GBP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GBP2
Entrez Gene ID	2634
Full Name	guanylate binding protein 2
General protein information	Preferred Names guanylate binding protein 2 Names guanylate-binding protein 2 GTP-binding protein 2 guanine nucleotide-binding protein 2 guanylate binding protein 2, interferon-inducible interferon-induced guanylate-binding protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p22.2
Summary	This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013].
Disorder MIM:	600412

mRNA and Protein(s)

mRNA	Protein	Name
NM_004120.5	NP_004111.2	guanylate-binding protein 2
NM_004120.4	NP_004111.2	guanylate-binding protein 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GBP4	NP_001095731.1
Pan troglodytes (chimpanzee)	GBP2	XP_513544.2
Gallus gallus (chicken)	LOC419563	XP_417710.3
Gallus gallus (chicken)	LOC415922	XP_004944473.1
Bos taurus (cattle)	LOC507055	XP_002686315.1
Mus musculus (house mouse)	Gbp2	NP_034390.1
Gallus gallus (chicken)	GBP	XP_004944466.1
Bos taurus (cattle)	LOC100336669	XP_005204413.1
Bos taurus (cattle)	LOC783604	XP_005204417.1
Rattus norvegicus (Norway rat)	Gbp2	NP_598308.1
Gallus gallus (chicken)	LOC100859554	XP_004950291.1
Homo sapiens (human)	GBP2	NP_004111.2
	GBP2	XP_001085895.1
Bos taurus (cattle)	LOC781675	XP_002707905.1
Bos taurus (cattle)	GBP2	XP_005204408.1

Gene Ontology
Bibliography

Related articles in PubMed

Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.
Zhang J, Zhang Y, Wu W, Wang F, Liu X, Shui G, Nie C
Cell death & disease8(10)e3151(2017 Oct)

Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response.
Godoy P, Cadenas C, Hellwig B, Marchan R, Stewart J, Reif R, Lohr M, Gehrmann M, Rahnenf?hrer J, Schmidt M, Hengstler JG
Breast cancer (Tokyo, Japan)21(4)491-9(2014 Jul)

miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation.
Lin X, Rice KL, Buzzai M, Hexner E, Costa FF, Kilpivaara O, Mullally A, Soares MB, Ebert BL, Levine R, Licht JD
Leukemia27(2)344-52(2013 Feb)

Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins.
Al-Zeer MA, Al-Younes HM, Lauster D, Abu Lubad M, Meyer TF
Autophagy9(1)50-62(2013 Jan)

Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells.
Christian SL, Zu D, Licursi M, Komatsu Y, Pongnopparat T, Codner DA, Hirasawa K
PloS one7(9)e44267(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low GBP2 expression is associated with metastasis in breast cancer.
Title: Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response.

Downregulation of MIR-433 is associated with myeloproliferative neoplasms.
Title: miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation.

GBP1/2 are critical effectors of antichlamydial interferon (IFN)gamma-mediated pathogen clearance via rerouting of bacterial inclusions in macrophages for lysosomal degradation.
Title: Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins.

The in vivo localization of GBP-2 at cellular membranes is regulated by isoprenylation and dimerization.
Title: Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

hGBP-1, hGBP-2 showed dimerization-related GTPase activity for GMP formation.
Title: Dimerization and its role in GMP formation by human guanylate binding proteins.

The following GBP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GBP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14636	NM_004120.5 Latest version!	Homo sapiens guanylate binding protein 2 (GBP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu14636	NM_004120.4	Homo sapiens guanylate binding protein 2 (GBP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GBP2 ( NM_004120.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004111.2 Homo sapiens guanylate binding protein 2 (GBP2), mRNA.

