Mmp24 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp24
Entrez Gene ID	17391
Full Name	matrix metallopeptidase 24
Synonyms	AU040325,MMP-21,MT5-MMP,MT5MMP,MTMMP5
General protein information	Preferred Names matrix metallopeptidase 24 Names matrix metalloproteinase-24 matrix metalloproteinase-21 membrane type 5-MMP membrane-type matrix metalloproteinase 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 H1\|2 77.26 cM
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein do not develop neuropathic pain with mechanical allodynia after sciatic nerve injury, display enhanced sensitivity to noxious thermal stimuli under basal conditions, and develop hyperalgesia during inflammation. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010808.3	NP_034938.3	matrix metalloproteinase-24 precursor
XM_030248212.1	XP_030104072.1	matrix metalloproteinase-24 isoform X1
NM_010808.4	NP_034938.3	matrix metalloproteinase-24 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	MMP24	NP_006681.1
Rattus norvegicus (Norway rat)	Mmp24	NP_113945.1
	MMP24	XP_001100890.2
Danio rerio (zebrafish)	mmp24	XP_699803.4
Xenopus tropicalis (tropical clawed frog)	mmp24	XP_002942325.2
Canis lupus familiaris (dog)	MMP24	XP_005635025.1
Bos taurus (cattle)	MMP24	XP_002692352.2
Pan troglodytes (chimpanzee)	MMP24	XP_003316927.1
Mus musculus (house mouse)	Mmp24	NP_034938.3
Gallus gallus (chicken)	MMP24	XP_417326.4

Gene Ontology
Bibliography

Related articles in PubMed

MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.
Sanz RL, Ferraro GB, Kacervosky J, Salesse C, Gowing E, Hua L, Rambaldi I, Beaubien F, Holmbeck K, Cloutier JF, L?vesque M, Murai K, Fournier AE
The Journal of neuroscience : the official journal of the Society for Neuroscience38(3)518-529(2018 Jan)

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S
Cellular and molecular life sciences : CMLS73(1)217-36(2016 Jan)

?-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, M?ller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, M?ller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C
Nature526(7573)443-7(2015 Oct)

Membrane-type matrix metalloproteinases: Their functions and regulations.
Itoh Y
Matrix biology : journal of the International Society for Matrix Biology44-46207-23(2015 May-Jul)

MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.
Porlan E, Mart?-Prado B, Morante-Redolat JM, Consiglio A, Delgado AC, Kypta R, L?pez-Ot?n C, Kirstein M, Fari?as I
Nature cell biology16(7)629-38(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MT5-MMP emerges as a new pro-amyloidogenic regulator of APP metabolism, whose deficiency alleviates amyloid pathology, neuroinflammation and cognitive decline.
Title: MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.

APP carboxy-terminal fragment generation is mediated in part by membrane-bound matrix metalloproteinases such as MT5-MMP, referred to as eta-secretase activity
Title: ?-Secretase processing of APP inhibits neuronal activity in the hippocampus.

identify MT5-MMP as a membrane-type metalloproteinase responsible for the shedding of the N-cadherin ectodomain in this niche
Title: MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.

Findings demonstrate an essential role of MT5-MMP in the development of dermal neuro-immune synapses and suggest that this metalloproteinase may be a target for pain control.
Title: Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.

These results suggest that ABP directs MT5-MMP proteolytic activity to growth cones and synaptic sites in neurons, where it may regulate axon pathfinding or synapse remodeling through proteolysis of cadherins or other ECM or cell adhesion molecules.
Title: Membrane localization of membrane type 5 matrix metalloproteinase by AMPA receptor binding protein and cleavage of cadherins.

The following Mmp24 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp24 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu87742	XM_030248212.1 Latest version!	Mus musculus matrix metallopeptidase 24 (Mmp24), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu06937	NM_010808.4 Latest version!	Mus musculus matrix metallopeptidase 24 (Mmp24), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$363.30 $519.00
View Old Accession Versions >>
OMu06937	NM_010808.3	Mus musculus matrix metallopeptidase 24 (Mmp24), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$363.30 $519.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp24 ( XM_030248212.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030104072.1 Mus musculus matrix metallopeptidase 24 (Mmp24), transcript variant X1, mRNA.

