RGS5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGS5
Entrez Gene ID	8490
Full Name	regulator of G protein signaling 5
Synonyms	MST092,MST106,MST129,MSTP032,MSTP092,MSTP106,MSTP129
General protein information	Preferred Names regulator of G protein signaling 5 Names regulator of G-protein signaling 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Summary	This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011].
Disorder MIM:	603276
Disorder Html:	[Blood pressure regulation QTL], 145500 (2)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001195303.2	NP_001182232.1	regulator of G-protein signaling 5 isoform 2
NM_001254748.1	NP_001241677.1	regulator of G-protein signaling 5 isoform 2
NM_001254749.1	NP_001241678.1	regulator of G-protein signaling 5 isoform 3
NM_003617.3	NP_003608.1	regulator of G-protein signaling 5 isoform 1
NM_001254749.2	NP_001241678.1	regulator of G-protein signaling 5 isoform 3
NM_003617.4	NP_003608.1	regulator of G-protein signaling 5 isoform 1
NM_001195303.3	NP_001182232.1	regulator of G-protein signaling 5 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	RGS5	NP_003608.1
Xenopus tropicalis (tropical clawed frog)	rgs5	NP_001072762.1
Pan troglodytes (chimpanzee)	RGS5	XP_001174440.1
	RGS5	XP_001082591.1
Danio rerio (zebrafish)	rgs5a	NP_956256.1
Bos taurus (cattle)	RGS5	NP_001029879.1
Rattus norvegicus (Norway rat)	Rgs5	NP_062214.1
Canis lupus familiaris (dog)	RGS5	XP_545784.2
Mus musculus (house mouse)	Rgs5	NP_033089.2
Gallus gallus (chicken)	RGS5	XP_001233314.1

Gene Ontology
Bibliography

Related articles in PubMed

Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
Song D, Nishiyama M, Kimura S
Journal of receptor and signal transduction research36(5)478-87(2016 Oct)

Potential Role of Regulator of G-Protein Signaling 5 in the Protection of Vagal-Related Bradycardia and Atrial Tachyarrhythmia.
Qin M, Liu X, Liu T, Wang T, Huang C
Journal of the American Heart Association5(3)e002783(2016 Mar)

Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.
Daniel JM, Prock A, Dutzmann J, Sonnenschein K, Thum T, Bauersachs J, Sedding DG
Arteriosclerosis, thrombosis, and vascular biology36(2)317-27(2016 Feb)

Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations.
Chang PY, Qin L, Zhao P, Liu ZY
Genetics and molecular research : GMR14(4)17641-50(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The chimeric RGS8 domains containing the first or the second exon part of RGS5 showed strong inhibitory effects similar to that of wild type RGS8, but the chimeric domain with the third exon part of RGS5 lost its activity
Title: Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.

Rgs5 prevents vagal-related bradycardia and atrial tachycardia by negatively regulating the IKA Ach current.
Title: Potential Role of Regulator of G-Protein Signaling 5 in the Protection of Vagal-Related Bradycardia and Atrial Tachyarrhythmia.

Downregulation of RGS5 is an important prerequisite for smooth muscle cell proliferation in vascular injury model.
Title: Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.

The pericyte marker RGS5 may be of future clinical utility for the evaluation of pericytic differentiation in soft tissue tumors.
Title: The pericyte antigen RGS5 in perivascular soft tissue tumors.

The rs16849802 of RGS5 and haplotype GAA independently increased the risk of essential hypertension in Mongolian patients, and may be used as a risk factor for the prediction of high blood pressure.
Title: Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations.

