Pa2g4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pa2g4
Entrez Gene ID	288778
Full Name	proliferation-associated 2G4
Synonyms	Ebp1
General protein information	Preferred Names proliferation-associated 2G4 Names proliferation-associated protein 2G4 ErbB3-binding protein 1 proliferation-associated 2G4, 38kDa
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q11
Summary	human and mouse homologs may be involved in coordinating ribosome biosynthesis and cell proliferation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004206.1	NP_001004206.1	proliferation-associated protein 2G4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PA2G4	NP_001029871.1
Drosophila melanogaster (fruit fly)	CG10576	NP_647984.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005108	XP_313985.4
Caenorhabditis elegans (roundworm)	W08E12.7	NP_500311.1
Magnaporthe oryzae (rice blast fungus)	MGG_06316	XP_003717269.1
Danio rerio (zebrafish)	pa2g4b	NP_997806.1
Arabidopsis thaliana (thale cress)	ATG2	NP_001190060.1
Pan troglodytes (chimpanzee)	PA2G4	NP_001233412.1
Canis lupus familiaris (dog)	PA2G4	XP_531629.2
Neurospora crassa	NCU00422	XP_956686.1
Oryza sativa (rice)	Os05g0350500	NP_001055274.1
Homo sapiens (human)	PA2G4	NP_006182.2
Mus musculus (house mouse)	Pa2g4	NP_035249.1
Rattus norvegicus (Norway rat)	Pa2g4	NP_001004206.1
Gallus gallus (chicken)	PA2G4	XP_423059.4
Danio rerio (zebrafish)	pa2g4a	NP_001002070.1
Schizosaccharomyces pombe (fission yeast)	cdb4	NP_593397.1
Xenopus tropicalis (tropical clawed frog)	pa2g4	NP_001008439.1

Gene Ontology
Bibliography

Related articles in PubMed

Upregulated expression of ebp1 contributes to schwann cell differentiation and migration after sciatic nerve crush.
Liu Y, Liu Y, Cao J, Zhu X, Nie X, Yao L, Chen M, Cheng X, Wang Y
Journal of molecular neuroscience : MN54(4)602-13(2014 Dec)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.
Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K
Molecular biology of the cell20(3)757-68(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ebp1 was upregulated in Schwann cells following sciatic nerve crush.
Title: Upregulated expression of ebp1 contributes to schwann cell differentiation and migration after sciatic nerve crush.

B23 distinctively binds Ebp1 isoforms and regulates cell proliferation and survival through p42 and p48, respectively.
Title: Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis.

PKC-delta antagonizes apoptosis through phosphorylating Ebp1 and protects it from apoptotic degradation.
Title: Protein kinase C-delta phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival.

Ebp1 might regulate cell survival and differentiation through two distinctive p48 and p42 isoforms.
Title: Ebp1 isoforms distinctively regulate cell survival and differentiation.

Results suggest that Ebp1 contributes to inhibition of DNA fragmentation by caspase-activated DNase, and that nuclear Akt might contribute to suppressing apoptosis through interaction with Ebp1.
Title: Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase.

The following Pa2g4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pa2g4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10071	NM_001004206.1 Latest version!	Rattus norvegicus proliferation-associated 2G4 (Pa2g4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pa2g4 ( NM_001004206.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004206.1 Rattus norvegicus proliferation-associated 2G4 (Pa2g4), mRNA.

Price & Availability↑

CloneID	ORa10071
Clone ID Related Accession (Same CDS sequence)	NM_001004206.1
Accession Version	NM_001004206.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	proliferation-associated protein 2G4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079095.1. On Sep 10, 2004 this sequence version replaced XM_213828.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC079095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGGCG AAGACGAGCA GCAGGAGCAA ACTATCGCCG AGGACCTGGT CGTGACCAAG 
TATAAGATGG GGGGCGACAT CGCCAACCGG GTGCTTCGAT CTTTGGTGGA AGCTTCTAGC 
TCAGGTGTGT CTGTACTGAG CTTGTGTGAG AAAGGTGACG CCATGATTAT GGAAGAGACA 
GGGAAGATCT TCAAGAAGGA GAAGGAGATG AAGAAAGGTA TTGCCTTTCC TACCAGCATT 
TCCGTAAATA ACTGTGTGTG TCACTTCTCC CCTTTGAAGA GTGACCAGGA CTATATACTC 
AAGGAAGGCG ACTTGGTAAA AATTGACCTT GGGGTTCATG TGGATGGCTT CATTGCCAAC 
GTGGCTCACA CTTTTGTAAT TGGTGTAGCT CAGGGGTCCC AGGTAACAGG TCGGAAAGCA 
GATGTCATTA AGGCTGCTCA CTTATGTGCC GAAGCTGCTT TACGACTGGT CAAACCTGGA 
AACCAGAACA CACAAGTGAC AGAAGCCTGG AACAAAGTCG CTCATTCATT TAACTGCACG 
CCAATAGAAG GTATGCTGTC ACACCAGTTG AAGCAGCATG TGATTGATGG AGAGAAAACC 
ATTATCCAGA ATCCTACAGA CCAGCAGAAG AAGGACCACG AAAAGGCAGA ATTTGAAGTG 
CATGAGGTTT ATGCTGTGGA TGTCCTCGTC AGCTCAGGAG AAGGCAAGGC CAAAGATGCA 
GGACAGAGAA CCACCATTTA CAAGCGAGAC CCCTCTAAAC AATATGGCCT GAAAATGAAA 
ACTTCACGTG CCTTTTTCAG TGAGGTGGAA AGGCGTTTTG ATGCTATGCC CTTTACTTTA 
AGAGCATTTG AGGATGAGAA GAAGGCTCGA ATGGGTGTGG TGGAGTGCGC CAAGCATGAG 
TTACTACAGC CATTCAACGT TCTCTATGAG AAGGAGGGTG AGTTTGTTGC CCAGTTTAAA 
TTTACAGTTC TACTCATGCC CAATGGCCCC ATGCGGATAA CCAGTGGTCC CTTTGAGCCC 
GACCTGTACA AGTCTGAGAT GGAGGTTCAG GATGCAGAGC TGAAGGCTCT TCTCCAGAGC 
TCTGCAAGTC GAAAAACCCA GAAAAAGAAG AAAAAGAAGG CCTCCAAGAC TGCAGAGAAC 
GCCACCAGTG GAGAGACATT AGAGGAGAAT GGAGCTGGGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004206.1
CDS	121..1305
Translation	MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIGVAQGSQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLEENGAGD

Target ORF information:

RefSeq Version	NM_001004206.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proliferation-associated 2G4 (Pa2g4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004206.1

ORF Insert Sequence:

ATGTCGGGCG AAGACGAGCA GCAGGAGCAA ACTATCGCCG AGGACCTGGT CGTGACCAAG 
TATAAGATGG GGGGCGACAT CGCCAACCGG GTGCTTCGAT CTTTGGTGGA AGCTTCTAGC 
TCAGGTGTGT CTGTACTGAG CTTGTGTGAG AAAGGTGACG CCATGATTAT GGAAGAGACA 
GGGAAGATCT TCAAGAAGGA GAAGGAGATG AAGAAAGGTA TTGCCTTTCC TACCAGCATT 
TCCGTAAATA ACTGTGTGTG TCACTTCTCC CCTTTGAAGA GTGACCAGGA CTATATACTC 
AAGGAAGGCG ACTTGGTAAA AATTGACCTT GGGGTTCATG TGGATGGCTT CATTGCCAAC 
GTGGCTCACA CTTTTGTAAT TGGTGTAGCT CAGGGGTCCC AGGTAACAGG TCGGAAAGCA 
GATGTCATTA AGGCTGCTCA CTTATGTGCC GAAGCTGCTT TACGACTGGT CAAACCTGGA 
AACCAGAACA CACAAGTGAC AGAAGCCTGG AACAAAGTCG CTCATTCATT TAACTGCACG 
CCAATAGAAG GTATGCTGTC ACACCAGTTG AAGCAGCATG TGATTGATGG AGAGAAAACC 
ATTATCCAGA ATCCTACAGA CCAGCAGAAG AAGGACCACG AAAAGGCAGA ATTTGAAGTG 
CATGAGGTTT ATGCTGTGGA TGTCCTCGTC AGCTCAGGAG AAGGCAAGGC CAAAGATGCA 
GGACAGAGAA CCACCATTTA CAAGCGAGAC CCCTCTAAAC AATATGGCCT GAAAATGAAA 
ACTTCACGTG CCTTTTTCAG TGAGGTGGAA AGGCGTTTTG ATGCTATGCC CTTTACTTTA 
AGAGCATTTG AGGATGAGAA GAAGGCTCGA ATGGGTGTGG TGGAGTGCGC CAAGCATGAG 
TTACTACAGC CATTCAACGT TCTCTATGAG AAGGAGGGTG AGTTTGTTGC CCAGTTTAAA 
TTTACAGTTC TACTCATGCC CAATGGCCCC ATGCGGATAA CCAGTGGTCC CTTTGAGCCC 
GACCTGTACA AGTCTGAGAT GGAGGTTCAG GATGCAGAGC TGAAGGCTCT TCTCCAGAGC 
TCTGCAAGTC GAAAAACCCA GAAAAAGAAG AAAAAGAAGG CCTCCAAGAC TGCAGAGAAC 
GCCACCAGTG GAGAGACATT AGAGGAGAAT GGAGCTGGGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Upregulated expression of ebp1 contributes to schwann cell differentiation and migration after sciatic nerve crush.
Journal of molecular neuroscience : MN54(4)602-13(2014 Dec)
Liu Y,Liu Y,Cao J,Zhu X,Nie X,Yao L,Chen M,Cheng X,Wang Y

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.
Molecular biology of the cell20(3)757-68(2009 Feb)
Liu Z,Oh SM,Okada M,Liu X,Cheng D,Peng J,Brat DJ,Sun SY,Zhou W,Gu W,Ye K

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Pa2g4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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