Tpo cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tpo
Entrez Gene ID	22018
Full Name	thyroid peroxidase
General protein information	Preferred Names thyroid peroxidase Names thyroid peroxidase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 A2\|12 13.0 cM
Summary	This gene encodes a membrane-bound glycoprotein. The encoded enzyme plays a central role in thyroid gland function. The enzyme functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mice with homozygous missense mutations in this gene exhibit hypothyroid dwarfism and hearing impairment. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009417.3	NP_033443.1	thyroid peroxidase precursor
XM_011243856.2	XP_011242158.1	thyroid peroxidase isoform X1
XM_011243856.1	XP_011242158.1	thyroid peroxidase isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TPO	NP_000538.3
Rattus norvegicus (Norway rat)	Tpo	NP_062226.2
Xenopus tropicalis (tropical clawed frog)	tpo	XP_002936348.2
Gallus gallus (chicken)	TPO	XP_001235673.2
Pan troglodytes (chimpanzee)	TPO	XP_003308907.1
Canis lupus familiaris (dog)	TPO	NP_001003009.2
Mus musculus (house mouse)	Tpo	NP_033443.1
Danio rerio (zebrafish)	LOC100331172	XP_003201429.2
	TPO	XP_001117795.1
Bos taurus (cattle)	TPO	XP_002683990.1

Gene Ontology
Bibliography

Related articles in PubMed

Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development.
Metwalli KA, Do MA, Nguyen K, Mallick S, Kin K, Farokhnia N, Jun G, Fakhouri WD
Journal of dental research97(2)226-236(2018 Feb)

Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.
Olivos DJ 3rd, Alvarez M, Cheng YH, Hooker RA, Ciovacco WA, Bethel M, McGough H, Yim C, Chitteti BR, Eleniste PP, Horowitz MC, Srour EF, Bruzzaniti A, Fuchs RK, Kacena MA
Journal of cellular biochemistry118(8)2231-2240(2017 Aug)

The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
Marotta P, Amendola E, Scarf? M, De Luca P, Zoppoli P, Amoresano A, De Felice M, Di Lauro R
Molecular and cellular endocrinology396(1-2)26-36(2014 Oct)

Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.
Johnson KR, Gagnon LH, Longo-Guess CM, Harris BS, Chang B
Journal of the Association for Research in Otolaryngology : JARO15(1)45-55(2014 Feb)

The targeted inactivation of TR? gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.
Selmi-Ruby S, Bouazza L, Obregon MJ, Conscience A, Flamant F, Samarut J, Borson-Chazot F, Rousset B
Endocrinology155(2)635-46(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype
Title: Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.

Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.
Title: Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.

Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO.
Title: Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.

A novel hypothyroid dwarfism is due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
Title: A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.

The following Tpo gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tpo cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17538	NM_009417.3 Latest version!	Mus musculus thyroid peroxidase (Tpo), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$538.30 $769.00
OMu68954	XM_011243856.2 Latest version!	Mus musculus thyroid peroxidase (Tpo), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
View Old Accession Versions >>
OMu68954	XM_011243856.1	Mus musculus thyroid peroxidase (Tpo), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tpo ( NM_009417.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033443.1 Mus musculus thyroid peroxidase (Tpo), mRNA.

