ITGA4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITGA4
Entrez Gene ID	3676
Full Name	integrin subunit alpha 4
Synonyms	CD49D,IA4
General protein information	Preferred Names integrin subunit alpha 4 Names integrin alpha-4 269C wild type CD49 antigen-like family member D VLA-4 subunit alpha alpha 4 subunit of VLA-4 receptor antigen CD49D, alpha-4 subunit of VLA-4 receptor integrin alpha-IV very late activation protein 4 receptor, alpha 4 subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.3
Summary	The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
Disorder MIM:	192975

mRNA and Protein(s)

mRNA	Protein	Name
NM_000885.4	NP_000876.3	integrin alpha-4 precursor
NM_000885.6	NP_000876.3	integrin alpha-4 isoform 1 preproprotein
NM_001316312.1	NP_001303241.1	integrin alpha-4 isoform 2 precursor
NM_000885.5	NP_000876.3	integrin alpha-4 isoform 1 preproprotein

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	itga4	XP_002663459.2
Xenopus tropicalis (tropical clawed frog)	itga4	XP_002932062.2
Rattus norvegicus (Norway rat)	Itga4	NP_001101207.1
Homo sapiens (human)	ITGA4	NP_000876.3
	ITGA4	XP_001100929.1
Canis lupus familiaris (dog)	ITGA4	XP_545551.3
Pan troglodytes (chimpanzee)	ITGA4	XP_525977.2
Bos taurus (cattle)	ITGA4	NP_777173.1
Mus musculus (house mouse)	Itga4	NP_034706.3
Gallus gallus (chicken)	ITGA4	XP_421974.3

Gene Ontology
Bibliography

Related articles in PubMed

Differences between chronic lymphocytic leukaemia and small lymphocytic lymphoma cells by proteomic profiling and SNP microarray analysis.
Tooze JA, Hamzic E, Willis F, Pettengell R
Cancer genetics218-21920-38(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ITGalpha4beta1 and TLR4 have roles in inducing fibrotic gene expression in response to fibronectin's EDA domain
Title: Integrin ?4?1 and TLR4 Cooperate to Induce Fibrotic Gene Expression in Response to Fibronectin's EDA Domain.

Low CD49D expression is associated with chronic lymphocytic leukaemia in comparison to small lymphocytic lymphoma.
Title: Differences between chronic lymphocytic leukaemia and small lymphocytic lymphoma cells by proteomic profiling and SNP microarray analysis.

study analyzes for the first time the expressions of epithelial-mesenchymal transition marker proteins - periostin, integrin alpha4, fibronectin - in metastatic castration-resistant prostate cancer
Title: Do the expressions of epithelial-mesenchymal transition proteins, periostin, integrin-?4 and fibronectin correlate with clinico-pathological features and prognosis of metastatic castration-resistant prostate cancer?

Glycosylation of V1V2 domain of HIV envelope protein determined its binding to alpha4ss7 integrin.
Title: Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by ?4?7 integrin.

Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Title: Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

The following ITGA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITGA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15868	NM_000885.5 Latest version!	Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$519.50-$727.30 $1039.00
OHu100297	NM_001316312.1 Latest version!	Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu107859	NM_000885.6 Latest version!	Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
View Old Accession Versions >>
OHu15868	NM_000885.4	Homo sapiens integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$519.50-$727.30 $1039.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITGA4 ( NM_000885.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000876.3 Homo sapiens integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4), mRNA.

Price & Availability↑

CloneID	OHu15868
Clone ID Related Accession (Same CDS sequence)	NM_000885.4 , NM_000885.5
Accession Version	NM_000885.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3099bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	integrin alpha-4 precursor
Comment

