Mesp2 cDNA ORF clone, Mus musculus(house mouse)

The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.
Bardot P, Vincent SD, Fournier M, Hubaud A, Joint M, Tora L, Pourqui? O
Development (Cambridge, England)144(20)3808-3818(2017 10)

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A
Developmental cell40(4)331-341.e4(2017 02)

Supt20 is required for development of the axial skeleton.
Warrier S, Nuwayhid S, Sabatino JA, Sugrue KF, Zohn IE
Developmental biology421(2)245-257(2017 Jan)

Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion.
Williams DR, Shifley ET, Braunreiter KM, Cole SE
Development (Cambridge, England)143(5)822-30(2016 Mar)

Studies indicate that mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2) double-knockout embryos exhibited defective development of the embryonic mesoderm.
Title: The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development.

conclusion was supported by analyses of Mesp2 KO and Ripply1/2 double KO embryos lacking rostral and caudal properties, respectively
Title: Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo.

current observations of the spatiotemporal disorder of vertebral organogenesis in the Mesp2-null mice provide further insight into the pathogenesis of SCDO and STDO, and the physiological development of the axial skeleton
Title: Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis.

Data demonstrate that Mesp2 is a novel component involved in the suppression of Notch target genes.
Title: The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis.

Data propose a novel function of Notch signaling, in which a progressive oscillating wave of Notch activity is translated into the rostral-caudal polarity of a somite by regulating Mesp2 expression in the anterior presomitic mesoderm.
Title: The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite.