St8sia2 cDNA ORF clone, Mus musculus(house mouse)

ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons.
Szewczyk LM, Brozko N, Nagalski A, R?ckle I, Werneburg S, Hildebrandt H, Wisniewska MB, Kuznicki J
Glia65(1)34-49(2017 Jan)

Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages.
Werneburg S, Buettner FF, Erben L, Mathews M, Neumann H, M?hlenhoff M, Hildebrandt H
Glia64(8)1314-30(2016 Aug)

Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice.
R?ckle I, Hildebrandt H
Developmental neurobiology76(4)421-33(2016 Apr)

Polysialic acid on SynCAM 1 in NG2 cells and on neuropilin-2 in microglia is confined to intracellular pools that are rapidly depleted upon stimulation.
Werneburg S, M?hlenhoff M, Stangel M, Hildebrandt H
Glia63(7)1240-55(2015 Jul)

Promotion of cell migration by neural cell adhesion molecule (NCAM) is enhanced by PSA in a polysialyltransferase-specific manner.
Guan F, Wang X, He F
PloS one10(4)e0124237(2015)

Results demonstrate that the early development of calbindin-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM and requires the activity of both St8sia2 and St8sia4
Title: Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice.

NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX enhanced NCAM-mediated cell migration, but not cell proliferation or motility.
Title: Promotion of cell migration by neural cell adhesion molecule (NCAM) is enhanced by PSA in a polysialyltransferase-specific manner.

These results reveal that reduced polysialylation in St8sia2 (-/-) mice leads to pathological brain development and schizophrenia-like behavior.
Title: Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.

This study demonstrated that St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.
Title: St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.

Results indicate that the polySTs ST8SiaII and ST8SiaIV not only recognize an acidic patch in the FN1 domain of NCAM but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.
Title: The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation.