Enpp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Enpp3
Entrez Gene ID	54410
Full Name	ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms	B10,E-NPP 3,Npp3,PD-Ibeta,RB13-6
General protein information	Preferred Names ectonucleotide pyrophosphatase/phosphodiesterase 3 Names ectonucleotide pyrophosphatase/phosphodiesterase family member 3 RB13-6 antigen alkaline phosphodiesterase phosphodiesterase I beta phosphodiesterase I/nucleotide pyrophosphatase 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p12
Summary	alkaline phosphodiesterase I; may be involved in regulation of vascular smooth muscle cell growth [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019370.2	NP_062243.2	ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	AT4G29690	NP_194698.1
Canis lupus familiaris (dog)	ENPP3	XP_005627149.1
Mus musculus (house mouse)	Enpp3	NP_598766.2
	ENPP3	XP_001103528.1
Gallus gallus (chicken)	ENPP3	XP_003641087.1
Arabidopsis thaliana (thale cress)	AT4G29700	NP_194699.1
Xenopus tropicalis (tropical clawed frog)	enpp3	XP_002936359.2
Pan troglodytes (chimpanzee)	ENPP3	XP_518741.2
Homo sapiens (human)	ENPP3	NP_005012.2
Bos taurus (cattle)	ENPP3	NP_001069391.1
Rattus norvegicus (Norway rat)	Enpp3	NP_062243.2

Gene Ontology
Bibliography

Related articles in PubMed

The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells.
Tsai SH, Kinoshita M, Kusu T, Kayama H, Okumura R, Ikeda K, Shimada Y, Takeda A, Yoshikawa S, Obata-Ninomiya K, Kurashima Y, Sato S, Umemoto E, Kiyono H, Karasuyama H, Takeda K
Immunity42(2)279-293(2015 Feb)

Expression of membrane-bound NPP-type ecto-phosphodiesterases in rat podocytes cultured at normal and high glucose concentrations.
Jankowski M, Piwkowska A, Rogacka D, Audzeyenka I, Janaszak-Jasiecka A, Angielski S
Biochemical and biophysical research communications416(1-2)64-9(2011 Dec)

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal of proteome research8(3)1304-14(2009 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ecto-nucleotide pyrophosphatase/phosphodiesterase 1 and 3 are expressed on podocytes, but changes in expression of these enzymes are most likely not involved in etiology of insulin resistance in podocytes.
Title: Expression of membrane-bound NPP-type ecto-phosphodiesterases in rat podocytes cultured at normal and high glucose concentrations.

The expression of NPP3 decreased during the aging mainly on cerebellum, hippocampus, and olfactory bulb.
Title: Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development.

Lubrol resistance is an intrinsic property of NPP3 but not NPP1, which is acquired early during the biosynthetic process irrespective of its final destination, and depends on positively charged residues in its cytoplasmic tail.
Title: Differential detergent resistance of the apical and basolateral NPPases: relationship with polarized targeting.

The following Enpp3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Enpp3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04583	NM_019370.2 Latest version!	Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Enpp3 ( NM_019370.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062243.2 Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA.

Price & Availability↑

CloneID	ORa04583
Clone ID Related Accession (Same CDS sequence)	NM_019370.2
Accession Version	NM_019370.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097326.1. On Dec 11, 2007 this sequence version replaced NM_019370.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097326.1, U78787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END##

