LCP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LCP2
Entrez Gene ID	3937
Full Name	lymphocyte cytosolic protein 2
Synonyms	SLP-76,SLP76
General protein information	Preferred Names lymphocyte cytosolic protein 2 Names lymphocyte cytosolic protein 2 76 kDa tyrosine phosphoprotein SH2 domain-containing leukocyte protein of 76 kDa SLP-76 tyrosine phosphoprotein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q35.1
Summary	This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016].
Disorder MIM:	601603

mRNA and Protein(s)

mRNA	Protein	Name
NM_005565.4	NP_005556.1	lymphocyte cytosolic protein 2
NM_005565.3	NP_005556.1	lymphocyte cytosolic protein 2
NM_005565.5	NP_005556.1	lymphocyte cytosolic protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LCP2	XP_001150122.1
Danio rerio (zebrafish)	lcp2a	NP_999882.1
Danio rerio (zebrafish)	lcp2b	XP_001343678.3
Canis lupus familiaris (dog)	LCP2	XP_866864.1
Bos taurus (cattle)	LCP2	NP_001070312.1
Homo sapiens (human)	LCP2	NP_005556.1
	LCP2	XP_001092472.1
Mus musculus (house mouse)	Lcp2	NP_034826.2
Rattus norvegicus (Norway rat)	Lcp2	NP_569105.1
Xenopus tropicalis (tropical clawed frog)	lcp2	NP_001121489.1
Gallus gallus (chicken)	LCP2	NP_990032.1

Gene Ontology
Bibliography

Related articles in PubMed

A PLC-?1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.
Belmont J, Gu T, Mudd A, Salomon AR
Journal of proteome research16(8)2729-2742(2017 Aug)

T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.
Breuning J, Brown MH
Molecular and cellular biology37(11)(2017 Jun)

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile ? motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
Thaker YR, Recino A, Raab M, Jabeen A, Wallberg M, Fernandez N, Rudd CE
The Journal of biological chemistry292(15)6281-6290(2017 04)

Development of nanoscale structure in LAT-based signaling complexes.
Barr VA, Sherman E, Yi J, Akpan I, Rouquette-Jazdanian AK, Samelson LE
Journal of cell science129(24)4548-4562(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 complex is required for costimulation by CD6.
Title: T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.

findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells.
Title: Activated Cdc42-associated kinase 1 (ACK1) binds the sterile ? motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.

LAT and SLP-76 are randomly dispersed throughout the clusters that form upon T cell receptor engagement.
Title: Development of nanoscale structure in LAT-based signaling complexes.

SLP76 is ectopically expressed in chronic lymphocytic leukemia cells where it plays a role in B-cell receptor signaling.
Title: SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course.

immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells
Title: The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.

The following LCP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LCP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25377	NM_005565.5 Latest version!	Homo sapiens lymphocyte cytosolic protein 2 (LCP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu25377	NM_005565.3	Homo sapiens lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu25377	NM_005565.4	Homo sapiens lymphocyte cytosolic protein 2 (LCP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LCP2 ( NM_005565.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005556.1 Homo sapiens lymphocyte cytosolic protein 2 (LCP2), mRNA.

Price & Availability↑

CloneID	OHu25377
Clone ID Related Accession (Same CDS sequence)	NM_005565.4 , NM_005565.3 , NM_005565.5
Accession Version	NM_005565.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1602bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-17
Organism	Homo sapiens(human)
Product	lymphocyte cytosolic protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB116470.1, U20158.2, AC034199.6, BC016618.1, BY995095.1 and AW291566.1. On Nov 17, 2016 this sequence version replaced NM_005565.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.196053.1, BC016618.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCACTGA GGAATGTGCC CTTTCGCTCA GAGGTCCTGG GCTGGGACCC CGACAGCCTT 
GCTGACTATT TCAAGAAGCT CAACTATAAG GACTGTGAGA AGGCAGTGAA GAAGTACCAC 
ATCGATGGGG CTCGCTTCTT GAACCTGACA GAAAATGACA TCCAGAAGTT CCCCAAGCTC 
CGGGTGCCGA TTCTCAGTAA GTTAAGTCAG GAAATCAACA AGAACGAAGA GAGGAGGAGC 
ATCTTCACAC GCAAACCCCA AGTCCCGCGG TTTCCTGAAG AGACAGAAAG CCACGAAGAG 
GACAATGGGG GCTGGTCGTC CTTTGAAGAA GACGATTATG AAAGTCCCAA TGATGACCAG 
GATGGGGAGG ATGATGGAGA CTATGAGTCC CCCAATGAGG AGGAAGAGGC ACCCGTGGAA 
GATGACGCGG ATTATGAGCC GCCACCCTCC AATGACGAGG AAGCTCTGCA GAACTCCATC 
CTGCCTGCCA AGCCTTTCCC CAACTCCAAC TCCATGTACA TCGACCGGCC CCCCTCTGGG 
AAAACCCCCC AGCAGCCTCC TGTGCCCCCC CAGAGACCGA TGGCCGCCCT CCCGCCCCCA 
CCAGCCGGCC GGAATCACTC GCCACTGCCC CCACCCCAGA CCAACCACGA AGAACCCAGC 
AGAAGCAGAA ACCACAAAAC GGCAAAGCTC CCTGCTCCTT CAATAGACAG AAGCACGAAA 
CCTCCCCTAG ATCGTTCATT AGCTCCGTTT GATAGAGAAC CCTTCACACT AGGAAAGAAA 
CCACCATTTT CTGACAAGCC CTCGATTCCA GCGGGAAGGT CACTCGGGGA GCATTTACCC 
AAGATTCAAA AGCCTCCTTT ACCACCGACC ACGGAAAGAC ATGAAAGGAG CAGCCCCCTG 
CCAGGGAAGA AGCCACCTGT GCCAAAGCAT GGATGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCC CAGCCAGCAC TACTTCCTAT GAGCTCCAAC 
ACTTTCCCTT CAAGATCTAC TAAGCCAAGT CCCATGAACC CTCTCCCATC CTCTCACATG 
CCTGGAGCAT TCTCAGAAAG TAACAGCAGT TTTCCACAGA GTGCCTCCCT GCCACCATAC 
TTCTCTCAAG GCCCTAGCAA CAGACCACCT ATCAGAGCCG AAGGCAGAAA CTTCCCCTTG 
CCACTTCCAA ACAAACCTCG GCCCCCATCC CCCGCGGAGG AAGAGAATTC ATTAAATGAA 
GAGTGGTACG TTTCTTATAT TACCCGACCA GAGGCAGAAG CTGCTCTTAG AAAGATAAAC 
CAGGATGGCA CATTTCTGGT CAGAGACAGC TCTAAAAAAA CAACAACCAA TCCATATGTC 
CTCATGGTGT TGTACAAAGA TAAAGTTTAC AACATCCAGA TCCGTTATCA GAAGGAAAGT 
CAAGTTTACT TGTTGGGAAC TGGACTCCGA GGGAAAGAGG ACTTTCTGTC TGTGTCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCACTT CTGCTCATTG ATGGGAAAAA CCGAGGTTCC 
AGATACCAGT GCACATTAAC GCATGCTGCA GGGTACCCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005556.1
CDS	232..1833
Translation	MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP

Target ORF information:

RefSeq Version	NM_005565.4
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte cytosolic protein 2 (LCP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005565.4

ORF Insert Sequence:

