Enpp3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Enpp3
Entrez Gene ID	209558
Full Name	ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms	AI876438,CD203c
General protein information	Preferred Names ectonucleotide pyrophosphatase/phosphodiesterase 3 Names ectonucleotide pyrophosphatase/phosphodiesterase family member 3 E-NPP 3 PD-Ibeta phosphodiesterase I beta phosphodiesterase I/nucleotide pyrophosphatase 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 A4

mRNA and Protein(s)

mRNA	Protein	Name
NM_134005.2	NP_598766.2	ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	AT4G29690	NP_194698.1
Canis lupus familiaris (dog)	ENPP3	XP_005627149.1
Mus musculus (house mouse)	Enpp3	NP_598766.2
	ENPP3	XP_001103528.1
Gallus gallus (chicken)	ENPP3	XP_003641087.1
Arabidopsis thaliana (thale cress)	AT4G29700	NP_194699.1
Xenopus tropicalis (tropical clawed frog)	enpp3	XP_002936359.2
Pan troglodytes (chimpanzee)	ENPP3	XP_518741.2
Homo sapiens (human)	ENPP3	NP_005012.2
Bos taurus (cattle)	ENPP3	NP_001069391.1
Rattus norvegicus (Norway rat)	Enpp3	NP_062243.2

Gene Ontology
Bibliography

Related articles in PubMed

E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.
Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K
PloS one12(2)e0172509(2017)

The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells.
Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K
Immunity42(2)279-293(2015 Feb)

Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality.
Lieben L, Stockmans I, Moermans K, Carmeliet G
Bone57(1)123-31(2013 Nov)

Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb).
Korekane H, Park JY, Matsumoto A, Nakajima K, Takamatsu S, Ohtsubo K, Miyamoto Y, Hanashima S, Kanekiyo K, Kitazume S, Yamaguchi Y, Matsuo I, Taniguchi N
The Journal of biological chemistry288(39)27912-26(2013 Sep)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In Enpp3-/- mice, ATP concentrations were increased in the intestinal lumen. Plasmacytoid dendritic cell (pDC) numbers were remarkably decreased in the small intestinal lamina propria and Peyer's patches. Intestinal pDCs of Enpp3-/- mice showed enhanced cell death.
Title: E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.

E-NPP3 decreases ATP concentration and suppresses basophil and mast cell activity.
Title: The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells.

The following Enpp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Enpp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21000	NM_134005.2 Latest version!	Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$517.30 $739.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Enpp3 ( NM_134005.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598766.2 Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA.

Price & Availability↑

CloneID	OMu21000
Clone ID Related Accession (Same CDS sequence)	NM_134005.2
Accession Version	NM_134005.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2625bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132256.1 and BB400671.1. On Jul 31, 2007 this sequence version replaced NM_134005.1. ##Evidence-Data-START## Transcript exon combination :: AK132256.1, AY630402.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END##

