Ro60 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ro60
Entrez Gene ID	20822
Full Name	TROVE domain family, member 2
Synonyms	1810007I17Rik,A530054J02Rik,AI646302,SS-A/Ro,Ssa,Ssa2
General protein information	Preferred Names TROVE domain family, member 2 Names 60 kDa SS-A/Ro ribonucleoprotein 60 kDa Ro protein 60 kDa ribonucleoprotein Ro Sjogren syndrome antigen A2 roRNP
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 F\|1 62.54 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_017319451.1	XP_017174940.1	60 kDa SS-A/Ro ribonucleoprotein isoform X1
XM_017319451.2	XP_017174940.1	60 kDa SS-A/Ro ribonucleoprotein isoform X1
NM_013835.2	NP_038863.1	60 kDa SS-A/Ro ribonucleoprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	TROVE2	NP_001166995.1
Canis lupus familiaris (dog)	TROVE2	XP_005640872.1
Bos taurus (cattle)	TROVE2	NP_001193112.1
Caenorhabditis elegans (roundworm)	rop-1	NP_505638.1
Gallus gallus (chicken)	TROVE2	XP_422201.1
Danio rerio (zebrafish)	trove2	NP_001032474.1
Xenopus tropicalis (tropical clawed frog)	trove2	XP_004913840.1
Pan troglodytes (chimpanzee)	TROVE2	XP_001166756.1
Mus musculus (house mouse)	Trove2	NP_038863.1
Rattus norvegicus (Norway rat)	Trove2	NP_001100653.1

Gene Ontology
Bibliography

Related articles in PubMed

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterl? S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, Lagier-Tourenne C, Dupuis L
The EMBO journal35(10)1077-97(2016 05)

Passive transfer of antibodies to the linear epitope 60?kD Ro 273-289 induces features of Sj?gren's syndrome in naive mice.
Maier-Moore JS, Kurien BT, D'Souza A, Bockus L, Asfa S, Dorri Y, Hubbell S, Yeliosof O, Obeso D, Schoeb TR, Jonsson R, Scofield RH
Clinical and experimental immunology180(1)19-27(2015 Apr)

Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus.
Reed JH, Sim S, Wolin SL, Clancy RM, Buyon JP
Journal of immunology (Baltimore, Md. : 1950)191(1)110-6(2013 Jul)

Functional characterization of putative cilia genes by high-content analysis.
Lai CK, Gupta N, Wen X, Rangell L, Chih B, Peterson AS, Bazan JF, Li L, Scales SJ
Molecular biology of the cell22(7)1104-19(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data support the hypothesis that antibodies to Ro274 deposit in salivary glands can enter intact salivary gland cells and are involved in the dysregulation of salivary flow in SS.
Title: Passive transfer of antibodies to the linear epitope 60?kD Ro 273-289 induces features of Sj?gren's syndrome in naive mice.

Ro protein has a role in preventing an autoimmune syndrome characterized by anti-ribosome antibodies, anti-chromatin antibodies, and glomerulonephritis
Title: A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.

differences in the epitope spreading after 60 kDa Ro peptide immunization in several strains of mice
Title: Immunization with peptides from 60 kDa Ro in diverse mouse strains.

Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.
Title: Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.

The following Ro60 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ro60 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu10034	NM_013835.2 Latest version!	Mus musculus Ro60, Y RNA binding protein (Ro60), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu10034	XM_017319451.2 Latest version!	Mus musculus Ro60, Y RNA binding protein (Ro60), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu10034	XM_017319451.1	Mus musculus TROVE domain family, member 2 (Trove2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ro60 ( NM_013835.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038863.1 Mus musculus Ro60, Y RNA binding protein (Ro60), mRNA.