ATGGCACTGA GGAATGTGCC CTTTCGCTCA GAGGTCCTGG GCTGGGACCC CGACAGCCTT 
GCTGACTATT TCAAGAAGCT CAACTATAAG GACTGTGAGA AGGCAGTGAA GAAGTACCAC 
ATCGATGGGG CTCGCTTCTT GAACCTGACA GAAAATGACA TCCAGAAGTT CCCCAAGCTC 
CGGGTGCCGA TTCTCAGTAA GTTAAGTCAG GAAATCAACA AGAACGAAGA GAGGAGGAGC 
ATCTTCACAC GCAAACCCCA AGTCCCGCGG TTTCCTGAAG AGACAGAAAG CCACGAAGAG 
GACAATGGGG GCTGGTCGTC CTTTGAAGAA GACGATTATG AAAGTCCCAA TGATGACCAG 
GATGGGGAGG ATGATGGAGA CTATGAGTCC CCCAATGAGG AGGAAGAGGC ACCCGTGGAA 
GATGACGCGG ATTATGAGCC GCCACCCTCC AATGACGAGG AAGCTCTGCA GAACTCCATC 
CTGCCTGCCA AGCCTTTCCC CAACTCCAAC TCCATGTACA TCGACCGGCC CCCCTCTGGG 
AAAACCCCCC AGCAGCCTCC TGTGCCCCCC CAGAGACCGA TGGCCGCCCT CCCGCCCCCA 
CCAGCCGGCC GGAATCACTC GCCACTGCCC CCACCCCAGA CCAACCACGA AGAACCCAGC 
AGAAGCAGAA ACCACAAAAC GGCAAAGCTC CCTGCTCCTT CAATAGACAG AAGCACGAAA 
CCTCCCCTAG ATCGTTCATT AGCTCCGTTT GATAGAGAAC CCTTCACACT AGGAAAGAAA 
CCACCATTTT CTGACAAGCC CTCGATTCCA GCGGGAAGGT CACTCGGGGA GCATTTACCC 
AAGATTCAAA AGCCTCCTTT ACCACCGACC ACGGAAAGAC ATGAAAGGAG CAGCCCCCTG 
CCAGGGAAGA AGCCACCTGT GCCAAAGCAT GGATGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCC CAGCCAGCAC TACTTCCTAT GAGCTCCAAC 
ACTTTCCCTT CAAGATCTAC TAAGCCAAGT CCCATGAACC CTCTCCCATC CTCTCACATG 
CCTGGAGCAT TCTCAGAAAG TAACAGCAGT TTTCCACAGA GTGCCTCCCT GCCACCATAC 
TTCTCTCAAG GCCCTAGCAA CAGACCACCT ATCAGAGCCG AAGGCAGAAA CTTCCCCTTG 
CCACTTCCAA ACAAACCTCG GCCCCCATCC CCCGCGGAGG AAGAGAATTC ATTAAATGAA 
GAGTGGTACG TTTCTTATAT TACCCGACCA GAGGCAGAAG CTGCTCTTAG AAAGATAAAC 
CAGGATGGCA CATTTCTGGT CAGAGACAGC TCTAAAAAAA CAACAACCAA TCCATATGTC 
CTCATGGTGT TGTACAAAGA TAAAGTTTAC AACATCCAGA TCCGTTATCA GAAGGAAAGT 
CAAGTTTACT TGTTGGGAAC TGGACTCCGA GGGAAAGAGG ACTTTCTGTC TGTGTCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCACTT CTGCTCATTG ATGGGAAAAA CCGAGGTTCC 
AGATACCAGT GCACATTAAC GCATGCTGCA GGGTACCCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LCP2 ( NM_005565.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005556.1 Homo sapiens lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2), mRNA.

Price & Availability↑

CloneID	OHu25377
Clone ID Related Accession (Same CDS sequence)	NM_005565.4 , NM_005565.3 , NM_005565.5
Accession Version	NM_005565.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1602bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	lymphocyte cytosolic protein 2
Comment

