Itga4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itga4
Entrez Gene ID	16401
Full Name	integrin alpha 4
Synonyms	CD49D,Itga4B
General protein information	Preferred Names integrin alpha 4 Names integrin alpha-4 CD49 antigen-like family member D LPAM subunit alpha VLA-4 receptor, alpha 4 subunit VLA-4 subunit alpha integrin alpha-IV integrin alpha4B lymphocyte Peyer patch adhesion molecules subunit alpha
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 C3\|2 47.38 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010576.3	NP_034706.3	integrin alpha-4 precursor
NM_010576.4	NP_034706.3	integrin alpha-4 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	itga4	XP_002663459.2
Xenopus tropicalis (tropical clawed frog)	itga4	XP_002932062.2
Rattus norvegicus (Norway rat)	Itga4	NP_001101207.1
Homo sapiens (human)	ITGA4	NP_000876.3
	ITGA4	XP_001100929.1
Canis lupus familiaris (dog)	ITGA4	XP_545551.3
Pan troglodytes (chimpanzee)	ITGA4	XP_525977.2
Bos taurus (cattle)	ITGA4	NP_777173.1
Mus musculus (house mouse)	Itga4	NP_034706.3
Gallus gallus (chicken)	ITGA4	XP_421974.3

Gene Ontology
Bibliography

Related articles in PubMed

The Chemokine Receptor CXCR3 Promotes CD8
Caldeira-Dantas S, Furmanak T, Smith C, Quinn M, Teos LY, Ertel A, Kurup D, Tandon M, Alevizos I, Snyder CM
Journal of immunology (Baltimore, Md. : 1950)200(3)1133-1145(2018 Feb)

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
Title: Blockade of ?E?7 integrin suppresses accumulation of CD8

Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Title: Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1, respectively; expression of the latter was upregulated in obesity.
Title: A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity.

this study shows that alpha4beta1 integrin mediates memory CD8+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus
Title: ?

investigation of the role of alpha4 integrin and the therapeutic effect of HCA3551, a newly synthesized orally active small molecule alpha4 integrin antagonist, in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease
Title: The role of ?4 integrin in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease: an infectious animal model for multiple sclerosis (MS).

The following Itga4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itga4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17733	NM_010576.4 Latest version!	Mus musculus integrin alpha 4 (Itga4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00
View Old Accession Versions >>
OMu17733	NM_010576.3	Mus musculus integrin alpha 4 (Itga4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$559.30 $799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itga4 ( NM_010576.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034706.3 Mus musculus integrin alpha 4 (Itga4), mRNA.

Price & Availability↑

CloneID	OMu17733
Clone ID Related Accession (Same CDS sequence)	NM_010576.3 , NM_010576.4
Accession Version	NM_010576.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3099bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-16
Organism	Mus musculus(house mouse)
Product	integrin alpha-4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB637533.1, AK051676.1, X53176.1 and AL844590.3. On Sep 14, 2006 this sequence version replaced NM_010576.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068313.1, X53176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCGG AAGCGAGGTG CAGACCGAGG TCCCGAGGGA TCGCCCTCCG GGAAGCGGTG 
ATGCTGTTGT TGTACTTCGG GGTGCCAACC GGGCACTCCT ACAACCTGGA CCCGGAGAAT 
GCACTGCTGT ACCAGGGCCC CTCCGGCACG CTGTTTGGCT ACTCGGTGGT GCTGCACAGC 
CACGGGTCGA AGCGCTGGCT CATCGTGGGG GCTCCCACTG CCAGCTGGCT CTCTAATGCC 
TCAGTGGTCA ATCCTGGGGC GATTTACAGA TGCGGGATCA GAAAGAATCC AAACCAGACC 
TGCGAACAGC TCCAGCTGGG TAGCCCCAGT GGAGAGCCTT GTGGGAAGAC ATGCCTGGAG 
GAGAGGGATA ACCAGTGGCT GGGGGTCACC CTTTCCAGAC AGCCTGGAGA AAATGGCTCT 
ATCGTGACTT GTGGGCACAG GTGGAAAAAT ATTTTTTACA TGAAGAGCGA TAACAAACTC 
CCCACTGGCA TTTGCTACGT CATGCCTTCT GATTTGCGGA CAGAACTGAG TAAAAGGATG 
GCCCCGTGTT ACAAAGATTA TACGAGAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCTA GTTTTTACAC ACAGGATTTA ATTGTGATGG GGGCCCCGGG ATCATCGTAC 
TGGACTGGCA CCGTCTTTGT CTACAATATA ACTACAAACC AATACAAAGC ATTTGTAGAC 
AGACAGAACC AAGTAAAATT TGGAAGCTAC TTAGGCTACT CAGTTGGAGC TGGACATTTT 
CGAAGTCCAC ATACTACCGA AGTCGTGGGA GGAGCCCCTC AACACGAACA GATAGGAAAA 
GCATATATAT TTAGCATTGA TGAAAACGAA CTGAACATCG TATATGAAAT GAAAGGTAAA 
AAGCTTGGCT CATACTTTGG AGCTTCTGTC TGCGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTCC TTGTTGGAGC TCCCATGCAG AGCACCATCA GGGAGGAAGG AAGAGTATTC 
GTGTACATCA ACTCTGGCAT GGGAGCTGTG ATGGTTGAAA TGGAAAGGGT CCTTGTCGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAG TCTATAGCGA ATCTTGGCGA CATTGACAAT 
GACGGCTTTG AAGATATTGC TATTGGTGCA CCACAAGAAG ACGACTTGAG AGGTGCTGTC 
TACATTTACA ATGGCCGAGT CGATGGAATC TCCTCCACCT ACTCACAGAG AATTGAAGGA 
CAGCAAATCA GCAAATCATT AAGGATGTTT GGACAATCTA TCTCAGGACA AATTGATGCA 
GACAACAATG GATATGTTGA TGTAGCCGTT GGTGCATTTC AATCTGATTC TGCAGTGTTG 
CTAAGGACAA GGCCTGTAGT GATTGTTGAA GCATCTTTAA GCCATCCTGA GTCTGTAAAT 
AGGACAAAGT TTGACTGTAC TGAAAATGGA CTTCCATCTG TGTGCATGCA TCTTACACTG 
TGTTTCTCAT ATAAAGGCAA AGAGGTCCCA GGCTACATCG TTTTGTTTTA CAATGTGAGC 
TTGGATGTGC ACAGGAAGGC AGAGTCTCCG TCAAGATTTT ATTTCTTCTC TAATGGGACT 
TCTGACGTGA TTACAGGAAG CATACGAGTT TCAAGCAGTG GAGAGAAATG TAGGACACAC 
CAGGCATTCA TGCGGAAAGA CGTGCGAGAC ATCCTTACCC CCATTCATGT AGAGGCCACA 
TACCACCTTG GGCATCATGT GATCACCAAA CGAAACACTG AGGAATTTCC ACCACTCCAG 
CCGATCCTTC AGCAGAAGAA AGAAAAAGAC GTTATTAGAA AAATGATAAA CTTTGCAAGG 
TTTTGTGCCT ATGAAAATTG CTCTGCTGAT CTCCAAGTTT CTGCAAAAGT TGGATTTTTG 
AAGCCATATG AAAATAAAAC CTATCTTGCT GTTGGGAGCA TGAAGACCAT AATGCTAAAC 
GTGTCCTTGT TCAACGCTGG CGATGATGCT TACGAAACCA CTCTGAATGT CCAACTCCCC 
ACAGGCCTTT ATTTCATTAA GATCTTAGAC CTGGAAGAGA AACAAATAAA CTGCGAAGTG 
ACTGAGAGCT CAGGCATAGT GAAGCTTGCC TGCAGCCTAG GTTACATATA TGTGGATCGC 
CTCTCAAGGA TAGACATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG GGCACATGAG 
GACCTCAGCA TCAGTGTGCA TGCCTCCTGT GAAAACGAGG GCGAATTGGA CCAAGTGAGG 
GACAACAGAG TGACCTTAAC GATACCTCTA AGGTATGAGG TTATGCTGAC TGTTCATGGG 
CTTGTGAACC CAACTTCATT TGTGTATGGA TCTAGCGAAG AAAACGAGCC AGAAACATGC 
ATGGCCGAGA AGCTGAACCT CACTTTCCAT GTTATAAACA CTGGGATTAG CATGGCTCCA 
AATGTTAGTG TGAAAATAAT GGTACCAAAT TCTTTTCTCC CTCAAGATGA TAAGTTGTTC 
AACGTTTTGG ATGTCCAGAC AACTACAGGG CAATGCCATT TTAAACACTA TGGAAGAGAG 
TGTACATTTG CACAGCAAAA AGGCATAGCG GGGACGTTGA CCGATATAGT CAAATTCCTA 
TCAAAGACTG ATAAGAGACT CCTGTATTGC ATGAAAGCTG ATCAACACTG TTTAGATTTC 
TTATGCAATT TCGGAAAAAT GGAAAGTGGG AAGGAAGCCA GCGTTCATAT TCAGCTGGAG 
GGCAGGCCAT CCATCTTGGA AATGGATGAG ACCTCATCAC TCAAGTTTGA AATAAAAGCA 
ACAGCTTTTC CAGAGCCACA CCCAAAAGTT ATTGAACTAA ATAAAGATGA GAACGTGGCC 
CATGTTTTCT TGGAAGGGCT CCATCATCAA AGACCCAAAC GACATTTCAC CATCATTATT 
ATTACCATCA GCTTGCTACT TGGACTTATT GTACTTTTAT TAATTTCATG TGTTATGTGG 
AAGGCTGGAT TCTTTAAAAG ACAGTACAAA TCTATCCTAC AAGAAGAAAA CAGGAGAGAC 
AGCTGGAGTT ATGTCAACAG CAAAAGCAAT GATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034706.3
CDS	236..3334
Translation	MAAEARCRPRSRGIALREAVMLLLYFGVPTGHSYNLDPENALLYQGPSGTLFGYSVVLHSHGSKRWLIVGAPTASWLSNASVVNPGAIYRCGIRKNPNQTCEQLQLGSPSGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYMKSDNKLPTGICYVMPSDLRTELSKRMAPCYKDYTRKFGENFASCQAGISSFYTQDLIVMGAPGSSYWTGTVFVYNITTNQYKAFVDRQNQVKFGSYLGYSVGAGHFRSPHTTEVVGGAPQHEQIGKAYIFSIDENELNIVYEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGMGAVMVEMERVLVGSDKYAARFGESIANLGDIDNDGFEDIAIGAPQEDDLRGAVYIYNGRVDGISSTYSQRIEGQQISKSLRMFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLPSVCMHLTLCFSYKGKEVPGYIVLFYNVSLDVHRKAESPSRFYFFSNGTSDVITGSIRVSSSGEKCRTHQAFMRKDVRDILTPIHVEATYHLGHHVITKRNTEEFPPLQPILQQKKEKDVIRKMINFARFCAYENCSADLQVSAKVGFLKPYENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLEEKQINCEVTESSGIVKLACSLGYIYVDRLSRIDISFLLDVSSLSRAHEDLSISVHASCENEGELDQVRDNRVTLTIPLRYEVMLTVHGLVNPTSFVYGSSEENEPETCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDKLFNVLDVQTTTGQCHFKHYGRECTFAQQKGIAGTLTDIVKFLSKTDKRLLYCMKADQHCLDFLCNFGKMESGKEASVHIQLEGRPSILEMDETSSLKFEIKATAFPEPHPKVIELNKDENVAHVFLEGLHHQRPKRHFTIIIITISLLLGLIVLLLISCVMWKAGFFKRQYKSILQEENRRDSWSYVNSKSNDD

Target ORF information:

RefSeq Version	NM_010576.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus integrin alpha 4 (Itga4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010576.3

ORF Insert Sequence:

ATGGCTGCGG AAGCGAGGTG CAGACCGAGG TCCCGAGGGA TCGCCCTCCG GGAAGCGGTG 
ATGCTGTTGT TGTACTTCGG GGTGCCAACC GGGCACTCCT ACAACCTGGA CCCGGAGAAT 
GCACTGCTGT ACCAGGGCCC CTCCGGCACG CTGTTTGGCT ACTCGGTGGT GCTGCACAGC 
CACGGGTCGA AGCGCTGGCT CATCGTGGGG GCTCCCACTG CCAGCTGGCT CTCTAATGCC 
TCAGTGGTCA ATCCTGGGGC GATTTACAGA TGCGGGATCA GAAAGAATCC AAACCAGACC 
TGCGAACAGC TCCAGCTGGG TAGCCCCAGT GGAGAGCCTT GTGGGAAGAC ATGCCTGGAG 
GAGAGGGATA ACCAGTGGCT GGGGGTCACC CTTTCCAGAC AGCCTGGAGA AAATGGCTCT 
ATCGTGACTT GTGGGCACAG GTGGAAAAAT ATTTTTTACA TGAAGAGCGA TAACAAACTC 
CCCACTGGCA TTTGCTACGT CATGCCTTCT GATTTGCGGA CAGAACTGAG TAAAAGGATG 
GCCCCGTGTT ACAAAGATTA TACGAGAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCTA GTTTTTACAC ACAGGATTTA ATTGTGATGG GGGCCCCGGG ATCATCGTAC 
TGGACTGGCA CCGTCTTTGT CTACAATATA ACTACAAACC AATACAAAGC ATTTGTAGAC 
AGACAGAACC AAGTAAAATT TGGAAGCTAC TTAGGCTACT CAGTTGGAGC TGGACATTTT 
CGAAGTCCAC ATACTACCGA AGTCGTGGGA GGAGCCCCTC AACACGAACA GATAGGAAAA 
GCATATATAT TTAGCATTGA TGAAAACGAA CTGAACATCG TATATGAAAT GAAAGGTAAA 
AAGCTTGGCT CATACTTTGG AGCTTCTGTC TGCGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTCC TTGTTGGAGC TCCCATGCAG AGCACCATCA GGGAGGAAGG AAGAGTATTC 
GTGTACATCA ACTCTGGCAT GGGAGCTGTG ATGGTTGAAA TGGAAAGGGT CCTTGTCGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAG TCTATAGCGA ATCTTGGCGA CATTGACAAT 
GACGGCTTTG AAGATATTGC TATTGGTGCA CCACAAGAAG ACGACTTGAG AGGTGCTGTC 
TACATTTACA ATGGCCGAGT CGATGGAATC TCCTCCACCT ACTCACAGAG AATTGAAGGA 
CAGCAAATCA GCAAATCATT AAGGATGTTT GGACAATCTA TCTCAGGACA AATTGATGCA 
GACAACAATG GATATGTTGA TGTAGCCGTT GGTGCATTTC AATCTGATTC TGCAGTGTTG 
CTAAGGACAA GGCCTGTAGT GATTGTTGAA GCATCTTTAA GCCATCCTGA GTCTGTAAAT 
AGGACAAAGT TTGACTGTAC TGAAAATGGA CTTCCATCTG TGTGCATGCA TCTTACACTG 
TGTTTCTCAT ATAAAGGCAA AGAGGTCCCA GGCTACATCG TTTTGTTTTA CAATGTGAGC 
TTGGATGTGC ACAGGAAGGC AGAGTCTCCG TCAAGATTTT ATTTCTTCTC TAATGGGACT 
TCTGACGTGA TTACAGGAAG CATACGAGTT TCAAGCAGTG GAGAGAAATG TAGGACACAC 
CAGGCATTCA TGCGGAAAGA CGTGCGAGAC ATCCTTACCC CCATTCATGT AGAGGCCACA 
TACCACCTTG GGCATCATGT GATCACCAAA CGAAACACTG AGGAATTTCC ACCACTCCAG 
CCGATCCTTC AGCAGAAGAA AGAAAAAGAC GTTATTAGAA AAATGATAAA CTTTGCAAGG 
TTTTGTGCCT ATGAAAATTG CTCTGCTGAT CTCCAAGTTT CTGCAAAAGT TGGATTTTTG 
AAGCCATATG AAAATAAAAC CTATCTTGCT GTTGGGAGCA TGAAGACCAT AATGCTAAAC 
GTGTCCTTGT TCAACGCTGG CGATGATGCT TACGAAACCA CTCTGAATGT CCAACTCCCC 
ACAGGCCTTT ATTTCATTAA GATCTTAGAC CTGGAAGAGA AACAAATAAA CTGCGAAGTG 
ACTGAGAGCT CAGGCATAGT GAAGCTTGCC TGCAGCCTAG GTTACATATA TGTGGATCGC 
CTCTCAAGGA TAGACATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG GGCACATGAG 
GACCTCAGCA TCAGTGTGCA TGCCTCCTGT GAAAACGAGG GCGAATTGGA CCAAGTGAGG 
GACAACAGAG TGACCTTAAC GATACCTCTA AGGTATGAGG TTATGCTGAC TGTTCATGGG 
CTTGTGAACC CAACTTCATT TGTGTATGGA TCTAGCGAAG AAAACGAGCC AGAAACATGC 
ATGGCCGAGA AGCTGAACCT CACTTTCCAT GTTATAAACA CTGGGATTAG CATGGCTCCA 
AATGTTAGTG TGAAAATAAT GGTACCAAAT TCTTTTCTCC CTCAAGATGA TAAGTTGTTC 
AACGTTTTGG ATGTCCAGAC AACTACAGGG CAATGCCATT TTAAACACTA TGGAAGAGAG 
TGTACATTTG CACAGCAAAA AGGCATAGCG GGGACGTTGA CCGATATAGT CAAATTCCTA 
TCAAAGACTG ATAAGAGACT CCTGTATTGC ATGAAAGCTG ATCAACACTG TTTAGATTTC 
TTATGCAATT TCGGAAAAAT GGAAAGTGGG AAGGAAGCCA GCGTTCATAT TCAGCTGGAG 
GGCAGGCCAT CCATCTTGGA AATGGATGAG ACCTCATCAC TCAAGTTTGA AATAAAAGCA 
ACAGCTTTTC CAGAGCCACA CCCAAAAGTT ATTGAACTAA ATAAAGATGA GAACGTGGCC 
CATGTTTTCT TGGAAGGGCT CCATCATCAA AGACCCAAAC GACATTTCAC CATCATTATT 
ATTACCATCA GCTTGCTACT TGGACTTATT GTACTTTTAT TAATTTCATG TGTTATGTGG 
AAGGCTGGAT TCTTTAAAAG ACAGTACAAA TCTATCCTAC AAGAAGAAAA CAGGAGAGAC 
AGCTGGAGTT ATGTCAACAG CAAAAGCAAT GATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itga4 ( NM_010576.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034706.3 Mus musculus integrin alpha 4 (Itga4), mRNA.

