Panx3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Panx3
Entrez Gene ID	315567
Full Name	pannexin 3
General protein information	Preferred Names pannexin 3 Names pannexin-3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q21
Summary	member of the gap junction family; expressed in brain [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_199398.1	NP_955430.1	pannexin-3

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PANX3	XP_852341.2
Bos taurus (cattle)	PANX3	NP_001137556.1
Danio rerio (zebrafish)	panx3	XP_005172766.1
Xenopus tropicalis (tropical clawed frog)	LOC101734171	XP_004916587.1
Homo sapiens (human)	PANX3	NP_443191.1
Gallus gallus (chicken)	PANX3	XP_001231503.1
Pan troglodytes (chimpanzee)	PANX3	XP_001138163.1
	PANX3	XP_001109098.1
Mus musculus (house mouse)	Panx3	NP_766042.2
Rattus norvegicus (Norway rat)	Panx3	NP_955430.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and roles of pannexins in ATP release in the pituitary gland.
Li S, Bjelobaba I, Yan Z, Kucka M, Tomic M, Stojilkovic SS
Endocrinology152(6)2342-52(2011 Jun)

Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat.
Turmel P, Dufresne J, Hermo L, Smith CE, Penuela S, Laird DW, Cyr DG
Molecular reproduction and development78(2)124-38(2011 Feb)

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation.
Celetti SJ, Cowan KN, Penuela S, Shao Q, Churko J, Laird DW
Journal of cell science123(Pt 8)1363-72(2010 Apr)

Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.
Bhalla-Gehi R, Penuela S, Churko JM, Shao Q, Laird DW
The Journal of biological chemistry285(12)9147-60(2010 Mar)

Identification and characterization of pannexin expression in the mammalian cochlea.
Wang XH, Streeter M, Liu YP, Zhao HB
The Journal of comparative neurology512(3)336-46(2009 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pituitary gland expresses mRNA and protein transcripts of pannexins 1 and 2 but not pannexin 3.
Title: Expression and roles of pannexins in ATP release in the pituitary gland.

In the testis, Panx1 localized to the basal compartment of the seminiferous epithelium, while Panx3 was expressed in Leydig cells. In the ED, both Panxs were expressed in the apical region of ciliated cells.
Title: Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat.

Panx1 and Panx3 are coexpressed in the mammalian epidermis, and the regulation of Panx1 plays a key role in keratinocyte differentiation.
Title: Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation.

although Panx1 and Panx3 share a common endoplasmic reticulum to Golgi secretory pathway to Cx43, their ultimate cell surface residency appears to be independent of cell contacts and the need for intact microtubules
Title: Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.

Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions.
Title: Identification and characterization of pannexin expression in the mammalian cochlea.

The following Panx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Panx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05315	NM_199398.1 Latest version!	Rattus norvegicus pannexin 3 (Panx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Panx3 ( NM_199398.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_955430.1 Rattus norvegicus pannexin 3 (Panx3), mRNA.

Price & Availability↑

CloneID	ORa05315
Clone ID Related Accession (Same CDS sequence)	NM_199398.1
Accession Version	NM_199398.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	pannexin-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ557017.1. On Jan 12, 2004 this sequence version replaced XM_236034.1. ##Evidence-Data-START## Transcript exon combination :: AJ557017.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689595, SAMN00632251 [ECO:0000350] ##Evidence-Data-END##

ATGTCACTCG CACACACAGC GGCAGAGTAC ATGCTCTCCG ATGCCCTGCT GCCTGACCGC 
AGGGGCTCTC GGCTCAAAGG GCTGCGTCTG GAACTGCCGC TGGATAAGAT GGTCAAGTTC 
GTTACTGTGG GCTTTCCCTT GCTGCTGATG TCTCTGGCTT TCGCCCAGGA GTTCTCATCA 
GGGTCTCCGA TCAGCTGCTT CTCTCCCAGC AACTTCAGTG TCAGACAGGC TGTGTTTGTG 
GACAGCTCCT GCTGGGACTC ACTGGCTCAC TATAAACAGG ATGAGGCTGG ACAGTACACG 
GTGAAATCTC TCTGGCCTCA CAAGGCTCTC CCCTACTCTC TACTGGCCCT GGCTGTGGCC 
ATGTATCTGC CAGTGCTGCT CTGGCAATAT GCAGCTGTGC CAGCCCTCAG CTCAGACCTG 
CTATTCATCA TCAGTGAGCT GGACAAGTCT TACAACCGCT CCATCCGCCT GGTACAGCAC 
ATGCTGAAGA TCCGGCAGAA GAGCTCTGAC CCTCATGTCT TCTGGGATGA GCTAGAGAAG 
GCCCGGAAGG AACGGTACTT TGAATTTCCC TTGCTAGAGC GGTACCTGGC ATGCAAGCAG 
CGCTCCCATT GGCTAGTGGC CACCTACCTC CTGAGGAACG CCCTTTTACT CCTCTTCACC 
TCAGCCACTT ACCTGTACCT TGGCCACTTC CATTTAGACG TCTTCTTTCA GGAAGAATTC 
AGCTGCTCCA TCAAGACAGG CCTACTCCAT GAGGAGACCC ACGTGCCAGA GCTGATCACA 
TGCAGGCTGA CCTCCCTGTC TGTATTCCAG ATTGTGAGTG TCTCCAGTGT AGCAATATAC 
ACCGTACTGG TCCCAGTGAT AATATACAAC CTCACGCGGC TGTGCCGGTG GGACAAACGA 
CTCCTCTCCA TCTACGAGAT GCTCCCAGCT TTTGATCTCC TCAGTAGAAA GATGCTAGGG 
TGCCCCATCA ATGACCTCAA TGTGATCCTT CTTTTCCTCC GAGCTAATAT CTCTGAGCTC 
ATCTCTTTTA GCTGGCTGAG TGTCTTATGT GTGTTGAAGG ATACAACCAC CCAGAAACAC 
AACATTGACA CAGTGGTCGA TTTTATGACC TTATTGGCTG GCTTAGAACC CTCAAAACCT 
AAACATCTCA CCCAACATAC GTATGATGAA CACCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955430.1
CDS	304..1482
Translation	MSLAHTAAEYMLSDALLPDRRGSRLKGLRLELPLDKMVKFVTVGFPLLLMSLAFAQEFSSGSPISCFSPSNFSVRQAVFVDSSCWDSLAHYKQDEAGQYTVKSLWPHKALPYSLLALAVAMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPHVFWDELEKARKERYFEFPLLERYLACKQRSHWLVATYLLRNALLLLFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLHEETHVPELITCRLTSLSVFQIVSVSSVAIYTVLVPVIIYNLTRLCRWDKRLLSIYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTQHTYDEHP

Target ORF information:

RefSeq Version	NM_199398.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus pannexin 3 (Panx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199398.1

ORF Insert Sequence:

ATGTCACTCG CACACACAGC GGCAGAGTAC ATGCTCTCCG ATGCCCTGCT GCCTGACCGC 
AGGGGCTCTC GGCTCAAAGG GCTGCGTCTG GAACTGCCGC TGGATAAGAT GGTCAAGTTC 
GTTACTGTGG GCTTTCCCTT GCTGCTGATG TCTCTGGCTT TCGCCCAGGA GTTCTCATCA 
GGGTCTCCGA TCAGCTGCTT CTCTCCCAGC AACTTCAGTG TCAGACAGGC TGTGTTTGTG 
GACAGCTCCT GCTGGGACTC ACTGGCTCAC TATAAACAGG ATGAGGCTGG ACAGTACACG 
GTGAAATCTC TCTGGCCTCA CAAGGCTCTC CCCTACTCTC TACTGGCCCT GGCTGTGGCC 
ATGTATCTGC CAGTGCTGCT CTGGCAATAT GCAGCTGTGC CAGCCCTCAG CTCAGACCTG 
CTATTCATCA TCAGTGAGCT GGACAAGTCT TACAACCGCT CCATCCGCCT GGTACAGCAC 
ATGCTGAAGA TCCGGCAGAA GAGCTCTGAC CCTCATGTCT TCTGGGATGA GCTAGAGAAG 
GCCCGGAAGG AACGGTACTT TGAATTTCCC TTGCTAGAGC GGTACCTGGC ATGCAAGCAG 
CGCTCCCATT GGCTAGTGGC CACCTACCTC CTGAGGAACG CCCTTTTACT CCTCTTCACC 
TCAGCCACTT ACCTGTACCT TGGCCACTTC CATTTAGACG TCTTCTTTCA GGAAGAATTC 
AGCTGCTCCA TCAAGACAGG CCTACTCCAT GAGGAGACCC ACGTGCCAGA GCTGATCACA 
TGCAGGCTGA CCTCCCTGTC TGTATTCCAG ATTGTGAGTG TCTCCAGTGT AGCAATATAC 
ACCGTACTGG TCCCAGTGAT AATATACAAC CTCACGCGGC TGTGCCGGTG GGACAAACGA 
CTCCTCTCCA TCTACGAGAT GCTCCCAGCT TTTGATCTCC TCAGTAGAAA GATGCTAGGG 
TGCCCCATCA ATGACCTCAA TGTGATCCTT CTTTTCCTCC GAGCTAATAT CTCTGAGCTC 
ATCTCTTTTA GCTGGCTGAG TGTCTTATGT GTGTTGAAGG ATACAACCAC CCAGAAACAC 
AACATTGACA CAGTGGTCGA TTTTATGACC TTATTGGCTG GCTTAGAACC CTCAAAACCT 
AAACATCTCA CCCAACATAC GTATGATGAA CACCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and roles of pannexins in ATP release in the pituitary gland.
Endocrinology152(6)2342-52(2011 Jun)
Li S,Bjelobaba I,Yan Z,Kucka M,Tomic M,Stojilkovic SS

Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat.
Molecular reproduction and development78(2)124-38(2011 Feb)
Turmel P,Dufresne J,Hermo L,Smith CE,Penuela S,Laird DW,Cyr DG

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation.
Journal of cell science123(Pt 8)1363-72(2010 Apr)
Celetti SJ,Cowan KN,Penuela S,Shao Q,Churko J,Laird DW

Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.
The Journal of biological chemistry285(12)9147-60(2010 Mar)
Bhalla-Gehi R,Penuela S,Churko JM,Shao Q,Laird DW

Identification and characterization of pannexin expression in the mammalian cochlea.
The Journal of comparative neurology512(3)336-46(2009 Jan)
Wang XH,Streeter M,Liu YP,Zhao HB

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Panx3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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