Gbp2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gbp2
Entrez Gene ID	14469
Full Name	guanylate binding protein 2
General protein information	Preferred Names guanylate binding protein 2 Names guanylate-binding protein 2 GBP-2 GTP-binding protein 2 guanine nucleotide-binding protein 2 guanylate nucleotide binding protein 2 guanylate-binding protein 1 interferon-induced guanylate-binding protein 2 mGBP-2 mGBP2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 H1\|3 66.69 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010260.1	NP_034390.1	guanylate-binding protein 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GBP4	NP_001095731.1
Pan troglodytes (chimpanzee)	GBP2	XP_513544.2
Gallus gallus (chicken)	LOC419563	XP_417710.3
Gallus gallus (chicken)	LOC415922	XP_004944473.1
Bos taurus (cattle)	LOC507055	XP_002686315.1
Mus musculus (house mouse)	Gbp2	NP_034390.1
Gallus gallus (chicken)	GBP	XP_004944466.1
Bos taurus (cattle)	LOC100336669	XP_005204413.1
Bos taurus (cattle)	LOC783604	XP_005204417.1
Rattus norvegicus (Norway rat)	Gbp2	NP_598308.1
Gallus gallus (chicken)	LOC100859554	XP_004950291.1
Homo sapiens (human)	GBP2	NP_004111.2
	GBP2	XP_001085895.1
Bos taurus (cattle)	LOC781675	XP_002707905.1
Bos taurus (cattle)	GBP2	XP_005204408.1

Gene Ontology
Bibliography

Related articles in PubMed

[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by ?-glucan].
Zhang S, Feng T, Ning Y, Zhang X, Qi C
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology33(9)1153-1159(2017 Sep)

G?2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.
Guo Y, He X, Zhao L, Liu L, Song H, Wang X, Xu J, Ju X, Guo W, Zhu X
Cerebral cortex (New York, N.Y. : 1991)27(6)3414-3426(2017 Jun)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.
Langlais D, Barreiro LB, Gros P
The Journal of experimental medicine213(4)585-603(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GBP1 GBP2 enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
Title: Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

this study identified guanylate-binding proteins GBP2 and GBP5 as key activators of AIM2 during infection with F. novicida.
Title: Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.
Title: Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.

the inducible multimerization of mGBP2 is dependent on a functional GTPase domain.
Title: The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.

IRGM proteins indirectly modulate the localization of GBP2 through a distinct mechanism from that through which they regulate IRG protein localization
Title: Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.

The following Gbp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gbp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05846	NM_010260.1 Latest version!	Mus musculus guanylate binding protein 2 (Gbp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$349.30 $499.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gbp2 ( NM_010260.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034390.1 Mus musculus guanylate binding protein 2 (Gbp2), mRNA.

Price & Availability↑

CloneID	OMu05846
Clone ID Related Accession (Same CDS sequence)	NM_010260.1
Accession Version	NM_010260.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	guanylate-binding protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF077007.1. On Dec 7, 2005 this sequence version replaced XM_915830.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF077007.1, BC011336.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCAG AGATCCACAT GTCGGAACCC ATGTGCCTCA TTGAGAACAC TGAGGCTCAA 
CTAGTGATCA ACCAGGAGGC TCTGAGGATC CTGTCTGCCA TTACACAGCC TGTGGTGGTG 
GTGGCAATCG TGGGCCTCTA CCGCACAGGC AAATCCTACC TGATGAACAA GCTAGCTGGG 
AAGAGGACAG GCTTTTCCCT GGGCTCCACT GTGCAGTCTC ACACCAAGGG CATCTGGATG 
TGGTGTGTGC CTCACCCCAA GAAGGCAGGG CAAACCCTGG TTCTGCTTGA CACTGAGGGC 
CTTGAAGATG TTGAGAAGGG TGACAACCAG AATGACTGCT GGATCTTTGC TTTGGCAGTC 
CTCCTCAGCA GCACCTTCAT CTACAACAGC ATAGGAACCA TCAACCAGCA GGCCATGGAC 
CAGCTGCACT ATGTGACGGA GCTAACTGAT CTTATCAAGT CAAAGTCATC ACCTGACCAG 
AGTGGGGTAG ACGATTCCGC TAACTTTGTG GGCTTCTTTC CAACCTTTGT GTGGACTCTG 
AGAGATTTCT CCCTCGAGCT GGAGGTTAAC GGAAAACCCG TCACTTCTGA TGAGTACCTG 
GAACATTCCC TGACCCTGAA AAAAGGAGCT GATAAGAAAA CTAAAAGCTT TAATGAGCCG 
CGACTGTGCA TCAGGAAATT CTTTCCAAAG AGGAAGTGCT TCATCTTTGA CAGGCCTGCT 
CAGAGGAAGC AACTTAGCAA ACTGGAGACT CTGCGGGAGG AGGAGCTGTG TGGTGAATTT 
GTAGAACAAG TTGCAGAATT CACCTCATAC ATCTTGAGCT ACTCTTCTGT CAAGACTCTG 
TGTGGTGGCA TCATAGTCAA TGGGCCACGT CTAAAGAGCC TGGTGCAGAC CTATGTTGGT 
GCCATCAGCA ATGGGTCTCT CCCCTGCATG GAGAGTGCTG TGCTGACTTT GGCCCAGATA 
GAGAACTCAG CAGCAGTGCA AAAGGCCATC ACCCACTATG AAGAACAGAT GAATCAGAAG 
ATTCAGATGC CCACAGAAAC CCTCCAGGAG CTCCTGGATC TGCACAGGCC AATTGAGAGT 
GAGGCCATTG AGGTCTTCCT GAAGAATTCT TTCAAGGATG TAGACCAAAA GTTCCAGACA 
GAATTAGGGA ACCTGCTGGT AGCCAAGCGA GATGCCTTTA TCAAGAAGAA CATGGATGTC 
TCATCAGCTC GTTGCTCAGA CTTGCTGGAG GATATTTTTG GACCCCTGGA AGAAGAAGTA 
AAATTAGGGA CATTTTCTAA ACCAGGAGGT TACTACCTCT TCCTTCAAAT GAGACAAGAG 
CTAGAGAAAA AGTATAACCA GGCTCCTGGG AAGGGGCTCC AGGCAGAAGC GATGCTGAAA 
AACTACTTTG ATTCCAAGGC AGATGTTGTT GAAACACTTC TACAGACGGA TCAGTCACTC 
ACAGAGGCAG CAAAGGAGGT AGAAGAGGAA CGTACGAAGG CTGAAGCTGC TGAAGCTGCA 
AACAGAGAGT TAGAAAAGAA GCAGAAGGAG TTCGAGCTGA TGATGCAGCA GAAGGAAAAG 
AGTTACCAGG AGCATGTGAA GAAGCTGACT GAGAAGATGA AAGACGAACA GAAACAGTTA 
TTAGCAGAAC AGGAAAACAT CATAGCTGCT AAACTTCGGG AACAGGAAAA ATTTCTTAAG 
GAAGGATTCG AGAATGAGAG CAAAAAACTT ATTCGAGAGA TTGATACCCT GAAGCAAAAC 
AAATCGTCTG GGAAGTGCAC TATACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034390.1
CDS	171..1940
Translation	MASEIHMSEPMCLIENTEAQLVINQEALRILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKRTGFSLGSTVQSHTKGIWMWCVPHPKKAGQTLVLLDTEGLEDVEKGDNQNDCWIFALAVLLSSTFIYNSIGTINQQAMDQLHYVTELTDLIKSKSSPDQSGVDDSANFVGFFPTFVWTLRDFSLELEVNGKPVTSDEYLEHSLTLKKGADKKTKSFNEPRLCIRKFFPKRKCFIFDRPAQRKQLSKLETLREEELCGEFVEQVAEFTSYILSYSSVKTLCGGIIVNGPRLKSLVQTYVGAISNGSLPCMESAVLTLAQIENSAAVQKAITHYEEQMNQKIQMPTETLQELLDLHRPIESEAIEVFLKNSFKDVDQKFQTELGNLLVAKRDAFIKKNMDVSSARCSDLLEDIFGPLEEEVKLGTFSKPGGYYLFLQMRQELEKKYNQAPGKGLQAEAMLKNYFDSKADVVETLLQTDQSLTEAAKEVEEERTKAEAAEAANRELEKKQKEFELMMQQKEKSYQEHVKKLTEKMKDEQKQLLAEQENIIAAKLREQEKFLKEGFENESKKLIREIDTLKQNKSSGKCTIL

Target ORF information:

RefSeq Version	NM_010260.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanylate binding protein 2 (Gbp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010260.1

ORF Insert Sequence:

ATGGCCTCAG AGATCCACAT GTCGGAACCC ATGTGCCTCA TTGAGAACAC TGAGGCTCAA 
CTAGTGATCA ACCAGGAGGC TCTGAGGATC CTGTCTGCCA TTACACAGCC TGTGGTGGTG 
GTGGCAATCG TGGGCCTCTA CCGCACAGGC AAATCCTACC TGATGAACAA GCTAGCTGGG 
AAGAGGACAG GCTTTTCCCT GGGCTCCACT GTGCAGTCTC ACACCAAGGG CATCTGGATG 
TGGTGTGTGC CTCACCCCAA GAAGGCAGGG CAAACCCTGG TTCTGCTTGA CACTGAGGGC 
CTTGAAGATG TTGAGAAGGG TGACAACCAG AATGACTGCT GGATCTTTGC TTTGGCAGTC 
CTCCTCAGCA GCACCTTCAT CTACAACAGC ATAGGAACCA TCAACCAGCA GGCCATGGAC 
CAGCTGCACT ATGTGACGGA GCTAACTGAT CTTATCAAGT CAAAGTCATC ACCTGACCAG 
AGTGGGGTAG ACGATTCCGC TAACTTTGTG GGCTTCTTTC CAACCTTTGT GTGGACTCTG 
AGAGATTTCT CCCTCGAGCT GGAGGTTAAC GGAAAACCCG TCACTTCTGA TGAGTACCTG 
GAACATTCCC TGACCCTGAA AAAAGGAGCT GATAAGAAAA CTAAAAGCTT TAATGAGCCG 
CGACTGTGCA TCAGGAAATT CTTTCCAAAG AGGAAGTGCT TCATCTTTGA CAGGCCTGCT 
CAGAGGAAGC AACTTAGCAA ACTGGAGACT CTGCGGGAGG AGGAGCTGTG TGGTGAATTT 
GTAGAACAAG TTGCAGAATT CACCTCATAC ATCTTGAGCT ACTCTTCTGT CAAGACTCTG 
TGTGGTGGCA TCATAGTCAA TGGGCCACGT CTAAAGAGCC TGGTGCAGAC CTATGTTGGT 
GCCATCAGCA ATGGGTCTCT CCCCTGCATG GAGAGTGCTG TGCTGACTTT GGCCCAGATA 
GAGAACTCAG CAGCAGTGCA AAAGGCCATC ACCCACTATG AAGAACAGAT GAATCAGAAG 
ATTCAGATGC CCACAGAAAC CCTCCAGGAG CTCCTGGATC TGCACAGGCC AATTGAGAGT 
GAGGCCATTG AGGTCTTCCT GAAGAATTCT TTCAAGGATG TAGACCAAAA GTTCCAGACA 
GAATTAGGGA ACCTGCTGGT AGCCAAGCGA GATGCCTTTA TCAAGAAGAA CATGGATGTC 
TCATCAGCTC GTTGCTCAGA CTTGCTGGAG GATATTTTTG GACCCCTGGA AGAAGAAGTA 
AAATTAGGGA CATTTTCTAA ACCAGGAGGT TACTACCTCT TCCTTCAAAT GAGACAAGAG 
CTAGAGAAAA AGTATAACCA GGCTCCTGGG AAGGGGCTCC AGGCAGAAGC GATGCTGAAA 
AACTACTTTG ATTCCAAGGC AGATGTTGTT GAAACACTTC TACAGACGGA TCAGTCACTC 
ACAGAGGCAG CAAAGGAGGT AGAAGAGGAA CGTACGAAGG CTGAAGCTGC TGAAGCTGCA 
AACAGAGAGT TAGAAAAGAA GCAGAAGGAG TTCGAGCTGA TGATGCAGCA GAAGGAAAAG 
AGTTACCAGG AGCATGTGAA GAAGCTGACT GAGAAGATGA AAGACGAACA GAAACAGTTA 
TTAGCAGAAC AGGAAAACAT CATAGCTGCT AAACTTCGGG AACAGGAAAA ATTTCTTAAG 
GAAGGATTCG AGAATGAGAG CAAAAAACTT ATTCGAGAGA TTGATACCCT GAAGCAAAAC 
AAATCGTCTG GGAAGTGCAC TATACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by ?-glucan].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology33(9)1153-1159(2017 Sep)
Zhang S,Feng T,Ning Y,Zhang X,Qi C

G?2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.
Cerebral cortex (New York, N.Y. : 1991)27(6)3414-3426(2017 Jun)
Guo Y,He X,Zhao L,Liu L,Song H,Wang X,Xu J,Ju X,Guo W,Zhu X

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.
The Journal of experimental medicine213(4)585-603(2016 Apr)
Langlais D,Barreiro LB,Gros P

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Gbp2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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