Rasd1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rasd1
Entrez Gene ID	19416
Full Name	RAS, dexamethasone-induced 1
Synonyms	Dexras1
General protein information	Preferred Names RAS, dexamethasone-induced 1 Names dexamethasone-induced Ras-related protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B1.3
Summary	This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009026.5	NP_033052.1	dexamethasone-induced Ras-related protein 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RASD1	XP_523573.2
Rattus norvegicus (Norway rat)	Rasd1	NP_001257883.1
Xenopus tropicalis (tropical clawed frog)	rasd1	NP_001072408.1
	RASD1	XP_001090082.1
Gallus gallus (chicken)	RASD1	NP_001038101.1
Bos taurus (cattle)	RASD1	NP_001193190.1
Homo sapiens (human)	RASD1	NP_057168.1
Mus musculus (house mouse)	Rasd1	NP_033052.1
Canis lupus familiaris (dog)	RASD1	XP_546661.2
Danio rerio (zebrafish)	rasd1	NP_956826.1
Drosophila melanogaster (fruit fly)	CG8641	NP_648073.1

Gene Ontology
Bibliography

Related articles in PubMed

Rapid expression of RASD1 is regulated by estrogen receptor-dependent intracellular signaling pathway in the mouse uterus.
Kim HR, Cho KS, Kim E, Lee OH, Yoon H, Lee S, Moon S, Park M, Hong K, Na Y, Shin JE, Kwon H, Song H, Choi DH, Choi Y
Molecular and cellular endocrinology44632-39(2017 May)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

RASD1 Knockdown Results in Failure of Oocyte Maturation.
Lee Y, Kim KH, Yoon H, Lee OH, Kim E, Park M, Jang H, Hong K, Song H, Ko JJ, Lee WS, Lee KA, Chang EM, Choi Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(6)1289-1302(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings suggest that RASD1 acts as a novel signaling molecule and plays an important role in regulating dynamic uterine remodeling during the estrous cycle in the uterus.
Title: Rapid expression of RASD1 is regulated by estrogen receptor-dependent intracellular signaling pathway in the mouse uterus.

This study demonstrated that provide unprecedented evidence for a selective epigenetic up-regulation of Dexras 1 gene expression in the striatum of EAE mice.
Title: Epigenetic modifications of Dexras 1 along the nNOS pathway in an animal model of multiple sclerosis.

Results suggest a potential role for Dexras1 in modulating a selective subset of psychiatric symptoms, possibly via its interaction with NMDARs and/or other disease-related binding-partners
Title: Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gating.

Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1
Title: Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1.

RASD1 is a novel factor in Metaphase I-Metaphase II oocyte transition and may be involved in regulating the progression of cytokinesis and spindle formation
Title: RASD1 Knockdown Results in Failure of Oocyte Maturation.

The following Rasd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rasd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13471	NM_009026.5 Latest version!	Mus musculus RAS, dexamethasone-induced 1 (Rasd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rasd1 ( NM_009026.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033052.1 Mus musculus RAS, dexamethasone-induced 1 (Rasd1), mRNA.