ATGGCACTGA GGAATGTGCC CTTTCGCTCA GAGGTCCTGG GCTGGGACCC CGACAGCCTT 
GCTGACTATT TCAAGAAGCT CAACTATAAG GACTGTGAGA AGGCAGTGAA GAAGTACCAC 
ATCGATGGGG CTCGCTTCTT GAACCTGACA GAAAATGACA TCCAGAAGTT CCCCAAGCTC 
CGGGTGCCGA TTCTCAGTAA GTTAAGTCAG GAAATCAACA AGAACGAAGA GAGGAGGAGC 
ATCTTCACAC GCAAACCCCA AGTCCCGCGG TTTCCTGAAG AGACAGAAAG CCACGAAGAG 
GACAATGGGG GCTGGTCGTC CTTTGAAGAA GACGATTATG AAAGTCCCAA TGATGACCAG 
GATGGGGAGG ATGATGGAGA CTATGAGTCC CCCAATGAGG AGGAAGAGGC ACCCGTGGAA 
GATGACGCGG ATTATGAGCC GCCACCCTCC AATGACGAGG AAGCTCTGCA GAACTCCATC 
CTGCCTGCCA AGCCTTTCCC CAACTCCAAC TCCATGTACA TCGACCGGCC CCCCTCTGGG 
AAAACCCCCC AGCAGCCTCC TGTGCCCCCC CAGAGACCGA TGGCCGCCCT CCCGCCCCCA 
CCAGCCGGCC GGAATCACTC GCCACTGCCC CCACCCCAGA CCAACCACGA AGAACCCAGC 
AGAAGCAGAA ACCACAAAAC GGCAAAGCTC CCTGCTCCTT CAATAGACAG AAGCACGAAA 
CCTCCCCTAG ATCGTTCATT AGCTCCGTTT GATAGAGAAC CCTTCACACT AGGAAAGAAA 
CCACCATTTT CTGACAAGCC CTCGATTCCA GCGGGAAGGT CACTCGGGGA GCATTTACCC 
AAGATTCAAA AGCCTCCTTT ACCACCGACC ACGGAAAGAC ATGAAAGGAG CAGCCCCCTG 
CCAGGGAAGA AGCCACCTGT GCCAAAGCAT GGATGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCC CAGCCAGCAC TACTTCCTAT GAGCTCCAAC 
ACTTTCCCTT CAAGATCTAC TAAGCCAAGT CCCATGAACC CTCTCCCATC CTCTCACATG 
CCTGGAGCAT TCTCAGAAAG TAACAGCAGT TTTCCACAGA GTGCCTCCCT GCCACCATAC 
TTCTCTCAAG GCCCTAGCAA CAGACCACCT ATCAGAGCCG AAGGCAGAAA CTTCCCCTTG 
CCACTTCCAA ACAAACCTCG GCCCCCATCC CCCGCGGAGG AAGAGAATTC ATTAAATGAA 
GAGTGGTACG TTTCTTATAT TACCCGACCA GAGGCAGAAG CTGCTCTTAG AAAGATAAAC 
CAGGATGGCA CATTTCTGGT CAGAGACAGC TCTAAAAAAA CAACAACCAA TCCATATGTC 
CTCATGGTGT TGTACAAAGA TAAAGTTTAC AACATCCAGA TCCGTTATCA GAAGGAAAGT 
CAAGTTTACT TGTTGGGAAC TGGACTCCGA GGGAAAGAGG ACTTTCTGTC TGTGTCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCACTT CTGCTCATTG ATGGGAAAAA CCGAGGTTCC 
AGATACCAGT GCACATTAAC GCATGCTGCA GGGTACCCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_005556.1

Translation

MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP

Target ORF information:

RefSeq Version	NM_005565.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005565.3

ORF Insert Sequence:

ATGGCACTGA GGAATGTGCC CTTTCGCTCA GAGGTCCTGG GCTGGGACCC CGACAGCCTT 
GCTGACTATT TCAAGAAGCT CAACTATAAG GACTGTGAGA AGGCAGTGAA GAAGTACCAC 
ATCGATGGGG CTCGCTTCTT GAACCTGACA GAAAATGACA TCCAGAAGTT CCCCAAGCTC 
CGGGTGCCGA TTCTCAGTAA GTTAAGTCAG GAAATCAACA AGAACGAAGA GAGGAGGAGC 
ATCTTCACAC GCAAACCCCA AGTCCCGCGG TTTCCTGAAG AGACAGAAAG CCACGAAGAG 
GACAATGGGG GCTGGTCGTC CTTTGAAGAA GACGATTATG AAAGTCCCAA TGATGACCAG 
GATGGGGAGG ATGATGGAGA CTATGAGTCC CCCAATGAGG AGGAAGAGGC ACCCGTGGAA 
GATGACGCGG ATTATGAGCC GCCACCCTCC AATGACGAGG AAGCTCTGCA GAACTCCATC 
CTGCCTGCCA AGCCTTTCCC CAACTCCAAC TCCATGTACA TCGACCGGCC CCCCTCTGGG 
AAAACCCCCC AGCAGCCTCC TGTGCCCCCC CAGAGACCGA TGGCCGCCCT CCCGCCCCCA 
CCAGCCGGCC GGAATCACTC GCCACTGCCC CCACCCCAGA CCAACCACGA AGAACCCAGC 
AGAAGCAGAA ACCACAAAAC GGCAAAGCTC CCTGCTCCTT CAATAGACAG AAGCACGAAA 
CCTCCCCTAG ATCGTTCATT AGCTCCGTTT GATAGAGAAC CCTTCACACT AGGAAAGAAA 
CCACCATTTT CTGACAAGCC CTCGATTCCA GCGGGAAGGT CACTCGGGGA GCATTTACCC 
AAGATTCAAA AGCCTCCTTT ACCACCGACC ACGGAAAGAC ATGAAAGGAG CAGCCCCCTG 
CCAGGGAAGA AGCCACCTGT GCCAAAGCAT GGATGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCC CAGCCAGCAC TACTTCCTAT GAGCTCCAAC 
ACTTTCCCTT CAAGATCTAC TAAGCCAAGT CCCATGAACC CTCTCCCATC CTCTCACATG 
CCTGGAGCAT TCTCAGAAAG TAACAGCAGT TTTCCACAGA GTGCCTCCCT GCCACCATAC 
TTCTCTCAAG GCCCTAGCAA CAGACCACCT ATCAGAGCCG AAGGCAGAAA CTTCCCCTTG 
CCACTTCCAA ACAAACCTCG GCCCCCATCC CCCGCGGAGG AAGAGAATTC ATTAAATGAA 
GAGTGGTACG TTTCTTATAT TACCCGACCA GAGGCAGAAG CTGCTCTTAG AAAGATAAAC 
CAGGATGGCA CATTTCTGGT CAGAGACAGC TCTAAAAAAA CAACAACCAA TCCATATGTC 
CTCATGGTGT TGTACAAAGA TAAAGTTTAC AACATCCAGA TCCGTTATCA GAAGGAAAGT 
CAAGTTTACT TGTTGGGAAC TGGACTCCGA GGGAAAGAGG ACTTTCTGTC TGTGTCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCACTT CTGCTCATTG ATGGGAAAAA CCGAGGTTCC 
AGATACCAGT GCACATTAAC GCATGCTGCA GGGTACCCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LCP2 ( NM_005565.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005556.1 Homo sapiens lymphocyte cytosolic protein 2 (LCP2), mRNA.