ATGGATTCCA GGCTAGCTTT AGCCACGGAG GAGCCCATTA AGAAAGACAG CCTGAAGAGA 
TATAAGATCC TTTGTGCGGT TCTTCTTGCT TTGCTGGTGA TCGTGTCGCT TGGATTGGGC 
CTGGGCCTGG GACTCAGGAA ACCTGAAGAG CATATAGGCA GCTGCAGGAA AAAATGCTTT 
GATTCGTCAC ACAGAGGACT GGAGGGTTGC CGCTGTGACT CCGGATGCAC AGACCGGGGA 
GACTGCTGCT GGGACTTTGA AGATACCTGT GTGAAATCAA CTCAAATCTG GACGTGTAAT 
TCGTTCCGCT GTGGGGAGAC CAGACTAGAG GCAGCCCTCT GTTCCTGTGC GGATGACTGT 
CTGCAGAGGA AGGACTGCTG CACTGACTAC AAGGCTGTGT GCCAAGGAGA AGTCCCATGG 
GTGACAGAAG CCTGTGCCTC ATCCCAGGAG CCCCAGTGTC CAGAAGGGTT TGACCAGCCA 
CCGGTTATCT TGTTCTCCAT GGACGGCTTT AGAGCGGAGT ACTTACAAAC ATGGAGCACC 
CTGCTGCCAA ACATTAACAA ACTGAAAACA TGTGGACTCC ATTCCAAATA TATGAGAGCA 
ATGTATCCCA CCAAAACCTT TCCAAATCAT TATACCATTG TCACGGGTTT GTATCCAGAG 
TCGCACGGCA TCATTGACAA TAACATGTAT GATGTGTACC TCAACAAGAA TTTTTCACTT 
TCTTCAGTGG AGAAAAGTAA CCCTGCCTGG TGGAGTGGGC AGCCGATTTG GTTAACAGCA 
ATGTATCAAG GCTTAAAAGC TGCTTCCTAC TACTGGCCAG GATCAGATGT GGCTGTCAAT 
GGCTCCTTCC CTAACATCTA CAGGAATTAC AGCAATTCCG TCCCATATGA AAGTAGGATT 
GCTACACTGT TGCAATGGCT GGACCTGCCC AAAGCTGAAC GACCCAGTTT TTACACCATA 
TATGTGGAAG AGCCCGATTC TGCGGGGCAC AAGAGTGGAC CAGTCAGTGC TGGAGTCATT 
AAAGCCTTAC AGTTAGTTGA TGATGCCTTT GGGATGCTGA TGGAGGGTTT GAAACAGAGG 
AATTTACACA ACTGTGTCAA CATAATCGTT CTGGCTGATC ATGGAATGGA CCAGACCTCT 
TGTGACAGAG TGGAATACAT GACAGATTAT TTTCCTGAAA TAAACTTCTA CATGTACCAA 
GGACCTGCCC CTCGAATCAG GACTCGTAAT ATACCTCAGG ACTTCTTTAC CTTTAATTCC 
GAAGAGATTG TCAGAGACCT CAGCTGTCGA AAATCCGATC AACACTTCAA ACCCTACTTG 
ACTCCGGATT TGCCGAAACG ACTGCACTAT GCCAAGAACG TCAGGATTGA CAAAGTTCAT 
CTAATGGTGG ATCGGCAATG GCTGGCTTAC AGGAACAAAG GGAGTTCCAA CTGCGAAGGC 
GGAACACACG GTTACAACAA TGAATTTAAA AGTATGGAGG CAATCTTTTT GGCACATGGA 
CCCAGCTTTA AAGAGAAGAC TGTTATCGAA CCATTTGAAA ACATCGAAGT CTATAATCTA 
CTGTGTGATC TTCTGCACAT CCAACCGGCA CCAAACAACG GTTCTCACGG TAGCCTGAAT 
CATCTTCTGA AGGCACCATT TTACCAGCCG TCGCATGCAG AGGAATTGTC AAAGTCTGCT 
