Lcp2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lcp2
Entrez Gene ID	16822
Full Name	lymphocyte cytosolic protein 2
Synonyms	AI323664,BB161688,SLP-76,SLP76,m1Khoe,twm
General protein information	Preferred Names lymphocyte cytosolic protein 2 Names lymphocyte cytosolic protein 2 SH2 domain-containing leukocyte protein of 76 kDa SLP-76 tyrosine phosphoprotein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 A4

mRNA and Protein(s)

mRNA	Protein	Name
NM_010696.4	NP_034826.2	lymphocyte cytosolic protein 2
NM_010696.3	NP_034826.2	lymphocyte cytosolic protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LCP2	XP_001150122.1
Danio rerio (zebrafish)	lcp2a	NP_999882.1
Danio rerio (zebrafish)	lcp2b	XP_001343678.3
Canis lupus familiaris (dog)	LCP2	XP_866864.1
Bos taurus (cattle)	LCP2	NP_001070312.1
Homo sapiens (human)	LCP2	NP_005556.1
	LCP2	XP_001092472.1
Mus musculus (house mouse)	Lcp2	NP_034826.2
Rattus norvegicus (Norway rat)	Lcp2	NP_569105.1
Xenopus tropicalis (tropical clawed frog)	lcp2	NP_001121489.1
Gallus gallus (chicken)	LCP2	NP_990032.1

Gene Ontology
Bibliography

Related articles in PubMed

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile ? motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
Thaker YR, Recino A, Raab M, Jabeen A, Wallberg M, Fernandez N, Rudd CE
The Journal of biological chemistry292(15)6281-6290(2017 04)

Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function.
Navas VH, Cuche C, Alcover A, Di Bartolo V
PloS one12(1)e0170396(2017)

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
Reppschl?ger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY
The Journal of biological chemistry291(43)22427-22441(2016 Oct)

Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.
Freund J, May RM, Yang E, Li H, McCullen M, Zhang B, Lenvik T, Cichocki F, Anderson SK, Kambayashi T
PLoS biology14(8)e1002526(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells.
Title: Activated Cdc42-associated kinase 1 (ACK1) binds the sterile ? motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.

Biochemical analyses revealed that mutant T cells were hypersensitive to TCR stimulation. Indeed, phosphorylation of several signaling proteins, including SLP76 itself, phospholipase Cgamma1 and the protein kinases AKT and ERK1/2, was increased
Title: Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function.

slp-76 contributes to the regulation of the tissue distribution, PLZF, and cytokine expression of iNKT cells via ADAP-dependent and -independent mechanisms.
Title: A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.

immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells
Title: The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.

these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice
Title: Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets.

The following Lcp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lcp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22938	NM_010696.4 Latest version!	Mus musculus lymphocyte cytosolic protein 2 (Lcp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$314.30 $449.00
View Old Accession Versions >>
OMu22938	NM_010696.3	Mus musculus lymphocyte cytosolic protein 2 (Lcp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$314.30 $449.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lcp2 ( NM_010696.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034826.2 Mus musculus lymphocyte cytosolic protein 2 (Lcp2), mRNA.

