATGAGCTCCG TGTTTGAGGA CAGCAATGTG 
TACATGCTGC ACATGATGTA CCAGGCCATG GGCGTCTGCC TGTACATGCA GGACTGGGAG 
GGAGCCCTGA AATACGGGCA GAAGATCATT AAGCCGTACA GTAAGCACTA CCCCGTGTAC 
TCCCTCAACG TGGCTTCCAT GTGGCTGAAG CTGGGAAGAC TGTACATGGG TCTGGAAAAC 
AAAGCGGCCG GCGAGAAGGC CCTGAAGAAG GCCATTGCCA TCATGGAGGT AGCTCACGGC 
AAGGACCATC CGTACATCTC TGAAATCAAG CAGGAGATTG AGAGCCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMYD2 ( XM_006497147.4 ) cDNA ORF clone, Mus musculus(House mouse) -> XP_006497210.1 Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X2, mRNA.

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CloneID	OMu28950
Clone ID Related Accession (Same CDS sequence)	XM_006497147.3 , XM_006497147.4
Accession Version	XM_006497147.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	N-lysine methyltransferase SMYD2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006497147.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAG 
GAAGACTGGC CCCTGCACAA GCTGGAATGC TCCTCCATGG TTGTTTTGGG GGAGAACTGG 
AATCCTTCGG AGACTGTGCG GCTCACAGCA AGAATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGGACAC CTTCAGAGAA ATTGTTGGCT GTGAGGGAGT TTGAGTCACA TCTGGACAAG 
CTAGACAACG AGAAGAAAGA TCTCATCCAG AGTGACATCG CCGCTCTCCA CCAGTTCTAC 
TCCAAGTACC TGGAATTCCC TGACCACAGC AGTCTCGTGG TGCTCTTCGC CCAGTGTTGC 
ATTGATGAAT CACAGCTGCT GCCCGAATGT CATTGTGACC TACAAAGGGA CCCTGGCAGA 
AGTCAGAGCT GTACAGGAGA TCCACCCAGG AGACGAGGTG TTCACCAGCT ACATCGACCT 
GCTATATCCA ACAGAAGACA GGAACGACCG GCTAAGAGAC TCCTATTTCT TTACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006497210.1
CDS	217..936
Translation	MRAEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVLGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQCCIDESQLLPECHCDLQRDPGRSQSCTGDPPRRRGVHQLHRPAISNRRQERPAKRLLFLYL

Target ORF information:

RefSeq Version	XM_006497147.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET and MYND domain containing 2 (Smyd2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006497147.4

ORF Insert Sequence:

ATGCGCGCCG AGGCCCGCGG CGGCCTGGAG CGCTTCTGCA GTGCGGGCAA GGGCCGGGGG 
CTCCGCGCGC TGCGGCCCTT CCACGTGGGC GACCTCCTCT TCTCCTGCCC GGCCTACGCC 
TGCGTGCTCA CCGTGGGCGA GCGGGGCCAC CACTGCGAGT GCTGCTTCGC CAGGAAAGAA 
GGATTGTCAA AATGTGGACG GTGCAAGCAG GCGTTCTACT GCGACGTGGA ATGTCAGAAG 
GAAGACTGGC CCCTGCACAA GCTGGAATGC TCCTCCATGG TTGTTTTGGG GGAGAACTGG 
AATCCTTCGG AGACTGTGCG GCTCACAGCA AGAATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGGACAC CTTCAGAGAA ATTGTTGGCT GTGAGGGAGT TTGAGTCACA TCTGGACAAG 
CTAGACAACG AGAAGAAAGA TCTCATCCAG AGTGACATCG CCGCTCTCCA CCAGTTCTAC 
TCCAAGTACC TGGAATTCCC TGACCACAGC AGTCTCGTGG TGCTCTTCGC CCAGTGTTGC 
ATTGATGAAT CACAGCTGCT GCCCGAATGT CATTGTGACC TACAAAGGGA CCCTGGCAGA 
AGTCAGAGCT GTACAGGAGA TCCACCCAGG AGACGAGGTG TTCACCAGCT ACATCGACCT 
GCTATATCCA ACAGAAGACA GGAACGACCG GCTAAGAGAC TCCTATTTCT TTACCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.
The Journal of clinical investigation127(7)2751-2764(2017 Jun)
Li LX,Fan LX,Zhou JX,Grantham JJ,Calvet JP,Sage J,Li X

Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
Oncotarget7(41)66398-66415(2016 Oct)
Bagislar S,Sab? A,Kress TR,Doni M,Nicoli P,Campaner S,Amati B

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.
Genes & development30(7)772-85(2016 Apr)
Reynoird N,Mazur PK,Stellfeld T,Flores NM,Lofgren SM,Carlson SM,Brambilla E,Hainaut P,Kaznowska EB,Arrowsmith CH,Khatri P,Stresemann C,Gozani O,Sage J

The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor ? (TNF-?) production.
The Journal of biological chemistry290(9)5414-23(2015 Feb)
Xu G,Liu G,Xiong S,Liu H,Chen X,Zheng B

Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis.
Biochimica et biophysica acta1843(11)2556-62(2014 Nov)
Sajjad A,Novoyatleva T,Vergarajauregui S,Troidl C,Schermuly RT,Tucker HO,Engel FB

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SMYD2 cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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