GGCTGTGGTT TTACTACTCC ATTGCCTAAG GACTCACTAA ACTGCTCCTG CCTCGCACTG 
CAGACTTCTG GTCAAGAAGA GCAAGTCAAC CAAAGACTAA ATCTCAGTGG AGGAGAGGTC 
TCAGCAACAG AGAAGACAAA TTTGCCATTT GGGAGGCCCA GGGTGATACA GAAGAACAAA 
GACCACTGTC TGCTTTACCA CAGGGAATAC GTCAGTGGGT TTGGGAAAGC TATGAAGATG 
CCCATGTGGA GTTCATACAC CGTTCCCAAG CCGGGAGACA CATCATCTCT TCCTCCCACA 
GTTCCAGACT GTCTGCGGGC TGATGTCAGG GTTGATCCTT CGGAGAGCCA AAAATGTTCC 
TTCTATTTAG CAGACCAGAA TATCGACCAT GGCTTCCTCT ATCCTCCCGC AATCAAAGGA 
AATAATGAGA GTCAATATGA TGCTTTAATT ACAAGTAATT TGGTCCCAAT GTATAAAGAA 
TTCAAAAAAA TGTGGGACTA CTTCCATAAA GTTCTCCTTA TAAAATACGC TATAGAAAGA 
AATGGAGTGA ATGTGGTTAG TGGACCCATA TTTGATTACA ATTATGATGG CCATTTTGAT 
GCCCCCGATG AAATCACAAA CTATGTAGCT GGCACCGATG TTCCTGTCCC GACACACTAC 
TTTGTGGTAC TGACAAGCTG TAAAAACAAA ACCCACACAC CCGACAGCTG CCCTGGGTGG 
CTGGATGTCC TGCCCTTTGT CGTCCCTCAC CGGCCCACCA ACGTGGAAAG CTGTCCTGAA 
AACAAAGCAG AAGACCTTTG GGTTGAAGAG AGATTTAAAG CACACATCGC CCGGGTCCGT 
GATGTGGAGC TCCTCACTGG CCTTGACTTT TATCAGGAAA AAACACAGCC CGTCTCTGAA 
ATTTTGCAGC TGAAGACATA TTTGCCCACA TTCGAAACCA TTATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062243.2
CDS	57..2684
Translation	MDSRLALATEEPIKKDSLKRYKILCAVLLALLVIVSLGLGLGLGLRKPEEHIGSCRKKCFDSSHRGLEGCRCDSGCTDRGDCCWDFEDTCVKSTQIWTCNSFRCGETRLEAALCSCADDCLQRKDCCTDYKAVCQGEVPWVTEACASSQEPQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNYSNSVPYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPEINFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRDLSCRKSDQHFKPYLTPDLPKRLHYAKNVRIDKVHLMVDRQWLAYRNKGSSNCEGGTHGYNNEFKSMEAIFLAHGPSFKEKTVIEPFENIEVYNLLCDLLHIQPAPNNGSHGSLNHLLKAPFYQPSHAEELSKSAGCGFTTPLPKDSLNCSCLALQTSGQEEQVNQRLNLSGGEVSATEKTNLPFGRPRVIQKNKDHCLLYHREYVSGFGKAMKMPMWSSYTVPKPGDTSSLPPTVPDCLRADVRVDPSESQKCSFYLADQNIDHGFLYPPAIKGNNESQYDALITSNLVPMYKEFKKMWDYFHKVLLIKYAIERNGVNVVSGPIFDYNYDGHFDAPDEITNYVAGTDVPVPTHYFVVLTSCKNKTHTPDSCPGWLDVLPFVVPHRPTNVESCPENKAEDLWVEERFKAHIARVRDVELLTGLDFYQEKTQPVSEILQLKTYLPTFETII