ATGGCTTGGG AAGCGAGGCG CGAACCCGGC CCCCGAAGGG CCGCCGTCCG GGAGACGGTG 
ATGCTGTTGC TGTGCCTGGG GGTCCCGACC GGCCGCCCCT ACAACGTGGA CACTGAGAGC 
GCGCTGCTTT ACCAGGGCCC CCACAACACG CTGTTCGGCT ACTCGGTCGT GCTGCACAGC 
CACGGGGCGA ACCGATGGCT CCTAGTGGGT GCGCCCACTG CCAACTGGCT CGCCAACGCT 
TCAGTGATCA ATCCCGGGGC GATTTACAGA TGCAGGATCG GAAAGAATCC CGGCCAGACG 
TGCGAACAGC TCCAGCTGGG TAGCCCTAAT GGAGAACCTT GTGGAAAGAC TTGTTTGGAA 
GAGAGAGACA ATCAGTGGTT GGGGGTCACA CTTTCCAGAC AGCCAGGAGA AAATGGATCC 
ATCGTGACTT GTGGGCATAG ATGGAAAAAT ATATTTTACA TAAAGAATGA AAATAAGCTC 
CCCACTGGTG GTTGCTATGG AGTGCCCCCT GATTTACGAA CAGAACTGAG TAAAAGAATA 
GCTCCGTGTT ATCAAGATTA TGTGAAAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCCA GTTTTTACAC AAAGGATTTA ATTGTGATGG GGGCCCCAGG ATCATCTTAC 
TGGACTGGCT CTCTTTTTGT CTACAATATA ACTACAAATA AATACAAGGC TTTTTTAGAC 
AAACAAAATC AAGTAAAATT TGGAAGTTAT TTAGGATATT CAGTCGGAGC TGGTCATTTT 
CGGAGCCAGC ATACTACCGA AGTAGTCGGA GGAGCTCCTC AACATGAGCA GATTGGTAAG 
GCATATATAT TCAGCATTGA TGAAAAAGAA CTAAATATCT TACATGAAAT GAAAGGTAAA 
AAGCTTGGAT CGTACTTTGG AGCTTCTGTC TGTGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTGC TCGTGGGAGC ACCCATGCAG AGCACCATCA GAGAGGAAGG AAGAGTGTTT 
GTGTACATCA ACTCTGGCTC GGGAGCAGTA ATGAATGCAA TGGAAACAAA CCTCGTTGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAA TCTATAGTTA ATCTTGGCGA CATTGACAAT 
GATGGCTTTG AAGATGTTGC TATCGGAGCT CCACAAGAAG ATGACTTGCA AGGTGCTATT 
TATATTTACA ATGGCCGTGC AGATGGGATC TCGTCAACCT TCTCACAGAG AATTGAAGGA 
CTTCAGATCA GCAAATCGTT AAGTATGTTT GGACAGTCTA TATCAGGACA AATTGATGCA 
GATAATAATG GCTATGTAGA TGTAGCAGTT GGTGCTTTTC GGTCTGATTC TGCTGTCTTG 
CTAAGGACAA GACCTGTAGT AATTGTTGAC GCTTCTTTAA GCCACCCTGA GTCAGTAAAT 
AGAACGAAAT TTGACTGTGT TGAAAATGGA TGGCCTTCTG TGTGCATAGA TCTAACACTT 
TGTTTCTCAT ATAAGGGCAA GGAAGTTCCA GGTTACATTG TTTTGTTTTA TAACATGAGT 
TTGGATGTGA ACAGAAAGGC AGAGTCTCCA CCAAGATTCT ATTTCTCTTC TAATGGAACT 
TCTGACGTGA TTACAGGAAG CATACAGGTG TCCAGCAGAG AAGCTAACTG TAGAACACAT 
CAAGCATTTA TGCGGAAAGA TGTGCGGGAC ATCCTCACCC CAATTCAGAT TGAAGCTGCT 
TACCACCTTG GTCCTCATGT CATCAGTAAA CGAAGTACAG AGGAATTCCC ACCACTTCAG 
CCAATTCTTC AGCAGAAGAA AGAAAAAGAC ATAATGAAAA AAACAATAAA CTTTGCAAGG 
TTTTGTGCCC ATGAAAATTG TTCTGCTGAT TTACAGGTTT CTGCAAAGAT TGGGTTTTTG 
AAGCCCCATG AAAATAAAAC ATATCTTGCT GTTGGGAGTA TGAAGACATT GATGTTGAAT 
GTGTCCTTGT TTAATGCTGG AGATGATGCA TATGAAACGA CTCTACATGT CAAACTACCC 
GTGGGTCTTT ATTTCATTAA GATTTTAGAG CTGGAAGAGA AGCAAATAAA CTGTGAAGTC 
ACAGATAACT CTGGCGTGGT ACAACTTGAC TGCAGTATTG GCTATATATA TGTAGATCAT 
CTCTCAAGGA TAGATATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG AGCGGAAGAG 
GACCTCAGTA TCACAGTGCA TGCTACCTGT GAAAATGAAG AGGAAATGGA CAATCTAAAG 
CACAGCAGAG TGACTGTAGC AATACCTTTA AAATATGAGG TTAAGCTGAC TGTTCATGGG 
TTTGTAAACC CAACTTCATT TGTGTATGGA TCAAATGATG AAAATGAGCC TGAAACGTGC 
ATGGTGGAGA AAATGAACTT AACTTTCCAT GTTATCAACA CTGGCAATAG TATGGCTCCC 
AATGTTAGTG TGGAAATAAT GGTACCAAAT TCTTTTAGCC CCCAAACTGA TAAGCTGTTC 
AACATTTTGG ATGTCCAGAC TACTACTGGA GAATGCCACT TTGAAAATTA TCAAAGAGTG 
TGTGCATTAG AGCAGCAAAA GAGTGCAATG CAGACCTTGA AAGGCATAGT CCGGTTCTTG 
TCCAAGACTG ATAAGAGGCT ATTGTACTGC ATAAAAGCTG ATCCACATTG TTTAAATTTC 
TTGTGTAATT TTGGGAAAAT GGAAAGTGGA AAAGAAGCCA GTGTTCATAT CCAACTGGAA 
GGCCGGCCAT CCATTTTAGA AATGGATGAG ACTTCAGCAC TCAAGTTTGA AATAAGAGCA 
ACAGGTTTTC CAGAGCCAAA TCCAAGAGTA ATTGAACTAA ACAAGGATGA GAATGTTGCG 
CATGTTCTAC TGGAAGGACT ACATCATCAA AGACCCAAAC GTTATTTCAC CATAGTGATT 
ATTTCAAGTA GCTTGCTACT TGGACTTATT GTACTTCTGT TGATCTCATA TGTTATGTGG 
AAGGCTGGCT TCTTTAAAAG ACAATACAAA TCTATCCTAC AAGAAGAAAA CAGAAGAGAC 
AGTTGGAGTT ATATCAACAG TAAAAGCAAT GATGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_000876.3

Translation

MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD

Target ORF information:

RefSeq Version	NM_000885.4
Organism	Homo sapiens(Human)
Definition	Homo sapiens integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (ITGA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000885.4

ORF Insert Sequence:

