SMYD2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SMYD2
Entrez Gene ID	56950
Full Name	SET and MYND domain containing 2
Synonyms	HSKM-B,KMT3C,ZMYND14
General protein information	Preferred Names SET and MYND domain containing 2 Names N-lysine methyltransferase SMYD2 SET and MYND domain-containing protein 2 histone methyltransferase SMYD2 lysine N-methyltransferase 3C zinc finger, MYND domain containing 14
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.3
Summary	SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008].
Disorder MIM:	610663

mRNA and Protein(s)

mRNA	Protein	Name
NM_020197.3	NP_064582.2	N-lysine methyltransferase SMYD2
NM_020197.2	NP_064582.2	N-lysine methyltransferase SMYD2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SMYD2	XP_537149.3
Xenopus tropicalis (tropical clawed frog)	LOC100495522	XP_002934751.2
Homo sapiens (human)	SMYD2	NP_064582.2
Rattus norvegicus (Norway rat)	Smyd2	NP_996733.1
Danio rerio (zebrafish)	smyd2a	NP_001013568.1
Pan troglodytes (chimpanzee)	SMYD2	XP_003308794.1
	SMYD2	XP_001106482.2
Bos taurus (cattle)	SMYD2	NP_001069832.1
Mus musculus (house mouse)	Smyd2	NP_081072.1
Gallus gallus (chicken)	SMYD2	NP_001264500.1

Gene Ontology
Bibliography

Related articles in PubMed

The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling.
Gao S, Wang Z, Wang W, Hu X, Chen P, Li J, Feng X, Wong J, Du JX
The Journal of biological chemistry292(30)12702-12712(2017 07)

Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells.
Wang R, Deng X, Yoshioka Y, Vougiouklakis T, Park JH, Suzuki T, Dohmae N, Ueda K, Hamamoto R, Nakamura Y
Cancer science108(6)1203-1209(2017 Jun)

SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M
Cell host & microbe21(5)569-579.e6(2017 May)

SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress.
Zipin-Roitman A, Aqaqe N, Yassin M, Biechonski S, Amar M, van Delft MF, Gan OI, McDermott SP, Buzina A, Ketela T, Shlush L, Xie S, Voisin V, Moffat J, Minden MD, Dick JE, Milyavsky M
Oncotarget8(10)16712-16727(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The SMYD2 may promote BMP signaling by directly methylating BMPR2, which, in turn, stimulates BMPR2 kinase activity and activation of the BMP pathway.
Title: The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling.

Knockdown of SMYD2 as well as treatment with a SMYD2 inhibitor in two NSCLC cell lines with an EML4-ALK gene significantly attenuated the phosphorylation levels of the EML4-ALK protein.
Title: Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells.

SMYD2-H4K20me1-L3MBTL1 axis contributes to HIV-1 latency and can be targeted with small-molecule SMYD2 inhibitors.
Title: SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.

SMYD2 knockdown confers relative resistance to human AML cells against multiple classes of DNA damaging agents.
Title: SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress.

Substrate crevices of Smyd2 and Smyd3 show distinct features in terms of spatial, hydration, and electrostatic properties that emphasize their characteristic modes of substrates interaction and entry pathways for inhibitor binding.
Title: Conformational Dynamics of Lysine Methyltransferase Smyd2. Insights into the Different Substrate Crevice Characteristics of Smyd2 and Smyd3.

The following SMYD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMYD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17495	NM_020197.3 Latest version!	Homo sapiens SET and MYND domain containing 2 (SMYD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu17495	NM_020197.2	Homo sapiens SET and MYND domain containing 2 (SMYD2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SMYD2 ( NM_020197.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_064582.2 Homo sapiens SET and MYND domain containing 2 (SMYD2), mRNA.