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CloneID	OMu87742
Clone ID Related Accession (Same CDS sequence)	XM_030248212.1
Accession Version	XM_030248212.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1566bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	matrix metalloproteinase-24 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGAGGA GCCGGGGCGG CCGCGCTGCG CCGGGCCAGG CCTCGCGCTG GAGCGGCTGG 
CGGGCCCCGG GGCGGCTGCT GCCGCTGCTG CCCGCGCTCT GCTGCCTCGC GGCGGCGGCG 
GGGGCCGGGA AGCCGGCCGG GGCGGACGCG CCCTTCGCTG GGCAGAACTG GTTAAAATCA 
TATGGCTATC TGCTTCCCTA TGAGTCGCGG GCATCTGCGT TGCATTCTGG GAAGGCCTTG 
CAGTCCGCGG TCTCCACTAT GCAGCAGTTT TACGGGATCC CAGTCACCGG TGTGTTGGAT 
CAGACAACAA TCGAGTGGAT GAAGAAACCT CGATGTGGCG TCCCTGATCA TCCCCACTTG 
AGCAGGAGGA GGAGAAATAA GCGATATGCC CTAACTGGAC AGAAGTGGAG GCAGAAACAC 
ATCACCTACA GCATTCACAA TTATACCCCA AAGGTGGGTG AGCTGGACAC ACGGAAGGCT 
ATTCGTCAGG CTTTCGATGT GTGGCAGAAG GTGACTCCAC TGACCTTTGA AGAGGTGCCA 
TACCATGAGA TCAAAAGTGA CCGGAAGGAG GCAGACATCA TGATCTTCTT TGCTTCTGGT 
TTCCATGGTG ACAGCTCCCC ATTTGATGGG GAAGGGGGAT TCCTAGCCCA TGCCTACTTT 
CCTGGCCCAG GGATCGGAGG AGACACTCAC TTTGATTCAG ATGAACCCTG GACGCTAGGA 
AATGCCAACC ATGATGGCAA TGACCTCTTC CTGGTGGCCG TGCATGAACT GGGCCATGCA 
CTGGGCTTGG AGCACTCTAA TGACCCCAGT GCTATCATGG CTCCCTTCTA CCAATACATG 
GAGACACACA ACTTCAAGCT ACCGCAGGAC GATCTCCAGG GCATCCAGAA GATTTACGGA 
CCCCCAGCTG AGCCTCTGGA GCCCACAAGG CCCCTCCCTA CACTCCCGGT CCGCAGGATC 
CACTCGCCAT CTGAGAGGAA GCACGAGCGG CACCCAAGGC CCCCACGGCC GCCTCTTGGG 
GACCGGCCAT CCACTCCAGG TGCCAAACCC AACATCTGCG ATGGCAACTT CAACACAGTG 
GCCCTCTTCC GAGGGGAGAT GTTTGTGTTC AAGGATCGCT GGTTCTGGCG CCTGCGCAAT 
AACCGGGTGC AGGAAGGCTA CCCCATGCAG ATCGAACAGT TCTGGAAGGG CCTGCCCGCC 
CGCATAGACG CAGCCTATGA AAGAGCTGAC GGGAGATTCG TCTTCTTCAA AGGAGACAAG 
TACTGGGTTT TCAAAGAAGT GACGGTGGAA CCTGGGTACC CCCACAGCTT GGGGGAGCTG 
GGAAGCTGCC TGCCCCGTGA AGGAATTGAC ACAGCTCTGC GCTGGGAACC TGTGGGCAAA 
ACCTACTTCT TCAAAGGCGA ACGATACTGG CGCTACAGCG AGGAGCGGCG AGCCACAGAC 
CCTGGCTACC CCAAGCCCAT CACCGTGTGG AAGGGCATCC CGCAGGCTCC GCAAGGGGCC 
TTCATCAGCA AGGAAGGATG TATATTACAC CTACTTCTAC AAAGGCCGGG ACTACTGGAA 
GTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030104072.1
CDS	129..1694
Translation	MPRSRGGRAAPGQASRWSGWRAPGRLLPLLPALCCLAAAAGAGKPAGADAPFAGQNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERHPRPPRPPLGDRPSTPGAKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGCILHLLLQRPGLLEV

Target ORF information:

RefSeq Version	XM_030248212.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 24 (Mmp24), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030248212.1

ORF Insert Sequence:

ATGCCGAGGA GCCGGGGCGG CCGCGCTGCG CCGGGCCAGG CCTCGCGCTG GAGCGGCTGG 
CGGGCCCCGG GGCGGCTGCT GCCGCTGCTG CCCGCGCTCT GCTGCCTCGC GGCGGCGGCG 
GGGGCCGGGA AGCCGGCCGG GGCGGACGCG CCCTTCGCTG GGCAGAACTG GTTAAAATCA 
TATGGCTATC TGCTTCCCTA TGAGTCGCGG GCATCTGCGT TGCATTCTGG GAAGGCCTTG 
CAGTCCGCGG TCTCCACTAT GCAGCAGTTT TACGGGATCC CAGTCACCGG TGTGTTGGAT 
CAGACAACAA TCGAGTGGAT GAAGAAACCT CGATGTGGCG TCCCTGATCA TCCCCACTTG 
AGCAGGAGGA GGAGAAATAA GCGATATGCC CTAACTGGAC AGAAGTGGAG GCAGAAACAC 
ATCACCTACA GCATTCACAA TTATACCCCA AAGGTGGGTG AGCTGGACAC ACGGAAGGCT 
ATTCGTCAGG CTTTCGATGT GTGGCAGAAG GTGACTCCAC TGACCTTTGA AGAGGTGCCA 
TACCATGAGA TCAAAAGTGA CCGGAAGGAG GCAGACATCA TGATCTTCTT TGCTTCTGGT 
TTCCATGGTG ACAGCTCCCC ATTTGATGGG GAAGGGGGAT TCCTAGCCCA TGCCTACTTT 
CCTGGCCCAG GGATCGGAGG AGACACTCAC TTTGATTCAG ATGAACCCTG GACGCTAGGA 
AATGCCAACC ATGATGGCAA TGACCTCTTC CTGGTGGCCG TGCATGAACT GGGCCATGCA 
CTGGGCTTGG AGCACTCTAA TGACCCCAGT GCTATCATGG CTCCCTTCTA CCAATACATG 
GAGACACACA ACTTCAAGCT ACCGCAGGAC GATCTCCAGG GCATCCAGAA GATTTACGGA 
CCCCCAGCTG AGCCTCTGGA GCCCACAAGG CCCCTCCCTA CACTCCCGGT CCGCAGGATC 
CACTCGCCAT CTGAGAGGAA GCACGAGCGG CACCCAAGGC CCCCACGGCC GCCTCTTGGG 
GACCGGCCAT CCACTCCAGG TGCCAAACCC AACATCTGCG ATGGCAACTT CAACACAGTG 
GCCCTCTTCC GAGGGGAGAT GTTTGTGTTC AAGGATCGCT GGTTCTGGCG CCTGCGCAAT 
AACCGGGTGC AGGAAGGCTA CCCCATGCAG ATCGAACAGT TCTGGAAGGG CCTGCCCGCC 
CGCATAGACG CAGCCTATGA AAGAGCTGAC GGGAGATTCG TCTTCTTCAA AGGAGACAAG 
TACTGGGTTT TCAAAGAAGT GACGGTGGAA CCTGGGTACC CCCACAGCTT GGGGGAGCTG 
GGAAGCTGCC TGCCCCGTGA AGGAATTGAC ACAGCTCTGC GCTGGGAACC TGTGGGCAAA 
ACCTACTTCT TCAAAGGCGA ACGATACTGG CGCTACAGCG AGGAGCGGCG AGCCACAGAC 
CCTGGCTACC CCAAGCCCAT CACCGTGTGG AAGGGCATCC CGCAGGCTCC GCAAGGGGCC 
TTCATCAGCA AGGAAGGATG TATATTACAC CTACTTCTAC AAAGGCCGGG ACTACTGGAA 
GTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mmp24 ( NM_010808.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034938.3 Mus musculus matrix metallopeptidase 24 (Mmp24), mRNA.

Price & Availability↑

CloneID	OMu06937
Clone ID Related Accession (Same CDS sequence)	NM_010808.3 , NM_010808.4
Accession Version	NM_010808.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1857bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	matrix metalloproteinase-24 precursor
Comment

ATGCCGAGGA GCCGGGGCGG CCGCGCTGCG CCGGGCCAGG CCTCGCGCTG GAGCGGCTGG 
CGGGCCCCGG GGCGGCTGCT GCCGCTGCTG CCCGCGCTCT GCTGCCTCGC GGCGGCGGCG 
GGGGCCGGGA AGCCGGCCGG GGCGGACGCG CCCTTCGCTG GGCAGAACTG GTTAAAATCA 
TATGGCTATC TGCTTCCCTA TGAGTCGCGG GCATCTGCGT TGCATTCTGG GAAGGCCTTG 
CAGTCCGCGG TCTCCACTAT GCAGCAGTTT TACGGGATCC CAGTCACCGG TGTGTTGGAT 
CAGACAACAA TCGAGTGGAT GAAGAAACCT CGATGTGGCG TCCCTGATCA TCCCCACTTG 
AGCAGGAGGA GGAGAAATAA GCGATATGCC CTAACTGGAC AGAAGTGGAG GCAGAAACAC 
ATCACCTACA GCATTCACAA TTATACCCCA AAGGTGGGTG AGCTGGACAC ACGGAAGGCT 
ATTCGTCAGG CTTTCGATGT GTGGCAGAAG GTGACTCCAC TGACCTTTGA AGAGGTGCCA 
TACCATGAGA TCAAAAGTGA CCGGAAGGAG GCAGACATCA TGATCTTCTT TGCTTCTGGT 
TTCCATGGTG ACAGCTCCCC ATTTGATGGG GAAGGGGGAT TCCTAGCCCA TGCCTACTTT 
CCTGGCCCAG GGATCGGAGG AGACACTCAC TTTGATTCAG ATGAACCCTG GACGCTAGGA 
AATGCCAACC ATGATGGCAA TGACCTCTTC CTGGTGGCCG TGCATGAACT GGGCCATGCA 
CTGGGCTTGG AGCACTCTAA TGACCCCAGT GCTATCATGG CTCCCTTCTA CCAATACATG 
GAGACACACA ACTTCAAGCT ACCGCAGGAC GATCTCCAGG GCATCCAGAA GATTTACGGA 
CCCCCAGCTG AGCCTCTGGA GCCCACAAGG CCCCTCCCTA CACTCCCGGT CCGCAGGATC 
CACTCGCCAT CTGAGAGGAA GCACGAGCGG CACCCAAGGC CCCCACGGCC GCCTCTTGGG 
GACCGGCCAT CCACTCCAGG TGCCAAACCC AACATCTGCG ATGGCAACTT CAACACAGTG 
GCCCTCTTCC GAGGGGAGAT GTTTGTGTTC AAGGATCGCT GGTTCTGGCG CCTGCGCAAT 
AACCGGGTGC AGGAAGGCTA CCCCATGCAG ATCGAACAGT TCTGGAAGGG CCTGCCCGCC 
CGCATAGACG CAGCCTATGA AAGAGCTGAC GGGAGATTCG TCTTCTTCAA AGGAGACAAG 
TACTGGGTTT TCAAAGAAGT GACGGTGGAA CCTGGGTACC CCCACAGCTT GGGGGAGCTG 
GGAAGCTGCC TGCCCCGTGA AGGAATTGAC ACAGCTCTGC GCTGGGAACC TGTGGGCAAA 
ACCTACTTCT TCAAAGGCGA ACGATACTGG CGCTACAGCG AGGAGCGGCG AGCCACAGAC 
CCTGGCTACC CCAAGCCCAT CACCGTGTGG AAGGGCATCC CGCAGGCTCC GCAAGGGGCC 
TTCATCAGCA AGGAAGGATA TTACACCTAC TTCTACAAAG GCCGGGACTA CTGGAAGTTT 
GACAACCAGA AACTGAGCGT GGAGCCAGGC TACCCACGCA ACATCCTGCG TGACTGGATG 
GGCTGCAAGC AGAAGGAGGT AGAGCGGCGT AAGGAGCGGA GGCTGCCCCA GGATGATGTG 
GACATCATGG TGACCATCGA TGACGTGCCA GGCTCTGTGA ACGCTGTGGC TGTGGTTGTC 
CCCTGCACAC TGTCCCTCTG CCTCCTGGTG CTGCTCTACA CTATCTTCCA ATTCAAGAAC 
AAGGCGGGTC CTCAGCCCGT CACCTACTAT AAGCGGCCGG TCCAGGAGTG GGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_034938.3

Translation

MPRSRGGRAAPGQASRWSGWRAPGRLLPLLPALCCLAAAAGAGKPAGADAPFAGQNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERHPRPPRPPLGDRPSTPGAKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCKQKEVERRKERRLPQDDVDIMVTIDDVPGSVNAVAVVVPCTLSLCLLVLLYTIFQFKNKAGPQPVTYYKRPVQEWV

Target ORF information:

RefSeq Version	NM_010808.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus matrix metallopeptidase 24 (Mmp24), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010808.3

ORF Insert Sequence:

ATGCCGAGGA GCCGGGGCGG CCGCGCTGCG CCGGGCCAGG CCTCGCGCTG GAGCGGCTGG 
CGGGCCCCGG GGCGGCTGCT GCCGCTGCTG CCCGCGCTCT GCTGCCTCGC GGCGGCGGCG 
GGGGCCGGGA AGCCGGCCGG GGCGGACGCG CCCTTCGCTG GGCAGAACTG GTTAAAATCA 
TATGGCTATC TGCTTCCCTA TGAGTCGCGG GCATCTGCGT TGCATTCTGG GAAGGCCTTG 
CAGTCCGCGG TCTCCACTAT GCAGCAGTTT TACGGGATCC CAGTCACCGG TGTGTTGGAT 
CAGACAACAA TCGAGTGGAT GAAGAAACCT CGATGTGGCG TCCCTGATCA TCCCCACTTG 
AGCAGGAGGA GGAGAAATAA GCGATATGCC CTAACTGGAC AGAAGTGGAG GCAGAAACAC 
ATCACCTACA GCATTCACAA TTATACCCCA AAGGTGGGTG AGCTGGACAC ACGGAAGGCT 
ATTCGTCAGG CTTTCGATGT GTGGCAGAAG GTGACTCCAC TGACCTTTGA AGAGGTGCCA 
TACCATGAGA TCAAAAGTGA CCGGAAGGAG GCAGACATCA TGATCTTCTT TGCTTCTGGT 
TTCCATGGTG ACAGCTCCCC ATTTGATGGG GAAGGGGGAT TCCTAGCCCA TGCCTACTTT 
CCTGGCCCAG GGATCGGAGG AGACACTCAC TTTGATTCAG ATGAACCCTG GACGCTAGGA 
AATGCCAACC ATGATGGCAA TGACCTCTTC CTGGTGGCCG TGCATGAACT GGGCCATGCA 
CTGGGCTTGG AGCACTCTAA TGACCCCAGT GCTATCATGG CTCCCTTCTA CCAATACATG 
GAGACACACA ACTTCAAGCT ACCGCAGGAC GATCTCCAGG GCATCCAGAA GATTTACGGA 
CCCCCAGCTG AGCCTCTGGA GCCCACAAGG CCCCTCCCTA CACTCCCGGT CCGCAGGATC 
CACTCGCCAT CTGAGAGGAA GCACGAGCGG CACCCAAGGC CCCCACGGCC GCCTCTTGGG 
GACCGGCCAT CCACTCCAGG TGCCAAACCC AACATCTGCG ATGGCAACTT CAACACAGTG 
GCCCTCTTCC GAGGGGAGAT GTTTGTGTTC AAGGATCGCT GGTTCTGGCG CCTGCGCAAT 
AACCGGGTGC AGGAAGGCTA CCCCATGCAG ATCGAACAGT TCTGGAAGGG CCTGCCCGCC 
CGCATAGACG CAGCCTATGA AAGAGCTGAC GGGAGATTCG TCTTCTTCAA AGGAGACAAG 
TACTGGGTTT TCAAAGAAGT GACGGTGGAA CCTGGGTACC CCCACAGCTT GGGGGAGCTG 
GGAAGCTGCC TGCCCCGTGA AGGAATTGAC ACAGCTCTGC GCTGGGAACC TGTGGGCAAA 
ACCTACTTCT TCAAAGGCGA ACGATACTGG CGCTACAGCG AGGAGCGGCG AGCCACAGAC 
CCTGGCTACC CCAAGCCCAT CACCGTGTGG AAGGGCATCC CGCAGGCTCC GCAAGGGGCC 
TTCATCAGCA AGGAAGGATA TTACACCTAC TTCTACAAAG GCCGGGACTA CTGGAAGTTT 
GACAACCAGA AACTGAGCGT GGAGCCAGGC TACCCACGCA ACATCCTGCG TGACTGGATG 
GGCTGCAAGC AGAAGGAGGT AGAGCGGCGT AAGGAGCGGA GGCTGCCCCA GGATGATGTG 
GACATCATGG TGACCATCGA TGACGTGCCA GGCTCTGTGA ACGCTGTGGC TGTGGTTGTC 
CCCTGCACAC TGTCCCTCTG CCTCCTGGTG CTGCTCTACA CTATCTTCCA ATTCAAGAAC 
AAGGCGGGTC CTCAGCCCGT CACCTACTAT AAGCGGCCGG TCCAGGAGTG GGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mmp24 ( NM_010808.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034938.3 Mus musculus matrix metallopeptidase 24 (Mmp24), mRNA.

Price & Availability↑

CloneID	OMu06937
Clone ID Related Accession (Same CDS sequence)	NM_010808.3 , NM_010808.4
Accession Version	NM_010808.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1857bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	matrix metalloproteinase-24 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL929233.9, CD355182.1, CF540062.1, CD348827.1, BQ745403.1, CA320413.1 and BM947491.1. On Feb 18, 2016 this sequence version replaced NM_010808.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB021226.1, AJ010262.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END##

ATGCCGAGGA GCCGGGGCGG CCGCGCTGCG CCGGGCCAGG CCTCGCGCTG GAGCGGCTGG 
CGGGCCCCGG GGCGGCTGCT GCCGCTGCTG CCCGCGCTCT GCTGCCTCGC GGCGGCGGCG 
GGGGCCGGGA AGCCGGCCGG GGCGGACGCG CCCTTCGCTG GGCAGAACTG GTTAAAATCA 
TATGGCTATC TGCTTCCCTA TGAGTCGCGG GCATCTGCGT TGCATTCTGG GAAGGCCTTG 
CAGTCCGCGG TCTCCACTAT GCAGCAGTTT TACGGGATCC CAGTCACCGG TGTGTTGGAT 
CAGACAACAA TCGAGTGGAT GAAGAAACCT CGATGTGGCG TCCCTGATCA TCCCCACTTG 
AGCAGGAGGA GGAGAAATAA GCGATATGCC CTAACTGGAC AGAAGTGGAG GCAGAAACAC 
ATCACCTACA GCATTCACAA TTATACCCCA AAGGTGGGTG AGCTGGACAC ACGGAAGGCT 
ATTCGTCAGG CTTTCGATGT GTGGCAGAAG GTGACTCCAC TGACCTTTGA AGAGGTGCCA 
TACCATGAGA TCAAAAGTGA CCGGAAGGAG GCAGACATCA TGATCTTCTT TGCTTCTGGT 
TTCCATGGTG ACAGCTCCCC ATTTGATGGG GAAGGGGGAT TCCTAGCCCA TGCCTACTTT 
CCTGGCCCAG GGATCGGAGG AGACACTCAC TTTGATTCAG ATGAACCCTG GACGCTAGGA 
AATGCCAACC ATGATGGCAA TGACCTCTTC CTGGTGGCCG TGCATGAACT GGGCCATGCA 
CTGGGCTTGG AGCACTCTAA TGACCCCAGT GCTATCATGG CTCCCTTCTA CCAATACATG 
GAGACACACA ACTTCAAGCT ACCGCAGGAC GATCTCCAGG GCATCCAGAA GATTTACGGA 
CCCCCAGCTG AGCCTCTGGA GCCCACAAGG CCCCTCCCTA CACTCCCGGT CCGCAGGATC 
CACTCGCCAT CTGAGAGGAA GCACGAGCGG CACCCAAGGC CCCCACGGCC GCCTCTTGGG 
GACCGGCCAT CCACTCCAGG TGCCAAACCC AACATCTGCG ATGGCAACTT CAACACAGTG 
GCCCTCTTCC GAGGGGAGAT GTTTGTGTTC AAGGATCGCT GGTTCTGGCG CCTGCGCAAT 
AACCGGGTGC AGGAAGGCTA CCCCATGCAG ATCGAACAGT TCTGGAAGGG CCTGCCCGCC 
CGCATAGACG CAGCCTATGA AAGAGCTGAC GGGAGATTCG TCTTCTTCAA AGGAGACAAG 
TACTGGGTTT TCAAAGAAGT GACGGTGGAA CCTGGGTACC CCCACAGCTT GGGGGAGCTG 
GGAAGCTGCC TGCCCCGTGA AGGAATTGAC ACAGCTCTGC GCTGGGAACC TGTGGGCAAA 
ACCTACTTCT TCAAAGGCGA ACGATACTGG CGCTACAGCG AGGAGCGGCG AGCCACAGAC 
CCTGGCTACC CCAAGCCCAT CACCGTGTGG AAGGGCATCC CGCAGGCTCC GCAAGGGGCC 
TTCATCAGCA AGGAAGGATA TTACACCTAC TTCTACAAAG GCCGGGACTA CTGGAAGTTT 
GACAACCAGA AACTGAGCGT GGAGCCAGGC TACCCACGCA ACATCCTGCG TGACTGGATG 
GGCTGCAAGC AGAAGGAGGT AGAGCGGCGT AAGGAGCGGA GGCTGCCCCA GGATGATGTG 
GACATCATGG TGACCATCGA TGACGTGCCA GGCTCTGTGA ACGCTGTGGC TGTGGTTGTC 
CCCTGCACAC TGTCCCTCTG CCTCCTGGTG CTGCTCTACA CTATCTTCCA ATTCAAGAAC 
AAGGCGGGTC CTCAGCCCGT CACCTACTAT AAGCGGCCGG TCCAGGAGTG GGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034938.3
CDS	132..1988
Translation	MPRSRGGRAAPGQASRWSGWRAPGRLLPLLPALCCLAAAAGAGKPAGADAPFAGQNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERHPRPPRPPLGDRPSTPGAKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCKQKEVERRKERRLPQDDVDIMVTIDDVPGSVNAVAVVVPCTLSLCLLVLLYTIFQFKNKAGPQPVTYYKRPVQEWV

Target ORF information:

RefSeq Version	NM_010808.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 24 (Mmp24), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010808.4

ORF Insert Sequence:

ATGCCGAGGA GCCGGGGCGG CCGCGCTGCG CCGGGCCAGG CCTCGCGCTG GAGCGGCTGG 
CGGGCCCCGG GGCGGCTGCT GCCGCTGCTG CCCGCGCTCT GCTGCCTCGC GGCGGCGGCG 
GGGGCCGGGA AGCCGGCCGG GGCGGACGCG CCCTTCGCTG GGCAGAACTG GTTAAAATCA 
TATGGCTATC TGCTTCCCTA TGAGTCGCGG GCATCTGCGT TGCATTCTGG GAAGGCCTTG 
CAGTCCGCGG TCTCCACTAT GCAGCAGTTT TACGGGATCC CAGTCACCGG TGTGTTGGAT 
CAGACAACAA TCGAGTGGAT GAAGAAACCT CGATGTGGCG TCCCTGATCA TCCCCACTTG 
AGCAGGAGGA GGAGAAATAA GCGATATGCC CTAACTGGAC AGAAGTGGAG GCAGAAACAC 
ATCACCTACA GCATTCACAA TTATACCCCA AAGGTGGGTG AGCTGGACAC ACGGAAGGCT 
ATTCGTCAGG CTTTCGATGT GTGGCAGAAG GTGACTCCAC TGACCTTTGA AGAGGTGCCA 
TACCATGAGA TCAAAAGTGA CCGGAAGGAG GCAGACATCA TGATCTTCTT TGCTTCTGGT 
TTCCATGGTG ACAGCTCCCC ATTTGATGGG GAAGGGGGAT TCCTAGCCCA TGCCTACTTT 
CCTGGCCCAG GGATCGGAGG AGACACTCAC TTTGATTCAG ATGAACCCTG GACGCTAGGA 
AATGCCAACC ATGATGGCAA TGACCTCTTC CTGGTGGCCG TGCATGAACT GGGCCATGCA 
CTGGGCTTGG AGCACTCTAA TGACCCCAGT GCTATCATGG CTCCCTTCTA CCAATACATG 
GAGACACACA ACTTCAAGCT ACCGCAGGAC GATCTCCAGG GCATCCAGAA GATTTACGGA 
CCCCCAGCTG AGCCTCTGGA GCCCACAAGG CCCCTCCCTA CACTCCCGGT CCGCAGGATC 
CACTCGCCAT CTGAGAGGAA GCACGAGCGG CACCCAAGGC CCCCACGGCC GCCTCTTGGG 
GACCGGCCAT CCACTCCAGG TGCCAAACCC AACATCTGCG ATGGCAACTT CAACACAGTG 
GCCCTCTTCC GAGGGGAGAT GTTTGTGTTC AAGGATCGCT GGTTCTGGCG CCTGCGCAAT 
AACCGGGTGC AGGAAGGCTA CCCCATGCAG ATCGAACAGT TCTGGAAGGG CCTGCCCGCC 
CGCATAGACG CAGCCTATGA AAGAGCTGAC GGGAGATTCG TCTTCTTCAA AGGAGACAAG 
TACTGGGTTT TCAAAGAAGT GACGGTGGAA CCTGGGTACC CCCACAGCTT GGGGGAGCTG 
GGAAGCTGCC TGCCCCGTGA AGGAATTGAC ACAGCTCTGC GCTGGGAACC TGTGGGCAAA 
ACCTACTTCT TCAAAGGCGA ACGATACTGG CGCTACAGCG AGGAGCGGCG AGCCACAGAC 
CCTGGCTACC CCAAGCCCAT CACCGTGTGG AAGGGCATCC CGCAGGCTCC GCAAGGGGCC 