ATGGCTTGGG AAGCGAGGCG CGAACCCGGC CCCCGAAGGG CCGCCGTCCG GGAGACGGTG 
ATGCTGTTGC TGTGCCTGGG GGTCCCGACC GGCCGCCCCT ACAACGTGGA CACTGAGAGC 
GCGCTGCTTT ACCAGGGCCC CCACAACACG CTGTTCGGCT ACTCGGTCGT GCTGCACAGC 
CACGGGGCGA ACCGATGGCT CCTAGTGGGT GCGCCCACTG CCAACTGGCT CGCCAACGCT 
TCAGTGATCA ATCCCGGGGC GATTTACAGA TGCAGGATCG GAAAGAATCC CGGCCAGACG 
TGCGAACAGC TCCAGCTGGG TAGCCCTAAT GGAGAACCTT GTGGAAAGAC TTGTTTGGAA 
GAGAGAGACA ATCAGTGGTT GGGGGTCACA CTTTCCAGAC AGCCAGGAGA AAATGGATCC 
ATCGTGACTT GTGGGCATAG ATGGAAAAAT ATATTTTACA TAAAGAATGA AAATAAGCTC 
CCCACTGGTG GTTGCTATGG AGTGCCCCCT GATTTACGAA CAGAACTGAG TAAAAGAATA 
GCTCCGTGTT ATCAAGATTA TGTGAAAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCCA GTTTTTACAC AAAGGATTTA ATTGTGATGG GGGCCCCAGG ATCATCTTAC 
TGGACTGGCT CTCTTTTTGT CTACAATATA ACTACAAATA AATACAAGGC TTTTTTAGAC 
AAACAAAATC AAGTAAAATT TGGAAGTTAT TTAGGATATT CAGTCGGAGC TGGTCATTTT 
CGGAGCCAGC ATACTACCGA AGTAGTCGGA GGAGCTCCTC AACATGAGCA GATTGGTAAG 
GCATATATAT TCAGCATTGA TGAAAAAGAA CTAAATATCT TACATGAAAT GAAAGGTAAA 
AAGCTTGGAT CGTACTTTGG AGCTTCTGTC TGTGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTGC TCGTGGGAGC ACCCATGCAG AGCACCATCA GAGAGGAAGG AAGAGTGTTT 
GTGTACATCA ACTCTGGCTC GGGAGCAGTA ATGAATGCAA TGGAAACAAA CCTCGTTGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAA TCTATAGTTA ATCTTGGCGA CATTGACAAT 
GATGGCTTTG AAGATGTTGC TATCGGAGCT CCACAAGAAG ATGACTTGCA AGGTGCTATT 
TATATTTACA ATGGCCGTGC AGATGGGATC TCGTCAACCT TCTCACAGAG AATTGAAGGA 
CTTCAGATCA GCAAATCGTT AAGTATGTTT GGACAGTCTA TATCAGGACA AATTGATGCA 
GATAATAATG GCTATGTAGA TGTAGCAGTT GGTGCTTTTC GGTCTGATTC TGCTGTCTTG 
CTAAGGACAA GACCTGTAGT AATTGTTGAC GCTTCTTTAA GCCACCCTGA GTCAGTAAAT 
AGAACGAAAT TTGACTGTGT TGAAAATGGA TGGCCTTCTG TGTGCATAGA TCTAACACTT 
TGTTTCTCAT ATAAGGGCAA GGAAGTTCCA GGTTACATTG TTTTGTTTTA TAACATGAGT 
TTGGATGTGA ACAGAAAGGC AGAGTCTCCA CCAAGATTCT ATTTCTCTTC TAATGGAACT 
TCTGACGTGA TTACAGGAAG CATACAGGTG TCCAGCAGAG AAGCTAACTG TAGAACACAT 
CAAGCATTTA TGCGGAAAGA TGTGCGGGAC ATCCTCACCC CAATTCAGAT TGAAGCTGCT 
TACCACCTTG GTCCTCATGT CATCAGTAAA CGAAGTACAG AGGAATTCCC ACCACTTCAG 
CCAATTCTTC AGCAGAAGAA AGAAAAAGAC ATAATGAAAA AAACAATAAA CTTTGCAAGG 
TTTTGTGCCC ATGAAAATTG TTCTGCTGAT TTACAGGTTT CTGCAAAGAT TGGGTTTTTG 
AAGCCCCATG AAAATAAAAC ATATCTTGCT GTTGGGAGTA TGAAGACATT GATGTTGAAT 
GTGTCCTTGT TTAATGCTGG AGATGATGCA TATGAAACGA CTCTACATGT CAAACTACCC 
GTGGGTCTTT ATTTCATTAA GATTTTAGAG CTGGAAGAGA AGCAAATAAA CTGTGAAGTC 
ACAGATAACT CTGGCGTGGT ACAACTTGAC TGCAGTATTG GCTATATATA TGTAGATCAT 
CTCTCAAGGA TAGATATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG AGCGGAAGAG 
GACCTCAGTA TCACAGTGCA TGCTACCTGT GAAAATGAAG AGGAAATGGA CAATCTAAAG 
CACAGCAGAG TGACTGTAGC AATACCTTTA AAATATGAGG TTAAGCTGAC TGTTCATGGG 
TTTGTAAACC CAACTTCATT TGTGTATGGA TCAAATGATG AAAATGAGCC TGAAACGTGC 
ATGGTGGAGA AAATGAACTT AACTTTCCAT GTTATCAACA CTGGCAATAG TATGGCTCCC 
AATGTTAGTG TGGAAATAAT GGTACCAAAT TCTTTTAGCC CCCAAACTGA TAAGCTGTTC 
AACATTTTGG ATGTCCAGAC TACTACTGGA GAATGCCACT TTGAAAATTA TCAAAGAGTG 
TGTGCATTAG AGCAGCAAAA GAGTGCAATG CAGACCTTGA AAGGCATAGT CCGGTTCTTG 
TCCAAGACTG ATAAGAGGCT ATTGTACTGC ATAAAAGCTG ATCCACATTG TTTAAATTTC 
TTGTGTAATT TTGGGAAAAT GGAAAGTGGA AAAGAAGCCA GTGTTCATAT CCAACTGGAA 
GGCCGGCCAT CCATTTTAGA AATGGATGAG ACTTCAGCAC TCAAGTTTGA AATAAGAGCA 
ACAGGTTTTC CAGAGCCAAA TCCAAGAGTA ATTGAACTAA ACAAGGATGA GAATGTTGCG 
CATGTTCTAC TGGAAGGACT ACATCATCAA AGACCCAAAC GTTATTTCAC CATAGTGATT 
ATTTCAAGTA GCTTGCTACT TGGACTTATT GTACTTCTGT TGATCTCATA TGTTATGTGG 
AAGGCTGGCT TCTTTAAAAG ACAATACAAA TCTATCCTAC AAGAAGAAAA CAGAAGAGAC 
AGTTGGAGTT ATATCAACAG TAAAAGCAAT GATGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGA4 ( NM_000885.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000876.3 Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15868
Clone ID Related Accession (Same CDS sequence)	NM_000885.4 , NM_000885.5