Price & Availability↑

CloneID	OMu17733
Clone ID Related Accession (Same CDS sequence)	NM_010576.3 , NM_010576.4
Accession Version	NM_010576.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3099bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Mus musculus(house mouse)
Product	integrin alpha-4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL844590.3. On Aug 17, 2018 this sequence version replaced NM_010576.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC068313.1, X53176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCGG AAGCGAGGTG CAGACCGAGG TCCCGAGGGA TCGCCCTCCG GGAAGCGGTG 
ATGCTGTTGT TGTACTTCGG GGTGCCAACC GGGCACTCCT ACAACCTGGA CCCGGAGAAT 
GCACTGCTGT ACCAGGGCCC CTCCGGCACG CTGTTTGGCT ACTCGGTGGT GCTGCACAGC 
CACGGGTCGA AGCGCTGGCT CATCGTGGGG GCTCCCACTG CCAGCTGGCT CTCTAATGCC 
TCAGTGGTCA ATCCTGGGGC GATTTACAGA TGCGGGATCA GAAAGAATCC AAACCAGACC 
TGCGAACAGC TCCAGCTGGG TAGCCCCAGT GGAGAGCCTT GTGGGAAGAC ATGCCTGGAG 
GAGAGGGATA ACCAGTGGCT GGGGGTCACC CTTTCCAGAC AGCCTGGAGA AAATGGCTCT 
ATCGTGACTT GTGGGCACAG GTGGAAAAAT ATTTTTTACA TGAAGAGCGA TAACAAACTC 
CCCACTGGCA TTTGCTACGT CATGCCTTCT GATTTGCGGA CAGAACTGAG TAAAAGGATG 
GCCCCGTGTT ACAAAGATTA TACGAGAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCTA GTTTTTACAC ACAGGATTTA ATTGTGATGG GGGCCCCGGG ATCATCGTAC 
TGGACTGGCA CCGTCTTTGT CTACAATATA ACTACAAACC AATACAAAGC ATTTGTAGAC 
AGACAGAACC AAGTAAAATT TGGAAGCTAC TTAGGCTACT CAGTTGGAGC TGGACATTTT 
CGAAGTCCAC ATACTACCGA AGTCGTGGGA GGAGCCCCTC AACACGAACA GATAGGAAAA 
GCATATATAT TTAGCATTGA TGAAAACGAA CTGAACATCG TATATGAAAT GAAAGGTAAA 
AAGCTTGGCT CATACTTTGG AGCTTCTGTC TGCGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTCC TTGTTGGAGC TCCCATGCAG AGCACCATCA GGGAGGAAGG AAGAGTATTC 
GTGTACATCA ACTCTGGCAT GGGAGCTGTG ATGGTTGAAA TGGAAAGGGT CCTTGTCGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAG TCTATAGCGA ATCTTGGCGA CATTGACAAT 
GACGGCTTTG AAGATATTGC TATTGGTGCA CCACAAGAAG ACGACTTGAG AGGTGCTGTC 
TACATTTACA ATGGCCGAGT CGATGGAATC TCCTCCACCT ACTCACAGAG AATTGAAGGA 
CAGCAAATCA GCAAATCATT AAGGATGTTT GGACAATCTA TCTCAGGACA AATTGATGCA 
GACAACAATG GATATGTTGA TGTAGCCGTT GGTGCATTTC AATCTGATTC TGCAGTGTTG 
CTAAGGACAA GGCCTGTAGT GATTGTTGAA GCATCTTTAA GCCATCCTGA GTCTGTAAAT 
AGGACAAAGT TTGACTGTAC TGAAAATGGA CTTCCATCTG TGTGCATGCA TCTTACACTG 
TGTTTCTCAT ATAAAGGCAA AGAGGTCCCA GGCTACATCG TTTTGTTTTA CAATGTGAGC 
TTGGATGTGC ACAGGAAGGC AGAGTCTCCG TCAAGATTTT ATTTCTTCTC TAATGGGACT 
TCTGACGTGA TTACAGGAAG CATACGAGTT TCAAGCAGTG GAGAGAAATG TAGGACACAC 
CAGGCATTCA TGCGGAAAGA CGTGCGAGAC ATCCTTACCC CCATTCATGT AGAGGCCACA 
TACCACCTTG GGCATCATGT GATCACCAAA CGAAACACTG AGGAATTTCC ACCACTCCAG 
CCGATCCTTC AGCAGAAGAA AGAAAAAGAC GTTATTAGAA AAATGATAAA CTTTGCAAGG 
TTTTGTGCCT ATGAAAATTG CTCTGCTGAT CTCCAAGTTT CTGCAAAAGT TGGATTTTTG 
AAGCCATATG AAAATAAAAC CTATCTTGCT GTTGGGAGCA TGAAGACCAT AATGCTAAAC 
GTGTCCTTGT TCAACGCTGG CGATGATGCT TACGAAACCA CTCTGAATGT CCAACTCCCC 
ACAGGCCTTT ATTTCATTAA GATCTTAGAC CTGGAAGAGA AACAAATAAA CTGCGAAGTG 
ACTGAGAGCT CAGGCATAGT GAAGCTTGCC TGCAGCCTAG GTTACATATA TGTGGATCGC 
CTCTCAAGGA TAGACATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG GGCACATGAG 
GACCTCAGCA TCAGTGTGCA TGCCTCCTGT GAAAACGAGG GCGAATTGGA CCAAGTGAGG 
GACAACAGAG TGACCTTAAC GATACCTCTA AGGTATGAGG TTATGCTGAC TGTTCATGGG 
CTTGTGAACC CAACTTCATT TGTGTATGGA TCTAGCGAAG AAAACGAGCC AGAAACATGC 
ATGGCCGAGA AGCTGAACCT CACTTTCCAT GTTATAAACA CTGGGATTAG CATGGCTCCA 
AATGTTAGTG TGAAAATAAT GGTACCAAAT TCTTTTCTCC CTCAAGATGA TAAGTTGTTC 
AACGTTTTGG ATGTCCAGAC AACTACAGGG CAATGCCATT TTAAACACTA TGGAAGAGAG 
TGTACATTTG CACAGCAAAA AGGCATAGCG GGGACGTTGA CCGATATAGT CAAATTCCTA 
TCAAAGACTG ATAAGAGACT CCTGTATTGC ATGAAAGCTG ATCAACACTG TTTAGATTTC 
TTATGCAATT TCGGAAAAAT GGAAAGTGGG AAGGAAGCCA GCGTTCATAT TCAGCTGGAG 
GGCAGGCCAT CCATCTTGGA AATGGATGAG ACCTCATCAC TCAAGTTTGA AATAAAAGCA 
ACAGCTTTTC CAGAGCCACA CCCAAAAGTT ATTGAACTAA ATAAAGATGA GAACGTGGCC 
CATGTTTTCT TGGAAGGGCT CCATCATCAA AGACCCAAAC GACATTTCAC CATCATTATT 
ATTACCATCA GCTTGCTACT TGGACTTATT GTACTTTTAT TAATTTCATG TGTTATGTGG 
AAGGCTGGAT TCTTTAAAAG ACAGTACAAA TCTATCCTAC AAGAAGAAAA CAGGAGAGAC 
AGCTGGAGTT ATGTCAACAG CAAAAGCAAT GATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034706.3
CDS	235..3333
Translation	MAAEARCRPRSRGIALREAVMLLLYFGVPTGHSYNLDPENALLYQGPSGTLFGYSVVLHSHGSKRWLIVGAPTASWLSNASVVNPGAIYRCGIRKNPNQTCEQLQLGSPSGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYMKSDNKLPTGICYVMPSDLRTELSKRMAPCYKDYTRKFGENFASCQAGISSFYTQDLIVMGAPGSSYWTGTVFVYNITTNQYKAFVDRQNQVKFGSYLGYSVGAGHFRSPHTTEVVGGAPQHEQIGKAYIFSIDENELNIVYEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGMGAVMVEMERVLVGSDKYAARFGESIANLGDIDNDGFEDIAIGAPQEDDLRGAVYIYNGRVDGISSTYSQRIEGQQISKSLRMFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLPSVCMHLTLCFSYKGKEVPGYIVLFYNVSLDVHRKAESPSRFYFFSNGTSDVITGSIRVSSSGEKCRTHQAFMRKDVRDILTPIHVEATYHLGHHVITKRNTEEFPPLQPILQQKKEKDVIRKMINFARFCAYENCSADLQVSAKVGFLKPYENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLEEKQINCEVTESSGIVKLACSLGYIYVDRLSRIDISFLLDVSSLSRAHEDLSISVHASCENEGELDQVRDNRVTLTIPLRYEVMLTVHGLVNPTSFVYGSSEENEPETCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDKLFNVLDVQTTTGQCHFKHYGRECTFAQQKGIAGTLTDIVKFLSKTDKRLLYCMKADQHCLDFLCNFGKMESGKEASVHIQLEGRPSILEMDETSSLKFEIKATAFPEPHPKVIELNKDENVAHVFLEGLHHQRPKRHFTIIIITISLLLGLIVLLLISCVMWKAGFFKRQYKSILQEENRRDSWSYVNSKSNDD

Target ORF information:

RefSeq Version	NM_010576.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus integrin alpha 4 (Itga4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010576.4

ORF Insert Sequence:

ATGGCTGCGG AAGCGAGGTG CAGACCGAGG TCCCGAGGGA TCGCCCTCCG GGAAGCGGTG 
ATGCTGTTGT TGTACTTCGG GGTGCCAACC GGGCACTCCT ACAACCTGGA CCCGGAGAAT 
GCACTGCTGT ACCAGGGCCC CTCCGGCACG CTGTTTGGCT ACTCGGTGGT GCTGCACAGC 
CACGGGTCGA AGCGCTGGCT CATCGTGGGG GCTCCCACTG CCAGCTGGCT CTCTAATGCC 
TCAGTGGTCA ATCCTGGGGC GATTTACAGA TGCGGGATCA GAAAGAATCC AAACCAGACC 
TGCGAACAGC TCCAGCTGGG TAGCCCCAGT GGAGAGCCTT GTGGGAAGAC ATGCCTGGAG 
GAGAGGGATA ACCAGTGGCT GGGGGTCACC CTTTCCAGAC AGCCTGGAGA AAATGGCTCT 
ATCGTGACTT GTGGGCACAG GTGGAAAAAT ATTTTTTACA TGAAGAGCGA TAACAAACTC 
CCCACTGGCA TTTGCTACGT CATGCCTTCT GATTTGCGGA CAGAACTGAG TAAAAGGATG 
GCCCCGTGTT ACAAAGATTA TACGAGAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCTA GTTTTTACAC ACAGGATTTA ATTGTGATGG GGGCCCCGGG ATCATCGTAC 
TGGACTGGCA CCGTCTTTGT CTACAATATA ACTACAAACC AATACAAAGC ATTTGTAGAC 
AGACAGAACC AAGTAAAATT TGGAAGCTAC TTAGGCTACT CAGTTGGAGC TGGACATTTT 
CGAAGTCCAC ATACTACCGA AGTCGTGGGA GGAGCCCCTC AACACGAACA GATAGGAAAA 
GCATATATAT TTAGCATTGA TGAAAACGAA CTGAACATCG TATATGAAAT GAAAGGTAAA 
AAGCTTGGCT CATACTTTGG AGCTTCTGTC TGCGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTCC TTGTTGGAGC TCCCATGCAG AGCACCATCA GGGAGGAAGG AAGAGTATTC 
GTGTACATCA ACTCTGGCAT GGGAGCTGTG ATGGTTGAAA TGGAAAGGGT CCTTGTCGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAG TCTATAGCGA ATCTTGGCGA CATTGACAAT 
GACGGCTTTG AAGATATTGC TATTGGTGCA CCACAAGAAG ACGACTTGAG AGGTGCTGTC 
TACATTTACA ATGGCCGAGT CGATGGAATC TCCTCCACCT ACTCACAGAG AATTGAAGGA 
CAGCAAATCA GCAAATCATT AAGGATGTTT GGACAATCTA TCTCAGGACA AATTGATGCA 
GACAACAATG GATATGTTGA TGTAGCCGTT GGTGCATTTC AATCTGATTC TGCAGTGTTG 
CTAAGGACAA GGCCTGTAGT GATTGTTGAA GCATCTTTAA GCCATCCTGA GTCTGTAAAT 
AGGACAAAGT TTGACTGTAC TGAAAATGGA CTTCCATCTG TGTGCATGCA TCTTACACTG 
TGTTTCTCAT ATAAAGGCAA AGAGGTCCCA GGCTACATCG TTTTGTTTTA CAATGTGAGC 
TTGGATGTGC ACAGGAAGGC AGAGTCTCCG TCAAGATTTT ATTTCTTCTC TAATGGGACT 
TCTGACGTGA TTACAGGAAG CATACGAGTT TCAAGCAGTG GAGAGAAATG TAGGACACAC 