ATGGATTCCA GGCTAGCATT AGCCACAGAG GAGCCCATTA AGAAAGACAG TCTCAAGAAA 
TACAAGATCC TTTGTGTGGT TCTTCTTGCT TTGTTGGTGA TTGTATCGCT TGGATTGGGG 
CTGGGACTGG GACTCAGGAA ACCTGAAGAA CAAGGCAGCT GCAGGAAAAA ATGCTTTGAC 
TCATCGCACA GAGGACTGGA GGGCTGCCGC TGTGACTCGG GATGCACAGG ACGAGGAGAC 
TGCTGCTGGG ACTTTGAAGA TACCTGTGTG AAATCAACTC AAATATGGAC GTGCAATTTA 
TTCCGTTGTG GGGAGAACAG ACTGGAGACA GCCCTCTGTT CCTGTGCGGA TGACTGTCTA 
CAGAGGAAGG ACTGCTGTGC TGACTACAAG ACTGTGTGCC AAGGCGAAAG CCCATGGGTG 
ACAGAAGCCT GTGCCTCATC CCAGGAGCCC CAGTGTCCAC CAGGGTTTGA CCTGCCACCA 
GTTATCTTGT TCTCCATGGA CGGTTTTAGA GCTGAGTATT TACAAACATG GAGTACCCTT 
TTGCCTAATA TCAACAAACT GAAAACATGT GGAATCCATT CTAAATATAT GAGAGCTATG 
TATCCCACCA AAACCTTCCC AAATCATTAT ACCATTGTCA CGGGTTTGTA TCCGGAGTCA 
CACGGCATCA TTGACAACAA CATGTATGAC GTGCACCTCA ACAAGAATTT TTCCCTTTCT 
TCAGTGGAGA AAAGCAATCC CGCCTGGTGG AGCGGGCAGC CGATTTGGCT AACGGCAATG 
TATCAAGGTT TAAAAGCTGC TTGCTACTAC TGGCCGGGAT CAGATGTGGC TGTCAATGGC 
TCCTTCCCTA CCATCTACAG GAATTACAGC AATTCTGTCC CATATGAAAG GAGGATTACA 
ACACTGTTAC AATGGCTGGA CCTGCCCAAA GCTGACCGAC CCAGTTTTTA TACCATCTAT 
GTGGAAGAGC CTGATTCTGC AGGGCATTCG AGTGGACCAG TCAGTGCTGG AGTAATTAAA 
GCCTTGCAGT CAGTTGACAA TGCCTTTGGA ATGTTGATGG AGGGTCTGAA ACAGAGGAAT 
TTACACAACT GTGTCAATAT AATCGTTCTG GCTGATCATG GAATGGACCA GACCTCCTGT 
GATAGAGTGG AATACATGAC AGATTATTTT CCTAAAATAA ACTTCTATAT GTATCAAGGA 
CCTGCTCCTC GAATCAGGAC TCGTAATATA CCTCAGGACT TCTTTACATT TAATTCTGAA 
GAGATTGTCA GGAACCTCAG TTGTCGAAAA CCTGACCAAC ACTTTAAACC CTACTTGACC 
CCTGATTTGC CGAAACGACT GCACTACGCC AAAAATGTCA GAATTGACAA AGCTCATCTC 
ATGGTGGATC GGCAATGGCT GGCTTTCAGG AGCAAAGGGA GTTCCAATTG TGGTGGAGGA 
ACACATGGCT ACAACAATGA GTTCAAGAGC ATGGAGGCAA TCTTTTTGGC ACATGGACCC 
AGCTTTATAG AGAAGACTGT TATTGAACCA TTTGAAAATA TTGAAGTCTA TAATCTACTG 
TGTGATCTTC TGCACATTGA ACCAGCACCA AACAACGGTA CTCATGGCAG TCTGAATCAT 
CTTCTGAAGA CACCGTTTTA CAAGCCATCA CATGCAGGAG AGTTGTCAAC GCCTGCTGAC 
TGTGGTTTTA CTACTCCCCT GCCTACAGAC CCACTAGACT GCTCATGCCC TGCACTACAG 
