MESP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MESP2
Entrez Gene ID	145873
Full Name	mesoderm posterior bHLH transcription factor 2
Synonyms	SCDO2,bHLHc6
General protein information	Preferred Names mesoderm posterior bHLH transcription factor 2 Names mesoderm posterior protein 2 class C basic helix-loop-helix protein 6 mesoderm posterior 2 homolog mesoderm posterior basic helix-loop-helix transcription factor 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q26.1
Summary	This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008].
Disorder MIM:	605195
Disorder Html:	Spondylocostal dysostosis 2, autosomal recessive, 608681 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039958.1	NP_001035047.1	mesoderm posterior protein 2
NM_001039958.2	NP_001035047.1	mesoderm posterior protein 2

Pathways from BioSystems

Homologies

	MESP2	XP_001093605.1
Mus musculus (house mouse)	Mesp2	NP_032615.2
Rattus norvegicus (Norway rat)	Mesp2	NP_001099743.1
Homo sapiens (human)	MESP2	NP_001035047.1
Canis lupus familiaris (dog)	MESP2	XP_003434391.1
Pan troglodytes (chimpanzee)	MESP2	XP_523152.2
Bos taurus (cattle)	MESP2	XP_002696623.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.
Qiu XS, Zhou S, Jiang H, Ji ML, Ding Q, Lv F, Liu Z, Tang N, Cheng JC, Qiu Y
Studies in health technology and informatics17652-5(2012)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome.
Cornier AS, Staehling-Hampton K, Delventhal KM, Saga Y, Caubet JF, Sasaki N, Ellard S, Young E, Ramirez N, Carlo SE, Torres J, Emans JB, Turnpenny PD, Pourqui? O
American journal of human genetics82(6)1334-41(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population.
Title: Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.

findings suggest a founder-effect mutation in the MESP2 gene as a major cause of the classical Puerto Rican form of spondylothoracic dysostosis/Jarcho-Levin syndrome
Title: Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome.

Mesp1 is down-regulated in the later stages of development by increasing levels of Mesp2 in the wild-type embryo.
Title: Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis.

Mutated MESP2 causes spondylocostal dysostosis
Title: Mutated MESP2 causes spondylocostal dysostosis in humans.

The following MESP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MESP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28715	NM_001039958.2 Latest version!	Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu28715	NM_001039958.1	Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MESP2 ( NM_001039958.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035047.1 Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA.

Price & Availability↑

CloneID	OHu28715
Clone ID Related Accession (Same CDS sequence)	NM_001039958.1 , NM_001039958.2
Accession Version	NM_001039958.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	mesoderm posterior protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK000142.1 and AC079075.6. This sequence is a reference standard in the RefSeqGene project. On or before Mar 25, 2006 this sequence version replaced XM_085261.4, XM_938609.1. ##Evidence-Data-START## Transcript exon combination :: BC111413.1, SRR1803613.386327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCAGT CGCCTCCTCC GCAGAGCCTC CTCGGCCACG ACCACTGGAT CTTCGCCCAG 
GGCTGGGGCT GGGCCGGCCA CTGGGACTCC ACGTCCCCGG CCTCCTCCTC CGATTCGTCG 
GGTTCGTGCC CCTGCGACGG CGCCCGCGGA CTCCCGCAGC CACAGCCTCC GAGCTGCAGC 
TCCCGAGCCG CAGAGGCAGC CGCGACGACG CCCAGACGAG CGCGCACCGG ACCAGCGGGC 
GGACAGCGGC AGAGCGCCAG CGAGCGGGAG AAACTGCGCA TGCGCACGCT GGCCCGCGCC 
CTGCACGAGT TGCGCCGCTT TCTGCCTCCC TCCTTGGCGC CGGCCGGCCA GAGCCTGACC 
AAGATCGAGA CGCTGCGCCT GGCCATCCGC TACATCGGCC ACCTATCGGC CGTGCTGGGT 
CTCAGCGAGG AGAGTCTGCA GTGCCGGCGC AGGCAGCGCG GGGACGCGGG GTCCCCTTGG 
GGCTGCCCGC TGTGCCCCGA CCGTGGCCCC GCAGAGGCGC AGACGCAGGC GGAGGGGCAG 
GGGCAAGGGC AGGGGCAGGG GCAGGGGCAA GGGCAGGGGC AAGGACAGGG GCAAGGACAG 
GGGCAAGGGC AGGGGCGCAG GCCGGGCCTG GTCTCCGCCG TCCTCGCCGA GGCGTCCTGG 
GGATCCCCGT CCGCCTGCCC CGGAGCCCAA GCCGCACCCG AGCGCCTGGG GAGGGGGGTC 
CACGACACGG ATCCCTGGGC AACACCCCCT TACTGCCCCA AGATACAGTC GCCCCCGTAT 
TCGTCCCAAG GGACAACCTC CGACGCGTCT CTTTGGACGC CACCCCAAGG CTGTCCCTGG 
ACGCAGTCGT CCCCAGAGCC CCGGAACCCA CCAGTGCCCT GGACGGCGGC CCCAGCAACT 
TTGGAGCTGG CCGCAGTGTA CCAGGGTCTC TCTGTGTCTC CAGAGCCCTG TCTGTCGCTG 
GGAGCTCCAT CTCTCCTGCC CCACCCATCA TGCCAGAGAC TGCAGCCTCA GACCCCCGGG 
AGGTGCTGGA GCCACAGTGC AGAGGTGGTG CCCAACTCAG AGGACCAGGG ACCGGGCGCC 
GCCTTCCAGC TCAGTGAAGC AAGCCCTCCC CAGAGCTCAG GCCTGCGGTT CAGTGGCTGC 
CCTGAACTTT GGCAAGAAGA TCTGGAGGGG GCCCGCCTGG GCATCTTCTA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035047.1
CDS	1..1194
Translation	MAQSPPPQSLLGHDHWIFAQGWGWAGHWDSTSPASSSDSSGSCPCDGARGLPQPQPPSCSSRAAEAAATTPRRARTGPAGGQRQSASEREKLRMRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESLQCRRRQRGDAGSPWGCPLCPDRGPAEAQTQAEGQGQGQGQGQGQGQGQGQGQGQGQGQGRRPGLVSAVLAEASWGSPSACPGAQAAPERLGRGVHDTDPWATPPYCPKIQSPPYSSQGTTSDASLWTPPQGCPWTQSSPEPRNPPVPWTAAPATLELAAVYQGLSVSPEPCLSLGAPSLLPHPSCQRLQPQTPGRCWSHSAEVVPNSEDQGPGAAFQLSEASPPQSSGLRFSGCPELWQEDLEGARLGIFY

Target ORF information:

RefSeq Version	NM_001039958.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039958.1

ORF Insert Sequence:

ATGGCCCAGT CGCCTCCTCC GCAGAGCCTC CTCGGCCACG ACCACTGGAT CTTCGCCCAG 
GGCTGGGGCT GGGCCGGCCA CTGGGACTCC ACGTCCCCGG CCTCCTCCTC CGATTCGTCG 
GGTTCGTGCC CCTGCGACGG CGCCCGCGGA CTCCCGCAGC CACAGCCTCC GAGCTGCAGC 
TCCCGAGCCG CAGAGGCAGC CGCGACGACG CCCAGACGAG CGCGCACCGG ACCAGCGGGC 
GGACAGCGGC AGAGCGCCAG CGAGCGGGAG AAACTGCGCA TGCGCACGCT GGCCCGCGCC 
CTGCACGAGT TGCGCCGCTT TCTGCCTCCC TCCTTGGCGC CGGCCGGCCA GAGCCTGACC 
AAGATCGAGA CGCTGCGCCT GGCCATCCGC TACATCGGCC ACCTATCGGC CGTGCTGGGT 
CTCAGCGAGG AGAGTCTGCA GTGCCGGCGC AGGCAGCGCG GGGACGCGGG GTCCCCTTGG 
GGCTGCCCGC TGTGCCCCGA CCGTGGCCCC GCAGAGGCGC AGACGCAGGC GGAGGGGCAG 
GGGCAAGGGC AGGGGCAGGG GCAGGGGCAA GGGCAGGGGC AAGGACAGGG GCAAGGACAG 
GGGCAAGGGC AGGGGCGCAG GCCGGGCCTG GTCTCCGCCG TCCTCGCCGA GGCGTCCTGG 
GGATCCCCGT CCGCCTGCCC CGGAGCCCAA GCCGCACCCG AGCGCCTGGG GAGGGGGGTC 
CACGACACGG ATCCCTGGGC AACACCCCCT TACTGCCCCA AGATACAGTC GCCCCCGTAT 
TCGTCCCAAG GGACAACCTC CGACGCGTCT CTTTGGACGC CACCCCAAGG CTGTCCCTGG 
ACGCAGTCGT CCCCAGAGCC CCGGAACCCA CCAGTGCCCT GGACGGCGGC CCCAGCAACT 
TTGGAGCTGG CCGCAGTGTA CCAGGGTCTC TCTGTGTCTC CAGAGCCCTG TCTGTCGCTG 
GGAGCTCCAT CTCTCCTGCC CCACCCATCA TGCCAGAGAC TGCAGCCTCA GACCCCCGGG 
AGGTGCTGGA GCCACAGTGC AGAGGTGGTG CCCAACTCAG AGGACCAGGG ACCGGGCGCC 
GCCTTCCAGC TCAGTGAAGC AAGCCCTCCC CAGAGCTCAG GCCTGCGGTT CAGTGGCTGC 
CCTGAACTTT GGCAAGAAGA TCTGGAGGGG GCCCGCCTGG GCATCTTCTA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MESP2 ( NM_001039958.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001035047.1 Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA.

