Pa2g4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pa2g4
Entrez Gene ID	18813
Full Name	proliferation-associated 2G4
Synonyms	38kDa,AA672939,Ebp1,Plfap
General protein information	Preferred Names proliferation-associated 2G4 Names proliferation-associated protein 2G4 ErbB3-binding protein 1 IRES-specific cellular trans-acting factor 45 kDa ITAF45 mpp1 proliferation-associated 2G4, 38kD proliferation-associated protein 1 protein p38-2G4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_011119.3	NP_035249.1	proliferation-associated protein 2G4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PA2G4	NP_001029871.1
Drosophila melanogaster (fruit fly)	CG10576	NP_647984.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005108	XP_313985.4
Caenorhabditis elegans (roundworm)	W08E12.7	NP_500311.1
Magnaporthe oryzae (rice blast fungus)	MGG_06316	XP_003717269.1
Danio rerio (zebrafish)	pa2g4b	NP_997806.1
Arabidopsis thaliana (thale cress)	ATG2	NP_001190060.1
Pan troglodytes (chimpanzee)	PA2G4	NP_001233412.1
Canis lupus familiaris (dog)	PA2G4	XP_531629.2
Neurospora crassa	NCU00422	XP_956686.1
Oryza sativa (rice)	Os05g0350500	NP_001055274.1
Homo sapiens (human)	PA2G4	NP_006182.2
Mus musculus (house mouse)	Pa2g4	NP_035249.1
Rattus norvegicus (Norway rat)	Pa2g4	NP_001004206.1
Gallus gallus (chicken)	PA2G4	XP_423059.4
Danio rerio (zebrafish)	pa2g4a	NP_001002070.1
Schizosaccharomyces pombe (fission yeast)	cdb4	NP_593397.1
Xenopus tropicalis (tropical clawed frog)	pa2g4	NP_001008439.1

Gene Ontology
Bibliography

Related articles in PubMed

ERBB3-Binding Protein (EBP1) is a novel DPPA4 cofactor in human pluripotent cells.
Somanath P, Bush KM, Knoepfler PS
Stem cells (Dayton, Ohio)(2018 Jan)

A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction.
Karlsson T, Altankhuyag A, Dobrovolska O, Turcu DC, Lewis AE
The Biochemical journal473(14)2033-47(2016 07)

P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.
Ko HR, Kim CK, Lee SB, Song J, Lee KH, Kim KK, Park KW, Cho SW, Ahn JY
Cell death & disease5e1131(2014 Mar)

ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells.
Figeac N, Serralbo O, Marcelle C, Zammit PS
Developmental biology386(1)135-51(2014 Feb)

EBP1, a novel host factor involved in primer binding site-dependent restriction of moloney murine leukemia virus in embryonic cells.
Wang GZ, Wolf D, Goff SP
Journal of virology88(3)1825-9(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results show that EBP1 interacts directly with PPIns and associate with PtdIns(3,4,5)P3 in the nucleolus.
Title: A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction.

Ebp1 p42 isoform regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.
Title: P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.

Ebp1 has a role in the regulation of embryonic muscle progenitors and adult muscle stem cells, which likely operates independently of ErbB3 signaling
Title: ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells.

EBP1 is a novel component of the ZFP809-TRIM28 silencing complex to restrict the moloney murine leukemia virus replication in embryonic cells.
Title: EBP1, a novel host factor involved in primer binding site-dependent restriction of moloney murine leukemia virus in embryonic cells.

IGF-1 production and IGBP-3 and 4 protein levels were reduced in both embryo fibroblasts and adult knock-out mice. The proliferation of fibroblasts derived from Day 12.5 knock out embryos was also decreased as compared to that of wild type cells.
Title: Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice.

The following Pa2g4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pa2g4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18186	NM_011119.3 Latest version!	Mus musculus proliferation-associated 2G4 (Pa2g4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pa2g4 ( NM_011119.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035249.1 Mus musculus proliferation-associated 2G4 (Pa2g4), mRNA.

