Panx3 cDNA ORF clone, Mus musculus(house mouse)

Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities.
Iwamoto T, Nakamura T, Ishikawa M, Yoshizaki K, Sugimoto A, Ida-Yonemochi H, Ohshima H, Saito M, Yamada Y, Fukumoto S
PloS one12(5)e0177557(2017)

Differential effects of pannexins on noise-induced hearing loss.
Abitbol JM, Kelly JJ, Barr K, Schormans AL, Laird DW, Allman BL
The Biochemical journal473(24)4665-4680(2016 12)

Panx3 modulates intracellular ATP levels, resulting in the inhibition of odontoblast proliferation through the AMPK/p21 signaling pathway and promotion of cell differentiation by the BMP/Smad signaling pathway.
Title: Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities.

data suggest that Panx1 and Panx3 are not essential for baseline hearing in mice tested, but the therapeutic targeting of Panx3 may prove protective against mid-high-frequency hearing loss caused by loud NE.
Title: Differential effects of pannexins on noise-induced hearing loss.

The study has identified several genetic loci that influence both body mass index and carcinogenesis and implicate Panx3 as a candidate gene that links these phenotypes through its effects on inflammation and lipid metabolism.
Title: Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.

Our results clearly show that Panx3 ablation produces phenotypic effects in mouse femora and humeri, and support the premise that Panx3 has a role in regulating long bone growth and development.
Title: Global deletion of Panx3 produces multiple phenotypic effects in mouse humeri and femora.

Panx3 functions as an endoplasmic reticulum (ER) Ca(2+) channel to promote differentiation, and it could rescue mineralization defects in Cx43(-/-) calvarial cells.
Title: Pannexin 3 and connexin 43 modulate skeletal development through their distinct functions and expression patterns.