Price & Availability↑

CloneID	OHu17495
Clone ID Related Accession (Same CDS sequence)	NM_020197.3 , NM_020197.2
Accession Version	NM_020197.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	N-lysine methyltransferase SMYD2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL929236.4, BG723585.1, BC098276.1 and AW474469.1. On Nov 24, 2018 this sequence version replaced NM_020197.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.74249.1, SRR3476690.886304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000366957.10/ ENSP00000355924.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGGCCG AGGGCCTCGG CGGCCTGGAG CGCTTCTGCA GCCCGGGCAA AGGCCGGGGG 
CTGCGGGCTC TGCAGCCCTT CCAGGTGGGG GACTTGCTGT TCTCCTGCCC GGCCTATGCC 
TACGTGCTCA CGGTCAACGA GCGGGGCAAC CACTGCGAGT ACTGCTTCAC CAGGAAAGAA 
GGATTGTCCA AATGTGGAAG ATGCAAGCAG GCATTTTACT GCAATGTGGA GTGTCAGAAA 
GAAGATTGGC CCATGCACAA GCTGGAATGT TCTCCCATGG TTGTTTTTGG GGAAAACTGG 
AATCCCTCGG AGACTGTAAG ACTAACAGCA AGGATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGAACAC CTTCGGAAAA ATTGTTAGCT GTGAAGGAGT TTGAATCACA TCTGGATAAG 
TTAGACAATG AGAAGAAGGA TTTGATTCAG AGTGACATAG CTGCTCTCCA TCACTTTTAC 
TCCAAGCATC TCGGATTCCC TGACAATGAT AGCCTCGTAG TACTCTTTGC ACAGGTTAAC 
TGTAATGGCT TCACAATTGA AGATGAAGAA CTTTCTCATT TGGGATCAGC GATATTTCCT 
GATGTTGCAT TGATGAATCA TAGCTGTTGC CCCAATGTCA TTGTGACCTA CAAAGGGACC 
CTGGCAGAAG TCAGAGCTGT ACAGGAAATC AAGCCGGGAG AGGAGGTTTT TACCAGCTAT 
ATTGATCTCC TGTACCCAAC GGAAGATAGA AATGACCGGT TAAGAGATTC TTATTTCTTT 
ACCTGTGAGT GCCAGGAGTG TACCACCAAG GACAAGGATA AGGCCAAGGT GGAAATCCGG 
AAGCTCAGCG ATCCCCCAAA GGCAGAAGCC ATCCGAGACA TGGTCAGATA TGCACGCAAC 
GTCATTGAAG AGTTCCGGAG GGCCAAGCAC TATAAATCCC CTAGTGAGCT GCTGGAGATC 
TGCGAGCTCA GCCAGGAGAA GATGAGCTCT GTGTTTGAGG ACAGTAACGT GTACATGTTG 
CACATGATGT ACCAGGCCAT GGGTGTCTGC TTGTACATGC AGGACTGGGA AGGAGCCCTG 
CAATATGGAC AGAAAATCAT TAAGCCCTAC AGTAAGCACT ATCCTTTGTA CTCCCTCAAC 
GTGGCCTCCA TGTGGTTGAA GCTAGGGAGA CTCTACATGG GCCTGGAACA CAAAGCCGCA 
GGGGAGAAAG CCCTGAAGAA GGCCATTGCA ATCATGGAAG TAGCTCACGG CAAAGATCAT 
CCATATATTT CTGAGATCAA ACAGGAAATT GAAAGCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064582.2
CDS	97..1398
Translation	MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

Target ORF information:

RefSeq Version	NM_020197.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SET and MYND domain containing 2 (SMYD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020197.3

ORF Insert Sequence:

ATGAGGGCCG AGGGCCTCGG CGGCCTGGAG CGCTTCTGCA GCCCGGGCAA AGGCCGGGGG 
CTGCGGGCTC TGCAGCCCTT CCAGGTGGGG GACTTGCTGT TCTCCTGCCC GGCCTATGCC 
TACGTGCTCA CGGTCAACGA GCGGGGCAAC CACTGCGAGT ACTGCTTCAC CAGGAAAGAA 
GGATTGTCCA AATGTGGAAG ATGCAAGCAG GCATTTTACT GCAATGTGGA GTGTCAGAAA 
GAAGATTGGC CCATGCACAA GCTGGAATGT TCTCCCATGG TTGTTTTTGG GGAAAACTGG 
AATCCCTCGG AGACTGTAAG ACTAACAGCA AGGATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGAACAC CTTCGGAAAA ATTGTTAGCT GTGAAGGAGT TTGAATCACA TCTGGATAAG 
TTAGACAATG AGAAGAAGGA TTTGATTCAG AGTGACATAG CTGCTCTCCA TCACTTTTAC 
TCCAAGCATC TCGGATTCCC TGACAATGAT AGCCTCGTAG TACTCTTTGC ACAGGTTAAC 
TGTAATGGCT TCACAATTGA AGATGAAGAA CTTTCTCATT TGGGATCAGC GATATTTCCT 
GATGTTGCAT TGATGAATCA TAGCTGTTGC CCCAATGTCA TTGTGACCTA CAAAGGGACC 
CTGGCAGAAG TCAGAGCTGT ACAGGAAATC AAGCCGGGAG AGGAGGTTTT TACCAGCTAT 
ATTGATCTCC TGTACCCAAC GGAAGATAGA AATGACCGGT TAAGAGATTC TTATTTCTTT 
ACCTGTGAGT GCCAGGAGTG TACCACCAAG GACAAGGATA AGGCCAAGGT GGAAATCCGG 
AAGCTCAGCG ATCCCCCAAA GGCAGAAGCC ATCCGAGACA TGGTCAGATA TGCACGCAAC 
GTCATTGAAG AGTTCCGGAG GGCCAAGCAC TATAAATCCC CTAGTGAGCT GCTGGAGATC 
TGCGAGCTCA GCCAGGAGAA GATGAGCTCT GTGTTTGAGG ACAGTAACGT GTACATGTTG 
CACATGATGT ACCAGGCCAT GGGTGTCTGC TTGTACATGC AGGACTGGGA AGGAGCCCTG 
CAATATGGAC AGAAAATCAT TAAGCCCTAC AGTAAGCACT ATCCTTTGTA CTCCCTCAAC 
GTGGCCTCCA TGTGGTTGAA GCTAGGGAGA CTCTACATGG GCCTGGAACA CAAAGCCGCA 
GGGGAGAAAG CCCTGAAGAA GGCCATTGCA ATCATGGAAG TAGCTCACGG CAAAGATCAT 
CCATATATTT CTGAGATCAA ACAGGAAATT GAAAGCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SMYD2 ( NM_020197.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_064582.2 Homo sapiens SET and MYND domain containing 2 (SMYD2), mRNA.