Price & Availability↑

CloneID	OMu10034
Clone ID Related Accession (Same CDS sequence)	XM_017319451.1 , XM_017319451.2 , NM_013835.2
Accession Version	NM_013835.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	60 kDa SS-A/Ro ribonucleoprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY121097.1, U66843.1, AL592403.6 and BQ032951.1. On Mar 27, 2007 this sequence version replaced NM_013835.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.17721.1, SRR1660813.224200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGGAT CTGCAAACCA GTTGCAGCCA CTGAGTGAGA CTCAAGTAGT TAACTCAGAG 
GGCGGCTGTG TATGGCAGGT CACCGACATG AACCGGCTGC GCCGCTTCTT GTGTTTTGGC 
TCTGAAGGTG GCACGTACTA TATCAAAGAA CAGAAGCTGG GCCTTGAGAA TGCTGAAGCC 
TTAATTAGAC TGATTGAAGA CGGCAGAGGA TGTGAAGTGA TCCAGGAAAT CAAGTCCTTT 
AGTCAGGAAG GCAGGACTGC CAAACAAGAG CCACTGCTGT TTGCACTGGC CGTTTGTTCC 
CAGTGTGCGG ACATAAACAC AAAGCAAGCA GCCTTTAAAG CTGTCCCTGA AGTGTGTCGC 
ATTCCGACCC ACCTCTTCAC TTTTATCCAG TTTAAGAAAG ACCTGAAGGA GAGCATGAAG 
TGTGGCATGT GGGGTCGCGC CCTCCGGAAG GCAGTGGCAG ACTGGTACAA TGAAAAAGGC 
GGCATGGCCG TGGCGCTGGT GGTTACAAAG TATAAACAAC GAAACGGCTG GTCTCACAAA 
GATCTCCTCC GACTGTCCCA CCTTAAGCCT TCCAGTGAAG GACTTGCTAT TGTGACCAAG 
TATATCACAA AGGGCTGGAA AGAAGTCCAT GAAGAGTATA AAGAAAAGGC GCTTTCTGTG 
GAGGCTGAGA AGCTGCTCAA GTACCTGGAG GCTGTGGAGA AAGTGAAGCG CACGAAAGAC 
GACCTGGAAG TCATTCATCT GATTGAAGAG CATCAGTTAG TTAGGGAACA CCTGCTGACA 
AATCACTTGA AGTCTAAAGA GGTATGGAAG GCTTTGTTAC AGGAAATGCC CCTTACTGCG 
CTCCTGAGGA ACCTGGGAAA GATGACTGCT AATTCAGTGC TTGAACCAGG AAACTCTGAA 
GTATCTTTAA TATGTGAAAA ACTGAGCAAT GAAAAGCTGC TCAAAAAGGC TCGTATACAT 
CCATTTCATG TTTTAATTGC ATTAGAGACC TACAGAGCAG GCCACGGGCT CAGAGGGAAA 
CTGAAGTGGA TTCCAGATAA AGACATCTTG CAAGCCTTAG ATGCTGCTTT TTATACAACA 
TTTAAGACTG TTGAACCAAC TGGGAAGCGC TTCTTGCTCG CTGTTGACGT CAGTGCCTCT 
ATGAACCAGA GAGCCTTGGG TAGTGTACTC AATGCTAGTA CTGTTGCCGC AGCAATGTGC 
ATGGTGGTTA CACGGACAGA AAAAGAGTCT TCGGTGGTTG CTTTTGCCTG TGATATGGTT 
CCGTTTCCAG TGACTACAGA CATGACATTA CAGCAGGTTT TAACGGCTAT GAATAAAGTT 
CCAGCAGGCA ACACGGATTG CTCTCTCCCA ATGATCTGGG CCCAGAAAAC AGACACAGCC 
GCAGATGTCT TCGTTGTGTT TACTGATAAT GAGACCTTTG CAGGGCAGGT GCATCCTGCT 
GTTGCCCTGA GAGAGTACCG AAAGAAAATG GATATTCCTG CTAAATTGAT TGTTTGTGGG 
ATGACATCAA ATGGCTTTAC CATTGCAGAC CCAGACGATA GAGGCATGTT GGATATGTGC 
GGCTTTGATA CTGCAGCTCT GGATGTAATT CGGAATTTCA CATTGGATGT CATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038863.1
CDS	153..1769
Translation	MEGSANQLQPLSETQVVNSEGGCVWQVTDMNRLRRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPLLFALAVCSQCADINTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMAVALVVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEEYKEKALSVEAEKLLKYLEAVEKVKRTKDDLEVIHLIEEHQLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLICEKLSNEKLLKKARIHPFHVLIALETYRAGHGLRGKLKWIPDKDILQALDAAFYTTFKTVEPTGKRFLLAVDVSASMNQRALGSVLNASTVAAAMCMVVTRTEKESSVVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGNTDCSLPMIWAQKTDTAADVFVVFTDNETFAGQVHPAVALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTAALDVIRNFTLDVI

Target ORF information:

RefSeq Version	NM_013835.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Ro60, Y RNA binding protein (Ro60), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013835.2

ORF Insert Sequence:

ATGGAAGGAT CTGCAAACCA GTTGCAGCCA CTGAGTGAGA CTCAAGTAGT TAACTCAGAG 
GGCGGCTGTG TATGGCAGGT CACCGACATG AACCGGCTGC GCCGCTTCTT GTGTTTTGGC 
TCTGAAGGTG GCACGTACTA TATCAAAGAA CAGAAGCTGG GCCTTGAGAA TGCTGAAGCC 
TTAATTAGAC TGATTGAAGA CGGCAGAGGA TGTGAAGTGA TCCAGGAAAT CAAGTCCTTT 
AGTCAGGAAG GCAGGACTGC CAAACAAGAG CCACTGCTGT TTGCACTGGC CGTTTGTTCC 
CAGTGTGCGG ACATAAACAC AAAGCAAGCA GCCTTTAAAG CTGTCCCTGA AGTGTGTCGC 
ATTCCGACCC ACCTCTTCAC TTTTATCCAG TTTAAGAAAG ACCTGAAGGA GAGCATGAAG 
TGTGGCATGT GGGGTCGCGC CCTCCGGAAG GCAGTGGCAG ACTGGTACAA TGAAAAAGGC 
GGCATGGCCG TGGCGCTGGT GGTTACAAAG TATAAACAAC GAAACGGCTG GTCTCACAAA 
GATCTCCTCC GACTGTCCCA CCTTAAGCCT TCCAGTGAAG GACTTGCTAT TGTGACCAAG 
TATATCACAA AGGGCTGGAA AGAAGTCCAT GAAGAGTATA AAGAAAAGGC GCTTTCTGTG 
GAGGCTGAGA AGCTGCTCAA GTACCTGGAG GCTGTGGAGA AAGTGAAGCG CACGAAAGAC 
GACCTGGAAG TCATTCATCT GATTGAAGAG CATCAGTTAG TTAGGGAACA CCTGCTGACA 
AATCACTTGA AGTCTAAAGA GGTATGGAAG GCTTTGTTAC AGGAAATGCC CCTTACTGCG 
CTCCTGAGGA ACCTGGGAAA GATGACTGCT AATTCAGTGC TTGAACCAGG AAACTCTGAA 
GTATCTTTAA TATGTGAAAA ACTGAGCAAT GAAAAGCTGC TCAAAAAGGC TCGTATACAT 
CCATTTCATG TTTTAATTGC ATTAGAGACC TACAGAGCAG GCCACGGGCT CAGAGGGAAA 
CTGAAGTGGA TTCCAGATAA AGACATCTTG CAAGCCTTAG ATGCTGCTTT TTATACAACA 
TTTAAGACTG TTGAACCAAC TGGGAAGCGC TTCTTGCTCG CTGTTGACGT CAGTGCCTCT 
ATGAACCAGA GAGCCTTGGG TAGTGTACTC AATGCTAGTA CTGTTGCCGC AGCAATGTGC 
ATGGTGGTTA CACGGACAGA AAAAGAGTCT TCGGTGGTTG CTTTTGCCTG TGATATGGTT 
CCGTTTCCAG TGACTACAGA CATGACATTA CAGCAGGTTT TAACGGCTAT GAATAAAGTT 
CCAGCAGGCA ACACGGATTG CTCTCTCCCA ATGATCTGGG CCCAGAAAAC AGACACAGCC 
GCAGATGTCT TCGTTGTGTT TACTGATAAT GAGACCTTTG CAGGGCAGGT GCATCCTGCT 
GTTGCCCTGA GAGAGTACCG AAAGAAAATG GATATTCCTG CTAAATTGAT TGTTTGTGGG 
ATGACATCAA ATGGCTTTAC CATTGCAGAC CCAGACGATA GAGGCATGTT GGATATGTGC 
GGCTTTGATA CTGCAGCTCT GGATGTAATT CGGAATTTCA CATTGGATGT CATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ro60 ( XM_017319451.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017174940.1 Mus musculus TROVE domain family, member 2 (Trove2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu10034
Clone ID Related Accession (Same CDS sequence)	XM_017319451.1 , XM_017319451.2 , NM_013835.2
Accession Version	XM_017319451.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	60 kDa SS-A/Ro ribonucleoprotein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGGAT CTGCAAACCA GTTGCAGCCA CTGAGTGAGA CTCAAGTAGT TAACTCAGAG 