Price & Availability↑

CloneID	OMu22938
Clone ID Related Accession (Same CDS sequence)	NM_010696.4 , NM_010696.3
Accession Version	NM_010696.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1602bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	lymphocyte cytosolic protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL645909.11. On Feb 15, 2018 this sequence version replaced NM_010696.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036727.1, BC006948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTTGA AGAATGTCCC GTTTCGCTCA GAGGTCCTAG CCTGGAACTC AGACAACCTC 
GCTGACTATT TCAGGAAGCT GAACTACAGG GACTGTGAGA AGGCTGTGAA GAAATACCAC 
ATTGATGGTG CTCGGTTTTT GAACCTGACA GAAAATGACA TTCAGAAGTT CCCTAAGCTG 
AGGATGCCAC TTCTCAGTAA GTTGAGTCAA GATATCAACA AGAACGAAGA GAGAAGGAGC 
ATTTTCACAC GCAAACCCCA GATTCCACGG TTTCTTGAGG AGACAGAAAG CCACGAAGAA 
GACGATGGTG GCTGGTCATC CTTTGAAGAT GACTATGAAA GTCCCAATGA TGATGATCCA 
GATGGGGAGG ACGATGGTGA CTATGAGTCC CCTAATGAGG AGGAACAGGC CCTGGTGGAC 
GATGCTGCTG ACTATGAGCC TCCACCCTCC AACAACGAGG AGGCTCTGCA GAGCTCCATC 
CTGCCCCCCA ACTCTTTCCA CAACACCAAC TCCATGTACA TCGACCGACC TCCCACTGGC 
AAGGTCTCCC AGCAGCCTCC AGTGCCCCCA CTGAGACCAA AACCTGCCCT CCCTCCCCTG 
CCAACAGGCA GGAATCACTC GCCACTGTCT CCACCCCATC CCAACCACGA AGAGCCCAGC 
AGAAGTGGAA ACAACAAGAC AGCAAAGTTG CCTGCTCCAT CAATAGACAG AAGCACAAAA 
CCTCCCCTGG ACCGCTCACT GGCCCCTCTT GACCGAGAGC CCTTCATACT AGGAAAGAAA 
CCACCATTTT CTGATAAGCC CTCAGCCCCA TTGGGGAGGG AACATTTACC CAAGATACAA 
AAGCCTCCTT TGCCACCAGC CATGGACAGA CACGAAAGAA ATGAAAGACT CGGACCCGTG 
ACAACGAGGA AGCCACCAGT TCCAAGGCAT GGAAGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCA CAGCCGTCAC TACCTTCCAT GAGCTCCAAC 
ACATTCCCTT CGAGATCTGT CCAGCCCAGC TCCAAGAACA CATTCCCATT GGCCCACATG 
CCGGGAGCCT TCTCAGAAAG CAACATTGGC TTTCAGCAGA GTGCCTCCCT GCCGCCATAC 
TTCTCTCAAG GTCCAGGCAA CAGGCCACCT CTCAGAAGTG AAGGCAGAAA CTTACCCTTG 
CCGGTTCCAA ACAGGCCTCA GCCTCCATCT CCTGGGGAAG AAGAGACACC CTTAGATGAA 
GAGTGGTATG TCTCTTATAT CACCCGACCA GAGGCAGAAG CTGCTCTGAG GAAGATAAAC 
CAGGATGGCA CCTTCCTGGT TAGAGACAGC TCTAAGAAGA CAGCGAACAA TCCGTATGTC 
CTCATGGTGC TGTACAAAGA CAAAGTTTAC AACATCCAAA TCCGCTACCA GGAGGAAAGT 
CAAGTCTACT TGTTGGGCAC TGGACTTCGA GGAAAAGAGG ACTTCCTGTC TGTATCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCGCTG TTGCTCATTG ATGGAAAGAA TCGAGGGTCC 
AGATACCAGT GCACACTAAC ACACGCTGCA GGCTGTCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034826.2
CDS	427..2028
Translation	MALKNVPFRSEVLAWNSDNLADYFRKLNYRDCEKAVKKYHIDGARFLNLTENDIQKFPKLRMPLLSKLSQDINKNEERRSIFTRKPQIPRFLEETESHEEDDGGWSSFEDDYESPNDDDPDGEDDGDYESPNEEEQALVDDAADYEPPPSNNEEALQSSILPPNSFHNTNSMYIDRPPTGKVSQQPPVPPLRPKPALPPLPTGRNHSPLSPPHPNHEEPSRSGNNKTAKLPAPSIDRSTKPPLDRSLAPLDREPFILGKKPPFSDKPSAPLGREHLPKIQKPPLPPAMDRHERNERLGPVTTRKPPVPRHGRGPDRRENDEDDVHQRPLPQPSLPSMSSNTFPSRSVQPSSKNTFPLAHMPGAFSESNIGFQQSASLPPYFSQGPGNRPPLRSEGRNLPLPVPNRPQPPSPGEEETPLDEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTANNPYVLMVLYKDKVYNIQIRYQEESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGCL

Target ORF information:

RefSeq Version	NM_010696.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus lymphocyte cytosolic protein 2 (Lcp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010696.4

ORF Insert Sequence:

ATGGCCTTGA AGAATGTCCC GTTTCGCTCA GAGGTCCTAG CCTGGAACTC AGACAACCTC 
GCTGACTATT TCAGGAAGCT GAACTACAGG GACTGTGAGA AGGCTGTGAA GAAATACCAC 
ATTGATGGTG CTCGGTTTTT GAACCTGACA GAAAATGACA TTCAGAAGTT CCCTAAGCTG 
AGGATGCCAC TTCTCAGTAA GTTGAGTCAA GATATCAACA AGAACGAAGA GAGAAGGAGC 
ATTTTCACAC GCAAACCCCA GATTCCACGG TTTCTTGAGG AGACAGAAAG CCACGAAGAA 
GACGATGGTG GCTGGTCATC CTTTGAAGAT GACTATGAAA GTCCCAATGA TGATGATCCA 
GATGGGGAGG ACGATGGTGA CTATGAGTCC CCTAATGAGG AGGAACAGGC CCTGGTGGAC 
GATGCTGCTG ACTATGAGCC TCCACCCTCC AACAACGAGG AGGCTCTGCA GAGCTCCATC 
CTGCCCCCCA ACTCTTTCCA CAACACCAAC TCCATGTACA TCGACCGACC TCCCACTGGC 
AAGGTCTCCC AGCAGCCTCC AGTGCCCCCA CTGAGACCAA AACCTGCCCT CCCTCCCCTG 
CCAACAGGCA GGAATCACTC GCCACTGTCT CCACCCCATC CCAACCACGA AGAGCCCAGC 
AGAAGTGGAA ACAACAAGAC AGCAAAGTTG CCTGCTCCAT CAATAGACAG AAGCACAAAA 
CCTCCCCTGG ACCGCTCACT GGCCCCTCTT GACCGAGAGC CCTTCATACT AGGAAAGAAA 
CCACCATTTT CTGATAAGCC CTCAGCCCCA TTGGGGAGGG AACATTTACC CAAGATACAA 
AAGCCTCCTT TGCCACCAGC CATGGACAGA CACGAAAGAA ATGAAAGACT CGGACCCGTG 
ACAACGAGGA AGCCACCAGT TCCAAGGCAT GGAAGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCA CAGCCGTCAC TACCTTCCAT GAGCTCCAAC 
ACATTCCCTT CGAGATCTGT CCAGCCCAGC TCCAAGAACA CATTCCCATT GGCCCACATG 
CCGGGAGCCT TCTCAGAAAG CAACATTGGC TTTCAGCAGA GTGCCTCCCT GCCGCCATAC 
TTCTCTCAAG GTCCAGGCAA CAGGCCACCT CTCAGAAGTG AAGGCAGAAA CTTACCCTTG 
CCGGTTCCAA ACAGGCCTCA GCCTCCATCT CCTGGGGAAG AAGAGACACC CTTAGATGAA 
GAGTGGTATG TCTCTTATAT CACCCGACCA GAGGCAGAAG CTGCTCTGAG GAAGATAAAC 
CAGGATGGCA CCTTCCTGGT TAGAGACAGC TCTAAGAAGA CAGCGAACAA TCCGTATGTC 
CTCATGGTGC TGTACAAAGA CAAAGTTTAC AACATCCAAA TCCGCTACCA GGAGGAAAGT 
CAAGTCTACT TGTTGGGCAC TGGACTTCGA GGAAAAGAGG ACTTCCTGTC TGTATCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCGCTG TTGCTCATTG ATGGAAAGAA TCGAGGGTCC 
AGATACCAGT GCACACTAAC ACACGCTGCA GGCTGTCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lcp2 ( NM_010696.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034826.2 Mus musculus lymphocyte cytosolic protein 2 (Lcp2), mRNA.

