Irs3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Irs3
Entrez Gene ID	16369
Full Name	insulin receptor substrate 3
Synonyms	AA408304
General protein information	Preferred Names insulin receptor substrate 3 Names insulin receptor substrate 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G2

mRNA and Protein(s)

mRNA	Protein	Name
NM_010571.3	NP_034701.1	insulin receptor substrate 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Irs3	NP_114463.1
Bos taurus (cattle)	LOC532330	XP_002698178.2
Mus musculus (house mouse)	Irs3	NP_034701.1

Gene Ontology
Bibliography

Related articles in PubMed

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.
Lee S, Lynn EG, Kim JA, Quon MJ
Endocrinology149(5)2451-8(2008 May)

IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.
Escribano O, Arribas M, Valverde AM, Benito M
Molecular and cellular endocrinology268(1-2)1-9(2007 Mar)

Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR
Molecular and cellular biology24(5)1918-29(2004 Mar)

Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.
Arribas M, Valverde AM, Benito M
The Journal of biological chemistry278(46)45189-99(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2.
Title: Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.

These results provide evidences suggesting that IRS-3/PI 3-kinase/PKC zeta signaling is the main responsible for the insulin-induced glucose uptake observed upon differentiation of brown adipocytes lacking IRS-2.
Title: IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.

These data indicate that both insulin receptor substrate (IRS)-1 and -3, but not IRS-2 or IRS-4, play key roles in the differentiation of brown adipocytes.
Title: Differential roles of insulin receptor substrates in brown adipocyte differentiation.

IRS-3 has a role in the insulin signaling of IRS-1-deficient brown adipocytes but not at the same level as IRS-1
Title: Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.

IRS-3 does not play a role compensating for the loss of IRS-2 in maintaining glucose homeostasis and the severity of diabetes in IRS-2(-/-) mice depends upon genetic background
Title: Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.

The following Irs3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Irs3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06364	NM_010571.3 Latest version!	Mus musculus insulin receptor substrate 3 (Irs3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Irs3 ( NM_010571.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034701.1 Mus musculus insulin receptor substrate 3 (Irs3), mRNA.

Price & Availability↑

CloneID	OMu06364
Clone ID Related Accession (Same CDS sequence)	NM_010571.3
Accession Version	NM_010571.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-01
Organism	Mus musculus(house mouse)
Product	insulin receptor substrate 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC124730.5. On Apr 28, 2007 this sequence version replaced NM_010571.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030311.1, AK040947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCCTG CAGGTACGGG CCCCACAGTC TCCTCCGGGG GCGAGTGCAC CGACGTGTCC 
CTCGGCTCAC CGTTTCCTTG GCCCTGCCTG CCCGACGTGC GGCTCTGTGG CCATCTGAGG 
AAGCAGAAGT CCCAGCGCCG CCGCTTTTTC GTGCTGCGCG CTGACCCACC ACGCCTGGAG 
TGCTACGAGA GCGAGAAGAA GTTCTTGGCC AGCGGCTGCC GCCCACCTAG ACCCCGGCGT 
ACCGTTAGCC TGGAGGGTGC CTGCACTATT AGCAAGCGCG CGGATGCCCG TCAGCGCCAC 
CTGATCGTCA TCTATACCAG CGACAGCAGC CTGGGCGTGG CGGCGGCCAG CGAAGCAGAG 
CAGCAAGCAT GGTACAGCGC CCTGCTCGAG GTGCGCGCCA CCGCCGCAGC CGCTGCTGCT 
ACTGCTATGG GTTTCAGTCC CCAAGAGGCC CCTGAGTCTT GGATCTTCGC CCCATTCCAG 
GACGTCTGGC CTGTGACACT GCGGTCCAAG GGGCTGGGGA GAGCACAAGG CCTGAGCAGC 
GGCAGCTATC GCCTGTGCCT GGGTTCTGGG GCCCTGAGCC TCCTGCGAAA GCCTGGAAGC 
AAAGGTTCCA GAGACAGCCG GGCAACGCCA CCACCAGTCC TGCGCTTGTC CTTGCTCAGT 
GTGCGCCGCT GTGGCCACGC AGACTCTTTT TTCTTCCTGG AACTCGGGCG CTCAGCGCCC 
ATTGGTCCTG GTGAGCTCTG GCTGCAGGCT CCTGATGCAG TGGTGGCCCA AAGCATTCAT 
GAGACAGTCC TGGCTGCCAT GAAGCGGCTG GGGAGCAATG CAGCTGGCAA AGCTGAGCCA 
CCGCCACAGG GAAATCCTCC AAAGAGTGTT CCTGCAGCTC CTACCCCGAC ACCATATGAA 
ATCCCTGCAT CGGCAGCACA AGCAAGAAGC CCCAGTGAGC GAGCAAAGCA GGACTACTTC 
AAGCCCCTGG AAAGGATGGG GTCAACACAC TCCTACAAGG GACTAGATCT GGGCGGGAAC 
TACATCACCA TGGGAGTCAG GAATGACTAT GTCCACATGG GGGGAGGAGA AGCAGGTGAC 
TATATGTGGA TGGCGCCCCC AGGCCTTCCT CCCACCCCTG CCAGGGCAGA TCCTAATAAG 
CAGCTCGAGG ATTGTGAGAG CACAGAGTAT GTGCCCATGA ATAGATTTTT ACCTGGGCCT 
TTTTACTACG AGCTCAAGGC CAGGGAGTCT GAACTTGGGC ATCCGGGTGC CCATTGTAGC 
CTTAGAGACA GATGGAGACC CACAGTGGCT CAGCCCCGCT CTTCCCAAGG GTCAGAGCTC 
TCTGGGGACT ACATGTCCAT CCCCGACTAT GTAGGAACGG ACAGTGCTAG GCTGGGGTCT 
CTGGACAGCT GCCTCAACTA TGTGGACCTG GACCTGGTCC CTCCCCTGGA GGTTCCTGGA 
GCAGCCCCAG GGAAGAGTCC ACATAGCTAT GCCAGCATCA AGTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034701.1
CDS	195..1682
Translation	MKPAGTGPTVSSGGECTDVSLGSPFPWPCLPDVRLCGHLRKQKSQRRRFFVLRADPPRLECYESEKKFLASGCRPPRPRRTVSLEGACTISKRADARQRHLIVIYTSDSSLGVAAASEAEQQAWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQDVWPVTLRSKGLGRAQGLSSGSYRLCLGSGALSLLRKPGSKGSRDSRATPPPVLRLSLLSVRRCGHADSFFFLELGRSAPIGPGELWLQAPDAVVAQSIHETVLAAMKRLGSNAAGKAEPPPQGNPPKSVPAAPTPTPYEIPASAAQARSPSERAKQDYFKPLERMGSTHSYKGLDLGGNYITMGVRNDYVHMGGGEAGDYMWMAPPGLPPTPARADPNKQLEDCESTEYVPMNRFLPGPFYYELKARESELGHPGAHCSLRDRWRPTVAQPRSSQGSELSGDYMSIPDYVGTDSARLGSLDSCLNYVDLDLVPPLEVPGAAPGKSPHSYASIKF