Target ORF information:

RefSeq Version	NM_019370.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase 3 (Enpp3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019370.2

ORF Insert Sequence:

ATGGATTCCA GGCTAGCTTT AGCCACGGAG GAGCCCATTA AGAAAGACAG CCTGAAGAGA 
TATAAGATCC TTTGTGCGGT TCTTCTTGCT TTGCTGGTGA TCGTGTCGCT TGGATTGGGC 
CTGGGCCTGG GACTCAGGAA ACCTGAAGAG CATATAGGCA GCTGCAGGAA AAAATGCTTT 
GATTCGTCAC ACAGAGGACT GGAGGGTTGC CGCTGTGACT CCGGATGCAC AGACCGGGGA 
GACTGCTGCT GGGACTTTGA AGATACCTGT GTGAAATCAA CTCAAATCTG GACGTGTAAT 
TCGTTCCGCT GTGGGGAGAC CAGACTAGAG GCAGCCCTCT GTTCCTGTGC GGATGACTGT 
CTGCAGAGGA AGGACTGCTG CACTGACTAC AAGGCTGTGT GCCAAGGAGA AGTCCCATGG 
GTGACAGAAG CCTGTGCCTC ATCCCAGGAG CCCCAGTGTC CAGAAGGGTT TGACCAGCCA 
CCGGTTATCT TGTTCTCCAT GGACGGCTTT AGAGCGGAGT ACTTACAAAC ATGGAGCACC 
CTGCTGCCAA ACATTAACAA ACTGAAAACA TGTGGACTCC ATTCCAAATA TATGAGAGCA 
ATGTATCCCA CCAAAACCTT TCCAAATCAT TATACCATTG TCACGGGTTT GTATCCAGAG 
TCGCACGGCA TCATTGACAA TAACATGTAT GATGTGTACC TCAACAAGAA TTTTTCACTT 
TCTTCAGTGG AGAAAAGTAA CCCTGCCTGG TGGAGTGGGC AGCCGATTTG GTTAACAGCA 
ATGTATCAAG GCTTAAAAGC TGCTTCCTAC TACTGGCCAG GATCAGATGT GGCTGTCAAT 
GGCTCCTTCC CTAACATCTA CAGGAATTAC AGCAATTCCG TCCCATATGA AAGTAGGATT 
GCTACACTGT TGCAATGGCT GGACCTGCCC AAAGCTGAAC GACCCAGTTT TTACACCATA 
TATGTGGAAG AGCCCGATTC TGCGGGGCAC AAGAGTGGAC CAGTCAGTGC TGGAGTCATT 
AAAGCCTTAC AGTTAGTTGA TGATGCCTTT GGGATGCTGA TGGAGGGTTT GAAACAGAGG 
AATTTACACA ACTGTGTCAA CATAATCGTT CTGGCTGATC ATGGAATGGA CCAGACCTCT 
TGTGACAGAG TGGAATACAT GACAGATTAT TTTCCTGAAA TAAACTTCTA CATGTACCAA 
GGACCTGCCC CTCGAATCAG GACTCGTAAT ATACCTCAGG ACTTCTTTAC CTTTAATTCC 
GAAGAGATTG TCAGAGACCT CAGCTGTCGA AAATCCGATC AACACTTCAA ACCCTACTTG 
ACTCCGGATT TGCCGAAACG ACTGCACTAT GCCAAGAACG TCAGGATTGA CAAAGTTCAT 
CTAATGGTGG ATCGGCAATG GCTGGCTTAC AGGAACAAAG GGAGTTCCAA CTGCGAAGGC 
GGAACACACG GTTACAACAA TGAATTTAAA AGTATGGAGG CAATCTTTTT GGCACATGGA 
CCCAGCTTTA AAGAGAAGAC TGTTATCGAA CCATTTGAAA ACATCGAAGT CTATAATCTA 
CTGTGTGATC TTCTGCACAT CCAACCGGCA CCAAACAACG GTTCTCACGG TAGCCTGAAT 
CATCTTCTGA AGGCACCATT TTACCAGCCG TCGCATGCAG AGGAATTGTC AAAGTCTGCT 
GGCTGTGGTT TTACTACTCC ATTGCCTAAG GACTCACTAA ACTGCTCCTG CCTCGCACTG 
CAGACTTCTG GTCAAGAAGA GCAAGTCAAC CAAAGACTAA ATCTCAGTGG AGGAGAGGTC 
TCAGCAACAG AGAAGACAAA TTTGCCATTT GGGAGGCCCA GGGTGATACA GAAGAACAAA 
GACCACTGTC TGCTTTACCA CAGGGAATAC GTCAGTGGGT TTGGGAAAGC TATGAAGATG 
CCCATGTGGA GTTCATACAC CGTTCCCAAG CCGGGAGACA CATCATCTCT TCCTCCCACA 
GTTCCAGACT GTCTGCGGGC TGATGTCAGG GTTGATCCTT CGGAGAGCCA AAAATGTTCC 
TTCTATTTAG CAGACCAGAA TATCGACCAT GGCTTCCTCT ATCCTCCCGC AATCAAAGGA 
AATAATGAGA GTCAATATGA TGCTTTAATT ACAAGTAATT TGGTCCCAAT GTATAAAGAA 
TTCAAAAAAA TGTGGGACTA CTTCCATAAA GTTCTCCTTA TAAAATACGC TATAGAAAGA 
AATGGAGTGA ATGTGGTTAG TGGACCCATA TTTGATTACA ATTATGATGG CCATTTTGAT 
GCCCCCGATG AAATCACAAA CTATGTAGCT GGCACCGATG TTCCTGTCCC GACACACTAC 
TTTGTGGTAC TGACAAGCTG TAAAAACAAA ACCCACACAC CCGACAGCTG CCCTGGGTGG 
CTGGATGTCC TGCCCTTTGT CGTCCCTCAC CGGCCCACCA ACGTGGAAAG CTGTCCTGAA 
AACAAAGCAG AAGACCTTTG GGTTGAAGAG AGATTTAAAG CACACATCGC CCGGGTCCGT 
GATGTGGAGC TCCTCACTGG CCTTGACTTT TATCAGGAAA AAACACAGCC CGTCTCTGAA 
ATTTTGCAGC TGAAGACATA TTTGCCCACA TTCGAAACCA TTATTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells.
Immunity42(2)279-293(2015 Feb)
Tsai SH,Kinoshita M,Kusu T,Kayama H,Okumura R,Ikeda K,Shimada Y,Takeda A,Yoshikawa S,Obata-Ninomiya K,Kurashima Y,Sato S,Umemoto E,Kiyono H,Karasuyama H,Takeda K

Expression of membrane-bound NPP-type ecto-phosphodiesterases in rat podocytes cultured at normal and high glucose concentrations.
Biochemical and biophysical research communications416(1-2)64-9(2011 Dec)
Jankowski M,Piwkowska A,Rogacka D,Audzeyenka I,Janaszak-Jasiecka A,Angielski S

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Journal of proteome research8(3)1304-14(2009 Mar)
Gonzalez-Begne M,Lu B,Han X,Hagen FK,Hand AR,Melvin JE,Yates JR

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Enpp3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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