Hoxa11 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hoxa11
Entrez Gene ID	15396
Full Name	homeobox A11
Synonyms	Hox-1.9,Hoxa-11
General protein information	Preferred Names homeobox A11 Names homeobox protein Hox-A11 homeo box A11 homeobox protein Hox-1.9
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 B3\|6 25.4 cM
Summary	This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_010450.3	NP_034580.1	homeobox protein Hox-A11

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	HOXA11	XP_519012.3
Rattus norvegicus (Norway rat)	LOC100911743	XP_003752232.1
Gallus gallus (chicken)	LOC100859078	XP_003640763.1
Gallus gallus (chicken)	LOC100858967	XP_003640756.1
Xenopus tropicalis (tropical clawed frog)	hoxa11	XP_004915452.1
Homo sapiens (human)	HOXA11	NP_005514.1
	LOC704713	XP_001093087.2
Canis lupus familiaris (dog)	HOXA11	XP_003431971.2
Mus musculus (house mouse)	Hoxa11	NP_034580.1
Rattus norvegicus (Norway rat)	Hoxa11	NP_001123350.1
Gallus gallus (chicken)	HOXA11	NP_989950.1
Bos taurus (cattle)	HOXA11	XP_002686900.1
Rattus norvegicus (Norway rat)	LOC100909443	XP_003749800.1
Danio rerio (zebrafish)	hoxa11b	NP_571222.1

Gene Ontology
Bibliography

Related articles in PubMed

Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.
Pradeepa MM, McKenna F, Taylor GC, Bengani H, Grimes GR, Wood AJ, Bhatia S, Bickmore WA
PLoS genetics13(4)e1006677(2017 04)

HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid in the uterine endometrium.
Chau YM, Pando S, Taylor HS
The Journal of clinical endocrinology and metabolism87(6)2674-80(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

On the basis of the polydactyly that we observed after expression of Hoxa11 in distal limbs, we propose that the evolution of Hoxa11 regulation contributed to the transition from polydactyl limbs in stem-group tetrapods to pentadactyl limbs in extant tetrapods.
Title: Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state.

the derived functional cooperativity between HOXA11 and FOXO1 is due to derived allosteric regulation of HOXA11 by FOXO1.
Title: A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1.

Shox2 expression restricted to the proximal limb along with Hoxd9 and Hoxa11 expression, juxtaposing the distal expression of Hoxa13 and Hoxd13.
Title: Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.

Hoxa-11 maintains cell proliferation in the mouse gubernaculum to facilitate testicular descent.
Title: Hoxa-11 maintains cell proliferation in the mouse gubernaculum to facilitate testicular descent.

Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.
Title: Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice.

The following Hoxa11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hoxa11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14158	NM_010450.3 Latest version!	Mus musculus homeobox A11 (Hoxa11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hoxa11 ( NM_010450.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034580.1 Mus musculus homeobox A11 (Hoxa11), mRNA.