Price & Availability↑

CloneID	OHu14636
Clone ID Related Accession (Same CDS sequence)	NM_004120.5 , NM_004120.4
Accession Version	NM_004120.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	guanylate-binding protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB274428.1, BC073163.1, BC022272.1, AI400402.1, AI445567.1, AI085798.1, AC104459.2, DB229415.1 and BM993865.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_004120.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.151866.1, SRR1803613.146996.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153932, SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370466.4/ ENSP00000359497.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCCAG AGATCAACTT GCCGGGCCCA ATGAGCCTCA TTGATAACAC TAAAGGGCAG 
CTGGTGGTGA ATCCAGAAGC TCTGAAGATC CTATCTGCAA TTACGCAGCC TGTGGTGGTG 
GTGGCGATTG TGGGCCTCTA TCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGG 
AAGAAAAACG GCTTCTCTCT AGGCTCCACA GTGAAGTCTC ACACCAAGGG AATCTGGATG 
TGGTGTGTGC CTCATCCCAA GAAGCCAGAA CACACCCTAG TTCTGCTCGA CACTGAGGGC 
CTGGGAGATA TAGAGAAGGG TGACAATGAG AATGACTCCT GGATCTTTGC CTTGGCCATC 
CTCCTGAGCA GCACCTTCGT GTACAATAGC ATGGGAACCA TCAACCAGCA GGCCATGGAC 
CAACTTCACT ATGTGACAGA GCTGACAGAT CGAATCAAGG CAAACTCCTC ACCTGGTAAC 
AATTCTGTAG ACGACTCAGC TGACTTTGTG AGCTTTTTTC CAGCATTTGT GTGGACTCTC 
AGAGATTTCA CCCTGGAACT GGAAGTAGAT GGAGAACCCA TCACTGCTGA TGACTACTTG 
GAGCTTTCGC TAAAGCTAAG AAAAGGTACT GATAAGAAAA GTAAAAGCTT TAATGATCCT 
CGGTTGTGCA TCCGAAAGTT CTTCCCCAAG AGGAAGTGCT TCGTCTTCGA TTGGCCCGCT 
CCTAAGAAGT ACCTTGCTCA CCTAGAGCAG CTAAAGGAGG AAGAGCTGAA CCCTGATTTC 
ATAGAACAAG TTGCAGAATT TTGTTCCTAC ATCCTCAGCC ATTCCAATGT CAAGACTCTT 
TCAGGTGGCA TTCCAGTCAA TGGGCCTCGT CTAGAGAGCC TGGTGCTGAC CTACGTCAAT 
GCCATCAGCA GTGGGGATCT ACCCTGCATG GAGAACGCAG TCCTGGCCTT GGCCCAGATA 
GAGAACTCAG CCGCAGTGGA AAAGGCTATT GCCCACTATG AACAGCAGAT GGGCCAGAAG 
GTGCAGCTGC CCACGGAAAC CCTCCAGGAG CTGCTGGACC TGCACAGGGA CAGTGAGAGA 
GAGGCCATTG AAGTCTTCAT GAAGAACTCT TTCAAGGATG TGGACCAAAT GTTCCAGAGG 
AAATTAGGGG CCCAGTTGGA AGCAAGGCGA GATGACTTTT GTAAGCAGAA TTCCAAAGCA 
TCATCAGATT GTTGCATGGC TTTACTTCAG GATATATTTG GCCCTTTAGA AGAAGATGTC 
AAGCAGGGAA CATTTTCTAA ACCAGGAGGT TACCGTCTCT TTACTCAGAA GCTGCAGGAG 
CTGAAGAATA AGTACTACCA GGTGCCAAGG AAGGGGATAC AGGCCAAAGA GGTGCTGAAA 
AAATATTTGG AGTCCAAGGA GGATGTGGCT GATGCACTTC TACAGACTGA TCAGTCACTC 
TCAGAAAAGG AAAAAGCGAT TGAAGTGGAA CGTATAAAGG CTGAATCTGC AGAAGCTGCA 
AAGAAAATGT TGGAGGAAAT ACAAAAGAAG AATGAGGAGA TGATGGAACA GAAAGAGAAG 
AGTTATCAGG AACATGTGAA ACAATTGACT GAGAAGATGG AGAGGGACAG GGCCCAGTTA 
ATGGCAGAGC AAGAGAAGAC CCTCGCTCTT AAACTTCAGG AACAGGAACG CCTTCTCAAG 
GAGGGATTCG AGAATGAGAG CAAGAGACTT CAAAAAGACA TATGGGATAT CCAGATGAGA 
AGCAAATCAT TGGAGCCAAT ATGTAACATA CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004111.2
CDS	270..2045
Translation	MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL

Target ORF information:

RefSeq Version	NM_004120.5
Organism	Homo sapiens(human)
Definition	Homo sapiens guanylate binding protein 2 (GBP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004120.5

ORF Insert Sequence:

ATGGCTCCAG AGATCAACTT GCCGGGCCCA ATGAGCCTCA TTGATAACAC TAAAGGGCAG 
CTGGTGGTGA ATCCAGAAGC TCTGAAGATC CTATCTGCAA TTACGCAGCC TGTGGTGGTG 
GTGGCGATTG TGGGCCTCTA TCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGG 
AAGAAAAACG GCTTCTCTCT AGGCTCCACA GTGAAGTCTC ACACCAAGGG AATCTGGATG 
TGGTGTGTGC CTCATCCCAA GAAGCCAGAA CACACCCTAG TTCTGCTCGA CACTGAGGGC 
CTGGGAGATA TAGAGAAGGG TGACAATGAG AATGACTCCT GGATCTTTGC CTTGGCCATC 
CTCCTGAGCA GCACCTTCGT GTACAATAGC ATGGGAACCA TCAACCAGCA GGCCATGGAC 
CAACTTCACT ATGTGACAGA GCTGACAGAT CGAATCAAGG CAAACTCCTC ACCTGGTAAC 
AATTCTGTAG ACGACTCAGC TGACTTTGTG AGCTTTTTTC CAGCATTTGT GTGGACTCTC 
AGAGATTTCA CCCTGGAACT GGAAGTAGAT GGAGAACCCA TCACTGCTGA TGACTACTTG 
GAGCTTTCGC TAAAGCTAAG AAAAGGTACT GATAAGAAAA GTAAAAGCTT TAATGATCCT 
CGGTTGTGCA TCCGAAAGTT CTTCCCCAAG AGGAAGTGCT TCGTCTTCGA TTGGCCCGCT 
CCTAAGAAGT ACCTTGCTCA CCTAGAGCAG CTAAAGGAGG AAGAGCTGAA CCCTGATTTC 
ATAGAACAAG TTGCAGAATT TTGTTCCTAC ATCCTCAGCC ATTCCAATGT CAAGACTCTT 
TCAGGTGGCA TTCCAGTCAA TGGGCCTCGT CTAGAGAGCC TGGTGCTGAC CTACGTCAAT 
GCCATCAGCA GTGGGGATCT ACCCTGCATG GAGAACGCAG TCCTGGCCTT GGCCCAGATA 
GAGAACTCAG CCGCAGTGGA AAAGGCTATT GCCCACTATG AACAGCAGAT GGGCCAGAAG 
GTGCAGCTGC CCACGGAAAC CCTCCAGGAG CTGCTGGACC TGCACAGGGA CAGTGAGAGA 
GAGGCCATTG AAGTCTTCAT GAAGAACTCT TTCAAGGATG TGGACCAAAT GTTCCAGAGG 
AAATTAGGGG CCCAGTTGGA AGCAAGGCGA GATGACTTTT GTAAGCAGAA TTCCAAAGCA 
TCATCAGATT GTTGCATGGC TTTACTTCAG GATATATTTG GCCCTTTAGA AGAAGATGTC 
AAGCAGGGAA CATTTTCTAA ACCAGGAGGT TACCGTCTCT TTACTCAGAA GCTGCAGGAG 
CTGAAGAATA AGTACTACCA GGTGCCAAGG AAGGGGATAC AGGCCAAAGA GGTGCTGAAA 
AAATATTTGG AGTCCAAGGA GGATGTGGCT GATGCACTTC TACAGACTGA TCAGTCACTC 
TCAGAAAAGG AAAAAGCGAT TGAAGTGGAA CGTATAAAGG CTGAATCTGC AGAAGCTGCA 
AAGAAAATGT TGGAGGAAAT ACAAAAGAAG AATGAGGAGA TGATGGAACA GAAAGAGAAG 
AGTTATCAGG AACATGTGAA ACAATTGACT GAGAAGATGG AGAGGGACAG GGCCCAGTTA 
ATGGCAGAGC AAGAGAAGAC CCTCGCTCTT AAACTTCAGG AACAGGAACG CCTTCTCAAG 
GAGGGATTCG AGAATGAGAG CAAGAGACTT CAAAAAGACA TATGGGATAT CCAGATGAGA 
AGCAAATCAT TGGAGCCAAT ATGTAACATA CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GBP2 ( NM_004120.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004111.2 Homo sapiens guanylate binding protein 2 (GBP2), mRNA.