Price & Availability↑

CloneID	OHu28715
Clone ID Related Accession (Same CDS sequence)	NM_001039958.1 , NM_001039958.2
Accession Version	NM_001039958.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	mesoderm posterior protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079075.6. This sequence is a reference standard in the RefSeqGene project. On Oct 31, 2018 this sequence version replaced NM_001039958.1. ##Evidence-Data-START## Transcript exon combination :: BC111413.1, SRR1803613.386327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000341735.5/ ENSP00000342392.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCCAGT CGCCTCCTCC GCAGAGCCTC CTCGGCCACG ACCACTGGAT CTTCGCCCAG 
GGCTGGGGCT GGGCCGGCCA CTGGGACTCC ACGTCCCCGG CCTCCTCCTC CGATTCGTCG 
GGTTCGTGCC CCTGCGACGG CGCCCGCGGA CTCCCGCAGC CACAGCCTCC GAGCTGCAGC 
TCCCGAGCCG CAGAGGCAGC CGCGACGACG CCCAGACGAG CGCGCACCGG ACCAGCGGGC 
GGACAGCGGC AGAGCGCCAG CGAGCGGGAG AAACTGCGCA TGCGCACGCT GGCCCGCGCC 
CTGCACGAGT TGCGCCGCTT TCTGCCTCCC TCCTTGGCGC CGGCCGGCCA GAGCCTGACC 
AAGATCGAGA CGCTGCGCCT GGCCATCCGC TACATCGGCC ACCTATCGGC CGTGCTGGGT 
CTCAGCGAGG AGAGTCTGCA GTGCCGGCGC AGGCAGCGCG GGGACGCGGG GTCCCCTTGG 
GGCTGCCCGC TGTGCCCCGA CCGTGGCCCC GCAGAGGCGC AGACGCAGGC GGAGGGGCAG 
GGGCAAGGGC AGGGGCAGGG GCAGGGGCAA GGGCAGGGGC AAGGACAGGG GCAAGGACAG 
GGGCAAGGGC AGGGGCGCAG GCCGGGCCTG GTCTCCGCCG TCCTCGCCGA GGCGTCCTGG 
GGATCCCCGT CCGCCTGCCC CGGAGCCCAA GCCGCACCCG AGCGCCTGGG GAGGGGGGTC 
CACGACACGG ATCCCTGGGC AACACCCCCT TACTGCCCCA AGATACAGTC GCCCCCGTAT 
TCGTCCCAAG GGACAACCTC CGACGCGTCT CTTTGGACGC CACCCCAAGG CTGTCCCTGG 
ACGCAGTCGT CCCCAGAGCC CCGGAACCCA CCAGTGCCCT GGACGGCGGC CCCAGCAACT 
TTGGAGCTGG CCGCAGTGTA CCAGGGTCTC TCTGTGTCTC CAGAGCCCTG TCTGTCGCTG 
GGAGCTCCAT CTCTCCTGCC CCACCCATCA TGCCAGAGAC TGCAGCCTCA GACCCCCGGG 
AGGTGCTGGA GCCACAGTGC AGAGGTGGTG CCCAACTCAG AGGACCAGGG ACCGGGCGCC 
GCCTTCCAGC TCAGTGAAGC AAGCCCTCCC CAGAGCTCAG GCCTGCGGTT CAGTGGCTGC 
CCTGAACTTT GGCAAGAAGA TCTGGAGGGG GCCCGCCTGG GCATCTTCTA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035047.1
CDS	27..1220
Translation	MAQSPPPQSLLGHDHWIFAQGWGWAGHWDSTSPASSSDSSGSCPCDGARGLPQPQPPSCSSRAAEAAATTPRRARTGPAGGQRQSASEREKLRMRTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESLQCRRRQRGDAGSPWGCPLCPDRGPAEAQTQAEGQGQGQGQGQGQGQGQGQGQGQGQGQGRRPGLVSAVLAEASWGSPSACPGAQAAPERLGRGVHDTDPWATPPYCPKIQSPPYSSQGTTSDASLWTPPQGCPWTQSSPEPRNPPVPWTAAPATLELAAVYQGLSVSPEPCLSLGAPSLLPHPSCQRLQPQTPGRCWSHSAEVVPNSEDQGPGAAFQLSEASPPQSSGLRFSGCPELWQEDLEGARLGIFY