Accession Version	NM_000885.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3099bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	integrin alpha-4 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB114726.1, BC055419.1, L12002.1, X16983.1, AC020595.7 and BU689519.1. This sequence is a reference standard in the RefSeqGene project. On Oct 10, 2015 this sequence version replaced NM_000885.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X16983.1, L12002.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTTGGG AAGCGAGGCG CGAACCCGGC CCCCGAAGGG CCGCCGTCCG GGAGACGGTG 
ATGCTGTTGC TGTGCCTGGG GGTCCCGACC GGCCGCCCCT ACAACGTGGA CACTGAGAGC 
GCGCTGCTTT ACCAGGGCCC CCACAACACG CTGTTCGGCT ACTCGGTCGT GCTGCACAGC 
CACGGGGCGA ACCGATGGCT CCTAGTGGGT GCGCCCACTG CCAACTGGCT CGCCAACGCT 
TCAGTGATCA ATCCCGGGGC GATTTACAGA TGCAGGATCG GAAAGAATCC CGGCCAGACG 
TGCGAACAGC TCCAGCTGGG TAGCCCTAAT GGAGAACCTT GTGGAAAGAC TTGTTTGGAA 
GAGAGAGACA ATCAGTGGTT GGGGGTCACA CTTTCCAGAC AGCCAGGAGA AAATGGATCC 
ATCGTGACTT GTGGGCATAG ATGGAAAAAT ATATTTTACA TAAAGAATGA AAATAAGCTC 
CCCACTGGTG GTTGCTATGG AGTGCCCCCT GATTTACGAA CAGAACTGAG TAAAAGAATA 
GCTCCGTGTT ATCAAGATTA TGTGAAAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCCA GTTTTTACAC AAAGGATTTA ATTGTGATGG GGGCCCCAGG ATCATCTTAC 
TGGACTGGCT CTCTTTTTGT CTACAATATA ACTACAAATA AATACAAGGC TTTTTTAGAC 
AAACAAAATC AAGTAAAATT TGGAAGTTAT TTAGGATATT CAGTCGGAGC TGGTCATTTT 
CGGAGCCAGC ATACTACCGA AGTAGTCGGA GGAGCTCCTC AACATGAGCA GATTGGTAAG 
GCATATATAT TCAGCATTGA TGAAAAAGAA CTAAATATCT TACATGAAAT GAAAGGTAAA 
AAGCTTGGAT CGTACTTTGG AGCTTCTGTC TGTGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTGC TCGTGGGAGC ACCCATGCAG AGCACCATCA GAGAGGAAGG AAGAGTGTTT 
GTGTACATCA ACTCTGGCTC GGGAGCAGTA ATGAATGCAA TGGAAACAAA CCTCGTTGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAA TCTATAGTTA ATCTTGGCGA CATTGACAAT 
GATGGCTTTG AAGATGTTGC TATCGGAGCT CCACAAGAAG ATGACTTGCA AGGTGCTATT 
TATATTTACA ATGGCCGTGC AGATGGGATC TCGTCAACCT TCTCACAGAG AATTGAAGGA 
CTTCAGATCA GCAAATCGTT AAGTATGTTT GGACAGTCTA TATCAGGACA AATTGATGCA 
GATAATAATG GCTATGTAGA TGTAGCAGTT GGTGCTTTTC GGTCTGATTC TGCTGTCTTG 
CTAAGGACAA GACCTGTAGT AATTGTTGAC GCTTCTTTAA GCCACCCTGA GTCAGTAAAT 
AGAACGAAAT TTGACTGTGT TGAAAATGGA TGGCCTTCTG TGTGCATAGA TCTAACACTT 
TGTTTCTCAT ATAAGGGCAA GGAAGTTCCA GGTTACATTG TTTTGTTTTA TAACATGAGT 
TTGGATGTGA ACAGAAAGGC AGAGTCTCCA CCAAGATTCT ATTTCTCTTC TAATGGAACT 
TCTGACGTGA TTACAGGAAG CATACAGGTG TCCAGCAGAG AAGCTAACTG TAGAACACAT 
CAAGCATTTA TGCGGAAAGA TGTGCGGGAC ATCCTCACCC CAATTCAGAT TGAAGCTGCT 
TACCACCTTG GTCCTCATGT CATCAGTAAA CGAAGTACAG AGGAATTCCC ACCACTTCAG 
CCAATTCTTC AGCAGAAGAA AGAAAAAGAC ATAATGAAAA AAACAATAAA CTTTGCAAGG 
TTTTGTGCCC ATGAAAATTG TTCTGCTGAT TTACAGGTTT CTGCAAAGAT TGGGTTTTTG 
AAGCCCCATG AAAATAAAAC ATATCTTGCT GTTGGGAGTA TGAAGACATT GATGTTGAAT 
GTGTCCTTGT TTAATGCTGG AGATGATGCA TATGAAACGA CTCTACATGT CAAACTACCC 
GTGGGTCTTT ATTTCATTAA GATTTTAGAG CTGGAAGAGA AGCAAATAAA CTGTGAAGTC 
ACAGATAACT CTGGCGTGGT ACAACTTGAC TGCAGTATTG GCTATATATA TGTAGATCAT 
CTCTCAAGGA TAGATATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG AGCGGAAGAG 
GACCTCAGTA TCACAGTGCA TGCTACCTGT GAAAATGAAG AGGAAATGGA CAATCTAAAG 
CACAGCAGAG TGACTGTAGC AATACCTTTA AAATATGAGG TTAAGCTGAC TGTTCATGGG 
TTTGTAAACC CAACTTCATT TGTGTATGGA TCAAATGATG AAAATGAGCC TGAAACGTGC 
ATGGTGGAGA AAATGAACTT AACTTTCCAT GTTATCAACA CTGGCAATAG TATGGCTCCC 
AATGTTAGTG TGGAAATAAT GGTACCAAAT TCTTTTAGCC CCCAAACTGA TAAGCTGTTC 
AACATTTTGG ATGTCCAGAC TACTACTGGA GAATGCCACT TTGAAAATTA TCAAAGAGTG 
TGTGCATTAG AGCAGCAAAA GAGTGCAATG CAGACCTTGA AAGGCATAGT CCGGTTCTTG 
TCCAAGACTG ATAAGAGGCT ATTGTACTGC ATAAAAGCTG ATCCACATTG TTTAAATTTC 
TTGTGTAATT TTGGGAAAAT GGAAAGTGGA AAAGAAGCCA GTGTTCATAT CCAACTGGAA 
GGCCGGCCAT CCATTTTAGA AATGGATGAG ACTTCAGCAC TCAAGTTTGA AATAAGAGCA 
ACAGGTTTTC CAGAGCCAAA TCCAAGAGTA ATTGAACTAA ACAAGGATGA GAATGTTGCG 
CATGTTCTAC TGGAAGGACT ACATCATCAA AGACCCAAAC GTTATTTCAC CATAGTGATT 
ATTTCAAGTA GCTTGCTACT TGGACTTATT GTACTTCTGT TGATCTCATA TGTTATGTGG 
AAGGCTGGCT TCTTTAAAAG ACAATACAAA TCTATCCTAC AAGAAGAAAA CAGAAGAGAC 
AGTTGGAGTT ATATCAACAG TAAAAGCAAT GATGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000876.3
CDS	764..3862
Translation	MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD

Target ORF information:

RefSeq Version	NM_000885.5
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000885.5

ORF Insert Sequence:

ATGGCTTGGG AAGCGAGGCG CGAACCCGGC CCCCGAAGGG CCGCCGTCCG GGAGACGGTG 
ATGCTGTTGC TGTGCCTGGG GGTCCCGACC GGCCGCCCCT ACAACGTGGA CACTGAGAGC 
GCGCTGCTTT ACCAGGGCCC CCACAACACG CTGTTCGGCT ACTCGGTCGT GCTGCACAGC 
CACGGGGCGA ACCGATGGCT CCTAGTGGGT GCGCCCACTG CCAACTGGCT CGCCAACGCT 
TCAGTGATCA ATCCCGGGGC GATTTACAGA TGCAGGATCG GAAAGAATCC CGGCCAGACG 
TGCGAACAGC TCCAGCTGGG TAGCCCTAAT GGAGAACCTT GTGGAAAGAC TTGTTTGGAA 
GAGAGAGACA ATCAGTGGTT GGGGGTCACA CTTTCCAGAC AGCCAGGAGA AAATGGATCC 
ATCGTGACTT GTGGGCATAG ATGGAAAAAT ATATTTTACA TAAAGAATGA AAATAAGCTC 
CCCACTGGTG GTTGCTATGG AGTGCCCCCT GATTTACGAA CAGAACTGAG TAAAAGAATA 
GCTCCGTGTT ATCAAGATTA TGTGAAAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCCA GTTTTTACAC AAAGGATTTA ATTGTGATGG GGGCCCCAGG ATCATCTTAC 
TGGACTGGCT CTCTTTTTGT CTACAATATA ACTACAAATA AATACAAGGC TTTTTTAGAC 
AAACAAAATC AAGTAAAATT TGGAAGTTAT TTAGGATATT CAGTCGGAGC TGGTCATTTT 
CGGAGCCAGC ATACTACCGA AGTAGTCGGA GGAGCTCCTC AACATGAGCA GATTGGTAAG 
GCATATATAT TCAGCATTGA TGAAAAAGAA CTAAATATCT TACATGAAAT GAAAGGTAAA 
AAGCTTGGAT CGTACTTTGG AGCTTCTGTC TGTGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTGC TCGTGGGAGC ACCCATGCAG AGCACCATCA GAGAGGAAGG AAGAGTGTTT 
GTGTACATCA ACTCTGGCTC GGGAGCAGTA ATGAATGCAA TGGAAACAAA CCTCGTTGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAA TCTATAGTTA ATCTTGGCGA CATTGACAAT 
GATGGCTTTG AAGATGTTGC TATCGGAGCT CCACAAGAAG ATGACTTGCA AGGTGCTATT 
TATATTTACA ATGGCCGTGC AGATGGGATC TCGTCAACCT TCTCACAGAG AATTGAAGGA 
CTTCAGATCA GCAAATCGTT AAGTATGTTT GGACAGTCTA TATCAGGACA AATTGATGCA 
GATAATAATG GCTATGTAGA TGTAGCAGTT GGTGCTTTTC GGTCTGATTC TGCTGTCTTG 
CTAAGGACAA GACCTGTAGT AATTGTTGAC GCTTCTTTAA GCCACCCTGA GTCAGTAAAT 
AGAACGAAAT TTGACTGTGT TGAAAATGGA TGGCCTTCTG TGTGCATAGA TCTAACACTT 
TGTTTCTCAT ATAAGGGCAA GGAAGTTCCA GGTTACATTG TTTTGTTTTA TAACATGAGT 
TTGGATGTGA ACAGAAAGGC AGAGTCTCCA CCAAGATTCT ATTTCTCTTC TAATGGAACT 
TCTGACGTGA TTACAGGAAG CATACAGGTG TCCAGCAGAG AAGCTAACTG TAGAACACAT 
CAAGCATTTA TGCGGAAAGA TGTGCGGGAC ATCCTCACCC CAATTCAGAT TGAAGCTGCT 
TACCACCTTG GTCCTCATGT CATCAGTAAA CGAAGTACAG AGGAATTCCC ACCACTTCAG 
CCAATTCTTC AGCAGAAGAA AGAAAAAGAC ATAATGAAAA AAACAATAAA CTTTGCAAGG 
TTTTGTGCCC ATGAAAATTG TTCTGCTGAT TTACAGGTTT CTGCAAAGAT TGGGTTTTTG 
AAGCCCCATG AAAATAAAAC ATATCTTGCT GTTGGGAGTA TGAAGACATT GATGTTGAAT 
GTGTCCTTGT TTAATGCTGG AGATGATGCA TATGAAACGA CTCTACATGT CAAACTACCC 
GTGGGTCTTT ATTTCATTAA GATTTTAGAG CTGGAAGAGA AGCAAATAAA CTGTGAAGTC 
ACAGATAACT CTGGCGTGGT ACAACTTGAC TGCAGTATTG GCTATATATA TGTAGATCAT 
CTCTCAAGGA TAGATATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG AGCGGAAGAG 
GACCTCAGTA TCACAGTGCA TGCTACCTGT GAAAATGAAG AGGAAATGGA CAATCTAAAG 
CACAGCAGAG TGACTGTAGC AATACCTTTA AAATATGAGG TTAAGCTGAC TGTTCATGGG 
TTTGTAAACC CAACTTCATT TGTGTATGGA TCAAATGATG AAAATGAGCC TGAAACGTGC 
ATGGTGGAGA AAATGAACTT AACTTTCCAT GTTATCAACA CTGGCAATAG TATGGCTCCC 
AATGTTAGTG TGGAAATAAT GGTACCAAAT TCTTTTAGCC CCCAAACTGA TAAGCTGTTC 
AACATTTTGG ATGTCCAGAC TACTACTGGA GAATGCCACT TTGAAAATTA TCAAAGAGTG 
TGTGCATTAG AGCAGCAAAA GAGTGCAATG CAGACCTTGA AAGGCATAGT CCGGTTCTTG 
TCCAAGACTG ATAAGAGGCT ATTGTACTGC ATAAAAGCTG ATCCACATTG TTTAAATTTC 
TTGTGTAATT TTGGGAAAAT GGAAAGTGGA AAAGAAGCCA GTGTTCATAT CCAACTGGAA 
GGCCGGCCAT CCATTTTAGA AATGGATGAG ACTTCAGCAC TCAAGTTTGA AATAAGAGCA 
ACAGGTTTTC CAGAGCCAAA TCCAAGAGTA ATTGAACTAA ACAAGGATGA GAATGTTGCG 
CATGTTCTAC TGGAAGGACT ACATCATCAA AGACCCAAAC GTTATTTCAC CATAGTGATT 
ATTTCAAGTA GCTTGCTACT TGGACTTATT GTACTTCTGT TGATCTCATA TGTTATGTGG 
AAGGCTGGCT TCTTTAAAAG ACAATACAAA TCTATCCTAC AAGAAGAAAA CAGAAGAGAC 
AGTTGGAGTT ATATCAACAG TAAAAGCAAT GATGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGA4 ( NM_001316312.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001303241.1 Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 2, mRNA.