Price & Availability↑

CloneID	OMu18186
Clone ID Related Accession (Same CDS sequence)	NM_011119.3
Accession Version	NM_011119.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	proliferation-associated protein 2G4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK168582.1. On Apr 6, 2007 this sequence version replaced NM_011119.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK168582.1, AK144645.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGGCG AAGACGAGCA GCAGGAGCAA ACTATCGCCG AGGACCTGGT CGTGACCAAG 
TATAAGATGG GGGGCGACAT CGCCAACCGG GTGCTTCGAT CTTTGGTGGA GGCTTCCAGC 
TCAGGTGTGT CTGTGCTGAG CTTGTGTGAG AAAGGTGATG CCATGATTAT GGAAGAGACA 
GGGAAGATCT TCAAGAAGGA AAAGGAGATG AAGAAAGGTA TTGCCTTTCC TACCAGCATT 
TCCGTAAATA ACTGTGTGTG TCACTTCTCC CCTTTGAAGA GTGACCAGGA CTATATACTC 
AAGGAAGGTG ACTTGGTAAA AATTGACCTT GGGGTTCATG TGGATGGCTT CATTGCCAAT 
GTGGCTCACA CTTTTGTAAT TGGTGTAGCT CAGGGGACCC AGGTAACAGG GCGGAAAGCA 
GATGTCATTA AGGCCGCTCA CCTATGTGCT GAAGCTGCCT TACGACTGGT CAAACCTGGA 
AACCAGAACA CACAAGTGAC TGAAGCATGG AACAAGGTTG CTCACTCATT TAACTGCACA 
CCAATAGAAG GTATGCTGTC ACACCAATTG AAGCAGCATG TGATTGATGG AGAGAAGACG 
ATTATCCAGA ACCCTACAGA CCAGCAGAAG AAGGACCATG AAAAGGCAGA ATTTGAGGTG 
CATGAGGTTT ATGCTGTAGA TGTCCTCGTC AGCTCAGGAG AAGGCAAGGC CAAAGATGCA 
GGACAGAGAA CCACCATCTA CAAGCGAGAC CCCTCTAAAC AATATGGCCT GAAAATGAAA 
ACTTCACGTG CCTTTTTCAG TGAGGTGGAA CGGCGTTTTG ATGCCATGCC GTTTACTTTA 
AGAGCATTTG AAGATGAGAA GAAGGCTCGA ATGGGTGTGG TAGAGTGTGC CAAACATGAG 
TTACTACAGC CATTTAACGT TCTCTATGAG AAGGAGGGTG AATTTGTTGC CCAGTTTAAA 
TTTACAGTTC TACTCATGCC CAACGGCCCC ATGCGGATAA CCAGTGGTCC CTTTGAGCCT 
GACCTGTACA AGTCTGAGAT GGAGGTTCAA GATGCAGAGC TGAAGGCTCT TCTCCAGAGT 
TCTGCAAGTA GAAAAACCCA GAAAAAGAAG AAAAAGAAGG CCTCCAAGAC TGTAGAGAAT 
GCCACCAGTG GAGAAACCTT AGAAGAGAAT GGAGCTGGGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035249.1
CDS	108..1292
Translation	MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTVENATSGETLEENGAGD

Target ORF information:

RefSeq Version	NM_011119.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus proliferation-associated 2G4 (Pa2g4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011119.3

ORF Insert Sequence:

ATGTCGGGCG AAGACGAGCA GCAGGAGCAA ACTATCGCCG AGGACCTGGT CGTGACCAAG 
TATAAGATGG GGGGCGACAT CGCCAACCGG GTGCTTCGAT CTTTGGTGGA GGCTTCCAGC 
TCAGGTGTGT CTGTGCTGAG CTTGTGTGAG AAAGGTGATG CCATGATTAT GGAAGAGACA 
GGGAAGATCT TCAAGAAGGA AAAGGAGATG AAGAAAGGTA TTGCCTTTCC TACCAGCATT 
TCCGTAAATA ACTGTGTGTG TCACTTCTCC CCTTTGAAGA GTGACCAGGA CTATATACTC 
AAGGAAGGTG ACTTGGTAAA AATTGACCTT GGGGTTCATG TGGATGGCTT CATTGCCAAT 
GTGGCTCACA CTTTTGTAAT TGGTGTAGCT CAGGGGACCC AGGTAACAGG GCGGAAAGCA 
GATGTCATTA AGGCCGCTCA CCTATGTGCT GAAGCTGCCT TACGACTGGT CAAACCTGGA 
AACCAGAACA CACAAGTGAC TGAAGCATGG AACAAGGTTG CTCACTCATT TAACTGCACA 
CCAATAGAAG GTATGCTGTC ACACCAATTG AAGCAGCATG TGATTGATGG AGAGAAGACG 
ATTATCCAGA ACCCTACAGA CCAGCAGAAG AAGGACCATG AAAAGGCAGA ATTTGAGGTG 
CATGAGGTTT ATGCTGTAGA TGTCCTCGTC AGCTCAGGAG AAGGCAAGGC CAAAGATGCA 
GGACAGAGAA CCACCATCTA CAAGCGAGAC CCCTCTAAAC AATATGGCCT GAAAATGAAA 
ACTTCACGTG CCTTTTTCAG TGAGGTGGAA CGGCGTTTTG ATGCCATGCC GTTTACTTTA 
AGAGCATTTG AAGATGAGAA GAAGGCTCGA ATGGGTGTGG TAGAGTGTGC CAAACATGAG 
TTACTACAGC CATTTAACGT TCTCTATGAG AAGGAGGGTG AATTTGTTGC CCAGTTTAAA 
TTTACAGTTC TACTCATGCC CAACGGCCCC ATGCGGATAA CCAGTGGTCC CTTTGAGCCT 
GACCTGTACA AGTCTGAGAT GGAGGTTCAA GATGCAGAGC TGAAGGCTCT TCTCCAGAGT 
TCTGCAAGTA GAAAAACCCA GAAAAAGAAG AAAAAGAAGG CCTCCAAGAC TGTAGAGAAT 
GCCACCAGTG GAGAAACCTT AGAAGAGAAT GGAGCTGGGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ERBB3-Binding Protein (EBP1) is a novel DPPA4 cofactor in human pluripotent cells.
Stem cells (Dayton, Ohio)(2018 Jan)
Somanath P,Bush KM,Knoepfler PS

A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction.
The Biochemical journal473(14)2033-47(2016 07)
Karlsson T,Altankhuyag A,Dobrovolska O,Turcu DC,Lewis AE

P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.
Cell death & disease5e1131(2014 Mar)
Ko HR,Kim CK,Lee SB,Song J,Lee KH,Kim KK,Park KW,Cho SW,Ahn JY

ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells.
Developmental biology386(1)135-51(2014 Feb)
Figeac N,Serralbo O,Marcelle C,Zammit PS

EBP1, a novel host factor involved in primer binding site-dependent restriction of moloney murine leukemia virus in embryonic cells.
Journal of virology88(3)1825-9(2014 Feb)
Wang GZ,Wolf D,Goff SP

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Pa2g4 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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