Price & Availability↑

CloneID	OMu17538
Clone ID Related Accession (Same CDS sequence)	NM_009417.3
Accession Version	NM_009417.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2745bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	thyroid peroxidase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC157276.2 and X60703.1. On Sep 15, 2015 this sequence version replaced NM_009417.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X60703.1, AK047843.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGAACAC TTGGAGCTAT GGCAATAATG CTGGTGGTTA TGGGAACTGT AATTTTCCTC 
TCTTTTATCC TGAGAAGCAG AGACATCTTG TGTGGGAAGA CCATGAAGTC CCATGTTATC 
AGTGCTGTGG AAACGAGCCA GCTCATGGTG GACCATGCAG TCTACAACAC CATGAAAAGA 
AACCTCAAGA AAAGGGAAGT CCTTTCTCCA GCCCAGCTTC TCTCTTTCTT TAAGCTGCCC 
GAGTCCACCA GTGGGGCTAT TTCCCGAGCA GCAGAGATTA TGGAAACATC AATACAAGTC 
ATGAAACGTG AACAGTCACA GTTCTCCACG GATGCCTTAT CAGCAGACAT TCTGGGCACA 
ATTGCCAACC TGTCAGGATG CTTGCCTTTC ATGCTGCCAC CAAGATGTCC TGACACCTGC 
CTGGCAAATA AGTACCGGCC CATCACAGGG GCGTGCAACA ATAGAGATCA CCCCAGATGG 
GGAGCCTCCA ACACAGCCCT AGCAAGATGG CTGCCTCCTG TCTATGAAGA TGGCTTCAGT 
CAGCCCAAAG GCTGGAACCC TAATTTCTTA TACCACGGCT TCCCACTGCC CCCGGTACGG 
GAAGTGACAA GGCACCTCAT TCAAGTTTCC AATGAGGCTG TGACCGAAGA TGACCAGTAC 
TCTGATTTTC TGCCGGTGTG GGGACAGTAC ATCGATCATG ACATTGCTCT CACACCACAG 
AGCACTAGCA CAGCAGCCTT CTGGGGAGGT GTCGACTGCC AGCTGACCTG TGAGAACCAA 
AATCCTTGCT TCCCCATACA GCTTCCCTCA AACTCCTCAG GGACCACTGC ATGCCTGCCT 
TTCTACCGCT CCTCCGCCGC TTGTGGCACT GGGGACCAAG GTGCTCTCTT TGGCAACCTG 
TCTGCAGCCA ATCCGAGGCA GCAGATGAAT GGCTTGACCT CCTTCCTTGA TGCTTCCACT 
GTGTACGGCA GCTCCCCTGG CGTTGAGAAG CAGCTGCGCA ACTGGAGCAG CTCGGCAGGA 
CTGCTGCGTG TCAACACTCT CCACCTAGAT GCTGGCCGTG CCTACCTGCC CTTCGCAACA 
GCCGCCTGCG CTCCAGAGCC TGGTACCCCA CGCACCAACC GCACGCCCTG CTTCCTGGCT 
GGAGACGGTC GCGCCAGTGA GGTCCCTGCC CTGGCAGCGG TACACACCTT GTGGCTGCGC 
GAGCACAACC GCCTGGCTTC GGCCTTCAAG GCCATTAACA AGCACTGGAG CGCCAACACT 
GCCTACCAGG AGGCGCGCAA GGTGGTAGGG GCACTGCACC AGATCATCAC CATGAGGGAT 
TATATCCCCA AAATCCTGGG TCCTGATGCC TTCAGGCAGT ATGTGGGCCC CTATGAAGGC 
TACAACCCCA CTGTGAACCC TACTGTGTCC AACATCTTCT CCACTGCTGC CTTTCGCTTT 
GGCCATGCCA CAGTCCATCC ACTGGTGAGA CGGCTAAACA CTGACTTCCA GGAGCACACA 
GAGCTCCCCA GGTTGCAGCT GCGTGATGTC TTCTTCAGAC CCTGGAGGCT TATCCAGGAA 
GGTGGTTTGG ATCCGATAGT GAGAGGCCTC CTGGCGAGAG CAGCCAAGCT GCAAGTCCAA 
GGGCAGCTGA TGAATGAGGA GCTGACCGAG AGGCTCTTCG TGCTGTCTAA CGTGGGCACC 
TTGGATCTGG CATCACTGAA CTTGCAGAGG GGCCGGGATC ATGGCTTACC AGACTACAAT 
GAATGGAGAG AGTTCTGTGG CTTGTCACGC CTGGAGACAC CAGCTGAGCT GAACAAGGCC 
ATTGCCAACA GAAGCATGGT CAACAAGATA ATGGACTTAT ACAAGCATGC TGACAACATT 
GACGTCTGGT TGGGAGGCTT GGCTGAAAAG TTCTTGCCGG GGGCCCGCAC TGGTCCTCTG 
TTTGCATGTA TCATTGGGAA GCAGATGAAG GCTCTGAGGG ATGGGGACAG GTTTTGGTGG 
GAGAACACCA ATGTCTTCAC AGACGCTCAG AGGCAGGAAC TAGAAAAGCA TTCACTACCT 
CGGGTCATCT GTGACAACAC TGGACTCACC AGAGTACCTG TGGATGCCTT CCGTATTGGA 
AAGTTCCCCC AAGACTTTGA ATCCTGTGAG GACATCCCGA GCATGGACCT TGAACTATGG 
AGGGAGACCT TCCCACAAGA TGACAAGTGT GTCTTCCCAG AGGAGGTGGA CAATGGGAAC 
TTTGTGCACT GTGAAGAGTC TGGGAAGCTG GTGCTTGTAT ACTCCTGTTT CCATGGATAC 
AAGCTGCAGG GCCAGGAGCA GGTCACATGT ACCCAGAAGG GATGGGACTC CGAACCTCCT 
GTCTGTAAAG ATGTTAATGA GTGTGCAGAT CTGACACACC CACCTTGCCA CCCCTCTGCA 
CAGTGCAAGA ACACCAAGGG AAGCTTCCAG TGTGTGTGCA CAGACCCCTA TGTGCTAGGT 
GAGGATGAGA AGACCTGCAT AGATTCTGGC AGGCTACCTC GGGCATCCTG GGTCTCCATT 
GCACTGGGTG CACTTCTCAT TGGTGGTTTG GCCAGTCTCA CCTGGATAGT AATTTGCAGG 
TGGACACATG CTGATAAGAA AGCCACATTG CCGATCACAG AGAGAGTGAC CACCCAGTCA 
GGATGCAGAA AGAGTCAGGG GAGGGGGATT TCACCACACA AGGCCGCAGC TCAAGACACT 
GGACAGGAAC CTGCAAGTGG ATCCAGGGTC CTCCTGTGCG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033443.1
CDS	89..2833
Translation	MRTLGAMAIMLVVMGTVIFLSFILRSRDILCGKTMKSHVISAVETSQLMVDHAVYNTMKRNLKKREVLSPAQLLSFFKLPESTSGAISRAAEIMETSIQVMKREQSQFSTDALSADILGTIANLSGCLPFMLPPRCPDTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSGTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLPFATAACAPEPGTPRTNRTPCFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQDFESCEDIPSMDLELWRETFPQDDKCVFPEEVDNGNFVHCEESGKLVLVYSCFHGYKLQGQEQVTCTQKGWDSEPPVCKDVNECADLTHPPCHPSAQCKNTKGSFQCVCTDPYVLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLTWIVICRWTHADKKATLPITERVTTQSGCRKSQGRGISPHKAAAQDTGQEPASGSRVLLCE

Target ORF information:

RefSeq Version	NM_009417.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus thyroid peroxidase (Tpo), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009417.3

ORF Insert Sequence:

ATGAGAACAC TTGGAGCTAT GGCAATAATG CTGGTGGTTA TGGGAACTGT AATTTTCCTC 
TCTTTTATCC TGAGAAGCAG AGACATCTTG TGTGGGAAGA CCATGAAGTC CCATGTTATC 
AGTGCTGTGG AAACGAGCCA GCTCATGGTG GACCATGCAG TCTACAACAC CATGAAAAGA 
AACCTCAAGA AAAGGGAAGT CCTTTCTCCA GCCCAGCTTC TCTCTTTCTT TAAGCTGCCC 
GAGTCCACCA GTGGGGCTAT TTCCCGAGCA GCAGAGATTA TGGAAACATC AATACAAGTC 
ATGAAACGTG AACAGTCACA GTTCTCCACG GATGCCTTAT CAGCAGACAT TCTGGGCACA 
ATTGCCAACC TGTCAGGATG CTTGCCTTTC ATGCTGCCAC CAAGATGTCC TGACACCTGC 
CTGGCAAATA AGTACCGGCC CATCACAGGG GCGTGCAACA ATAGAGATCA CCCCAGATGG 
GGAGCCTCCA ACACAGCCCT AGCAAGATGG CTGCCTCCTG TCTATGAAGA TGGCTTCAGT 
CAGCCCAAAG GCTGGAACCC TAATTTCTTA TACCACGGCT TCCCACTGCC CCCGGTACGG 
GAAGTGACAA GGCACCTCAT TCAAGTTTCC AATGAGGCTG TGACCGAAGA TGACCAGTAC 
TCTGATTTTC TGCCGGTGTG GGGACAGTAC ATCGATCATG ACATTGCTCT CACACCACAG 
AGCACTAGCA CAGCAGCCTT CTGGGGAGGT GTCGACTGCC AGCTGACCTG TGAGAACCAA 
AATCCTTGCT TCCCCATACA GCTTCCCTCA AACTCCTCAG GGACCACTGC ATGCCTGCCT 
TTCTACCGCT CCTCCGCCGC TTGTGGCACT GGGGACCAAG GTGCTCTCTT TGGCAACCTG 
TCTGCAGCCA ATCCGAGGCA GCAGATGAAT GGCTTGACCT CCTTCCTTGA TGCTTCCACT 
GTGTACGGCA GCTCCCCTGG CGTTGAGAAG CAGCTGCGCA ACTGGAGCAG CTCGGCAGGA 
CTGCTGCGTG TCAACACTCT CCACCTAGAT GCTGGCCGTG CCTACCTGCC CTTCGCAACA 
GCCGCCTGCG CTCCAGAGCC TGGTACCCCA CGCACCAACC GCACGCCCTG CTTCCTGGCT 
GGAGACGGTC GCGCCAGTGA GGTCCCTGCC CTGGCAGCGG TACACACCTT GTGGCTGCGC 
GAGCACAACC GCCTGGCTTC GGCCTTCAAG GCCATTAACA AGCACTGGAG CGCCAACACT 
GCCTACCAGG AGGCGCGCAA GGTGGTAGGG GCACTGCACC AGATCATCAC CATGAGGGAT 
TATATCCCCA AAATCCTGGG TCCTGATGCC TTCAGGCAGT ATGTGGGCCC CTATGAAGGC 
TACAACCCCA CTGTGAACCC TACTGTGTCC AACATCTTCT CCACTGCTGC CTTTCGCTTT 
GGCCATGCCA CAGTCCATCC ACTGGTGAGA CGGCTAAACA CTGACTTCCA GGAGCACACA 
GAGCTCCCCA GGTTGCAGCT GCGTGATGTC TTCTTCAGAC CCTGGAGGCT TATCCAGGAA 
GGTGGTTTGG ATCCGATAGT GAGAGGCCTC CTGGCGAGAG CAGCCAAGCT GCAAGTCCAA 
GGGCAGCTGA TGAATGAGGA GCTGACCGAG AGGCTCTTCG TGCTGTCTAA CGTGGGCACC 
TTGGATCTGG CATCACTGAA CTTGCAGAGG GGCCGGGATC ATGGCTTACC AGACTACAAT 
GAATGGAGAG AGTTCTGTGG CTTGTCACGC CTGGAGACAC CAGCTGAGCT GAACAAGGCC 
ATTGCCAACA GAAGCATGGT CAACAAGATA ATGGACTTAT ACAAGCATGC TGACAACATT 
GACGTCTGGT TGGGAGGCTT GGCTGAAAAG TTCTTGCCGG GGGCCCGCAC TGGTCCTCTG 
TTTGCATGTA TCATTGGGAA GCAGATGAAG GCTCTGAGGG ATGGGGACAG GTTTTGGTGG 
GAGAACACCA ATGTCTTCAC AGACGCTCAG AGGCAGGAAC TAGAAAAGCA TTCACTACCT 
CGGGTCATCT GTGACAACAC TGGACTCACC AGAGTACCTG TGGATGCCTT CCGTATTGGA 
AAGTTCCCCC AAGACTTTGA ATCCTGTGAG GACATCCCGA GCATGGACCT TGAACTATGG 