Price & Availability↑

CloneID	OMu22938
Clone ID Related Accession (Same CDS sequence)	NM_010696.4 , NM_010696.3
Accession Version	NM_010696.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1602bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Mus musculus(house mouse)
Product	lymphocyte cytosolic protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL645909.11. On Nov 17, 2006 this sequence version replaced NM_010696.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006948.1, AK036727.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTTGA AGAATGTCCC GTTTCGCTCA GAGGTCCTAG CCTGGAACTC AGACAACCTC 
GCTGACTATT TCAGGAAGCT GAACTACAGG GACTGTGAGA AGGCTGTGAA GAAATACCAC 
ATTGATGGTG CTCGGTTTTT GAACCTGACA GAAAATGACA TTCAGAAGTT CCCTAAGCTG 
AGGATGCCAC TTCTCAGTAA GTTGAGTCAA GATATCAACA AGAACGAAGA GAGAAGGAGC 
ATTTTCACAC GCAAACCCCA GATTCCACGG TTTCTTGAGG AGACAGAAAG CCACGAAGAA 
GACGATGGTG GCTGGTCATC CTTTGAAGAT GACTATGAAA GTCCCAATGA TGATGATCCA 
GATGGGGAGG ACGATGGTGA CTATGAGTCC CCTAATGAGG AGGAACAGGC CCTGGTGGAC 
GATGCTGCTG ACTATGAGCC TCCACCCTCC AACAACGAGG AGGCTCTGCA GAGCTCCATC 
CTGCCCCCCA ACTCTTTCCA CAACACCAAC TCCATGTACA TCGACCGACC TCCCACTGGC 
AAGGTCTCCC AGCAGCCTCC AGTGCCCCCA CTGAGACCAA AACCTGCCCT CCCTCCCCTG 
CCAACAGGCA GGAATCACTC GCCACTGTCT CCACCCCATC CCAACCACGA AGAGCCCAGC 
AGAAGTGGAA ACAACAAGAC AGCAAAGTTG CCTGCTCCAT CAATAGACAG AAGCACAAAA 
CCTCCCCTGG ACCGCTCACT GGCCCCTCTT GACCGAGAGC CCTTCATACT AGGAAAGAAA 
CCACCATTTT CTGATAAGCC CTCAGCCCCA TTGGGGAGGG AACATTTACC CAAGATACAA 
AAGCCTCCTT TGCCACCAGC CATGGACAGA CACGAAAGAA ATGAAAGACT CGGACCCGTG 
ACAACGAGGA AGCCACCAGT TCCAAGGCAT GGAAGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCA CAGCCGTCAC TACCTTCCAT GAGCTCCAAC 
ACATTCCCTT CGAGATCTGT CCAGCCCAGC TCCAAGAACA CATTCCCATT GGCCCACATG 
CCGGGAGCCT TCTCAGAAAG CAACATTGGC TTTCAGCAGA GTGCCTCCCT GCCGCCATAC 
TTCTCTCAAG GTCCAGGCAA CAGGCCACCT CTCAGAAGTG AAGGCAGAAA CTTACCCTTG 
CCGGTTCCAA ACAGGCCTCA GCCTCCATCT CCTGGGGAAG AAGAGACACC CTTAGATGAA 
GAGTGGTATG TCTCTTATAT CACCCGACCA GAGGCAGAAG CTGCTCTGAG GAAGATAAAC 
CAGGATGGCA CCTTCCTGGT TAGAGACAGC TCTAAGAAGA CAGCGAACAA TCCGTATGTC 
CTCATGGTGC TGTACAAAGA CAAAGTTTAC AACATCCAAA TCCGCTACCA GGAGGAAAGT 
CAAGTCTACT TGTTGGGCAC TGGACTTCGA GGAAAAGAGG ACTTCCTGTC TGTATCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCGCTG TTGCTCATTG ATGGAAAGAA TCGAGGGTCC 
AGATACCAGT GCACACTAAC ACACGCTGCA GGCTGTCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034826.2
CDS	154..1755
Translation	MALKNVPFRSEVLAWNSDNLADYFRKLNYRDCEKAVKKYHIDGARFLNLTENDIQKFPKLRMPLLSKLSQDINKNEERRSIFTRKPQIPRFLEETESHEEDDGGWSSFEDDYESPNDDDPDGEDDGDYESPNEEEQALVDDAADYEPPPSNNEEALQSSILPPNSFHNTNSMYIDRPPTGKVSQQPPVPPLRPKPALPPLPTGRNHSPLSPPHPNHEEPSRSGNNKTAKLPAPSIDRSTKPPLDRSLAPLDREPFILGKKPPFSDKPSAPLGREHLPKIQKPPLPPAMDRHERNERLGPVTTRKPPVPRHGRGPDRRENDEDDVHQRPLPQPSLPSMSSNTFPSRSVQPSSKNTFPLAHMPGAFSESNIGFQQSASLPPYFSQGPGNRPPLRSEGRNLPLPVPNRPQPPSPGEEETPLDEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTANNPYVLMVLYKDKVYNIQIRYQEESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGCL

Target ORF information:

RefSeq Version	NM_010696.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lymphocyte cytosolic protein 2 (Lcp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010696.3

ORF Insert Sequence:

ATGGCCTTGA AGAATGTCCC GTTTCGCTCA GAGGTCCTAG CCTGGAACTC AGACAACCTC 
GCTGACTATT TCAGGAAGCT GAACTACAGG GACTGTGAGA AGGCTGTGAA GAAATACCAC 
ATTGATGGTG CTCGGTTTTT GAACCTGACA GAAAATGACA TTCAGAAGTT CCCTAAGCTG 
AGGATGCCAC TTCTCAGTAA GTTGAGTCAA GATATCAACA AGAACGAAGA GAGAAGGAGC 
ATTTTCACAC GCAAACCCCA GATTCCACGG TTTCTTGAGG AGACAGAAAG CCACGAAGAA 
GACGATGGTG GCTGGTCATC CTTTGAAGAT GACTATGAAA GTCCCAATGA TGATGATCCA 
GATGGGGAGG ACGATGGTGA CTATGAGTCC CCTAATGAGG AGGAACAGGC CCTGGTGGAC 
GATGCTGCTG ACTATGAGCC TCCACCCTCC AACAACGAGG AGGCTCTGCA GAGCTCCATC 
CTGCCCCCCA ACTCTTTCCA CAACACCAAC TCCATGTACA TCGACCGACC TCCCACTGGC 
AAGGTCTCCC AGCAGCCTCC AGTGCCCCCA CTGAGACCAA AACCTGCCCT CCCTCCCCTG 
CCAACAGGCA GGAATCACTC GCCACTGTCT CCACCCCATC CCAACCACGA AGAGCCCAGC 
AGAAGTGGAA ACAACAAGAC AGCAAAGTTG CCTGCTCCAT CAATAGACAG AAGCACAAAA 
CCTCCCCTGG ACCGCTCACT GGCCCCTCTT GACCGAGAGC CCTTCATACT AGGAAAGAAA 
CCACCATTTT CTGATAAGCC CTCAGCCCCA TTGGGGAGGG AACATTTACC CAAGATACAA 
AAGCCTCCTT TGCCACCAGC CATGGACAGA CACGAAAGAA ATGAAAGACT CGGACCCGTG 
ACAACGAGGA AGCCACCAGT TCCAAGGCAT GGAAGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCA CAGCCGTCAC TACCTTCCAT GAGCTCCAAC 
ACATTCCCTT CGAGATCTGT CCAGCCCAGC TCCAAGAACA CATTCCCATT GGCCCACATG 
CCGGGAGCCT TCTCAGAAAG CAACATTGGC TTTCAGCAGA GTGCCTCCCT GCCGCCATAC 
TTCTCTCAAG GTCCAGGCAA CAGGCCACCT CTCAGAAGTG AAGGCAGAAA CTTACCCTTG 
CCGGTTCCAA ACAGGCCTCA GCCTCCATCT CCTGGGGAAG AAGAGACACC CTTAGATGAA 
GAGTGGTATG TCTCTTATAT CACCCGACCA GAGGCAGAAG CTGCTCTGAG GAAGATAAAC 
CAGGATGGCA CCTTCCTGGT TAGAGACAGC TCTAAGAAGA CAGCGAACAA TCCGTATGTC 
CTCATGGTGC TGTACAAAGA CAAAGTTTAC AACATCCAAA TCCGCTACCA GGAGGAAAGT 
CAAGTCTACT TGTTGGGCAC TGGACTTCGA GGAAAAGAGG ACTTCCTGTC TGTATCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCGCTG TTGCTCATTG ATGGAAAGAA TCGAGGGTCC 
AGATACCAGT GCACACTAAC ACACGCTGCA GGCTGTCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile ? motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
The Journal of biological chemistry292(15)6281-6290(2017 04)
Thaker YR,Recino A,Raab M,Jabeen A,Wallberg M,Fernandez N,Rudd CE

Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function.
PloS one12(1)e0170396(2017)
Navas VH,Cuche C,Alcover A,Di Bartolo V

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
The Journal of biological chemistry291(43)22427-22441(2016 Oct)
Reppschl?ger K,Gosselin J,Dangelmaier CA,Thomas DH,Carpino N,McKenzie SE,Kunapuli SP,Tsygankov AY

Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells.
PLoS biology14(8)e1002526(2016 Aug)
Freund J,May RM,Yang E,Li H,McCullen M,Zhang B,Lenvik T,Cichocki F,Anderson SK,Kambayashi T

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Lcp2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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