GGCGGCTGTG TATGGCAGGT CACCGACATG AACCGGCTGC GCCGCTTCTT GTGTTTTGGC 
TCTGAAGGTG GCACGTACTA TATCAAAGAA CAGAAGCTGG GCCTTGAGAA TGCTGAAGCC 
TTAATTAGAC TGATTGAAGA CGGCAGAGGA TGTGAAGTGA TCCAGGAAAT CAAGTCCTTT 
AGTCAGGAAG GCAGGACTGC CAAACAAGAG CCACTGCTGT TTGCACTGGC CGTTTGTTCC 
CAGTGTGCGG ACATAAACAC AAAGCAAGCA GCCTTTAAAG CTGTCCCTGA AGTGTGTCGC 
ATTCCGACCC ACCTCTTCAC TTTTATCCAG TTTAAGAAAG ACCTGAAGGA GAGCATGAAG 
TGTGGCATGT GGGGTCGCGC CCTCCGGAAG GCAGTGGCAG ACTGGTACAA TGAAAAAGGC 
GGCATGGCCG TGGCGCTGGT GGTTACAAAG TATAAACAAC GAAACGGCTG GTCTCACAAA 
GATCTCCTCC GACTGTCCCA CCTTAAGCCT TCCAGTGAAG GACTTGCTAT TGTGACCAAG 
TATATCACAA AGGGCTGGAA AGAAGTCCAT GAAGAGTATA AAGAAAAGGC GCTTTCTGTG 
GAGGCTGAGA AGCTGCTCAA GTACCTGGAG GCTGTGGAGA AAGTGAAGCG CACGAAAGAC 
GACCTGGAAG TCATTCATCT GATTGAAGAG CATCAGTTAG TTAGGGAACA CCTGCTGACA 
AATCACTTGA AGTCTAAAGA GGTATGGAAG GCTTTGTTAC AGGAAATGCC CCTTACTGCG 
CTCCTGAGGA ACCTGGGAAA GATGACTGCT AATTCAGTGC TTGAACCAGG AAACTCTGAA 
GTATCTTTAA TATGTGAAAA ACTGAGCAAT GAAAAGCTGC TCAAAAAGGC TCGTATACAT 
CCATTTCATG TTTTAATTGC ATTAGAGACC TACAGAGCAG GCCACGGGCT CAGAGGGAAA 
CTGAAGTGGA TTCCAGATAA AGACATCTTG CAAGCCTTAG ATGCTGCTTT TTATACAACA 
TTTAAGACTG TTGAACCAAC TGGGAAGCGC TTCTTGCTCG CTGTTGACGT CAGTGCCTCT 
ATGAACCAGA GAGCCTTGGG TAGTGTACTC AATGCTAGTA CTGTTGCCGC AGCAATGTGC 
ATGGTGGTTA CACGGACAGA AAAAGAGTCT TCGGTGGTTG CTTTTGCCTG TGATATGGTT 
CCGTTTCCAG TGACTACAGA CATGACATTA CAGCAGGTTT TAACGGCTAT GAATAAAGTT 
CCAGCAGGCA ACACGGATTG CTCTCTCCCA ATGATCTGGG CCCAGAAAAC AGACACAGCC 
GCAGATGTCT TCGTTGTGTT TACTGATAAT GAGACCTTTG CAGGGCAGGT GCATCCTGCT 
GTTGCCCTGA GAGAGTACCG AAAGAAAATG GATATTCCTG CTAAATTGAT TGTTTGTGGG 
ATGACATCAA ATGGCTTTAC CATTGCAGAC CCAGACGATA GAGGCATGTT GGATATGTGC 
GGCTTTGATA CTGCAGCTCT GGATGTAATT CGGAATTTCA CATTGGATGT CATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017174940.1
CDS	166..1782
Translation	MEGSANQLQPLSETQVVNSEGGCVWQVTDMNRLRRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPLLFALAVCSQCADINTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMAVALVVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEEYKEKALSVEAEKLLKYLEAVEKVKRTKDDLEVIHLIEEHQLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLICEKLSNEKLLKKARIHPFHVLIALETYRAGHGLRGKLKWIPDKDILQALDAAFYTTFKTVEPTGKRFLLAVDVSASMNQRALGSVLNASTVAAAMCMVVTRTEKESSVVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGNTDCSLPMIWAQKTDTAADVFVVFTDNETFAGQVHPAVALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTAALDVIRNFTLDVI

Target ORF information:

RefSeq Version	XM_017319451.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus TROVE domain family, member 2 (Trove2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319451.1

ORF Insert Sequence:

ATGGAAGGAT CTGCAAACCA GTTGCAGCCA CTGAGTGAGA CTCAAGTAGT TAACTCAGAG 
GGCGGCTGTG TATGGCAGGT CACCGACATG AACCGGCTGC GCCGCTTCTT GTGTTTTGGC 
TCTGAAGGTG GCACGTACTA TATCAAAGAA CAGAAGCTGG GCCTTGAGAA TGCTGAAGCC 
TTAATTAGAC TGATTGAAGA CGGCAGAGGA TGTGAAGTGA TCCAGGAAAT CAAGTCCTTT 
AGTCAGGAAG GCAGGACTGC CAAACAAGAG CCACTGCTGT TTGCACTGGC CGTTTGTTCC 
CAGTGTGCGG ACATAAACAC AAAGCAAGCA GCCTTTAAAG CTGTCCCTGA AGTGTGTCGC 
ATTCCGACCC ACCTCTTCAC TTTTATCCAG TTTAAGAAAG ACCTGAAGGA GAGCATGAAG 
TGTGGCATGT GGGGTCGCGC CCTCCGGAAG GCAGTGGCAG ACTGGTACAA TGAAAAAGGC 
GGCATGGCCG TGGCGCTGGT GGTTACAAAG TATAAACAAC GAAACGGCTG GTCTCACAAA 
GATCTCCTCC GACTGTCCCA CCTTAAGCCT TCCAGTGAAG GACTTGCTAT TGTGACCAAG 
TATATCACAA AGGGCTGGAA AGAAGTCCAT GAAGAGTATA AAGAAAAGGC GCTTTCTGTG 
GAGGCTGAGA AGCTGCTCAA GTACCTGGAG GCTGTGGAGA AAGTGAAGCG CACGAAAGAC 
GACCTGGAAG TCATTCATCT GATTGAAGAG CATCAGTTAG TTAGGGAACA CCTGCTGACA 
AATCACTTGA AGTCTAAAGA GGTATGGAAG GCTTTGTTAC AGGAAATGCC CCTTACTGCG 
CTCCTGAGGA ACCTGGGAAA GATGACTGCT AATTCAGTGC TTGAACCAGG AAACTCTGAA 
GTATCTTTAA TATGTGAAAA ACTGAGCAAT GAAAAGCTGC TCAAAAAGGC TCGTATACAT 
CCATTTCATG TTTTAATTGC ATTAGAGACC TACAGAGCAG GCCACGGGCT CAGAGGGAAA 
CTGAAGTGGA TTCCAGATAA AGACATCTTG CAAGCCTTAG ATGCTGCTTT TTATACAACA 
TTTAAGACTG TTGAACCAAC TGGGAAGCGC TTCTTGCTCG CTGTTGACGT CAGTGCCTCT 
ATGAACCAGA GAGCCTTGGG TAGTGTACTC AATGCTAGTA CTGTTGCCGC AGCAATGTGC 
ATGGTGGTTA CACGGACAGA AAAAGAGTCT TCGGTGGTTG CTTTTGCCTG TGATATGGTT 
CCGTTTCCAG TGACTACAGA CATGACATTA CAGCAGGTTT TAACGGCTAT GAATAAAGTT 
CCAGCAGGCA ACACGGATTG CTCTCTCCCA ATGATCTGGG CCCAGAAAAC AGACACAGCC 
GCAGATGTCT TCGTTGTGTT TACTGATAAT GAGACCTTTG CAGGGCAGGT GCATCCTGCT 
GTTGCCCTGA GAGAGTACCG AAAGAAAATG GATATTCCTG CTAAATTGAT TGTTTGTGGG 
ATGACATCAA ATGGCTTTAC CATTGCAGAC CCAGACGATA GAGGCATGTT GGATATGTGC 
GGCTTTGATA CTGCAGCTCT GGATGTAATT CGGAATTTCA CATTGGATGT CATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ro60 ( XM_017319451.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017174940.1 Mus musculus Ro60, Y RNA binding protein (Ro60), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu10034
Clone ID Related Accession (Same CDS sequence)	XM_017319451.1 , XM_017319451.2 , NM_013835.2
Accession Version	XM_017319451.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1617bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	60 kDa SS-A/Ro ribonucleoprotein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017319451.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGGAT CTGCAAACCA GTTGCAGCCA CTGAGTGAGA CTCAAGTAGT TAACTCAGAG 