Price & Availability↑

CloneID	OMu13471
Clone ID Related Accession (Same CDS sequence)	NM_009026.5
Accession Version	NM_009026.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Mus musculus(house mouse)
Product	dexamethasone-induced Ras-related protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK038932.1 and AW060444.1. On Sep 18, 2015 this sequence version replaced NM_009026.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF009246.1, BC034166.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACTGG CCGCGATGAT CAAGAAGATG TGCCCAAGCG ACTCTGAACT GAGTATCCCG 
GCCAAGAACT GCTACAGGAT GGTCATCCTC GGCTCATCCA AAGTGGGCAA GACGGCCATT 
GTGTCGCGCT TCCTCACGGG CCGTTTCGAG GATGCTTACA CCCCTACCAT CGAGGACTTC 
CACCGAAAGT TTTACTCGAT CCGCGGCGAA GTCTACCAGT TGGACATACT GGACACATCC 
GGCAATCATC CGTTTCCCGC CATGCGGCGC CTCTCTATCC TCACAGGAGA CGTTTTCATT 
CTGGTGTTCA GCTTAGACAA CCGCGACTCA TTCGAAGAGG TGCAAAGGCT CAAACAGCAG 
ATCCTAGACA CCAAGTCCTG TCTCAAGAAC AAAACCAAAG AGAATGTGGA CGTGCCGCTG 
GTCATTTGCG GTAACAAAGG GGACCGGGAC TTCTACCGGG AAGTAGAGCA GCGGGAGATT 
GAGCAGCTGG TGGGTGACGA CCCTCAGCGT TGTGCCTACT TCGAGATCTC AGCCAAGAAG 
AACAGCAGCT TGGACCAGAT GTTCCGTGCG CTCTTTGCCA TGGCCAAGCT GCCTAGCGAG 
ATGAGCCCCG ACTTGCACCG CAAGGTATCT GTGCAGTACT GCGACGTACT GCACAAGAAG 
GCTCTGAGGA ACAAGAAGCT TCTGCGTGCG GGCAGCGGAG GCGGGGGCGA CCACGGCGAT 
GCCTTTGGCA TCTTGGCGCC CTTTGCTCGC AGACCCAGCG TGCACAGCGA CCTCATGTAC 
ATTCGTGAAA AAACCAGTGT CGGCAGCCAG GCTAAGGACA AGGAGCGCTG TGTCATCAGT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033052.1
CDS	140..982
Translation	MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRFLTGRFEDAYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRDSFEEVQRLKQQILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVEQREIEQLVGDDPQRCAYFEISAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLHKKALRNKKLLRAGSGGGGDHGDAFGILAPFARRPSVHSDLMYIREKTSVGSQAKDKERCVIS

Target ORF information:

RefSeq Version	NM_009026.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAS, dexamethasone-induced 1 (Rasd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009026.5

ORF Insert Sequence:

ATGAAACTGG CCGCGATGAT CAAGAAGATG TGCCCAAGCG ACTCTGAACT GAGTATCCCG 
GCCAAGAACT GCTACAGGAT GGTCATCCTC GGCTCATCCA AAGTGGGCAA GACGGCCATT 
GTGTCGCGCT TCCTCACGGG CCGTTTCGAG GATGCTTACA CCCCTACCAT CGAGGACTTC 
CACCGAAAGT TTTACTCGAT CCGCGGCGAA GTCTACCAGT TGGACATACT GGACACATCC 
GGCAATCATC CGTTTCCCGC CATGCGGCGC CTCTCTATCC TCACAGGAGA CGTTTTCATT 
CTGGTGTTCA GCTTAGACAA CCGCGACTCA TTCGAAGAGG TGCAAAGGCT CAAACAGCAG 
ATCCTAGACA CCAAGTCCTG TCTCAAGAAC AAAACCAAAG AGAATGTGGA CGTGCCGCTG 
GTCATTTGCG GTAACAAAGG GGACCGGGAC TTCTACCGGG AAGTAGAGCA GCGGGAGATT 
GAGCAGCTGG TGGGTGACGA CCCTCAGCGT TGTGCCTACT TCGAGATCTC AGCCAAGAAG 
AACAGCAGCT TGGACCAGAT GTTCCGTGCG CTCTTTGCCA TGGCCAAGCT GCCTAGCGAG 
ATGAGCCCCG ACTTGCACCG CAAGGTATCT GTGCAGTACT GCGACGTACT GCACAAGAAG 
GCTCTGAGGA ACAAGAAGCT TCTGCGTGCG GGCAGCGGAG GCGGGGGCGA CCACGGCGAT 
GCCTTTGGCA TCTTGGCGCC CTTTGCTCGC AGACCCAGCG TGCACAGCGA CCTCATGTAC 
ATTCGTGAAA AAACCAGTGT CGGCAGCCAG GCTAAGGACA AGGAGCGCTG TGTCATCAGT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rapid expression of RASD1 is regulated by estrogen receptor-dependent intracellular signaling pathway in the mouse uterus.
Molecular and cellular endocrinology44632-39(2017 May)
Kim HR,Cho KS,Kim E,Lee OH,Yoon H,Lee S,Moon S,Park M,Hong K,Na Y,Shin JE,Kwon H,Song H,Choi DH,Choi Y

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

RASD1 Knockdown Results in Failure of Oocyte Maturation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(6)1289-1302(2016)
Lee Y,Kim KH,Yoon H,Lee OH,Kim E,Park M,Jang H,Hong K,Song H,Ko JJ,Lee WS,Lee KA,Chang EM,Choi Y

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Rasd1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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