Price & Availability↑

CloneID	OHu14636
Clone ID Related Accession (Same CDS sequence)	NM_004120.5 , NM_004120.4
Accession Version	NM_004120.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1776bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	guanylate-binding protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB274428.1, BC073163.1, BC022272.1, AI400402.1, AI445567.1, AI085798.1, AC104459.2, DB229415.1 and BM993865.1. This sequence is a reference standard in the RefSeqGene project. On Jul 4, 2013 this sequence version replaced NM_004120.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.146996.1, SRR1803617.264876.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153932, SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCAG AGATCAACTT GCCGGGCCCA ATGAGCCTCA TTGATAACAC TAAAGGGCAG 
CTGGTGGTGA ATCCAGAAGC TCTGAAGATC CTATCTGCAA TTACGCAGCC TGTGGTGGTG 
GTGGCGATTG TGGGCCTCTA TCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGG 
AAGAAAAACG GCTTCTCTCT AGGCTCCACA GTGAAGTCTC ACACCAAGGG AATCTGGATG 
TGGTGTGTGC CTCATCCCAA GAAGCCAGAA CACACCCTAG TTCTGCTCGA CACTGAGGGC 
CTGGGAGATA TAGAGAAGGG TGACAATGAG AATGACTCCT GGATCTTTGC CTTGGCCATC 
CTCCTGAGCA GCACCTTCGT GTACAATAGC ATGGGAACCA TCAACCAGCA GGCCATGGAC 
CAACTTCACT ATGTGACAGA GCTGACAGAT CGAATCAAGG CAAACTCCTC ACCTGGTAAC 
AATTCTGTAG ACGACTCAGC TGACTTTGTG AGCTTTTTTC CAGCATTTGT GTGGACTCTC 
AGAGATTTCA CCCTGGAACT GGAAGTAGAT GGAGAACCCA TCACTGCTGA TGACTACTTG 
GAGCTTTCGC TAAAGCTAAG AAAAGGTACT GATAAGAAAA GTAAAAGCTT TAATGATCCT 
CGGTTGTGCA TCCGAAAGTT CTTCCCCAAG AGGAAGTGCT TCGTCTTCGA TTGGCCCGCT 
CCTAAGAAGT ACCTTGCTCA CCTAGAGCAG CTAAAGGAGG AAGAGCTGAA CCCTGATTTC 
ATAGAACAAG TTGCAGAATT TTGTTCCTAC ATCCTCAGCC ATTCCAATGT CAAGACTCTT 
TCAGGTGGCA TTCCAGTCAA TGGGCCTCGT CTAGAGAGCC TGGTGCTGAC CTACGTCAAT 
GCCATCAGCA GTGGGGATCT ACCCTGCATG GAGAACGCAG TCCTGGCCTT GGCCCAGATA 
GAGAACTCAG CCGCAGTGGA AAAGGCTATT GCCCACTATG AACAGCAGAT GGGCCAGAAG 
GTGCAGCTGC CCACGGAAAC CCTCCAGGAG CTGCTGGACC TGCACAGGGA CAGTGAGAGA 
GAGGCCATTG AAGTCTTCAT GAAGAACTCT TTCAAGGATG TGGACCAAAT GTTCCAGAGG 
AAATTAGGGG CCCAGTTGGA AGCAAGGCGA GATGACTTTT GTAAGCAGAA TTCCAAAGCA 
TCATCAGATT GTTGCATGGC TTTACTTCAG GATATATTTG GCCCTTTAGA AGAAGATGTC 
AAGCAGGGAA CATTTTCTAA ACCAGGAGGT TACCGTCTCT TTACTCAGAA GCTGCAGGAG 
CTGAAGAATA AGTACTACCA GGTGCCAAGG AAGGGGATAC AGGCCAAAGA GGTGCTGAAA 
AAATATTTGG AGTCCAAGGA GGATGTGGCT GATGCACTTC TACAGACTGA TCAGTCACTC 
TCAGAAAAGG AAAAAGCGAT TGAAGTGGAA CGTATAAAGG CTGAATCTGC AGAAGCTGCA 
AAGAAAATGT TGGAGGAAAT ACAAAAGAAG AATGAGGAGA TGATGGAACA GAAAGAGAAG 
AGTTATCAGG AACATGTGAA ACAATTGACT GAGAAGATGG AGAGGGACAG GGCCCAGTTA 
ATGGCAGAGC AAGAGAAGAC CCTCGCTCTT AAACTTCAGG AACAGGAACG CCTTCTCAAG 
GAGGGATTCG AGAATGAGAG CAAGAGACTT CAAAAAGACA TATGGGATAT CCAGATGAGA 
AGCAAATCAT TGGAGCCAAT ATGTAACATA CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004111.2
CDS	315..2090
Translation	MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL

Target ORF information:

RefSeq Version	NM_004120.4
Organism	Homo sapiens(human)
Definition	Homo sapiens guanylate binding protein 2 (GBP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004120.4

ORF Insert Sequence:

ATGGCTCCAG AGATCAACTT GCCGGGCCCA ATGAGCCTCA TTGATAACAC TAAAGGGCAG 
CTGGTGGTGA ATCCAGAAGC TCTGAAGATC CTATCTGCAA TTACGCAGCC TGTGGTGGTG 
GTGGCGATTG TGGGCCTCTA TCGCACAGGC AAATCCTACC TGATGAACAA GCTGGCTGGG 
AAGAAAAACG GCTTCTCTCT AGGCTCCACA GTGAAGTCTC ACACCAAGGG AATCTGGATG 
TGGTGTGTGC CTCATCCCAA GAAGCCAGAA CACACCCTAG TTCTGCTCGA CACTGAGGGC 
CTGGGAGATA TAGAGAAGGG TGACAATGAG AATGACTCCT GGATCTTTGC CTTGGCCATC 
CTCCTGAGCA GCACCTTCGT GTACAATAGC ATGGGAACCA TCAACCAGCA GGCCATGGAC 
CAACTTCACT ATGTGACAGA GCTGACAGAT CGAATCAAGG CAAACTCCTC ACCTGGTAAC 
AATTCTGTAG ACGACTCAGC TGACTTTGTG AGCTTTTTTC CAGCATTTGT GTGGACTCTC 
AGAGATTTCA CCCTGGAACT GGAAGTAGAT GGAGAACCCA TCACTGCTGA TGACTACTTG 
GAGCTTTCGC TAAAGCTAAG AAAAGGTACT GATAAGAAAA GTAAAAGCTT TAATGATCCT 
CGGTTGTGCA TCCGAAAGTT CTTCCCCAAG AGGAAGTGCT TCGTCTTCGA TTGGCCCGCT 
CCTAAGAAGT ACCTTGCTCA CCTAGAGCAG CTAAAGGAGG AAGAGCTGAA CCCTGATTTC 
ATAGAACAAG TTGCAGAATT TTGTTCCTAC ATCCTCAGCC ATTCCAATGT CAAGACTCTT 
TCAGGTGGCA TTCCAGTCAA TGGGCCTCGT CTAGAGAGCC TGGTGCTGAC CTACGTCAAT 
GCCATCAGCA GTGGGGATCT ACCCTGCATG GAGAACGCAG TCCTGGCCTT GGCCCAGATA 
GAGAACTCAG CCGCAGTGGA AAAGGCTATT GCCCACTATG AACAGCAGAT GGGCCAGAAG 
GTGCAGCTGC CCACGGAAAC CCTCCAGGAG CTGCTGGACC TGCACAGGGA CAGTGAGAGA 
GAGGCCATTG AAGTCTTCAT GAAGAACTCT TTCAAGGATG TGGACCAAAT GTTCCAGAGG 
AAATTAGGGG CCCAGTTGGA AGCAAGGCGA GATGACTTTT GTAAGCAGAA TTCCAAAGCA 
TCATCAGATT GTTGCATGGC TTTACTTCAG GATATATTTG GCCCTTTAGA AGAAGATGTC 
