Saa3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Saa3
Entrez Gene ID	20210
Full Name	serum amyloid A 3
Synonyms	AV098916,Saa-3,l7R3
General protein information	Preferred Names serum amyloid A 3 Names serum amyloid A-3 protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 30.51 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_030242257.1	XP_030098117.1	serum amyloid A-3 protein isoform X1
NM_011315.3	NP_035445.1	serum amyloid A-3 protein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC100613368	XP_003312987.1
Mus musculus (house mouse)	Saa3	NP_035445.1
Rattus norvegicus (Norway rat)	Saal1	XP_003748908.2
	SAA3P	XP_001083767.2

Gene Ontology
Bibliography

Related articles in PubMed

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
Djurec M, Gra?a O, Lee A, Troul? K, Espinet E, Cabras L, Navas C, Blasco MT, Mart?n-D?az L, Burdiel M, Li J, Liu Z, Vallespin?s M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B Jr., Al-Shahrour F, Rabadan R, Guerra C, Barbacid M
Proceedings of the National Academy of Sciences of the United States of America(2018 Jan)

Serum Amyloid A3 is a High-Density Lipoprotein-associated Acute Phase Protein.
Tannock LR, De Beer MC, Ji A, Shridas P, Noffsinger VP, den Hartigh L, Chait A, de Beer FC, Webb NR
Journal of lipid research(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The induction of Saa3 by PTH may explain the suppression of bone formation when PTH is applied continuously and may be a new therapeutic target for osteoporosis.
Title: Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts.

Expression of Saa3 in osteoblasts positively correlates with increased cellular maturation toward the osteocyte phenotype.
Title: Acute-phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis.

These results suggest that SAA3 plays a role in host innate immunity in the colon by up-regulating MUC2 mucin production, which builds a physiological barrier of colonic epithelia against bacterial invasion.
Title: Up-regulation of MUC2 mucin expression by serum amyloid A3 protein in mouse colonic epithelial cells.

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.
Title: Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.

results also suggest that Saa3 influences liver-specific SAA1/2 expression, and that SAA3 could play a larger role in the acute phase response than previously thought
Title: Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice.

The following Saa3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Saa3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19669	NM_011315.3 Latest version!	Mus musculus serum amyloid A 3 (Saa3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu89397	XM_030242257.1 Latest version!	Mus musculus serum amyloid A 3 (Saa3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Saa3 ( NM_011315.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035445.1 Mus musculus serum amyloid A 3 (Saa3), mRNA.

Price & Availability↑

CloneID	OMu19669
Clone ID Related Accession (Same CDS sequence)	NM_011315.3
Accession Version	NM_011315.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 369bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-02
Organism	Mus musculus(house mouse)
Product	serum amyloid A-3 protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC090122.26. On Nov 17, 2006 this sequence version replaced NM_011315.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC055885.1, CJ135837.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164135 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCCTT CCATTGCCAT CATTCTTTGC ATCTTGATCC TGGGAGTTGA CAGCCAAAGA 
TGGGTCCAGT TCATGAAAGA AGCTGGTCAA GGGTCTAGAG ACATGTGGCG AGCCTACTCT 
GACATGAAGA AAGCTAACTG GAAAAACTCA GACAAATACT TCCATGCTCG GGGGAACTAT 
GATGCTGCCC GGAGGGGTCC CGGGGGAGCC TGGGCTGCTA AAGTCATCAG CGATGCCAGA 
GAGGCTGTTC AGAAGTTCAC GGGACATGGA GCAGAGGACT CAAGAGCTGA CCAGTTTGCC 
AATGAGTGGG GCCGGAGTGG CAAAGACCCC AACCACTTCC GACCTGCTGG CCTGCCTAAA 
AGATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035445.1
CDS	35..403
Translation	MKPSIAIILCILILGVDSQRWVQFMKEAGQGSRDMWRAYSDMKKANWKNSDKYFHARGNYDAARRGPGGAWAAKVISDAREAVQKFTGHGAEDSRADQFANEWGRSGKDPNHFRPAGLPKRY

Target ORF information:

RefSeq Version	NM_011315.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus serum amyloid A 3 (Saa3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011315.3

ORF Insert Sequence:

ATGAAGCCTT CCATTGCCAT CATTCTTTGC ATCTTGATCC TGGGAGTTGA CAGCCAAAGA 
TGGGTCCAGT TCATGAAAGA AGCTGGTCAA GGGTCTAGAG ACATGTGGCG AGCCTACTCT 
GACATGAAGA AAGCTAACTG GAAAAACTCA GACAAATACT TCCATGCTCG GGGGAACTAT 
GATGCTGCCC GGAGGGGTCC CGGGGGAGCC TGGGCTGCTA AAGTCATCAG CGATGCCAGA 
GAGGCTGTTC AGAAGTTCAC GGGACATGGA GCAGAGGACT CAAGAGCTGA CCAGTTTGCC 
AATGAGTGGG GCCGGAGTGG CAAAGACCCC AACCACTTCC GACCTGCTGG CCTGCCTAAA 
AGATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Saa3 ( XM_030242257.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030098117.1 Mus musculus serum amyloid A 3 (Saa3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu89397
Clone ID Related Accession (Same CDS sequence)	XM_030242257.1
Accession Version	XM_030242257.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	serum amyloid A-3 protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGAAGA CTTCAGAAAG TCCTAACTGG CCACATTTCT GGAAATGCCT AGATGGCGCA 
ATCTGGGGAA AGAAGATGTA CATGAAGGAA AAGTTATCTT CTGAAAGAGA AATTATGGGT 
AAGTGGGATT ATGCAAGATC AAACAGGGAT TGCTCCATTA GTGGAGTGAC AGTATATATA 
GATATCCTCG GCCACATCTC CTCAGCAAAG GACAGAAGCC ACTCACCTGG GGTCCCAGAA 
GGAGCTCGCA GCACGAGCAG GATGAAGCCT TCCATTGCCA TCATTCTTTG CATCTTGATC 
CTGGGAGTTG ACAGCCAAAG ATGGGTCCAG TTCATGAAAG AAGCTGGTCA AGGGTCTAGA 
GACATGTGGC GAGCCTACTC TGACATGAAG AAAGCTAACT GGAAAAACTC AGACAAATAC 
TTCCATGCTC GGGGGAACTA TGATGCTGCC CGGAGGGGTC CCGGGGGAGC CTGGGCTGCT 
AAAGTCATCA GCGATGCCAG AGAGGCTGTT CAGAAGTTCA CGGGACATGG AGCAGAGGAC 
TCAAGAGCTG ACCAGTTTGC CAATGAGTGG GGCCGGAGTG GCAAAGACCC CAACCACTTC 
CGACCTGCTG GCCTGCCTAA AAGATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030098117.1
CDS	26..655
Translation	MAKTSESPNWPHFWKCLDGAIWGKKMYMKEKLSSEREIMGKWDYARSNRDCSISGVTVYIDILGHISSAKDRSHSPGVPEGARSTSRMKPSIAIILCILILGVDSQRWVQFMKEAGQGSRDMWRAYSDMKKANWKNSDKYFHARGNYDAARRGPGGAWAAKVISDAREAVQKFTGHGAEDSRADQFANEWGRSGKDPNHFRPAGLPKRY

Target ORF information:

RefSeq Version	XM_030242257.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus serum amyloid A 3 (Saa3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030242257.1

ORF Insert Sequence:

ATGGCGAAGA CTTCAGAAAG TCCTAACTGG CCACATTTCT GGAAATGCCT AGATGGCGCA 
ATCTGGGGAA AGAAGATGTA CATGAAGGAA AAGTTATCTT CTGAAAGAGA AATTATGGGT 
AAGTGGGATT ATGCAAGATC AAACAGGGAT TGCTCCATTA GTGGAGTGAC AGTATATATA 
GATATCCTCG GCCACATCTC CTCAGCAAAG GACAGAAGCC ACTCACCTGG GGTCCCAGAA 
GGAGCTCGCA GCACGAGCAG GATGAAGCCT TCCATTGCCA TCATTCTTTG CATCTTGATC 
CTGGGAGTTG ACAGCCAAAG ATGGGTCCAG TTCATGAAAG AAGCTGGTCA AGGGTCTAGA 
GACATGTGGC GAGCCTACTC TGACATGAAG AAAGCTAACT GGAAAAACTC AGACAAATAC 
TTCCATGCTC GGGGGAACTA TGATGCTGCC CGGAGGGGTC CCGGGGGAGC CTGGGCTGCT 
AAAGTCATCA GCGATGCCAG AGAGGCTGTT CAGAAGTTCA CGGGACATGG AGCAGAGGAC 
TCAAGAGCTG ACCAGTTTGC CAATGAGTGG GGCCGGAGTG GCAAAGACCC CAACCACTTC 
CGACCTGCTG GCCTGCCTAA AAGATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
Proceedings of the National Academy of Sciences of the United States of America(2018 Jan)
Djurec M,Gra?a O,Lee A,Troul? K,Espinet E,Cabras L,Navas C,Blasco MT,Mart?n-D?az L,Burdiel M,Li J,Liu Z,Vallespin?s M,Sanchez-Bueno F,Sprick MR,Trumpp A,Sainz B Jr.,Al-Shahrour F,Rabadan R,Guerra C,Barbacid M

Serum Amyloid A3 is a High-Density Lipoprotein-associated Acute Phase Protein.
Journal of lipid research(2017 Dec)
Tannock LR,De Beer MC,Ji A,Shridas P,Noffsinger VP,den Hartigh L,Chait A,de Beer FC,Webb NR

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Saa3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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