Price & Availability↑

CloneID	OHu17495
Clone ID Related Accession (Same CDS sequence)	NM_020197.3 , NM_020197.2
Accession Version	NM_020197.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	N-lysine methyltransferase SMYD2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG723585.1, BC098276.1 and AW474469.1. On May 14, 2008 this sequence version replaced NM_020197.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.160870.1, SRR1803616.83153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGCCG AGGGCCTCGG CGGCCTGGAG CGCTTCTGCA GCCCGGGCAA AGGCCGGGGG 
CTGCGGGCTC TGCAGCCCTT CCAGGTGGGG GACTTGCTGT TCTCCTGCCC GGCCTATGCC 
TACGTGCTCA CGGTCAACGA GCGGGGCAAC CACTGCGAGT ACTGCTTCAC CAGGAAAGAA 
GGATTGTCCA AATGTGGAAG ATGCAAGCAG GCATTTTACT GCAATGTGGA GTGTCAGAAA 
GAAGATTGGC CCATGCACAA GCTGGAATGT TCTCCCATGG TTGTTTTTGG GGAAAACTGG 
AATCCCTCGG AGACTGTAAG ACTAACAGCA AGGATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGAACAC CTTCGGAAAA ATTGTTAGCT GTGAAGGAGT TTGAATCACA TCTGGATAAG 
TTAGACAATG AGAAGAAGGA TTTGATTCAG AGTGACATAG CTGCTCTCCA TCACTTTTAC 
TCCAAGCATC TCGGATTCCC TGACAATGAT AGCCTCGTAG TACTCTTTGC ACAGGTTAAC 
TGTAATGGCT TCACAATTGA AGATGAAGAA CTTTCTCATT TGGGATCAGC GATATTTCCT 
GATGTTGCAT TGATGAATCA TAGCTGTTGC CCCAATGTCA TTGTGACCTA CAAAGGGACC 
CTGGCAGAAG TCAGAGCTGT ACAGGAAATC AAGCCGGGAG AGGAGGTTTT TACCAGCTAT 
ATTGATCTCC TGTACCCAAC GGAAGATAGA AATGACCGGT TAAGAGATTC TTATTTCTTT 
ACCTGTGAGT GCCAGGAGTG TACCACCAAG GACAAGGATA AGGCCAAGGT GGAAATCCGG 
AAGCTCAGCG ATCCCCCAAA GGCAGAAGCC ATCCGAGACA TGGTCAGATA TGCACGCAAC 
GTCATTGAAG AGTTCCGGAG GGCCAAGCAC TATAAATCCC CTAGTGAGCT GCTGGAGATC 
TGCGAGCTCA GCCAGGAGAA GATGAGCTCT GTGTTTGAGG ACAGTAACGT GTACATGTTG 
CACATGATGT ACCAGGCCAT GGGTGTCTGC TTGTACATGC AGGACTGGGA AGGAGCCCTG 
CAATATGGAC AGAAAATCAT TAAGCCCTAC AGTAAGCACT ATCCTTTGTA CTCCCTCAAC 
GTGGCCTCCA TGTGGTTGAA GCTAGGGAGA CTCTACATGG GCCTGGAACA CAAAGCCGCA 
GGGGAGAAAG CCCTGAAGAA GGCCATTGCA ATCATGGAAG TAGCTCACGG CAAAGATCAT 
CCATATATTT CTGAGATCAA ACAGGAAATT GAAAGCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064582.2
CDS	34..1335
Translation	MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH

Target ORF information:

RefSeq Version	NM_020197.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SET and MYND domain containing 2 (SMYD2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020197.2

ORF Insert Sequence:

ATGAGGGCCG AGGGCCTCGG CGGCCTGGAG CGCTTCTGCA GCCCGGGCAA AGGCCGGGGG 
CTGCGGGCTC TGCAGCCCTT CCAGGTGGGG GACTTGCTGT TCTCCTGCCC GGCCTATGCC 
TACGTGCTCA CGGTCAACGA GCGGGGCAAC CACTGCGAGT ACTGCTTCAC CAGGAAAGAA 
GGATTGTCCA AATGTGGAAG ATGCAAGCAG GCATTTTACT GCAATGTGGA GTGTCAGAAA 
GAAGATTGGC CCATGCACAA GCTGGAATGT TCTCCCATGG TTGTTTTTGG GGAAAACTGG 
AATCCCTCGG AGACTGTAAG ACTAACAGCA AGGATTCTGG CCAAACAGAA AATCCACCCA 
GAGAGAACAC CTTCGGAAAA ATTGTTAGCT GTGAAGGAGT TTGAATCACA TCTGGATAAG 
TTAGACAATG AGAAGAAGGA TTTGATTCAG AGTGACATAG CTGCTCTCCA TCACTTTTAC 
TCCAAGCATC TCGGATTCCC TGACAATGAT AGCCTCGTAG TACTCTTTGC ACAGGTTAAC 
TGTAATGGCT TCACAATTGA AGATGAAGAA CTTTCTCATT TGGGATCAGC GATATTTCCT 
GATGTTGCAT TGATGAATCA TAGCTGTTGC CCCAATGTCA TTGTGACCTA CAAAGGGACC 
CTGGCAGAAG TCAGAGCTGT ACAGGAAATC AAGCCGGGAG AGGAGGTTTT TACCAGCTAT 
ATTGATCTCC TGTACCCAAC GGAAGATAGA AATGACCGGT TAAGAGATTC TTATTTCTTT 
ACCTGTGAGT GCCAGGAGTG TACCACCAAG GACAAGGATA AGGCCAAGGT GGAAATCCGG 
AAGCTCAGCG ATCCCCCAAA GGCAGAAGCC ATCCGAGACA TGGTCAGATA TGCACGCAAC 
GTCATTGAAG AGTTCCGGAG GGCCAAGCAC TATAAATCCC CTAGTGAGCT GCTGGAGATC 
TGCGAGCTCA GCCAGGAGAA GATGAGCTCT GTGTTTGAGG ACAGTAACGT GTACATGTTG 
CACATGATGT ACCAGGCCAT GGGTGTCTGC TTGTACATGC AGGACTGGGA AGGAGCCCTG 
CAATATGGAC AGAAAATCAT TAAGCCCTAC AGTAAGCACT ATCCTTTGTA CTCCCTCAAC 
GTGGCCTCCA TGTGGTTGAA GCTAGGGAGA CTCTACATGG GCCTGGAACA CAAAGCCGCA 
GGGGAGAAAG CCCTGAAGAA GGCCATTGCA ATCATGGAAG TAGCTCACGG CAAAGATCAT 
CCATATATTT CTGAGATCAA ACAGGAAATT GAAAGCCACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling.
The Journal of biological chemistry292(30)12702-12712(2017 07)
Gao S,Wang Z,Wang W,Hu X,Chen P,Li J,Feng X,Wong J,Du JX

Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells.
Cancer science108(6)1203-1209(2017 Jun)
Wang R,Deng X,Yoshioka Y,Vougiouklakis T,Park JH,Suzuki T,Dohmae N,Ueda K,Hamamoto R,Nakamura Y

SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
Cell host & microbe21(5)569-579.e6(2017 May)
Boehm D,Jeng M,Camus G,Gramatica A,Schwarzer R,Johnson JR,Hull PA,Montano M,Sakane N,Pagans S,Godin R,Deeks SG,Krogan NJ,Greene WC,Ott M

SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress.
Oncotarget8(10)16712-16727(2017 Mar)
Zipin-Roitman A,Aqaqe N,Yassin M,Biechonski S,Amar M,van Delft MF,Gan OI,McDermott SP,Buzina A,Ketela T,Shlush L,Xie S,Voisin V,Moffat J,Minden MD,Dick JE,Milyavsky M

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SMYD2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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