AAGCAGGGAA CATTTTCTAA ACCAGGAGGT TACCGTCTCT TTACTCAGAA GCTGCAGGAG 
CTGAAGAATA AGTACTACCA GGTGCCAAGG AAGGGGATAC AGGCCAAAGA GGTGCTGAAA 
AAATATTTGG AGTCCAAGGA GGATGTGGCT GATGCACTTC TACAGACTGA TCAGTCACTC 
TCAGAAAAGG AAAAAGCGAT TGAAGTGGAA CGTATAAAGG CTGAATCTGC AGAAGCTGCA 
AAGAAAATGT TGGAGGAAAT ACAAAAGAAG AATGAGGAGA TGATGGAACA GAAAGAGAAG 
AGTTATCAGG AACATGTGAA ACAATTGACT GAGAAGATGG AGAGGGACAG GGCCCAGTTA 
ATGGCAGAGC AAGAGAAGAC CCTCGCTCTT AAACTTCAGG AACAGGAACG CCTTCTCAAG 
GAGGGATTCG AGAATGAGAG CAAGAGACTT CAAAAAGACA TATGGGATAT CCAGATGAGA 
AGCAAATCAT TGGAGCCAAT ATGTAACATA CTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.
Cell death & disease8(10)e3151(2017 Oct)
Zhang J,Zhang Y,Wu W,Wang F,Liu X,Shui G,Nie C

Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response.
Breast cancer (Tokyo, Japan)21(4)491-9(2014 Jul)
Godoy P,Cadenas C,Hellwig B,Marchan R,Stewart J,Reif R,Lohr M,Gehrmann M,Rahnenf?hrer J,Schmidt M,Hengstler JG

miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation.
Leukemia27(2)344-52(2013 Feb)
Lin X,Rice KL,Buzzai M,Hexner E,Costa FF,Kilpivaara O,Mullally A,Soares MB,Ebert BL,Levine R,Licht JD

Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins.
Autophagy9(1)50-62(2013 Jan)
Al-Zeer MA,Al-Younes HM,Lauster D,Abu Lubad M,Meyer TF

Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells.
PloS one7(9)e44267(2012)
Christian SL,Zu D,Licursi M,Komatsu Y,Pongnopparat T,Codner DA,Hirasawa K

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GBP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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