The following RGS5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGS5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14694	NM_001195303.3 Latest version!	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14694	NM_001254748.1 Latest version!	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14762	NM_001254749.2 Latest version!	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22885	NM_003617.4 Latest version!	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu14762	NM_001254749.1	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22885	NM_003617.3	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu14694	NM_001195303.2	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGS5 ( NM_001195303.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182232.1 Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14694
Clone ID Related Accession (Same CDS sequence)	NM_001195303.2 , NM_001254748.1 , NM_001195303.3
Accession Version	NM_001195303.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 5 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA731601.1, DA699380.1, AJ891044.1, BX537427.1, AL583850.5 and AL157502.1. On or before Dec 16, 2011 this sequence version replaced XR_111966.1, XR_108295.1, NM_001195303.1. Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ891044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGA AGGCAAAGCA AATTTATGAA GAATTCATTC AAACGGAGGC TCCTAAAGAG 
GTGAATATTG ACCACTTCAC TAAGGACATC ACAATGAAGA ACCTGGTGGA ACCTTCCCTG 
AGCAGCTTTG ACATGGCCCA GAAAAGAATC CATGCCCTGA TGGAAAAGGA TTCTCTGCCT 
CGCTTTGTGC GCTCTGAGTT TTATCAGGAG TTAATCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182232.1
CDS	490..711
Translation	MAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK

Target ORF information:

RefSeq Version	NM_001195303.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195303.2

ORF Insert Sequence:

ATGGCTGAGA AGGCAAAGCA AATTTATGAA GAATTCATTC AAACGGAGGC TCCTAAAGAG 
GTGAATATTG ACCACTTCAC TAAGGACATC ACAATGAAGA ACCTGGTGGA ACCTTCCCTG 
AGCAGCTTTG ACATGGCCCA GAAAAGAATC CATGCCCTGA TGGAAAAGGA TTCTCTGCCT 
CGCTTTGTGC GCTCTGAGTT TTATCAGGAG TTAATCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS5 ( NM_001254748.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001241677.1 Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu14694
Clone ID Related Accession (Same CDS sequence)	NM_001195303.2 , NM_001254748.1 , NM_001195303.3
Accession Version	NM_001254748.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 5 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB991106.1, BP292867.1, BX537427.1, AL583850.5 and AL157502.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.191880.1, SRR1660805.217522.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGA AGGCAAAGCA AATTTATGAA GAATTCATTC AAACGGAGGC TCCTAAAGAG 
GTGAATATTG ACCACTTCAC TAAGGACATC ACAATGAAGA ACCTGGTGGA ACCTTCCCTG 
AGCAGCTTTG ACATGGCCCA GAAAAGAATC CATGCCCTGA TGGAAAAGGA TTCTCTGCCT 
CGCTTTGTGC GCTCTGAGTT TTATCAGGAG TTAATCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001241677.1
CDS	548..769
Translation	MAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK

Target ORF information:

RefSeq Version	NM_001254748.1
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001254748.1

ORF Insert Sequence:

ATGGCTGAGA AGGCAAAGCA AATTTATGAA GAATTCATTC AAACGGAGGC TCCTAAAGAG 
GTGAATATTG ACCACTTCAC TAAGGACATC ACAATGAAGA ACCTGGTGGA ACCTTCCCTG 
AGCAGCTTTG ACATGGCCCA GAAAAGAATC CATGCCCTGA TGGAAAAGGA TTCTCTGCCT 
CGCTTTGTGC GCTCTGAGTT TTATCAGGAG TTAATCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS5 ( NM_001195303.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182232.1 Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14694
Clone ID Related Accession (Same CDS sequence)	NM_001195303.2 , NM_001254748.1 , NM_001195303.3
Accession Version	NM_001195303.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 222bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 5 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA699380.1, AJ891044.1, BX537427.1, AL583850.5 and AL157502.1. On Jun 1, 2019 this sequence version replaced NM_001195303.2. Transcript Variant: This variant (2) lacks two alternate exons in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2, also known as RGS5s), which is localized almost exclusively to the cytosolic fraction, is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 3 encode isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.632040.1, AJ891044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGA AGGCAAAGCA AATTTATGAA GAATTCATTC AAACGGAGGC TCCTAAAGAG 
GTGAATATTG ACCACTTCAC TAAGGACATC ACAATGAAGA ACCTGGTGGA ACCTTCCCTG 
AGCAGCTTTG ACATGGCCCA GAAAAGAATC CATGCCCTGA TGGAAAAGGA TTCTCTGCCT 
CGCTTTGTGC GCTCTGAGTT TTATCAGGAG TTAATCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182232.1
CDS	233..454
Translation	MAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK

Target ORF information:

RefSeq Version	NM_001195303.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195303.3