GGCGGCTGTG TATGGCAGGT CACCGACATG AACCGGCTGC GCCGCTTCTT GTGTTTTGGC 
TCTGAAGGTG GCACGTACTA TATCAAAGAA CAGAAGCTGG GCCTTGAGAA TGCTGAAGCC 
TTAATTAGAC TGATTGAAGA CGGCAGAGGA TGTGAAGTGA TCCAGGAAAT CAAGTCCTTT 
AGTCAGGAAG GCAGGACTGC CAAACAAGAG CCACTGCTGT TTGCACTGGC CGTTTGTTCC 
CAGTGTGCGG ACATAAACAC AAAGCAAGCA GCCTTTAAAG CTGTCCCTGA AGTGTGTCGC 
ATTCCGACCC ACCTCTTCAC TTTTATCCAG TTTAAGAAAG ACCTGAAGGA GAGCATGAAG 
TGTGGCATGT GGGGTCGCGC CCTCCGGAAG GCAGTGGCAG ACTGGTACAA TGAAAAAGGC 
GGCATGGCCG TGGCGCTGGT GGTTACAAAG TATAAACAAC GAAACGGCTG GTCTCACAAA 
GATCTCCTCC GACTGTCCCA CCTTAAGCCT TCCAGTGAAG GACTTGCTAT TGTGACCAAG 
TATATCACAA AGGGCTGGAA AGAAGTCCAT GAAGAGTATA AAGAAAAGGC GCTTTCTGTG 
GAGGCTGAGA AGCTGCTCAA GTACCTGGAG GCTGTGGAGA AAGTGAAGCG CACGAAAGAC 
GACCTGGAAG TCATTCATCT GATTGAAGAG CATCAGTTAG TTAGGGAACA CCTGCTGACA 
AATCACTTGA AGTCTAAAGA GGTATGGAAG GCTTTGTTAC AGGAAATGCC CCTTACTGCG 
CTCCTGAGGA ACCTGGGAAA GATGACTGCT AATTCAGTGC TTGAACCAGG AAACTCTGAA 
GTATCTTTAA TATGTGAAAA ACTGAGCAAT GAAAAGCTGC TCAAAAAGGC TCGTATACAT 
CCATTTCATG TTTTAATTGC ATTAGAGACC TACAGAGCAG GCCACGGGCT CAGAGGGAAA 
CTGAAGTGGA TTCCAGATAA AGACATCTTG CAAGCCTTAG ATGCTGCTTT TTATACAACA 
TTTAAGACTG TTGAACCAAC TGGGAAGCGC TTCTTGCTCG CTGTTGACGT CAGTGCCTCT 
ATGAACCAGA GAGCCTTGGG TAGTGTACTC AATGCTAGTA CTGTTGCCGC AGCAATGTGC 
ATGGTGGTTA CACGGACAGA AAAAGAGTCT TCGGTGGTTG CTTTTGCCTG TGATATGGTT 
CCGTTTCCAG TGACTACAGA CATGACATTA CAGCAGGTTT TAACGGCTAT GAATAAAGTT 
CCAGCAGGCA ACACGGATTG CTCTCTCCCA ATGATCTGGG CCCAGAAAAC AGACACAGCC 
GCAGATGTCT TCGTTGTGTT TACTGATAAT GAGACCTTTG CAGGGCAGGT GCATCCTGCT 
GTTGCCCTGA GAGAGTACCG AAAGAAAATG GATATTCCTG CTAAATTGAT TGTTTGTGGG 
ATGACATCAA ATGGCTTTAC CATTGCAGAC CCAGACGATA GAGGCATGTT GGATATGTGC 
GGCTTTGATA CTGCAGCTCT GGATGTAATT CGGAATTTCA CATTGGATGT CATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017174940.1
CDS	171..1787
Translation	MEGSANQLQPLSETQVVNSEGGCVWQVTDMNRLRRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQEIKSFSQEGRTAKQEPLLFALAVCSQCADINTKQAAFKAVPEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRKAVADWYNEKGGMAVALVVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHEEYKEKALSVEAEKLLKYLEAVEKVKRTKDDLEVIHLIEEHQLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSEVSLICEKLSNEKLLKKARIHPFHVLIALETYRAGHGLRGKLKWIPDKDILQALDAAFYTTFKTVEPTGKRFLLAVDVSASMNQRALGSVLNASTVAAAMCMVVTRTEKESSVVAFACDMVPFPVTTDMTLQQVLTAMNKVPAGNTDCSLPMIWAQKTDTAADVFVVFTDNETFAGQVHPAVALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTAALDVIRNFTLDVI

Target ORF information:

RefSeq Version	XM_017319451.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus Ro60, Y RNA binding protein (Ro60), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319451.2

ORF Insert Sequence:

ATGGAAGGAT CTGCAAACCA GTTGCAGCCA CTGAGTGAGA CTCAAGTAGT TAACTCAGAG 
GGCGGCTGTG TATGGCAGGT CACCGACATG AACCGGCTGC GCCGCTTCTT GTGTTTTGGC 
TCTGAAGGTG GCACGTACTA TATCAAAGAA CAGAAGCTGG GCCTTGAGAA TGCTGAAGCC 
TTAATTAGAC TGATTGAAGA CGGCAGAGGA TGTGAAGTGA TCCAGGAAAT CAAGTCCTTT 
AGTCAGGAAG GCAGGACTGC CAAACAAGAG CCACTGCTGT TTGCACTGGC CGTTTGTTCC 
CAGTGTGCGG ACATAAACAC AAAGCAAGCA GCCTTTAAAG CTGTCCCTGA AGTGTGTCGC 
ATTCCGACCC ACCTCTTCAC TTTTATCCAG TTTAAGAAAG ACCTGAAGGA GAGCATGAAG 
TGTGGCATGT GGGGTCGCGC CCTCCGGAAG GCAGTGGCAG ACTGGTACAA TGAAAAAGGC 
GGCATGGCCG TGGCGCTGGT GGTTACAAAG TATAAACAAC GAAACGGCTG GTCTCACAAA 
GATCTCCTCC GACTGTCCCA CCTTAAGCCT TCCAGTGAAG GACTTGCTAT TGTGACCAAG 
TATATCACAA AGGGCTGGAA AGAAGTCCAT GAAGAGTATA AAGAAAAGGC GCTTTCTGTG 
GAGGCTGAGA AGCTGCTCAA GTACCTGGAG GCTGTGGAGA AAGTGAAGCG CACGAAAGAC 
GACCTGGAAG TCATTCATCT GATTGAAGAG CATCAGTTAG TTAGGGAACA CCTGCTGACA 
AATCACTTGA AGTCTAAAGA GGTATGGAAG GCTTTGTTAC AGGAAATGCC CCTTACTGCG 
CTCCTGAGGA ACCTGGGAAA GATGACTGCT AATTCAGTGC TTGAACCAGG AAACTCTGAA 
GTATCTTTAA TATGTGAAAA ACTGAGCAAT GAAAAGCTGC TCAAAAAGGC TCGTATACAT 
CCATTTCATG TTTTAATTGC ATTAGAGACC TACAGAGCAG GCCACGGGCT CAGAGGGAAA 
CTGAAGTGGA TTCCAGATAA AGACATCTTG CAAGCCTTAG ATGCTGCTTT TTATACAACA 
TTTAAGACTG TTGAACCAAC TGGGAAGCGC TTCTTGCTCG CTGTTGACGT CAGTGCCTCT 
ATGAACCAGA GAGCCTTGGG TAGTGTACTC AATGCTAGTA CTGTTGCCGC AGCAATGTGC 
ATGGTGGTTA CACGGACAGA AAAAGAGTCT TCGGTGGTTG CTTTTGCCTG TGATATGGTT 