Target ORF information:

RefSeq Version	NM_001039958.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039958.2

ORF Insert Sequence:

ATGGCCCAGT CGCCTCCTCC GCAGAGCCTC CTCGGCCACG ACCACTGGAT CTTCGCCCAG 
GGCTGGGGCT GGGCCGGCCA CTGGGACTCC ACGTCCCCGG CCTCCTCCTC CGATTCGTCG 
GGTTCGTGCC CCTGCGACGG CGCCCGCGGA CTCCCGCAGC CACAGCCTCC GAGCTGCAGC 
TCCCGAGCCG CAGAGGCAGC CGCGACGACG CCCAGACGAG CGCGCACCGG ACCAGCGGGC 
GGACAGCGGC AGAGCGCCAG CGAGCGGGAG AAACTGCGCA TGCGCACGCT GGCCCGCGCC 
CTGCACGAGT TGCGCCGCTT TCTGCCTCCC TCCTTGGCGC CGGCCGGCCA GAGCCTGACC 
AAGATCGAGA CGCTGCGCCT GGCCATCCGC TACATCGGCC ACCTATCGGC CGTGCTGGGT 
CTCAGCGAGG AGAGTCTGCA GTGCCGGCGC AGGCAGCGCG GGGACGCGGG GTCCCCTTGG 
GGCTGCCCGC TGTGCCCCGA CCGTGGCCCC GCAGAGGCGC AGACGCAGGC GGAGGGGCAG 
GGGCAAGGGC AGGGGCAGGG GCAGGGGCAA GGGCAGGGGC AAGGACAGGG GCAAGGACAG 
GGGCAAGGGC AGGGGCGCAG GCCGGGCCTG GTCTCCGCCG TCCTCGCCGA GGCGTCCTGG 
GGATCCCCGT CCGCCTGCCC CGGAGCCCAA GCCGCACCCG AGCGCCTGGG GAGGGGGGTC 
CACGACACGG ATCCCTGGGC AACACCCCCT TACTGCCCCA AGATACAGTC GCCCCCGTAT 
TCGTCCCAAG GGACAACCTC CGACGCGTCT CTTTGGACGC CACCCCAAGG CTGTCCCTGG 
ACGCAGTCGT CCCCAGAGCC CCGGAACCCA CCAGTGCCCT GGACGGCGGC CCCAGCAACT 
TTGGAGCTGG CCGCAGTGTA CCAGGGTCTC TCTGTGTCTC CAGAGCCCTG TCTGTCGCTG 
GGAGCTCCAT CTCTCCTGCC CCACCCATCA TGCCAGAGAC TGCAGCCTCA GACCCCCGGG 
AGGTGCTGGA GCCACAGTGC AGAGGTGGTG CCCAACTCAG AGGACCAGGG ACCGGGCGCC 
GCCTTCCAGC TCAGTGAAGC AAGCCCTCCC CAGAGCTCAG GCCTGCGGTT CAGTGGCTGC 
CCTGAACTTT GGCAAGAAGA TCTGGAGGGG GCCCGCCTGG GCATCTTCTA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis.
Studies in health technology and informatics17652-5(2012)
Qiu XS,Zhou S,Jiang H,Ji ML,Ding Q,Lv F,Liu Z,Tang N,Cheng JC,Qiu Y

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome.
American journal of human genetics82(6)1334-41(2008 Jun)
Cornier AS,Staehling-Hampton K,Delventhal KM,Saga Y,Caubet JF,Sasaki N,Ellard S,Young E,Ramirez N,Carlo SE,Torres J,Emans JB,Turnpenny PD,Pourqui? O

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MESP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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