TTCATCAGCA AGGAAGGATA TTACACCTAC TTCTACAAAG GCCGGGACTA CTGGAAGTTT 
GACAACCAGA AACTGAGCGT GGAGCCAGGC TACCCACGCA ACATCCTGCG TGACTGGATG 
GGCTGCAAGC AGAAGGAGGT AGAGCGGCGT AAGGAGCGGA GGCTGCCCCA GGATGATGTG 
GACATCATGG TGACCATCGA TGACGTGCCA GGCTCTGTGA ACGCTGTGGC TGTGGTTGTC 
CCCTGCACAC TGTCCCTCTG CCTCCTGGTG CTGCTCTACA CTATCTTCCA ATTCAAGAAC 
AAGGCGGGTC CTCAGCCCGT CACCTACTAT AAGCGGCCGG TCCAGGAGTG GGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.
The Journal of neuroscience : the official journal of the Society for Neuroscience38(3)518-529(2018 Jan)
Sanz RL,Ferraro GB,Kacervosky J,Salesse C,Gowing E,Hua L,Rambaldi I,Beaubien F,Holmbeck K,Cloutier JF,L?vesque M,Murai K,Fournier AE

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Cellular and molecular life sciences : CMLS73(1)217-36(2016 Jan)
Baranger K,Marchalant Y,Bonnet AE,Crouzin N,Carrete A,Paumier JM,Py NA,Bernard A,Bauer C,Charrat E,Moschke K,Seiki M,Vignes M,Lichtenthaler SF,Checler F,Khrestchatisky M,Rivera S

?-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Nature526(7573)443-7(2015 Oct)
Willem M,Tahirovic S,Busche MA,Ovsepian SV,Chafai M,Kootar S,Hornburg D,Evans LD,Moore S,Daria A,Hampel H,M?ller V,Giudici C,Nuscher B,Wenninger-Weinzierl A,Kremmer E,Heneka MT,Thal DR,Giedraitis V,Lannfelt L,M?ller U,Livesey FJ,Meissner F,Herms J,Konnerth A,Marie H,Haass C

Membrane-type matrix metalloproteinases: Their functions and regulations.
Matrix biology : journal of the International Society for Matrix Biology44-46207-23(2015 May-Jul)
Itoh Y

MT5-MMP regulates adult neural stem cell functional quiescence through the cleavage of N-cadherin.
Nature cell biology16(7)629-38(2014 Jul)
Porlan E,Mart?-Prado B,Morante-Redolat JM,Consiglio A,Delgado AC,Kypta R,L?pez-Ot?n C,Kirstein M,Fari?as I

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Mmp24 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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