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CloneID	OHu100297
Clone ID Related Accession (Same CDS sequence)	NM_001316312.1
Accession Version	NM_001316312.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	integrin alpha-4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB114726.1 and BC055419.1. Transcript Variant: This variant (2) contains an alternate 3' terminal exon, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC055419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162823, SAMEA2163105 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTTGGG AAGCGAGGCG CGAACCCGGC CCCCGAAGGG CCGCCGTCCG GGAGACGGTG 
ATGCTGTTGC TGTGCCTGGG GGTCCCGACC GGCCGCCCCT ACAACGTGGA CACTGAGAGC 
GCGCTGCTTT ACCAGGGCCC CCACAACACG CTGTTCGGCT ACTCGGTCGT GCTGCACAGC 
CACGGGGCGA ACCGATGGCT CCTAGTGGGT GCGCCCACTG CCAACTGGCT CGCCAACGCT 
TCAGTGATCA ATCCCGGGGC GATTTACAGA TGCAGGATCG GAAAGAATCC CGGCCAGACG 
TGCGAACAGC TCCAGCTGGG TAGCCCTAAT GGAGAACCTT GTGGAAAGAC TTGTTTGGAA 
GAGAGAGACA ATCAGTGGTT GGGGGTCACA CTTTCCAGAC AGCCAGGAGA AAATGGATCC 
ATCGTGACTT GTGGGCATAG ATGGAAAAAT ATATTTTACA TAAAGAATGA AAATAAGCTC 
CCCACTGGTG GTTGCTATGG AGTGCCCCCT GATTTACGAA CAGAACTGAG TAAAAGAATA 
GCTCCGTGTT ATCAAGGTAG CATCAGCAAG TACAGAGCTA GGACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001303241.1
CDS	764..1351
Translation	MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQGSISKYRART

Target ORF information:

RefSeq Version	NM_001316312.1
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001316312.1

ORF Insert Sequence:

ATGGCTTGGG AAGCGAGGCG CGAACCCGGC CCCCGAAGGG CCGCCGTCCG GGAGACGGTG 
ATGCTGTTGC TGTGCCTGGG GGTCCCGACC GGCCGCCCCT ACAACGTGGA CACTGAGAGC 
GCGCTGCTTT ACCAGGGCCC CCACAACACG CTGTTCGGCT ACTCGGTCGT GCTGCACAGC 
CACGGGGCGA ACCGATGGCT CCTAGTGGGT GCGCCCACTG CCAACTGGCT CGCCAACGCT 
TCAGTGATCA ATCCCGGGGC GATTTACAGA TGCAGGATCG GAAAGAATCC CGGCCAGACG 
TGCGAACAGC TCCAGCTGGG TAGCCCTAAT GGAGAACCTT GTGGAAAGAC TTGTTTGGAA 
GAGAGAGACA ATCAGTGGTT GGGGGTCACA CTTTCCAGAC AGCCAGGAGA AAATGGATCC 
ATCGTGACTT GTGGGCATAG ATGGAAAAAT ATATTTTACA TAAAGAATGA AAATAAGCTC 
CCCACTGGTG GTTGCTATGG AGTGCCCCCT GATTTACGAA CAGAACTGAG TAAAAGAATA 
GCTCCGTGTT ATCAAGGTAG CATCAGCAAG TACAGAGCTA GGACATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGA4 ( NM_000885.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000876.3 Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 1, mRNA.