Price & Availability↑

CloneID	OHu25377
Clone ID Related Accession (Same CDS sequence)	NM_005565.4 , NM_005565.3 , NM_005565.5
Accession Version	NM_005565.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1602bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	lymphocyte cytosolic protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB116470.1, U20158.2, AC034199.6, BC016618.1, BY995095.1 and AW291566.1. On Nov 23, 2018 this sequence version replaced NM_005565.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016618.1, SRR1163658.196053.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000046794.10/ ENSP00000046794.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCACTGA GGAATGTGCC CTTTCGCTCA GAGGTCCTGG GCTGGGACCC CGACAGCCTT 
GCTGACTATT TCAAGAAGCT CAACTATAAG GACTGTGAGA AGGCAGTGAA GAAGTACCAC 
ATCGATGGGG CTCGCTTCTT GAACCTGACA GAAAATGACA TCCAGAAGTT CCCCAAGCTC 
CGGGTGCCGA TTCTCAGTAA GTTAAGTCAG GAAATCAACA AGAACGAAGA GAGGAGGAGC 
ATCTTCACAC GCAAACCCCA AGTCCCGCGG TTTCCTGAAG AGACAGAAAG CCACGAAGAG 
GACAATGGGG GCTGGTCGTC CTTTGAAGAA GACGATTATG AAAGTCCCAA TGATGACCAG 
GATGGGGAGG ATGATGGAGA CTATGAGTCC CCCAATGAGG AGGAAGAGGC ACCCGTGGAA 
GATGACGCGG ATTATGAGCC GCCACCCTCC AATGACGAGG AAGCTCTGCA GAACTCCATC 
CTGCCTGCCA AGCCTTTCCC CAACTCCAAC TCCATGTACA TCGACCGGCC CCCCTCTGGG 
AAAACCCCCC AGCAGCCTCC TGTGCCCCCC CAGAGACCGA TGGCCGCCCT CCCGCCCCCA 
CCAGCCGGCC GGAATCACTC GCCACTGCCC CCACCCCAGA CCAACCACGA AGAACCCAGC 
AGAAGCAGAA ACCACAAAAC GGCAAAGCTC CCTGCTCCTT CAATAGACAG AAGCACGAAA 
CCTCCCCTAG ATCGTTCATT AGCTCCGTTT GATAGAGAAC CCTTCACACT AGGAAAGAAA 
CCACCATTTT CTGACAAGCC CTCGATTCCA GCGGGAAGGT CACTCGGGGA GCATTTACCC 
AAGATTCAAA AGCCTCCTTT ACCACCGACC ACGGAAAGAC ATGAAAGGAG CAGCCCCCTG 
CCAGGGAAGA AGCCACCTGT GCCAAAGCAT GGATGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCC CAGCCAGCAC TACTTCCTAT GAGCTCCAAC 
ACTTTCCCTT CAAGATCTAC TAAGCCAAGT CCCATGAACC CTCTCCCATC CTCTCACATG 
CCTGGAGCAT TCTCAGAAAG TAACAGCAGT TTTCCACAGA GTGCCTCCCT GCCACCATAC 
TTCTCTCAAG GCCCTAGCAA CAGACCACCT ATCAGAGCCG AAGGCAGAAA CTTCCCCTTG 
CCACTTCCAA ACAAACCTCG GCCCCCATCC CCCGCGGAGG AAGAGAATTC ATTAAATGAA 
GAGTGGTACG TTTCTTATAT TACCCGACCA GAGGCAGAAG CTGCTCTTAG AAAGATAAAC 
CAGGATGGCA CATTTCTGGT CAGAGACAGC TCTAAAAAAA CAACAACCAA TCCATATGTC 
CTCATGGTGT TGTACAAAGA TAAAGTTTAC AACATCCAGA TCCGTTATCA GAAGGAAAGT 
CAAGTTTACT TGTTGGGAAC TGGACTCCGA GGGAAAGAGG ACTTTCTGTC TGTGTCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCACTT CTGCTCATTG ATGGGAAAAA CCGAGGTTCC 
AGATACCAGT GCACATTAAC GCATGCTGCA GGGTACCCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005556.1
CDS	167..1768
Translation	MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGARFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDNGGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSILPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEEPSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLGEHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPALLPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIRAEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDSSKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKMPLLLIDGKNRGSRYQCTLTHAAGYP

Target ORF information:

RefSeq Version	NM_005565.5
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte cytosolic protein 2 (LCP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005565.5

ORF Insert Sequence:

ATGGCACTGA GGAATGTGCC CTTTCGCTCA GAGGTCCTGG GCTGGGACCC CGACAGCCTT 
GCTGACTATT TCAAGAAGCT CAACTATAAG GACTGTGAGA AGGCAGTGAA GAAGTACCAC 
ATCGATGGGG CTCGCTTCTT GAACCTGACA GAAAATGACA TCCAGAAGTT CCCCAAGCTC 
CGGGTGCCGA TTCTCAGTAA GTTAAGTCAG GAAATCAACA AGAACGAAGA GAGGAGGAGC 
ATCTTCACAC GCAAACCCCA AGTCCCGCGG TTTCCTGAAG AGACAGAAAG CCACGAAGAG 
GACAATGGGG GCTGGTCGTC CTTTGAAGAA GACGATTATG AAAGTCCCAA TGATGACCAG 
GATGGGGAGG ATGATGGAGA CTATGAGTCC CCCAATGAGG AGGAAGAGGC ACCCGTGGAA 
GATGACGCGG ATTATGAGCC GCCACCCTCC AATGACGAGG AAGCTCTGCA GAACTCCATC 
CTGCCTGCCA AGCCTTTCCC CAACTCCAAC TCCATGTACA TCGACCGGCC CCCCTCTGGG 
AAAACCCCCC AGCAGCCTCC TGTGCCCCCC CAGAGACCGA TGGCCGCCCT CCCGCCCCCA 
CCAGCCGGCC GGAATCACTC GCCACTGCCC CCACCCCAGA CCAACCACGA AGAACCCAGC 
AGAAGCAGAA ACCACAAAAC GGCAAAGCTC CCTGCTCCTT CAATAGACAG AAGCACGAAA 
CCTCCCCTAG ATCGTTCATT AGCTCCGTTT GATAGAGAAC CCTTCACACT AGGAAAGAAA 
CCACCATTTT CTGACAAGCC CTCGATTCCA GCGGGAAGGT CACTCGGGGA GCATTTACCC 
AAGATTCAAA AGCCTCCTTT ACCACCGACC ACGGAAAGAC ATGAAAGGAG CAGCCCCCTG 
CCAGGGAAGA AGCCACCTGT GCCAAAGCAT GGATGGGGAC CAGACAGAAG AGAGAATGAT 
GAAGATGATG TGCATCAGAG ACCTTTGCCC CAGCCAGCAC TACTTCCTAT GAGCTCCAAC 
ACTTTCCCTT CAAGATCTAC TAAGCCAAGT CCCATGAACC CTCTCCCATC CTCTCACATG 
CCTGGAGCAT TCTCAGAAAG TAACAGCAGT TTTCCACAGA GTGCCTCCCT GCCACCATAC 
TTCTCTCAAG GCCCTAGCAA CAGACCACCT ATCAGAGCCG AAGGCAGAAA CTTCCCCTTG 
CCACTTCCAA ACAAACCTCG GCCCCCATCC CCCGCGGAGG AAGAGAATTC ATTAAATGAA 
GAGTGGTACG TTTCTTATAT TACCCGACCA GAGGCAGAAG CTGCTCTTAG AAAGATAAAC 
CAGGATGGCA CATTTCTGGT CAGAGACAGC TCTAAAAAAA CAACAACCAA TCCATATGTC 
CTCATGGTGT TGTACAAAGA TAAAGTTTAC AACATCCAGA TCCGTTATCA GAAGGAAAGT 
CAAGTTTACT TGTTGGGAAC TGGACTCCGA GGGAAAGAGG ACTTTCTGTC TGTGTCAGAT 
ATTATTGACT ACTTCAGGAA AATGCCACTT CTGCTCATTG ATGGGAAAAA CCGAGGTTCC 
AGATACCAGT GCACATTAAC GCATGCTGCA GGGTACCCAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A PLC-?1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.
Journal of proteome research16(8)2729-2742(2017 Aug)
Belmont J,Gu T,Mudd A,Salomon AR

T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.
Molecular and cellular biology37(11)(2017 Jun)
Breuning J,Brown MH

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile ? motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
The Journal of biological chemistry292(15)6281-6290(2017 04)
Thaker YR,Recino A,Raab M,Jabeen A,Wallberg M,Fernandez N,Rudd CE

Development of nanoscale structure in LAT-based signaling complexes.
Journal of cell science129(24)4548-4562(2016 12)
Barr VA,Sherman E,Yi J,Akpan I,Rouquette-Jazdanian AK,Samelson LE

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LCP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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