Rgs5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rgs5
Entrez Gene ID	19737
Full Name	regulator of G-protein signaling 5
Synonyms	1110070A02Rik
General protein information	Preferred Names regulator of G-protein signaling 5 Names regulator of G-protein signaling 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H2.3\|1 76.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009063.4	NP_033089.2	regulator of G-protein signaling 5 isoform 1
NM_001313705.1	NP_001300634.1	regulator of G-protein signaling 5 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	RGS5	NP_003608.1
Xenopus tropicalis (tropical clawed frog)	rgs5	NP_001072762.1
Pan troglodytes (chimpanzee)	RGS5	XP_001174440.1
	RGS5	XP_001082591.1
Danio rerio (zebrafish)	rgs5a	NP_956256.1
Bos taurus (cattle)	RGS5	NP_001029879.1
Rattus norvegicus (Norway rat)	Rgs5	NP_062214.1
Canis lupus familiaris (dog)	RGS5	XP_545784.2
Mus musculus (house mouse)	Rgs5	NP_033089.2
Gallus gallus (chicken)	RGS5	XP_001233314.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5.
Arnold C, Demirel E, Feldner A, Genov? G, Zhang H, Sticht C, Wieland T, Hecker M, Heximer S, Korff T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Dec)

Regulator of G protein signaling 5 (RGS5) inhibits sonic hedgehog function in mouse cortical neurons.
Liu C, Hu Q, Jing J, Zhang Y, Jin J, Zhang L, Mu L, Liu Y, Sun B, Zhang T, Kong Q, Wang G, Wang D, Zhang Y, Liu X, Zhao W, Wang J, Feng T, Li H
Molecular and cellular neurosciences8365-73(2017 Sep)

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies show that RGS5 protects cardiomyocytes against apoptosis during myocardial ischemia-reperfusion injury through inhibiting both JNK1/2 and p38 signaling pathways.
Title: Regulator of G-protein signaling 5 protects cardiomyocytes against apoptosis during in?vitro cardiac ischemia-reperfusion in mice by inhibiting both JNK1/2 and P38 signaling pathways.

Rgs5 prevents vagal-related bradycardia and atrial tachycardia by negatively regulating the IKA Ach current.
Title: Potential Role of Regulator of G-Protein Signaling 5 in the Protection of Vagal-Related Bradycardia and Atrial Tachyarrhythmia.

Downregulation of RGS5 is an important prerequisite for smooth muscle cell proliferation in vascular injury model.
Title: Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.

RGS5 deletion accelerated development of atherosclerosis and decreased the stability of atherosclerotic plaques partly through activating NF-kappaB and the MEK-ERK1/2 signalling pathways
Title: Regulator of G-protein signalling 5 protects against atherosclerosis in apolipoprotein E-deficient mice.

findings highlight a key role of RGS5 at the interface between AngII and PPAR signaling
Title: Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia.

The following Rgs5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgs5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu68617	NM_001313705.1 Latest version!	Mus musculus regulator of G-protein signaling 5 (Rgs5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu03438	NM_009063.4 Latest version!	Mus musculus regulator of G-protein signaling 5 (Rgs5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rgs5 ( NM_001313705.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001300634.1 Mus musculus regulator of G-protein signaling 5 (Rgs5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu68617
Clone ID Related Accession (Same CDS sequence)	NM_001313705.1
Accession Version	NM_001313705.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 225bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	regulator of G-protein signaling 5 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC117808.8 and AC115766.9. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK795249.1, AA611978.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTAAGG GACTGGCAGC TCTGCCGCAC TCATGCCTGG AAAGGGCCAA GGAGATCAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCTGCTG TTGACCTTGT CATTCCATAC 
AATGAGAAGC CAGAGAAGCC TGCCAAGGCA CACAAGCCCT CACTGGAGGA GGTCCTGCAG 
TGGCGCCAGT CCCTGGACAA GCTTCTCCAG AACAGCTGTT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001300634.1
CDS	78..302
Translation	MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQNSCS

Target ORF information:

RefSeq Version	NM_001313705.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus regulator of G-protein signaling 5 (Rgs5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001313705.1

ORF Insert Sequence:

ATGTGTAAGG GACTGGCAGC TCTGCCGCAC TCATGCCTGG AAAGGGCCAA GGAGATCAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCTGCTG TTGACCTTGT CATTCCATAC 
AATGAGAAGC CAGAGAAGCC TGCCAAGGCA CACAAGCCCT CACTGGAGGA GGTCCTGCAG 
TGGCGCCAGT CCCTGGACAA GCTTCTCCAG AACAGCTGTT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rgs5 ( NM_009063.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033089.2 Mus musculus regulator of G-protein signaling 5 (Rgs5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu03438
Clone ID Related Accession (Same CDS sequence)	NM_009063.4
Accession Version	NM_009063.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	regulator of G-protein signaling 5 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK054098.1 and AC115766.9. On Aug 27, 2015 this sequence version replaced NM_009063.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028765.1, SRR1660817.308525.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTAAGG GACTGGCAGC TCTGCCGCAC TCATGCCTGG AAAGGGCCAA GGAGATCAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCTGCTG TTGACCTTGT CATTCCATAC 
AATGAGAAGC CAGAGAAGCC TGCCAAGGCA CACAAGCCCT CACTGGAGGA GGTCCTGCAG 
TGGCGCCAGT CCCTGGACAA GCTTCTCCAG AACAGCTATG GATTTGCCAG CTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGGTTGCCTG TGAGAATTAC 
AAGAAGATCA AGTCCCCCAT CAAAATGGCG GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATCCAGACAG AGGCCCCTAA AGAGGTGAAC ATTGACCACT TCACTAAAGA CATCACCATG 
AAGAACCTGG TGGAACCGTC TCCTCGCAGC TTTGACTTGG CCCAGAAAAG GATCTATGCC 
CTGATGGAGA AGGATTCTCT GCCCCGCTTT GTGCGCTCTG AATTTTATAA GGAGCTAATC 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033089.2
CDS	78..623
Translation	MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKPEKPAKAHKPSLEEVLQWRQSLDKLLQNSYGFASFKSFLKSEFSEENLEFWVACENYKKIKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPRSFDLAQKRIYALMEKDSLPRFVRSEFYKELIK

Target ORF information:

RefSeq Version	NM_009063.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus regulator of G-protein signaling 5 (Rgs5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009063.4

ORF Insert Sequence:

ATGTGTAAGG GACTGGCAGC TCTGCCGCAC TCATGCCTGG AAAGGGCCAA GGAGATCAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCTGCTG TTGACCTTGT CATTCCATAC 
AATGAGAAGC CAGAGAAGCC TGCCAAGGCA CACAAGCCCT CACTGGAGGA GGTCCTGCAG 
TGGCGCCAGT CCCTGGACAA GCTTCTCCAG AACAGCTATG GATTTGCCAG CTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGGTTGCCTG TGAGAATTAC 
AAGAAGATCA AGTCCCCCAT CAAAATGGCG GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATCCAGACAG AGGCCCCTAA AGAGGTGAAC ATTGACCACT TCACTAAAGA CATCACCATG 
AAGAACCTGG TGGAACCGTC TCCTCGCAGC TTTGACTTGG CCCAGAAAAG GATCTATGCC 
CTGATGGAGA AGGATTCTCT GCCCCGCTTT GTGCGCTCTG AATTTTATAA GGAGCTAATC 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Dec)
Arnold C,Demirel E,Feldner A,Genov? G,Zhang H,Sticht C,Wieland T,Hecker M,Heximer S,Korff T

Regulator of G protein signaling 5 (RGS5) inhibits sonic hedgehog function in mouse cortical neurons.
Molecular and cellular neurosciences8365-73(2017 Sep)
Liu C,Hu Q,Jing J,Zhang Y,Jin J,Zhang L,Mu L,Liu Y,Sun B,Zhang T,Kong Q,Wang G,Wang D,Zhang Y,Liu X,Zhao W,Wang J,Feng T,Li H

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

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Rgs5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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