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CloneID	OHu107859
Clone ID Related Accession (Same CDS sequence)	NM_000885.6
Accession Version	NM_000885.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3099bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	integrin alpha-4 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC020595.7. On Nov 22, 2018 this sequence version replaced NM_000885.5. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X16983.1, L12002.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000397033.7/ ENSP00000380227.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTGGG AAGCGAGGCG CGAACCCGGC CCCCGAAGGG CCGCCGTCCG GGAGACGGTG 
ATGCTGTTGC TGTGCCTGGG GGTCCCGACC GGCCGCCCCT ACAACGTGGA CACTGAGAGC 
GCGCTGCTTT ACCAGGGCCC CCACAACACG CTGTTCGGCT ACTCGGTCGT GCTGCACAGC 
CACGGGGCGA ACCGATGGCT CCTAGTGGGT GCGCCCACTG CCAACTGGCT CGCCAACGCT 
TCAGTGATCA ATCCCGGGGC GATTTACAGA TGCAGGATCG GAAAGAATCC CGGCCAGACG 
TGCGAACAGC TCCAGCTGGG TAGCCCTAAT GGAGAACCTT GTGGAAAGAC TTGTTTGGAA 
GAGAGAGACA ATCAGTGGTT GGGGGTCACA CTTTCCAGAC AGCCAGGAGA AAATGGATCC 
ATCGTGACTT GTGGGCATAG ATGGAAAAAT ATATTTTACA TAAAGAATGA AAATAAGCTC 
CCCACTGGTG GTTGCTATGG AGTGCCCCCT GATTTACGAA CAGAACTGAG TAAAAGAATA 
GCTCCGTGTT ATCAAGATTA TGTGAAAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCCA GTTTTTACAC AAAGGATTTA ATTGTGATGG GGGCCCCAGG ATCATCTTAC 
TGGACTGGCT CTCTTTTTGT CTACAATATA ACTACAAATA AATACAAGGC TTTTTTAGAC 
AAACAAAATC AAGTAAAATT TGGAAGTTAT TTAGGATATT CAGTCGGAGC TGGTCATTTT 
CGGAGCCAGC ATACTACCGA AGTAGTCGGA GGAGCTCCTC AACATGAGCA GATTGGTAAG 
GCATATATAT TCAGCATTGA TGAAAAAGAA CTAAATATCT TACATGAAAT GAAAGGTAAA 
AAGCTTGGAT CGTACTTTGG AGCTTCTGTC TGTGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTGC TCGTGGGAGC ACCCATGCAG AGCACCATCA GAGAGGAAGG AAGAGTGTTT 
GTGTACATCA ACTCTGGCTC GGGAGCAGTA ATGAATGCAA TGGAAACAAA CCTCGTTGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAA TCTATAGTTA ATCTTGGCGA CATTGACAAT 
GATGGCTTTG AAGATGTTGC TATCGGAGCT CCACAAGAAG ATGACTTGCA AGGTGCTATT 
TATATTTACA ATGGCCGTGC AGATGGGATC TCGTCAACCT TCTCACAGAG AATTGAAGGA 
CTTCAGATCA GCAAATCGTT AAGTATGTTT GGACAGTCTA TATCAGGACA AATTGATGCA 
GATAATAATG GCTATGTAGA TGTAGCAGTT GGTGCTTTTC GGTCTGATTC TGCTGTCTTG 
CTAAGGACAA GACCTGTAGT AATTGTTGAC GCTTCTTTAA GCCACCCTGA GTCAGTAAAT 
AGAACGAAAT TTGACTGTGT TGAAAATGGA TGGCCTTCTG TGTGCATAGA TCTAACACTT 
TGTTTCTCAT ATAAGGGCAA GGAAGTTCCA GGTTACATTG TTTTGTTTTA TAACATGAGT 
TTGGATGTGA ACAGAAAGGC AGAGTCTCCA CCAAGATTCT ATTTCTCTTC TAATGGAACT 
TCTGACGTGA TTACAGGAAG CATACAGGTG TCCAGCAGAG AAGCTAACTG TAGAACACAT 
CAAGCATTTA TGCGGAAAGA TGTGCGGGAC ATCCTCACCC CAATTCAGAT TGAAGCTGCT 
TACCACCTTG GTCCTCATGT CATCAGTAAA CGAAGTACAG AGGAATTCCC ACCACTTCAG 
CCAATTCTTC AGCAGAAGAA AGAAAAAGAC ATAATGAAAA AAACAATAAA CTTTGCAAGG 
TTTTGTGCCC ATGAAAATTG TTCTGCTGAT TTACAGGTTT CTGCAAAGAT TGGGTTTTTG 
AAGCCCCATG AAAATAAAAC ATATCTTGCT GTTGGGAGTA TGAAGACATT GATGTTGAAT 
GTGTCCTTGT TTAATGCTGG AGATGATGCA TATGAAACGA CTCTACATGT CAAACTACCC 
GTGGGTCTTT ATTTCATTAA GATTTTAGAG CTGGAAGAGA AGCAAATAAA CTGTGAAGTC 
ACAGATAACT CTGGCGTGGT ACAACTTGAC TGCAGTATTG GCTATATATA TGTAGATCAT 
CTCTCAAGGA TAGATATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG AGCGGAAGAG 
GACCTCAGTA TCACAGTGCA TGCTACCTGT GAAAATGAAG AGGAAATGGA CAATCTAAAG 
CACAGCAGAG TGACTGTAGC AATACCTTTA AAATATGAGG TTAAGCTGAC TGTTCATGGG 
TTTGTAAACC CAACTTCATT TGTGTATGGA TCAAATGATG AAAATGAGCC TGAAACGTGC 
ATGGTGGAGA AAATGAACTT AACTTTCCAT GTTATCAACA CTGGCAATAG TATGGCTCCC 
AATGTTAGTG TGGAAATAAT GGTACCAAAT TCTTTTAGCC CCCAAACTGA TAAGCTGTTC 
AACATTTTGG ATGTCCAGAC TACTACTGGA GAATGCCACT TTGAAAATTA TCAAAGAGTG 
TGTGCATTAG AGCAGCAAAA GAGTGCAATG CAGACCTTGA AAGGCATAGT CCGGTTCTTG 
TCCAAGACTG ATAAGAGGCT ATTGTACTGC ATAAAAGCTG ATCCACATTG TTTAAATTTC 
TTGTGTAATT TTGGGAAAAT GGAAAGTGGA AAAGAAGCCA GTGTTCATAT CCAACTGGAA 
GGCCGGCCAT CCATTTTAGA AATGGATGAG ACTTCAGCAC TCAAGTTTGA AATAAGAGCA 
ACAGGTTTTC CAGAGCCAAA TCCAAGAGTA ATTGAACTAA ACAAGGATGA GAATGTTGCG 
CATGTTCTAC TGGAAGGACT ACATCATCAA AGACCCAAAC GTTATTTCAC CATAGTGATT 
ATTTCAAGTA GCTTGCTACT TGGACTTATT GTACTTCTAT TGATCTCATA TGTTATGTGG 
AAGGCTGGCT TCTTTAAAAG ACAATACAAA TCTATCCTAC AAGAAGAAAA CAGAAGAGAC 
AGTTGGAGTT ATATCAACAG TAAAAGCAAT GATGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000876.3
CDS	270..3368
Translation	MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD

Target ORF information:

RefSeq Version	NM_000885.6
Organism	Homo sapiens(human)
Definition	Homo sapiens integrin subunit alpha 4 (ITGA4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000885.6

ORF Insert Sequence:

ATGGCTTGGG AAGCGAGGCG CGAACCCGGC CCCCGAAGGG CCGCCGTCCG GGAGACGGTG 
ATGCTGTTGC TGTGCCTGGG GGTCCCGACC GGCCGCCCCT ACAACGTGGA CACTGAGAGC 
GCGCTGCTTT ACCAGGGCCC CCACAACACG CTGTTCGGCT ACTCGGTCGT GCTGCACAGC 
CACGGGGCGA ACCGATGGCT CCTAGTGGGT GCGCCCACTG CCAACTGGCT CGCCAACGCT 
TCAGTGATCA ATCCCGGGGC GATTTACAGA TGCAGGATCG GAAAGAATCC CGGCCAGACG 
TGCGAACAGC TCCAGCTGGG TAGCCCTAAT GGAGAACCTT GTGGAAAGAC TTGTTTGGAA 
GAGAGAGACA ATCAGTGGTT GGGGGTCACA CTTTCCAGAC AGCCAGGAGA AAATGGATCC 
ATCGTGACTT GTGGGCATAG ATGGAAAAAT ATATTTTACA TAAAGAATGA AAATAAGCTC 
CCCACTGGTG GTTGCTATGG AGTGCCCCCT GATTTACGAA CAGAACTGAG TAAAAGAATA 
GCTCCGTGTT ATCAAGATTA TGTGAAAAAA TTTGGAGAAA ATTTTGCATC ATGTCAAGCT 
GGAATATCCA GTTTTTACAC AAAGGATTTA ATTGTGATGG GGGCCCCAGG ATCATCTTAC 
TGGACTGGCT CTCTTTTTGT CTACAATATA ACTACAAATA AATACAAGGC TTTTTTAGAC 
AAACAAAATC AAGTAAAATT TGGAAGTTAT TTAGGATATT CAGTCGGAGC TGGTCATTTT 
CGGAGCCAGC ATACTACCGA AGTAGTCGGA GGAGCTCCTC AACATGAGCA GATTGGTAAG 
GCATATATAT TCAGCATTGA TGAAAAAGAA CTAAATATCT TACATGAAAT GAAAGGTAAA 
AAGCTTGGAT CGTACTTTGG AGCTTCTGTC TGTGCTGTGG ACCTCAATGC AGATGGCTTC 
TCAGATCTGC TCGTGGGAGC ACCCATGCAG AGCACCATCA GAGAGGAAGG AAGAGTGTTT 
GTGTACATCA ACTCTGGCTC GGGAGCAGTA ATGAATGCAA TGGAAACAAA CCTCGTTGGA 
AGTGACAAAT ATGCTGCAAG ATTTGGGGAA TCTATAGTTA ATCTTGGCGA CATTGACAAT 
GATGGCTTTG AAGATGTTGC TATCGGAGCT CCACAAGAAG ATGACTTGCA AGGTGCTATT 
TATATTTACA ATGGCCGTGC AGATGGGATC TCGTCAACCT TCTCACAGAG AATTGAAGGA 
CTTCAGATCA GCAAATCGTT AAGTATGTTT GGACAGTCTA TATCAGGACA AATTGATGCA 
GATAATAATG GCTATGTAGA TGTAGCAGTT GGTGCTTTTC GGTCTGATTC TGCTGTCTTG 
CTAAGGACAA GACCTGTAGT AATTGTTGAC GCTTCTTTAA GCCACCCTGA GTCAGTAAAT 
AGAACGAAAT TTGACTGTGT TGAAAATGGA TGGCCTTCTG TGTGCATAGA TCTAACACTT 
TGTTTCTCAT ATAAGGGCAA GGAAGTTCCA GGTTACATTG TTTTGTTTTA TAACATGAGT 
TTGGATGTGA ACAGAAAGGC AGAGTCTCCA CCAAGATTCT ATTTCTCTTC TAATGGAACT 
TCTGACGTGA TTACAGGAAG CATACAGGTG TCCAGCAGAG AAGCTAACTG TAGAACACAT 
CAAGCATTTA TGCGGAAAGA TGTGCGGGAC ATCCTCACCC CAATTCAGAT TGAAGCTGCT 
TACCACCTTG GTCCTCATGT CATCAGTAAA CGAAGTACAG AGGAATTCCC ACCACTTCAG 
CCAATTCTTC AGCAGAAGAA AGAAAAAGAC ATAATGAAAA AAACAATAAA CTTTGCAAGG 
TTTTGTGCCC ATGAAAATTG TTCTGCTGAT TTACAGGTTT CTGCAAAGAT TGGGTTTTTG 
AAGCCCCATG AAAATAAAAC ATATCTTGCT GTTGGGAGTA TGAAGACATT GATGTTGAAT 
GTGTCCTTGT TTAATGCTGG AGATGATGCA TATGAAACGA CTCTACATGT CAAACTACCC 
GTGGGTCTTT ATTTCATTAA GATTTTAGAG CTGGAAGAGA AGCAAATAAA CTGTGAAGTC 
ACAGATAACT CTGGCGTGGT ACAACTTGAC TGCAGTATTG GCTATATATA TGTAGATCAT 
CTCTCAAGGA TAGATATTAG CTTTCTCCTG GATGTGAGCT CACTCAGCAG AGCGGAAGAG 
GACCTCAGTA TCACAGTGCA TGCTACCTGT GAAAATGAAG AGGAAATGGA CAATCTAAAG 
CACAGCAGAG TGACTGTAGC AATACCTTTA AAATATGAGG TTAAGCTGAC TGTTCATGGG 
TTTGTAAACC CAACTTCATT TGTGTATGGA TCAAATGATG AAAATGAGCC TGAAACGTGC 
ATGGTGGAGA AAATGAACTT AACTTTCCAT GTTATCAACA CTGGCAATAG TATGGCTCCC 
AATGTTAGTG TGGAAATAAT GGTACCAAAT TCTTTTAGCC CCCAAACTGA TAAGCTGTTC 
AACATTTTGG ATGTCCAGAC TACTACTGGA GAATGCCACT TTGAAAATTA TCAAAGAGTG 
TGTGCATTAG AGCAGCAAAA GAGTGCAATG CAGACCTTGA AAGGCATAGT CCGGTTCTTG 
TCCAAGACTG ATAAGAGGCT ATTGTACTGC ATAAAAGCTG ATCCACATTG TTTAAATTTC 
TTGTGTAATT TTGGGAAAAT GGAAAGTGGA AAAGAAGCCA GTGTTCATAT CCAACTGGAA 
GGCCGGCCAT CCATTTTAGA AATGGATGAG ACTTCAGCAC TCAAGTTTGA AATAAGAGCA 
ACAGGTTTTC CAGAGCCAAA TCCAAGAGTA ATTGAACTAA ACAAGGATGA GAATGTTGCG 
CATGTTCTAC TGGAAGGACT ACATCATCAA AGACCCAAAC GTTATTTCAC CATAGTGATT 
ATTTCAAGTA GCTTGCTACT TGGACTTATT GTACTTCTAT TGATCTCATA TGTTATGTGG 
AAGGCTGGCT TCTTTAAAAG ACAATACAAA TCTATCCTAC AAGAAGAAAA CAGAAGAGAC 
AGTTGGAGTT ATATCAACAG TAAAAGCAAT GATGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differences between chronic lymphocytic leukaemia and small lymphocytic lymphoma cells by proteomic profiling and SNP microarray analysis.
Cancer genetics218-21920-38(2017 Dec)
Tooze JA,Hamzic E,Willis F,Pettengell R

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ITGA4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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