AGGGAGACCT TCCCACAAGA TGACAAGTGT GTCTTCCCAG AGGAGGTGGA CAATGGGAAC 
TTTGTGCACT GTGAAGAGTC TGGGAAGCTG GTGCTTGTAT ACTCCTGTTT CCATGGATAC 
AAGCTGCAGG GCCAGGAGCA GGTCACATGT ACCCAGAAGG GATGGGACTC CGAACCTCCT 
GTCTGTAAAG ATGTTAATGA GTGTGCAGAT CTGACACACC CACCTTGCCA CCCCTCTGCA 
CAGTGCAAGA ACACCAAGGG AAGCTTCCAG TGTGTGTGCA CAGACCCCTA TGTGCTAGGT 
GAGGATGAGA AGACCTGCAT AGATTCTGGC AGGCTACCTC GGGCATCCTG GGTCTCCATT 
GCACTGGGTG CACTTCTCAT TGGTGGTTTG GCCAGTCTCA CCTGGATAGT AATTTGCAGG 
TGGACACATG CTGATAAGAA AGCCACATTG CCGATCACAG AGAGAGTGAC CACCCAGTCA 
GGATGCAGAA AGAGTCAGGG GAGGGGGATT TCACCACACA AGGCCGCAGC TCAAGACACT 
GGACAGGAAC CTGCAAGTGG ATCCAGGGTC CTCCTGTGCG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tpo ( XM_011243856.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011242158.1 Mus musculus thyroid peroxidase (Tpo), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu68954
Clone ID Related Accession (Same CDS sequence)	XM_011243856.2 , XM_011243856.1
Accession Version	XM_011243856.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2748bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	thyroid peroxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAACAC TTGGAGCTAT GGCAATAATG CTGGTGGTTA TGGGAACTGT AATTTTCCTC 
TCTTTTATCC TGAGAAGCAG AGACATCTTG TGTGGGAAGA CCATGAAGTC CCATGTTATC 
AGTGCTGTGG AAACGAGCCA GCTCATGGTG GACCATGCAG TCTACAACAC CATGAAAAGA 
AACCTCAAGA AAAGGGAAGT CCTTTCTCCA GCCCAGCTTC TCTCTTTCTT TAAGCTGCCC 
GAGTCCACCA GTGGGGCTAT TTCCCGAGCA GCAGAGATTA TGGAAACATC AATACAAGTC 
ATGAAACGTG AACAGTCACA GTTCTCCACG GATGCCTTAT CAGCAGACAT TCTGGGCACA 
ATTGCCAACC TGTCAGGATG CTTGCCTTTC ATGCTGCCAC CAAGATGTCC TGACACCTGC 
CTGGCAAATA AGTACCGGCC CATCACAGGG GCGTGCAACA ATAGAGATCA CCCCAGATGG 
GGAGCCTCCA ACACAGCCCT AGCAAGATGG CTGCCTCCTG TCTATGAAGA TGGCTTCAGT 
CAGCCCAAAG GCTGGAACCC TAATTTCTTA TACCACGGCT TCCCACTGCC CCCGGTACGG 
GAAGTGACAA GGCACCTCAT TCAAGTTTCC AATGAGGCTG TGACCGAAGA TGACCAGTAC 
TCTGATTTTC TGCCGGTGTG GGGACAGTAC ATCGATCATG ACATTGCTCT CACACCACAG 
AGCACTAGCA CAGCAGCCTT CTGGGGAGGT GTCGACTGCC AGCTGACCTG TGAGAACCAA 
AATCCTTGCT TCCCCATACA GCTTCCCTCA AACTCCTCAG GGACCACTGC ATGCCTGCCT 
TTCTACCGCT CCTCCGCCGC TTGTGGCACT GGGGACCAAG GTGCTCTCTT TGGCAACCTG 
TCTGCAGCCA ATCCGAGGCA GCAGATGAAT GGCTTGACCT CCTTCCTTGA TGCTTCCACT 
GTGTACGGCA GCTCCCCTGG CGTTGAGAAG CAGCTGCGCA ACTGGAGCAG CTCGGCAGGA 
CTGCTGCGTG TCAACACTCT CCACCTAGAT GCTGGCCGTG CCTACCTGCC CTTCGCAACA 
GCCGCCTGCG CTCCAGAGCC TGGTACCCCA CGCACCAACC GCACGCCCTG CTTCCTGGCT 
GGAGACGGTC GCGCCAGTGA GGTCCCTGCC CTGGCAGCGG TACACACCTT GTGGCTGCGC 
GAGCACAACC GCCTGGCTTC GGCCTTCAAG GCCATTAACA AGCACTGGAG CGCCAACACT 
GCCTACCAGG AGGCGCGCAA GGTGGTAGGG GCACTGCACC AGATCATCAC CATGAGGGAT 
TATATCCCCA AAATCCTGGG TCCTGATGCC TTCAGGCAGT ATGTGGGCCC CTATGAAGGC 
TACAACCCCA CTGTGAACCC TACTGTGTCC AACATCTTCT CCACTGCTGC CTTTCGCTTT 
GGCCATGCCA CAGTCCATCC ACTGGTGAGA CGGCTAAACA CTGACTTCCA GGAGCACACA 
GAGCTCCCCA GGTTGCAGCT GCGTGATGTC TTCTTCAGAC CCTGGAGGCT TATCCAGGAA 
GGTGGTTTGG ATCCGATAGT GAGAGGCCTC CTGGCGAGAG CAGCCAAGCT GCAAGTCCAA 
GGGCAGCTGA TGAATGAGGA GCTGACCGAG AGGCTCTTCG TGCTGTCTAA CGTGGGCACC 
TTGGATCTGG CATCACTGAA CTTGCAGAGG GGCCGGGATC ATGGCTTACC AGACTACAAT 
GAATGGAGAG AGTTCTGTGG CTTGTCACGC CTGGAGACAC CAGCTGAGCT GAACAAGGCC 
ATTGCCAACA GAAGCATGGT CAACAAGATA ATGGACTTAT ACAAGCATGC TGACAACATT 
GACGTCTGGT TGGGAGGCTT GGCTGAAAAG TTCTTGCCGG GGGCCCGCAC TGGTCCTCTG 
TTTGCATGTA TCATTGGGAA GCAGATGAAG GCTCTGAGGG ATGGGGACAG GTTTTGGTGG 
GAGAACACCA ATGTCTTCAC AGACGCTCAG AGGCAGGAAC TAGAAAAGCA TTCACTACCT 
CGGGTCATCT GTGACAACAC TGGACTCACC AGAGTACCTG TGGATGCCTT CCGTATTGGA 
AAGTTCCCCC AAGACTTTGA ATCCTGTGAG GACATCCCGA GCATGGACCT TGAACTATGG 
AGGGAGACCT TCCCACAAGA TGACAAGTGT GTCTTCCCAG AGGAGGTGGA CAATGGGAAC 
TTTGTGCACT GTGAAGAGTC TGGGAAGCTG GTGCTTGTAT ACTCCTGTTT CCATGGATAC 
AAGCTGCAGG GCCAGGAGCA GGTCACATGT ACCCAGAAGG GATGGGACTC CGAACCTCCT 
GTCTGTAAAG ATGTTAATGA GTGTGCAGAT CTGACACACC CACCTTGCCA CCCCTCTGCA 
CAGTGCAAGA ACACCAAGGG AAGCTTCCAG TGTGTGTGCA CAGACCCCTA TGTGCTAGGT 
GAGGATGAGA AGACCTGCAT AGATTCTGGC AGGCTACCTC GGGCATCCTG GGTCTCCATT 
GCACTGGGTG CACTTCTCAT TGGTGGTTTG GCCAGTCTCA CCTGGATAGT AATTTGCAGG 
TGGACACATG CTGATAAGAA AGCCACATTG CCGATCACAG AGAGAGTGAC CACCCAGTCA 
GGATGCAGAA AGAGTCAGGG GAGGGGGATT TCACCACACA AGGCCGCAGC TCAAGACACT 
GGACAGTCCC TACCTGTCCC AGCAGATTTC CAATCAACTG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011242158.1
CDS	449..3196
Translation	MRTLGAMAIMLVVMGTVIFLSFILRSRDILCGKTMKSHVISAVETSQLMVDHAVYNTMKRNLKKREVLSPAQLLSFFKLPESTSGAISRAAEIMETSIQVMKREQSQFSTDALSADILGTIANLSGCLPFMLPPRCPDTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSGTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLPFATAACAPEPGTPRTNRTPCFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQDFESCEDIPSMDLELWRETFPQDDKCVFPEEVDNGNFVHCEESGKLVLVYSCFHGYKLQGQEQVTCTQKGWDSEPPVCKDVNECADLTHPPCHPSAQCKNTKGSFQCVCTDPYVLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLTWIVICRWTHADKKATLPITERVTTQSGCRKSQGRGISPHKAAAQDTGQSLPVPADFQSTED