CCGTTTCCAG TGACTACAGA CATGACATTA CAGCAGGTTT TAACGGCTAT GAATAAAGTT 
CCAGCAGGCA ACACGGATTG CTCTCTCCCA ATGATCTGGG CCCAGAAAAC AGACACAGCC 
GCAGATGTCT TCGTTGTGTT TACTGATAAT GAGACCTTTG CAGGGCAGGT GCATCCTGCT 
GTTGCCCTGA GAGAGTACCG AAAGAAAATG GATATTCCTG CTAAATTGAT TGTTTGTGGG 
ATGACATCAA ATGGCTTTAC CATTGCAGAC CCAGACGATA GAGGCATGTT GGATATGTGC 
GGCTTTGATA CTGCAGCTCT GGATGTAATT CGGAATTTCA CATTGGATGT CATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.
The EMBO journal35(10)1077-97(2016 05)
Scekic-Zahirovic J,Sendscheid O,El Oussini H,Jambeau M,Sun Y,Mersmann S,Wagner M,Dieterl? S,Sinniger J,Dirrig-Grosch S,Drenner K,Birling MC,Qiu J,Zhou Y,Li H,Fu XD,Rouaux C,Shelkovnikova T,Witting A,Ludolph AC,Kiefer F,Storkebaum E,Lagier-Tourenne C,Dupuis L

Passive transfer of antibodies to the linear epitope 60?kD Ro 273-289 induces features of Sj?gren's syndrome in naive mice.
Clinical and experimental immunology180(1)19-27(2015 Apr)
Maier-Moore JS,Kurien BT,D'Souza A,Bockus L,Asfa S,Dorri Y,Hubbell S,Yeliosof O,Obeso D,Schoeb TR,Jonsson R,Scofield RH

Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus.
Journal of immunology (Baltimore, Md. : 1950)191(1)110-6(2013 Jul)
Reed JH,Sim S,Wolin SL,Clancy RM,Buyon JP

Functional characterization of putative cilia genes by high-content analysis.
Molecular biology of the cell22(7)1104-19(2011 Apr)
Lai CK,Gupta N,Wen X,Rangell L,Chih B,Peterson AS,Bazan JF,Li L,Scales SJ

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Ro60 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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