Price & Availability↑

CloneID	OMu14158
Clone ID Related Accession (Same CDS sequence)	NM_010450.3
Accession Version	NM_010450.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 942bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Mus musculus(house mouse)
Product	homeobox protein Hox-A11
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK133481.1 and AC015583.34. On Mar 23, 2013 this sequence version replaced NM_010450.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133481.1, BC052232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATGGATT TTGATGAGCG TGGTCCCTGC TCCTCTAACA TGTATTTGCC AAGTTGTACT 
TACTACGTCT CGGGTCCAGA TTTCTCCAGC CTCCCTTCTT TTTTGCCCCA GACCCCGTCT 
TCGCGCCCAA TGACATACTC CTACTCCTCC AACCTGCCCC AGGTCCAACC CGTGCGCGAA 
GTGACCTTCA GAGAGTACGC CATTGAGCCC GCCACTAAAT GGCACCCCCG CGGCAATCTG 
GCCCACTGCT ACTCCGCGGA GGAGCTCGTG CACAGAGACT GTCTGCAGGC GCCCAGCGCG 
GCCGGCGTGC CTGGCGACGT GCTGGCCAAG AGCTCGGCCA ACGTCTACCA CCACCCCACC 
CCCGCCGTCT CGTCCAATTT CTATAGCACG GTGGGCAGGA ACGGCGTTCT GCCACAGGCT 
TTCGACCAGT TTTTCGAGAC GGCTTACGGC ACCCCGGAAA ACCTCGCTTC CTCCGACTAC 
CCCGGGGACA AGAACGCCGA GAAGGGGCCC CAAGCAGCAG CTGCGACCTC CGCTGCGGCG 
GTGGCGGCGG CGGCCACGGG CGCGCCGGCA ACTTCAAGTT CGGACGGCGG CGGTGGCGGC 
GGCTGTCAGG AGGCGGCGGC GGAGGAGAAG GAGCGACGGC GGCGACCCGA GAGCAGCAGC 
AGCCCCGAGT CGTCTTCCGG CCACACTGAG GACAAGGCCG GTGGCTCCGG TGGCCAACGC 
ACCCGCAAAA AGCGCTGCCC TTATACCAAA TACCAGATCC GAGAGCTGGA GCGAGAGTTC 
TTCTTCAGCG TCTACATCAA CAAAGAGAAG CGTCTGCAAC TGTCCCGCAT GCTCAACCTC 
ACCGACCGTC AAGTCAAAAT CTGGTTTCAG AACAGAAGAA TGAAGGAAAA AAAGATTAAC 
AGAGACCGGT TACAGTACTA CTCAGCTAAT CCACTTCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034580.1
CDS	92..1033
Translation	MMDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDYPGDKNAEKGPQAAAATSAAAVAAAATGAPATSSSDGGGGGGCQEAAAEEKERRRRPESSSSPESSSGHTEDKAGGSGGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL

Target ORF information:

RefSeq Version	NM_010450.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus homeobox A11 (Hoxa11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010450.3

ORF Insert Sequence:

ATGATGGATT TTGATGAGCG TGGTCCCTGC TCCTCTAACA TGTATTTGCC AAGTTGTACT 
TACTACGTCT CGGGTCCAGA TTTCTCCAGC CTCCCTTCTT TTTTGCCCCA GACCCCGTCT 
TCGCGCCCAA TGACATACTC CTACTCCTCC AACCTGCCCC AGGTCCAACC CGTGCGCGAA 
GTGACCTTCA GAGAGTACGC CATTGAGCCC GCCACTAAAT GGCACCCCCG CGGCAATCTG 
GCCCACTGCT ACTCCGCGGA GGAGCTCGTG CACAGAGACT GTCTGCAGGC GCCCAGCGCG 
GCCGGCGTGC CTGGCGACGT GCTGGCCAAG AGCTCGGCCA ACGTCTACCA CCACCCCACC 
CCCGCCGTCT CGTCCAATTT CTATAGCACG GTGGGCAGGA ACGGCGTTCT GCCACAGGCT 
TTCGACCAGT TTTTCGAGAC GGCTTACGGC ACCCCGGAAA ACCTCGCTTC CTCCGACTAC 
CCCGGGGACA AGAACGCCGA GAAGGGGCCC CAAGCAGCAG CTGCGACCTC CGCTGCGGCG 
GTGGCGGCGG CGGCCACGGG CGCGCCGGCA ACTTCAAGTT CGGACGGCGG CGGTGGCGGC 
GGCTGTCAGG AGGCGGCGGC GGAGGAGAAG GAGCGACGGC GGCGACCCGA GAGCAGCAGC 
AGCCCCGAGT CGTCTTCCGG CCACACTGAG GACAAGGCCG GTGGCTCCGG TGGCCAACGC 
ACCCGCAAAA AGCGCTGCCC TTATACCAAA TACCAGATCC GAGAGCTGGA GCGAGAGTTC 
TTCTTCAGCG TCTACATCAA CAAAGAGAAG CGTCTGCAAC TGTCCCGCAT GCTCAACCTC 
ACCGACCGTC AAGTCAAAAT CTGGTTTCAG AACAGAAGAA TGAAGGAAAA AAAGATTAAC 
AGAGACCGGT TACAGTACTA CTCAGCTAAT CCACTTCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.
PLoS genetics13(4)e1006677(2017 04)
Pradeepa MM,McKenna F,Taylor GC,Bengani H,Grimes GR,Wood AJ,Bhatia S,Bickmore WA

HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid in the uterine endometrium.
The Journal of clinical endocrinology and metabolism87(6)2674-80(2002 Jun)
Chau YM,Pando S,Taylor HS

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Hoxa11 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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