Target ORF information:

RefSeq Version	XM_011243856.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus thyroid peroxidase (Tpo), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011243856.1

ORF Insert Sequence:

ATGAGAACAC TTGGAGCTAT GGCAATAATG CTGGTGGTTA TGGGAACTGT AATTTTCCTC 
TCTTTTATCC TGAGAAGCAG AGACATCTTG TGTGGGAAGA CCATGAAGTC CCATGTTATC 
AGTGCTGTGG AAACGAGCCA GCTCATGGTG GACCATGCAG TCTACAACAC CATGAAAAGA 
AACCTCAAGA AAAGGGAAGT CCTTTCTCCA GCCCAGCTTC TCTCTTTCTT TAAGCTGCCC 
GAGTCCACCA GTGGGGCTAT TTCCCGAGCA GCAGAGATTA TGGAAACATC AATACAAGTC 
ATGAAACGTG AACAGTCACA GTTCTCCACG GATGCCTTAT CAGCAGACAT TCTGGGCACA 
ATTGCCAACC TGTCAGGATG CTTGCCTTTC ATGCTGCCAC CAAGATGTCC TGACACCTGC 
CTGGCAAATA AGTACCGGCC CATCACAGGG GCGTGCAACA ATAGAGATCA CCCCAGATGG 
GGAGCCTCCA ACACAGCCCT AGCAAGATGG CTGCCTCCTG TCTATGAAGA TGGCTTCAGT 
CAGCCCAAAG GCTGGAACCC TAATTTCTTA TACCACGGCT TCCCACTGCC CCCGGTACGG 
GAAGTGACAA GGCACCTCAT TCAAGTTTCC AATGAGGCTG TGACCGAAGA TGACCAGTAC 
TCTGATTTTC TGCCGGTGTG GGGACAGTAC ATCGATCATG ACATTGCTCT CACACCACAG 
AGCACTAGCA CAGCAGCCTT CTGGGGAGGT GTCGACTGCC AGCTGACCTG TGAGAACCAA 
AATCCTTGCT TCCCCATACA GCTTCCCTCA AACTCCTCAG GGACCACTGC ATGCCTGCCT 
TTCTACCGCT CCTCCGCCGC TTGTGGCACT GGGGACCAAG GTGCTCTCTT TGGCAACCTG 
TCTGCAGCCA ATCCGAGGCA GCAGATGAAT GGCTTGACCT CCTTCCTTGA TGCTTCCACT 
GTGTACGGCA GCTCCCCTGG CGTTGAGAAG CAGCTGCGCA ACTGGAGCAG CTCGGCAGGA 
CTGCTGCGTG TCAACACTCT CCACCTAGAT GCTGGCCGTG CCTACCTGCC CTTCGCAACA 
GCCGCCTGCG CTCCAGAGCC TGGTACCCCA CGCACCAACC GCACGCCCTG CTTCCTGGCT 
GGAGACGGTC GCGCCAGTGA GGTCCCTGCC CTGGCAGCGG TACACACCTT GTGGCTGCGC 
GAGCACAACC GCCTGGCTTC GGCCTTCAAG GCCATTAACA AGCACTGGAG CGCCAACACT 
GCCTACCAGG AGGCGCGCAA GGTGGTAGGG GCACTGCACC AGATCATCAC CATGAGGGAT 
TATATCCCCA AAATCCTGGG TCCTGATGCC TTCAGGCAGT ATGTGGGCCC CTATGAAGGC 
TACAACCCCA CTGTGAACCC TACTGTGTCC AACATCTTCT CCACTGCTGC CTTTCGCTTT 
GGCCATGCCA CAGTCCATCC ACTGGTGAGA CGGCTAAACA CTGACTTCCA GGAGCACACA 
GAGCTCCCCA GGTTGCAGCT GCGTGATGTC TTCTTCAGAC CCTGGAGGCT TATCCAGGAA 
GGTGGTTTGG ATCCGATAGT GAGAGGCCTC CTGGCGAGAG CAGCCAAGCT GCAAGTCCAA 
GGGCAGCTGA TGAATGAGGA GCTGACCGAG AGGCTCTTCG TGCTGTCTAA CGTGGGCACC 
TTGGATCTGG CATCACTGAA CTTGCAGAGG GGCCGGGATC ATGGCTTACC AGACTACAAT 
GAATGGAGAG AGTTCTGTGG CTTGTCACGC CTGGAGACAC CAGCTGAGCT GAACAAGGCC 
ATTGCCAACA GAAGCATGGT CAACAAGATA ATGGACTTAT ACAAGCATGC TGACAACATT 
GACGTCTGGT TGGGAGGCTT GGCTGAAAAG TTCTTGCCGG GGGCCCGCAC TGGTCCTCTG 
TTTGCATGTA TCATTGGGAA GCAGATGAAG GCTCTGAGGG ATGGGGACAG GTTTTGGTGG 
GAGAACACCA ATGTCTTCAC AGACGCTCAG AGGCAGGAAC TAGAAAAGCA TTCACTACCT 
CGGGTCATCT GTGACAACAC TGGACTCACC AGAGTACCTG TGGATGCCTT CCGTATTGGA 
AAGTTCCCCC AAGACTTTGA ATCCTGTGAG GACATCCCGA GCATGGACCT TGAACTATGG 
AGGGAGACCT TCCCACAAGA TGACAAGTGT GTCTTCCCAG AGGAGGTGGA CAATGGGAAC 
TTTGTGCACT GTGAAGAGTC TGGGAAGCTG GTGCTTGTAT ACTCCTGTTT CCATGGATAC 
AAGCTGCAGG GCCAGGAGCA GGTCACATGT ACCCAGAAGG GATGGGACTC CGAACCTCCT 
GTCTGTAAAG ATGTTAATGA GTGTGCAGAT CTGACACACC CACCTTGCCA CCCCTCTGCA 
CAGTGCAAGA ACACCAAGGG AAGCTTCCAG TGTGTGTGCA CAGACCCCTA TGTGCTAGGT 
GAGGATGAGA AGACCTGCAT AGATTCTGGC AGGCTACCTC GGGCATCCTG GGTCTCCATT 
GCACTGGGTG CACTTCTCAT TGGTGGTTTG GCCAGTCTCA CCTGGATAGT AATTTGCAGG 
TGGACACATG CTGATAAGAA AGCCACATTG CCGATCACAG AGAGAGTGAC CACCCAGTCA 
GGATGCAGAA AGAGTCAGGG GAGGGGGATT TCACCACACA AGGCCGCAGC TCAAGACACT 
GGACAGTCCC TACCTGTCCC AGCAGATTTC CAATCAACTG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tpo ( XM_011243856.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011242158.1 Mus musculus thyroid peroxidase (Tpo), transcript variant X1, mRNA.