ORF Insert Sequence:

ATGGCTGAGA AGGCAAAGCA AATTTATGAA GAATTCATTC AAACGGAGGC TCCTAAAGAG 
GTGAATATTG ACCACTTCAC TAAGGACATC ACAATGAAGA ACCTGGTGGA ACCTTCCCTG 
AGCAGCTTTG ACATGGCCCA GAAAAGAATC CATGCCCTGA TGGAAAAGGA TTCTCTGCCT 
CGCTTTGTGC GCTCTGAGTT TTATCAGGAG TTAATCAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS5 ( NM_001254749.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001241678.1 Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu14762
Clone ID Related Accession (Same CDS sequence)	NM_001254749.1 , NM_001254749.2
Accession Version	NM_001254749.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 5 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA731601.1, DA699380.1, BU172751.1, BX537427.1, AL583850.5 and AL157502.1. Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.46406.1, SRR1803617.360514.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCAAAG GACTTGCAGC TTTGCCCCAC TCATGCCTGG AAAGGGCCAA GGAGATTAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCAGTTG GTGACCTTGT CATTCCGTAC 
AATGAGAAGC CAGAGAAACC AGCCAAGACC CAGAAAACCT CGCTGGACGA GGCCCTGCAG 
TGGCGTGATT CCCTGGACAA ACTCCTGCAG AACAACTATG GACTTGCCAG TTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGATTGCCTG TGAGGATTAC 
AAGAAGATCA AGTCCCCTGC CAAGATGGCT GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATTCAAACGG AGGCTCCTAA AGAGGTTGGT CTCTGGGTGA ATATTGACCA CTTCACTAAG 
GACATCACAA TGAAGAACCT GGTGGAACCT TCCCTGAGCA GCTTTGACAT GGCCCAGAAA 
AGAATCCATG CCCTGATGGA AAAGGATTCT CTGCCTCGCT TTGTGCGCTC TGAGTTTTAT 
CAGGAGTTAA TCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001241678.1
CDS	339..896
Translation	MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVGLWVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK

Target ORF information:

RefSeq Version	NM_001254749.1
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001254749.1

ORF Insert Sequence:

ATGTGCAAAG GACTTGCAGC TTTGCCCCAC TCATGCCTGG AAAGGGCCAA GGAGATTAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCAGTTG GTGACCTTGT CATTCCGTAC 
AATGAGAAGC CAGAGAAACC AGCCAAGACC CAGAAAACCT CGCTGGACGA GGCCCTGCAG 
TGGCGTGATT CCCTGGACAA ACTCCTGCAG AACAACTATG GACTTGCCAG TTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGATTGCCTG TGAGGATTAC 
AAGAAGATCA AGTCCCCTGC CAAGATGGCT GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATTCAAACGG AGGCTCCTAA AGAGGTTGGT CTCTGGGTGA ATATTGACCA CTTCACTAAG 
GACATCACAA TGAAGAACCT GGTGGAACCT TCCCTGAGCA GCTTTGACAT GGCCCAGAAA 
AGAATCCATG CCCTGATGGA AAAGGATTCT CTGCCTCGCT TTGTGCGCTC TGAGTTTTAT 
CAGGAGTTAA TCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS5 ( NM_001254749.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001241678.1 Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu14762
Clone ID Related Accession (Same CDS sequence)	NM_001254749.1 , NM_001254749.2
Accession Version	NM_001254749.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 5 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA699380.1, BU172751.1, BX537427.1, AL583850.5 and AL157502.1. On Jun 1, 2019 this sequence version replaced NM_001254749.1. Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.46406.1, SRR5189667.140517.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCAAAG GACTTGCAGC TTTGCCCCAC TCATGCCTGG AAAGGGCCAA GGAGATTAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCAGTTG GTGACCTTGT CATTCCGTAC 
AATGAGAAGC CAGAGAAACC AGCCAAGACC CAGAAAACCT CGCTGGACGA GGCCCTGCAG 
TGGCGTGATT CCCTGGACAA ACTCCTGCAG AACAACTATG GACTTGCCAG TTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGATTGCCTG TGAGGATTAC 
AAGAAGATCA AGTCCCCTGC CAAGATGGCT GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATTCAAACGG AGGCTCCTAA AGAGGTTGGT CTCTGGGTGA ATATTGACCA CTTCACTAAG 
GACATCACAA TGAAGAACCT GGTGGAACCT TCCCTGAGCA GCTTTGACAT GGCCCAGAAA 
AGAATCCATG CCCTGATGGA AAAGGATTCT CTGCCTCGCT TTGTGCGCTC TGAGTTTTAT 
CAGGAGTTAA TCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001241678.1
CDS	82..639
Translation	MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVGLWVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK

Target ORF information:

RefSeq Version	NM_001254749.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001254749.2

ORF Insert Sequence:

ATGTGCAAAG GACTTGCAGC TTTGCCCCAC TCATGCCTGG AAAGGGCCAA GGAGATTAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCAGTTG GTGACCTTGT CATTCCGTAC 
AATGAGAAGC CAGAGAAACC AGCCAAGACC CAGAAAACCT CGCTGGACGA GGCCCTGCAG 
TGGCGTGATT CCCTGGACAA ACTCCTGCAG AACAACTATG GACTTGCCAG TTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGATTGCCTG TGAGGATTAC 
AAGAAGATCA AGTCCCCTGC CAAGATGGCT GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATTCAAACGG AGGCTCCTAA AGAGGTTGGT CTCTGGGTGA ATATTGACCA CTTCACTAAG 
GACATCACAA TGAAGAACCT GGTGGAACCT TCCCTGAGCA GCTTTGACAT GGCCCAGAAA 
AGAATCCATG CCCTGATGGA AAAGGATTCT CTGCCTCGCT TTGTGCGCTC TGAGTTTTAT 
CAGGAGTTAA TCAAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS5 ( NM_003617.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003608.1 Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 1, mRNA.

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CloneID	OHu22885
Clone ID Related Accession (Same CDS sequence)	NM_003617.3 , NM_003617.4
Accession Version	NM_003617.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL451063.4, BC030059.1 and AL583850.5. This sequence is a reference standard in the RefSeqGene project. On May 7, 2010 this sequence version replaced NM_003617.2. Transcript Variant: This variant (1) encodes isoform 1 (also known as RGS5), which is present in both the membrane and cytosolic fractions. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.20891.1, SRR1803611.109999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267754 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCAAAG GACTTGCAGC TTTGCCCCAC TCATGCCTGG AAAGGGCCAA GGAGATTAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCAGTTG GTGACCTTGT CATTCCGTAC 
AATGAGAAGC CAGAGAAACC AGCCAAGACC CAGAAAACCT CGCTGGACGA GGCCCTGCAG 
TGGCGTGATT CCCTGGACAA ACTCCTGCAG AACAACTATG GACTTGCCAG TTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGATTGCCTG TGAGGATTAC 
AAGAAGATCA AGTCCCCTGC CAAGATGGCT GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATTCAAACGG AGGCTCCTAA AGAGGTGAAT ATTGACCACT TCACTAAGGA CATCACAATG 
AAGAACCTGG TGGAACCTTC CCTGAGCAGC TTTGACATGG CCCAGAAAAG AATCCATGCC 
CTGATGGAAA AGGATTCTCT GCCTCGCTTT GTGCGCTCTG AGTTTTATCA GGAGTTAATC 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003608.1
CDS	339..884
Translation	MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK

Target ORF information:

RefSeq Version	NM_003617.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003617.3

ORF Insert Sequence:

ATGTGCAAAG GACTTGCAGC TTTGCCCCAC TCATGCCTGG AAAGGGCCAA GGAGATTAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCAGTTG GTGACCTTGT CATTCCGTAC 
AATGAGAAGC CAGAGAAACC AGCCAAGACC CAGAAAACCT CGCTGGACGA GGCCCTGCAG 
TGGCGTGATT CCCTGGACAA ACTCCTGCAG AACAACTATG GACTTGCCAG TTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGATTGCCTG TGAGGATTAC 
AAGAAGATCA AGTCCCCTGC CAAGATGGCT GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATTCAAACGG AGGCTCCTAA AGAGGTGAAT ATTGACCACT TCACTAAGGA CATCACAATG 
AAGAACCTGG TGGAACCTTC CCTGAGCAGC TTTGACATGG CCCAGAAAAG AATCCATGCC 
CTGATGGAAA AGGATTCTCT GCCTCGCTTT GTGCGCTCTG AGTTTTATCA GGAGTTAATC 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS5 ( NM_003617.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003608.1 Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22885
Clone ID Related Accession (Same CDS sequence)	NM_003617.3 , NM_003617.4
Accession Version	NM_003617.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 5 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL451063.4, BC030059.1 and AL583850.5. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003617.3. Transcript Variant: This variant (1) encodes isoform 1 (also known as RGS5), which is present in both the membrane and cytosolic fractions. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.108252.1, SRR1660803.20891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267754 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000313961.10/ ENSP00000319308.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTGCAAAG GACTTGCAGC TTTGCCCCAC TCATGCCTGG AAAGGGCCAA GGAGATTAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCAGTTG GTGACCTTGT CATTCCGTAC 
AATGAGAAGC CAGAGAAACC AGCCAAGACC CAGAAAACCT CGCTGGACGA GGCCCTGCAG 
TGGCGTGATT CCCTGGACAA ACTCCTGCAG AACAACTATG GACTTGCCAG TTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGATTGCCTG TGAGGATTAC 
AAGAAGATCA AGTCCCCTGC CAAGATGGCT GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATTCAAACGG AGGCTCCTAA AGAGGTGAAT ATTGACCACT TCACTAAGGA CATCACAATG 
AAGAACCTGG TGGAACCTTC CCTGAGCAGC TTTGACATGG CCCAGAAAAG AATCCATGCC 
CTGATGGAAA AGGATTCTCT GCCTCGCTTT GTGCGCTCTG AGTTTTATCA GGAGTTAATC 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003608.1
CDS	82..627
Translation	MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELIK

Target ORF information:

RefSeq Version	NM_003617.4
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 5 (RGS5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003617.4

ORF Insert Sequence:

ATGTGCAAAG GACTTGCAGC TTTGCCCCAC TCATGCCTGG AAAGGGCCAA GGAGATTAAG 
ATCAAGTTGG GAATTCTCCT CCAGAAGCCA GACTCAGTTG GTGACCTTGT CATTCCGTAC 
AATGAGAAGC CAGAGAAACC AGCCAAGACC CAGAAAACCT CGCTGGACGA GGCCCTGCAG 
TGGCGTGATT CCCTGGACAA ACTCCTGCAG AACAACTATG GACTTGCCAG TTTCAAAAGT 
TTCCTGAAGT CTGAATTCAG TGAGGAAAAC CTTGAGTTCT GGATTGCCTG TGAGGATTAC 
AAGAAGATCA AGTCCCCTGC CAAGATGGCT GAGAAGGCAA AGCAAATTTA TGAAGAATTC 
ATTCAAACGG AGGCTCCTAA AGAGGTGAAT ATTGACCACT TCACTAAGGA CATCACAATG 
AAGAACCTGG TGGAACCTTC CCTGAGCAGC TTTGACATGG CCCAGAAAAG AATCCATGCC 
CTGATGGAAA AGGATTCTCT GCCTCGCTTT GTGCGCTCTG AGTTTTATCA GGAGTTAATC 
AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
Journal of receptor and signal transduction research36(5)478-87(2016 Oct)
Song D,Nishiyama M,Kimura S

Potential Role of Regulator of G-Protein Signaling 5 in the Protection of Vagal-Related Bradycardia and Atrial Tachyarrhythmia.
Journal of the American Heart Association5(3)e002783(2016 Mar)
Qin M,Liu X,Liu T,Wang T,Huang C

Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.
Arteriosclerosis, thrombosis, and vascular biology36(2)317-27(2016 Feb)
Daniel JM,Prock A,Dutzmann J,Sonnenschein K,Thum T,Bauersachs J,Sedding DG

Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations.
Genetics and molecular research : GMR14(4)17641-50(2015 Dec)
Chang PY,Qin L,Zhao P,Liu ZY

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RGS5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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