AATACGCCTG GTCTAGAAGA GCAAGCAAAC CAAAGGCTAA ATCTTAGCGA AGGCGAGGTT 
GCAGCAACGG TGAAAGCAAA TTTGCCATTT GGGAGGCCCA GGGTGATGCA GAAGAACGGA 
GACCACTGTC TCCTTTACCA CAGGGACTAC ATCAGTGGGT ACGGCAAAGC TATGAAGATG 
CCCATGTGGA GTTCATACAC CGTTCTCAAG CCGGGAGACA CATCATCTCT TCCTCCCACA 
GTTCCAGACT GTCTGCGGGC TGATGTCAGG GTTGCTCCTT CTGAGAGCCA AAAATGTTCC 
TTCTATTTAG CAGACAAGAA TATCACCCAT GGCTTCCTCT ATCCTGCAAT CAAAGGAACT 
AATGAGAGTC GATATGATGC CTTAATTACA AGTAATTTGG TCCCAATGTA TAAAGAATTC 
AAAAAAATGT GGGACTACTT CCATGAGGTT CTTCTTATAA AATATGCTAT AGAAAGAAAT 
GGACTGAATG TGGTTAGTGG ACCCATCTTT GATTATAATT ATGATGGCCA TTTTGATGCT 
CCGGATGAAA TCACACAATA TGTAGCTGGC ACTGATGTCC CTATCCCAAC ACACTACTTT 
GTGGTGCTGA CAAGTTGTAA AGACCAAACC CACACACCCG ACAGCTGCCC TGGGTGGCTG 
GATGTCCTGC CCTTCATCGT CCCTCACCGG CCCACCAACA TAGAAAGCTG TTCTGAAAAC 
AAGACCGAGG ACCTTTGGGT TGAAGAGAGG TTCCAAGCAC ACGCCGCCCG GGTCCGAGAT 
GTGGAGCTCC TCACTGGCCT TGACTTTTAT CAGGAGAAAG CACAGCCCGT CTCTCAGATT 
TTGCAACTAA AGACGTATCT GCCCACGTTT GAAACCATTA TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598766.2
CDS	103..2727
Translation	MDSRLALATEEPIKKDSLKKYKILCVVLLALLVIVSLGLGLGLGLRKPEEQGSCRKKCFDSSHRGLEGCRCDSGCTGRGDCCWDFEDTCVKSTQIWTCNLFRCGENRLETALCSCADDCLQRKDCCADYKTVCQGESPWVTEACASSQEPQCPPGFDLPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVHLNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAACYYWPGSDVAVNGSFPTIYRNYSNSVPYERRITTLLQWLDLPKADRPSFYTIYVEEPDSAGHSSGPVSAGVIKALQSVDNAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPKINFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKAHLMVDRQWLAFRSKGSSNCGGGTHGYNNEFKSMEAIFLAHGPSFIEKTVIEPFENIEVYNLLCDLLHIEPAPNNGTHGSLNHLLKTPFYKPSHAGELSTPADCGFTTPLPTDPLDCSCPALQNTPGLEEQANQRLNLSEGEVAATVKANLPFGRPRVMQKNGDHCLLYHRDYISGYGKAMKMPMWSSYTVLKPGDTSSLPPTVPDCLRADVRVAPSESQKCSFYLADKNITHGFLYPAIKGTNESRYDALITSNLVPMYKEFKKMWDYFHEVLLIKYAIERNGLNVVSGPIFDYNYDGHFDAPDEITQYVAGTDVPIPTHYFVVLTSCKDQTHTPDSCPGWLDVLPFIVPHRPTNIESCSENKTEDLWVEERFQAHAARVRDVELLTGLDFYQEKAQPVSQILQLKTYLPTFETII