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CloneID	OMu68954
Clone ID Related Accession (Same CDS sequence)	XM_011243856.2 , XM_011243856.1
Accession Version	XM_011243856.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2748bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	thyroid peroxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011243856.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAACAC TTGGAGCTAT GGCAATAATG CTGGTGGTTA TGGGAACTGT AATTTTCCTC 
TCTTTTATCC TGAGAAGCAG AGACATCTTG TGTGGGAAGA CCATGAAGTC CCATGTTATC 
AGTGCTGTGG AAACGAGCCA GCTCATGGTG GACCATGCAG TCTACAACAC CATGAAAAGA 
AACCTCAAGA AAAGGGAAGT CCTTTCTCCA GCCCAGCTTC TCTCTTTCTT TAAGCTGCCC 
GAGTCCACCA GTGGGGCTAT TTCCCGAGCA GCAGAGATTA TGGAAACATC AATACAAGTC 
ATGAAACGTG AACAGTCACA GTTCTCCACG GATGCCTTAT CAGCAGACAT TCTGGGCACA 
ATTGCCAACC TGTCAGGATG CTTGCCTTTC ATGCTGCCAC CAAGATGTCC TGACACCTGC 
CTGGCAAATA AGTACCGGCC CATCACAGGG GCGTGCAACA ATAGAGATCA CCCCAGATGG 
GGAGCCTCCA ACACAGCCCT AGCAAGATGG CTGCCTCCTG TCTATGAAGA TGGCTTCAGT 
CAGCCCAAAG GCTGGAACCC TAATTTCTTA TACCACGGCT TCCCACTGCC CCCGGTACGG 
GAAGTGACAA GGCACCTCAT TCAAGTTTCC AATGAGGCTG TGACCGAAGA TGACCAGTAC 
TCTGATTTTC TGCCGGTGTG GGGACAGTAC ATCGATCATG ACATTGCTCT CACACCACAG 
AGCACTAGCA CAGCAGCCTT CTGGGGAGGT GTCGACTGCC AGCTGACCTG TGAGAACCAA 
AATCCTTGCT TCCCCATACA GCTTCCCTCA AACTCCTCAG GGACCACTGC ATGCCTGCCT 
TTCTACCGCT CCTCCGCCGC TTGTGGCACT GGGGACCAAG GTGCTCTCTT TGGCAACCTG 
TCTGCAGCCA ATCCGAGGCA GCAGATGAAT GGCTTGACCT CCTTCCTTGA TGCTTCCACT 
GTGTACGGCA GCTCCCCTGG CGTTGAGAAG CAGCTGCGCA ACTGGAGCAG CTCGGCAGGA 
CTGCTGCGTG TCAACACTCT CCACCTAGAT GCTGGCCGTG CCTACCTGCC CTTCGCAACA 
GCCGCCTGCG CTCCAGAGCC TGGTACCCCA CGCACCAACC GCACGCCCTG CTTCCTGGCT 
GGAGACGGTC GCGCCAGTGA GGTCCCTGCC CTGGCAGCGG TACACACCTT GTGGCTGCGC 
GAGCACAACC GCCTGGCTTC GGCCTTCAAG GCCATTAACA AGCACTGGAG CGCCAACACT 
GCCTACCAGG AGGCGCGCAA GGTGGTAGGG GCACTGCACC AGATCATCAC CATGAGGGAT 
TATATCCCCA AAATCCTGGG TCCTGATGCC TTCAGGCAGT ATGTGGGCCC CTATGAAGGC 
TACAACCCCA CTGTGAACCC TACTGTGTCC AACATCTTCT CCACTGCTGC CTTTCGCTTT 
GGCCATGCCA CAGTCCATCC ACTGGTGAGA CGGCTAAACA CTGACTTCCA GGAGCACACA 
GAGCTCCCCA GGTTGCAGCT GCGTGATGTC TTCTTCAGAC CCTGGAGGCT TATCCAGGAA 
GGTGGTTTGG ATCCGATAGT GAGAGGCCTC CTGGCGAGAG CAGCCAAGCT GCAAGTCCAA 
GGGCAGCTGA TGAATGAGGA GCTGACCGAG AGGCTCTTCG TGCTGTCTAA CGTGGGCACC 
TTGGATCTGG CATCACTGAA CTTGCAGAGG GGCCGGGATC ATGGCTTACC AGACTACAAT 
GAATGGAGAG AGTTCTGTGG CTTGTCACGC CTGGAGACAC CAGCTGAGCT GAACAAGGCC 
ATTGCCAACA GAAGCATGGT CAACAAGATA ATGGACTTAT ACAAGCATGC TGACAACATT 
GACGTCTGGT TGGGAGGCTT GGCTGAAAAG TTCTTGCCGG GGGCCCGCAC TGGTCCTCTG 
TTTGCATGTA TCATTGGGAA GCAGATGAAG GCTCTGAGGG ATGGGGACAG GTTTTGGTGG 
GAGAACACCA ATGTCTTCAC AGACGCTCAG AGGCAGGAAC TAGAAAAGCA TTCACTACCT 
CGGGTCATCT GTGACAACAC TGGACTCACC AGAGTACCTG TGGATGCCTT CCGTATTGGA 
AAGTTCCCCC AAGACTTTGA ATCCTGTGAG GACATCCCGA GCATGGACCT TGAACTATGG 
AGGGAGACCT TCCCACAAGA TGACAAGTGT GTCTTCCCAG AGGAGGTGGA CAATGGGAAC 
TTTGTGCACT GTGAAGAGTC TGGGAAGCTG GTGCTTGTAT ACTCCTGTTT CCATGGATAC 
AAGCTGCAGG GCCAGGAGCA GGTCACATGT ACCCAGAAGG GATGGGACTC CGAACCTCCT 
GTCTGTAAAG ATGTTAATGA GTGTGCAGAT CTGACACACC CACCTTGCCA CCCCTCTGCA 
CAGTGCAAGA ACACCAAGGG AAGCTTCCAG TGTGTGTGCA CAGACCCCTA TGTGCTAGGT 
GAGGATGAGA AGACCTGCAT AGATTCTGGC AGGCTACCTC GGGCATCCTG GGTCTCCATT 
GCACTGGGTG CACTTCTCAT TGGTGGTTTG GCCAGTCTCA CCTGGATAGT AATTTGCAGG 
TGGACACATG CTGATAAGAA AGCCACATTG CCGATCACAG AGAGAGTGAC CACCCAGTCA 
GGATGCAGAA AGAGTCAGGG GAGGGGGATT TCACCACACA AGGCCGCAGC TCAAGACACT 
GGACAGTCCC TACCTGTCCC AGCAGATTTC CAATCAACTG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011242158.1
CDS	449..3196
Translation	MRTLGAMAIMLVVMGTVIFLSFILRSRDILCGKTMKSHVISAVETSQLMVDHAVYNTMKRNLKKREVLSPAQLLSFFKLPESTSGAISRAAEIMETSIQVMKREQSQFSTDALSADILGTIANLSGCLPFMLPPRCPDTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSGTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLPFATAACAPEPGTPRTNRTPCFLAGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQDFESCEDIPSMDLELWRETFPQDDKCVFPEEVDNGNFVHCEESGKLVLVYSCFHGYKLQGQEQVTCTQKGWDSEPPVCKDVNECADLTHPPCHPSAQCKNTKGSFQCVCTDPYVLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLTWIVICRWTHADKKATLPITERVTTQSGCRKSQGRGISPHKAAAQDTGQSLPVPADFQSTED