Target ORF information:

RefSeq Version	NM_010571.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin receptor substrate 3 (Irs3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010571.3

ORF Insert Sequence:

ATGAAGCCTG CAGGTACGGG CCCCACAGTC TCCTCCGGGG GCGAGTGCAC CGACGTGTCC 
CTCGGCTCAC CGTTTCCTTG GCCCTGCCTG CCCGACGTGC GGCTCTGTGG CCATCTGAGG 
AAGCAGAAGT CCCAGCGCCG CCGCTTTTTC GTGCTGCGCG CTGACCCACC ACGCCTGGAG 
TGCTACGAGA GCGAGAAGAA GTTCTTGGCC AGCGGCTGCC GCCCACCTAG ACCCCGGCGT 
ACCGTTAGCC TGGAGGGTGC CTGCACTATT AGCAAGCGCG CGGATGCCCG TCAGCGCCAC 
CTGATCGTCA TCTATACCAG CGACAGCAGC CTGGGCGTGG CGGCGGCCAG CGAAGCAGAG 
CAGCAAGCAT GGTACAGCGC CCTGCTCGAG GTGCGCGCCA CCGCCGCAGC CGCTGCTGCT 
ACTGCTATGG GTTTCAGTCC CCAAGAGGCC CCTGAGTCTT GGATCTTCGC CCCATTCCAG 
GACGTCTGGC CTGTGACACT GCGGTCCAAG GGGCTGGGGA GAGCACAAGG CCTGAGCAGC 
GGCAGCTATC GCCTGTGCCT GGGTTCTGGG GCCCTGAGCC TCCTGCGAAA GCCTGGAAGC 
AAAGGTTCCA GAGACAGCCG GGCAACGCCA CCACCAGTCC TGCGCTTGTC CTTGCTCAGT 
GTGCGCCGCT GTGGCCACGC AGACTCTTTT TTCTTCCTGG AACTCGGGCG CTCAGCGCCC 
ATTGGTCCTG GTGAGCTCTG GCTGCAGGCT CCTGATGCAG TGGTGGCCCA AAGCATTCAT 
GAGACAGTCC TGGCTGCCAT GAAGCGGCTG GGGAGCAATG CAGCTGGCAA AGCTGAGCCA 
CCGCCACAGG GAAATCCTCC AAAGAGTGTT CCTGCAGCTC CTACCCCGAC ACCATATGAA 
ATCCCTGCAT CGGCAGCACA AGCAAGAAGC CCCAGTGAGC GAGCAAAGCA GGACTACTTC 
AAGCCCCTGG AAAGGATGGG GTCAACACAC TCCTACAAGG GACTAGATCT GGGCGGGAAC 
TACATCACCA TGGGAGTCAG GAATGACTAT GTCCACATGG GGGGAGGAGA AGCAGGTGAC 
TATATGTGGA TGGCGCCCCC AGGCCTTCCT CCCACCCCTG CCAGGGCAGA TCCTAATAAG 
CAGCTCGAGG ATTGTGAGAG CACAGAGTAT GTGCCCATGA ATAGATTTTT ACCTGGGCCT 
TTTTACTACG AGCTCAAGGC CAGGGAGTCT GAACTTGGGC ATCCGGGTGC CCATTGTAGC 
CTTAGAGACA GATGGAGACC CACAGTGGCT CAGCCCCGCT CTTCCCAAGG GTCAGAGCTC 
TCTGGGGACT ACATGTCCAT CCCCGACTAT GTAGGAACGG ACAGTGCTAG GCTGGGGTCT 
CTGGACAGCT GCCTCAACTA TGTGGACCTG GACCTGGTCC CTCCCCTGGA GGTTCCTGGA 
GCAGCCCCAG GGAAGAGTCC ACATAGCTAT GCCAGCATCA AGTTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.
Endocrinology149(5)2451-8(2008 May)
Lee S,Lynn EG,Kim JA,Quon MJ

IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.
Molecular and cellular endocrinology268(1-2)1-9(2007 Mar)
Escribano O,Arribas M,Valverde AM,Benito M

Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Molecular and cellular biology24(5)1918-29(2004 Mar)
Tseng YH,Kriauciunas KM,Kokkotou E,Kahn CR

Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.
The Journal of biological chemistry278(46)45189-99(2003 Nov)
Arribas M,Valverde AM,Benito M

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Irs3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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