Target ORF information:

RefSeq Version	NM_134005.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134005.2

ORF Insert Sequence:

ATGGATTCCA GGCTAGCATT AGCCACAGAG GAGCCCATTA AGAAAGACAG TCTCAAGAAA 
TACAAGATCC TTTGTGTGGT TCTTCTTGCT TTGTTGGTGA TTGTATCGCT TGGATTGGGG 
CTGGGACTGG GACTCAGGAA ACCTGAAGAA CAAGGCAGCT GCAGGAAAAA ATGCTTTGAC 
TCATCGCACA GAGGACTGGA GGGCTGCCGC TGTGACTCGG GATGCACAGG ACGAGGAGAC 
TGCTGCTGGG ACTTTGAAGA TACCTGTGTG AAATCAACTC AAATATGGAC GTGCAATTTA 
TTCCGTTGTG GGGAGAACAG ACTGGAGACA GCCCTCTGTT CCTGTGCGGA TGACTGTCTA 
CAGAGGAAGG ACTGCTGTGC TGACTACAAG ACTGTGTGCC AAGGCGAAAG CCCATGGGTG 
ACAGAAGCCT GTGCCTCATC CCAGGAGCCC CAGTGTCCAC CAGGGTTTGA CCTGCCACCA 
GTTATCTTGT TCTCCATGGA CGGTTTTAGA GCTGAGTATT TACAAACATG GAGTACCCTT 
TTGCCTAATA TCAACAAACT GAAAACATGT GGAATCCATT CTAAATATAT GAGAGCTATG 
TATCCCACCA AAACCTTCCC AAATCATTAT ACCATTGTCA CGGGTTTGTA TCCGGAGTCA 
CACGGCATCA TTGACAACAA CATGTATGAC GTGCACCTCA ACAAGAATTT TTCCCTTTCT 
TCAGTGGAGA AAAGCAATCC CGCCTGGTGG AGCGGGCAGC CGATTTGGCT AACGGCAATG 
TATCAAGGTT TAAAAGCTGC TTGCTACTAC TGGCCGGGAT CAGATGTGGC TGTCAATGGC 
TCCTTCCCTA CCATCTACAG GAATTACAGC AATTCTGTCC CATATGAAAG GAGGATTACA 
ACACTGTTAC AATGGCTGGA CCTGCCCAAA GCTGACCGAC CCAGTTTTTA TACCATCTAT 
GTGGAAGAGC CTGATTCTGC AGGGCATTCG AGTGGACCAG TCAGTGCTGG AGTAATTAAA 
GCCTTGCAGT CAGTTGACAA TGCCTTTGGA ATGTTGATGG AGGGTCTGAA ACAGAGGAAT 
TTACACAACT GTGTCAATAT AATCGTTCTG GCTGATCATG GAATGGACCA GACCTCCTGT 
GATAGAGTGG AATACATGAC AGATTATTTT CCTAAAATAA ACTTCTATAT GTATCAAGGA 
CCTGCTCCTC GAATCAGGAC TCGTAATATA CCTCAGGACT TCTTTACATT TAATTCTGAA 
GAGATTGTCA GGAACCTCAG TTGTCGAAAA CCTGACCAAC ACTTTAAACC CTACTTGACC 
CCTGATTTGC CGAAACGACT GCACTACGCC AAAAATGTCA GAATTGACAA AGCTCATCTC 
ATGGTGGATC GGCAATGGCT GGCTTTCAGG AGCAAAGGGA GTTCCAATTG TGGTGGAGGA 
ACACATGGCT ACAACAATGA GTTCAAGAGC ATGGAGGCAA TCTTTTTGGC ACATGGACCC 
AGCTTTATAG AGAAGACTGT TATTGAACCA TTTGAAAATA TTGAAGTCTA TAATCTACTG 
TGTGATCTTC TGCACATTGA ACCAGCACCA AACAACGGTA CTCATGGCAG TCTGAATCAT 
CTTCTGAAGA CACCGTTTTA CAAGCCATCA CATGCAGGAG AGTTGTCAAC GCCTGCTGAC 
TGTGGTTTTA CTACTCCCCT GCCTACAGAC CCACTAGACT GCTCATGCCC TGCACTACAG 
AATACGCCTG GTCTAGAAGA GCAAGCAAAC CAAAGGCTAA ATCTTAGCGA AGGCGAGGTT 
GCAGCAACGG TGAAAGCAAA TTTGCCATTT GGGAGGCCCA GGGTGATGCA GAAGAACGGA 
GACCACTGTC TCCTTTACCA CAGGGACTAC ATCAGTGGGT ACGGCAAAGC TATGAAGATG 
CCCATGTGGA GTTCATACAC CGTTCTCAAG CCGGGAGACA CATCATCTCT TCCTCCCACA 
GTTCCAGACT GTCTGCGGGC TGATGTCAGG GTTGCTCCTT CTGAGAGCCA AAAATGTTCC 
TTCTATTTAG CAGACAAGAA TATCACCCAT GGCTTCCTCT ATCCTGCAAT CAAAGGAACT 
AATGAGAGTC GATATGATGC CTTAATTACA AGTAATTTGG TCCCAATGTA TAAAGAATTC 
AAAAAAATGT GGGACTACTT CCATGAGGTT CTTCTTATAA AATATGCTAT AGAAAGAAAT 
GGACTGAATG TGGTTAGTGG ACCCATCTTT GATTATAATT ATGATGGCCA TTTTGATGCT 
CCGGATGAAA TCACACAATA TGTAGCTGGC ACTGATGTCC CTATCCCAAC ACACTACTTT 
GTGGTGCTGA CAAGTTGTAA AGACCAAACC CACACACCCG ACAGCTGCCC TGGGTGGCTG 
GATGTCCTGC CCTTCATCGT CCCTCACCGG CCCACCAACA TAGAAAGCTG TTCTGAAAAC 
AAGACCGAGG ACCTTTGGGT TGAAGAGAGG TTCCAAGCAC ACGCCGCCCG GGTCCGAGAT 
GTGGAGCTCC TCACTGGCCT TGACTTTTAT CAGGAGAAAG CACAGCCCGT CTCTCAGATT 
TTGCAACTAA AGACGTATCT GCCCACGTTT GAAACCATTA TTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.
PloS one12(2)e0172509(2017)
Furuta Y,Tsai SH,Kinoshita M,Fujimoto K,Okumura R,Umemoto E,Kurashima Y,Kiyono H,Kayama H,Takeda K

The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells.
Immunity42(2)279-293(2015 Feb)
Tsai SH,Kinoshita M,Kusu T,Kayama H,Okumura R,Ikeda K,Shimada Y,Takeda A,Yoshikawa S,Obata-Ninomiya K,Kurashima Y,Sato S,Umemoto E,Kiyono H,Karasuyama H,Takeda K

Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality.
Bone57(1)123-31(2013 Nov)
Lieben L,Stockmans I,Moermans K,Carmeliet G

Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb).
The Journal of biological chemistry288(39)27912-26(2013 Sep)
Korekane H,Park JY,Matsumoto A,Nakajima K,Takamatsu S,Ohtsubo K,Miyamoto Y,Hanashima S,Kanekiyo K,Kitazume S,Yamaguchi Y,Matsuo I,Taniguchi N

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

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Enpp3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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