CAGGCATTCA TGCGGAAAGA CGTGCGAGAC ATCCTTACCC CCATTCATGT AGAGGCCACA 
TACCACCTTG GGCATCATGT GATCACCAAA CGAAACACTG AGGAATTTCC ACCACTCCAG 
CCGATCCTTC AGCAGAAGAA AGAAAAAGAC GTTATTAGAA AAATGATAAA CTTTGCAAGG 
TTTTGTGCCT ATGAAAATTG CTCTGCTGAT CTCCAAGTTT CTGCAAAAGT TGGATTTTTG 
AAGCCATATG AAAATAAAAC CTATCTTGCT GTTGGGAGCA TGAAGACCAT AATGCTAAAC 
GTGTCCTTGT TCAACGCTGG CGATGATGCT TACGAAACCA CTCTGAATGT CCAACTCCCC 
ACAGGCCTTT ATTTCATTAA GATCTTAGAC CTGGAAGAGA AACAAATAAA CTGCGAAGTG 
ACTGAGAGCT CAGGCATAGT GAAGCTTGCC TGCAGCCTAG GTTACATATA TGTGGATCGC 
CTCTCAAGGA TAGACATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG GGCACATGAG 
GACCTCAGCA TCAGTGTGCA TGCCTCCTGT GAAAACGAGG GCGAATTGGA CCAAGTGAGG 
GACAACAGAG TGACCTTAAC GATACCTCTA AGGTATGAGG TTATGCTGAC TGTTCATGGG 
CTTGTGAACC CAACTTCATT TGTGTATGGA TCTAGCGAAG AAAACGAGCC AGAAACATGC 
ATGGCCGAGA AGCTGAACCT CACTTTCCAT GTTATAAACA CTGGGATTAG CATGGCTCCA 
AATGTTAGTG TGAAAATAAT GGTACCAAAT TCTTTTCTCC CTCAAGATGA TAAGTTGTTC 
AACGTTTTGG ATGTCCAGAC AACTACAGGG CAATGCCATT TTAAACACTA TGGAAGAGAG 
TGTACATTTG CACAGCAAAA AGGCATAGCG GGGACGTTGA CCGATATAGT CAAATTCCTA 
TCAAAGACTG ATAAGAGACT CCTGTATTGC ATGAAAGCTG ATCAACACTG TTTAGATTTC 
TTATGCAATT TCGGAAAAAT GGAAAGTGGG AAGGAAGCCA GCGTTCATAT TCAGCTGGAG 
GGCAGGCCAT CCATCTTGGA AATGGATGAG ACCTCATCAC TCAAGTTTGA AATAAAAGCA 
ACAGCTTTTC CAGAGCCACA CCCAAAAGTT ATTGAACTAA ATAAAGATGA GAACGTGGCC 
CATGTTTTCT TGGAAGGGCT CCATCATCAA AGACCCAAAC GACATTTCAC CATCATTATT 
ATTACCATCA GCTTGCTACT TGGACTTATT GTACTTTTAT TAATTTCATG TGTTATGTGG 
AAGGCTGGAT TCTTTAAAAG ACAGTACAAA TCTATCCTAC AAGAAGAAAA CAGGAGAGAC 
AGCTGGAGTT ATGTCAACAG CAAAAGCAAT GATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Chemokine Receptor CXCR3 Promotes CD8
Journal of immunology (Baltimore, Md. : 1950)200(3)1133-1145(2018 Feb)
Caldeira-Dantas S,Furmanak T,Smith C,Quinn M,Teos LY,Ertel A,Kurup D,Tandon M,Alevizos I,Snyder CM

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

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Itga4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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