Target ORF information:

RefSeq Version	XM_011243856.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus thyroid peroxidase (Tpo), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011243856.2

ORF Insert Sequence:

ATGAGAACAC TTGGAGCTAT GGCAATAATG CTGGTGGTTA TGGGAACTGT AATTTTCCTC 
TCTTTTATCC TGAGAAGCAG AGACATCTTG TGTGGGAAGA CCATGAAGTC CCATGTTATC 
AGTGCTGTGG AAACGAGCCA GCTCATGGTG GACCATGCAG TCTACAACAC CATGAAAAGA 
AACCTCAAGA AAAGGGAAGT CCTTTCTCCA GCCCAGCTTC TCTCTTTCTT TAAGCTGCCC 
GAGTCCACCA GTGGGGCTAT TTCCCGAGCA GCAGAGATTA TGGAAACATC AATACAAGTC 
ATGAAACGTG AACAGTCACA GTTCTCCACG GATGCCTTAT CAGCAGACAT TCTGGGCACA 
ATTGCCAACC TGTCAGGATG CTTGCCTTTC ATGCTGCCAC CAAGATGTCC TGACACCTGC 
CTGGCAAATA AGTACCGGCC CATCACAGGG GCGTGCAACA ATAGAGATCA CCCCAGATGG 
GGAGCCTCCA ACACAGCCCT AGCAAGATGG CTGCCTCCTG TCTATGAAGA TGGCTTCAGT 
CAGCCCAAAG GCTGGAACCC TAATTTCTTA TACCACGGCT TCCCACTGCC CCCGGTACGG 
GAAGTGACAA GGCACCTCAT TCAAGTTTCC AATGAGGCTG TGACCGAAGA TGACCAGTAC 
TCTGATTTTC TGCCGGTGTG GGGACAGTAC ATCGATCATG ACATTGCTCT CACACCACAG 
AGCACTAGCA CAGCAGCCTT CTGGGGAGGT GTCGACTGCC AGCTGACCTG TGAGAACCAA 
AATCCTTGCT TCCCCATACA GCTTCCCTCA AACTCCTCAG GGACCACTGC ATGCCTGCCT 
TTCTACCGCT CCTCCGCCGC TTGTGGCACT GGGGACCAAG GTGCTCTCTT TGGCAACCTG 
TCTGCAGCCA ATCCGAGGCA GCAGATGAAT GGCTTGACCT CCTTCCTTGA TGCTTCCACT 
GTGTACGGCA GCTCCCCTGG CGTTGAGAAG CAGCTGCGCA ACTGGAGCAG CTCGGCAGGA 
CTGCTGCGTG TCAACACTCT CCACCTAGAT GCTGGCCGTG CCTACCTGCC CTTCGCAACA 
GCCGCCTGCG CTCCAGAGCC TGGTACCCCA CGCACCAACC GCACGCCCTG CTTCCTGGCT 
GGAGACGGTC GCGCCAGTGA GGTCCCTGCC CTGGCAGCGG TACACACCTT GTGGCTGCGC 
GAGCACAACC GCCTGGCTTC GGCCTTCAAG GCCATTAACA AGCACTGGAG CGCCAACACT 
GCCTACCAGG AGGCGCGCAA GGTGGTAGGG GCACTGCACC AGATCATCAC CATGAGGGAT 
TATATCCCCA AAATCCTGGG TCCTGATGCC TTCAGGCAGT ATGTGGGCCC CTATGAAGGC 
TACAACCCCA CTGTGAACCC TACTGTGTCC AACATCTTCT CCACTGCTGC CTTTCGCTTT 
GGCCATGCCA CAGTCCATCC ACTGGTGAGA CGGCTAAACA CTGACTTCCA GGAGCACACA 
GAGCTCCCCA GGTTGCAGCT GCGTGATGTC TTCTTCAGAC CCTGGAGGCT TATCCAGGAA 
GGTGGTTTGG ATCCGATAGT GAGAGGCCTC CTGGCGAGAG CAGCCAAGCT GCAAGTCCAA 
GGGCAGCTGA TGAATGAGGA GCTGACCGAG AGGCTCTTCG TGCTGTCTAA CGTGGGCACC 
TTGGATCTGG CATCACTGAA CTTGCAGAGG GGCCGGGATC ATGGCTTACC AGACTACAAT 
GAATGGAGAG AGTTCTGTGG CTTGTCACGC CTGGAGACAC CAGCTGAGCT GAACAAGGCC 
ATTGCCAACA GAAGCATGGT CAACAAGATA ATGGACTTAT ACAAGCATGC TGACAACATT 
GACGTCTGGT TGGGAGGCTT GGCTGAAAAG TTCTTGCCGG GGGCCCGCAC TGGTCCTCTG 
TTTGCATGTA TCATTGGGAA GCAGATGAAG GCTCTGAGGG ATGGGGACAG GTTTTGGTGG 
GAGAACACCA ATGTCTTCAC AGACGCTCAG AGGCAGGAAC TAGAAAAGCA TTCACTACCT 
CGGGTCATCT GTGACAACAC TGGACTCACC AGAGTACCTG TGGATGCCTT CCGTATTGGA 
AAGTTCCCCC AAGACTTTGA ATCCTGTGAG GACATCCCGA GCATGGACCT TGAACTATGG 
AGGGAGACCT TCCCACAAGA TGACAAGTGT GTCTTCCCAG AGGAGGTGGA CAATGGGAAC 
TTTGTGCACT GTGAAGAGTC TGGGAAGCTG GTGCTTGTAT ACTCCTGTTT CCATGGATAC 
AAGCTGCAGG GCCAGGAGCA GGTCACATGT ACCCAGAAGG GATGGGACTC CGAACCTCCT 
GTCTGTAAAG ATGTTAATGA GTGTGCAGAT CTGACACACC CACCTTGCCA CCCCTCTGCA 
CAGTGCAAGA ACACCAAGGG AAGCTTCCAG TGTGTGTGCA CAGACCCCTA TGTGCTAGGT 
GAGGATGAGA AGACCTGCAT AGATTCTGGC AGGCTACCTC GGGCATCCTG GGTCTCCATT 
GCACTGGGTG CACTTCTCAT TGGTGGTTTG GCCAGTCTCA CCTGGATAGT AATTTGCAGG 
TGGACACATG CTGATAAGAA AGCCACATTG CCGATCACAG AGAGAGTGAC CACCCAGTCA 
GGATGCAGAA AGAGTCAGGG GAGGGGGATT TCACCACACA AGGCCGCAGC TCAAGACACT 
GGACAGTCCC TACCTGTCCC AGCAGATTTC CAATCAACTG AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development.
Journal of dental research97(2)226-236(2018 Feb)
Metwalli KA,Do MA,Nguyen K,Mallick S,Kin K,Farokhnia N,Jun G,Fakhouri WD

Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.
Journal of cellular biochemistry118(8)2231-2240(2017 Aug)
Olivos DJ 3rd,Alvarez M,Cheng YH,Hooker RA,Ciovacco WA,Bethel M,McGough H,Yim C,Chitteti BR,Eleniste PP,Horowitz MC,Srour EF,Bruzzaniti A,Fuchs RK,Kacena MA

The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
Molecular and cellular endocrinology396(1-2)26-36(2014 Oct)
Marotta P,Amendola E,Scarf? M,De Luca P,Zoppoli P,Amoresano A,De Felice M,Di Lauro R

Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.
Journal of the Association for Research in Otolaryngology : JARO15(1)45-55(2014 Feb)
Johnson KR,Gagnon LH,Longo-Guess CM,Harris BS,Chang B

The targeted inactivation of TR? gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.
Endocrinology155(2)635-46(2014 Feb)
Selmi-Ruby S,Bouazza L,Obregon MJ,Conscience A,Flamant F,Samarut J,Borson-Chazot F,Rousset B

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Tpo cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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