Fgf3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgf3
Entrez Gene ID	14174
Full Name	fibroblast growth factor 3
Synonyms	Fgf-3,Int-2,Int-P
General protein information	Preferred Names fibroblast growth factor 3 Names fibroblast growth factor 3 HBGF-3 INT-2 proto-oncogene protein heparin-binding growth factor 3 proto-oncogene Int-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 F5\|7 88.85 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008007.2	NP_032033.2	fibroblast growth factor 3 precursor
XM_011241980.2	XP_011240282.1	fibroblast growth factor 3 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	FGF3	NP_005238.1
	FGF3	XP_001100658.1
Rattus norvegicus (Norway rat)	Fgf3	NP_570830.1
Xenopus tropicalis (tropical clawed frog)	fgf3	NP_001008154.1
Bos taurus (cattle)	FGF3	XP_002699485.1
Mus musculus (house mouse)	Fgf3	NP_032033.2
Pan troglodytes (chimpanzee)	FGF3	XP_522092.2
Gallus gallus (chicken)	FGF3	NP_990658.1
Danio rerio (zebrafish)	fgf3	NP_571366.1

Gene Ontology
Bibliography

Related articles in PubMed

Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome.
Whittaker DE, Kasah S, Donovan APA, Ellegood J, Riegman KLH, Volk HA, McGonnell I, Lerch JP, Basson MA
American journal of medical genetics. Part C, Seminars in medical genetics175(4)(2017 Dec)

An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.
Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH
eLife6(2017 Nov)

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J
Nature communications8(1)1819(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results indicate that Fgf3 hypomethylation and gene overexpression, but not protein expression, occurred in the early stage of oral carcinogenesis induced by DBP
Title: Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene.

We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist.
Title: An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.

FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing beta-catenin signaling.
Title: FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing ?-catenin signaling.

Data suggest that Fgf3/Fgfr3 signaling is required for maintenance of Gnrh (gonadotropin-releasing hormone) neurons in aging hypothalamus; postnatal Gnrh system is plastic/resilient, able to override preexisting defects and respond to external cues.
Title: Opposite-sex housing reactivates the declining GnRH system in aged transgenic male mice with FGF signaling deficiency.

Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos.
Title: Ectopic expression of Fgf3 leads to aberrant lineage segregation in the mouse parthenote preimplantation embryos.

The following Fgf3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01213	NM_008007.2 Latest version!	Mus musculus fibroblast growth factor 3 (Fgf3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu01213	XM_011241980.2 Latest version!	Mus musculus fibroblast growth factor 3 (Fgf3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgf3 ( NM_008007.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032033.2 Mus musculus fibroblast growth factor 3 (Fgf3), mRNA.

Price & Availability↑

CloneID	OMu01213
Clone ID Related Accession (Same CDS sequence)	NM_008007.2 , XM_011241980.2
Accession Version	NM_008007.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	fibroblast growth factor 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU923457.1, BC117059.1 and BM942045.1. On Oct 20, 2007 this sequence version replaced NM_008007.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU923457.1, AK133901.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCTGA TCTGGCTTCT GCTGCTCAGC TTGCTGGAAC CCAGCTGGCC AACTACGGGG 
CCCGGGACGC GACTACGACG CGATGCGGGC GGCCGTGGTG GCGTTTACGA GCACCTCGGC 
GGGGCGCCAC GGCGCCGCAA GCTCTACTGC GCTACCAAGT ACCACCTCCA GCTGCACCCA 
AGCGGCCGCG TGAACGGCAG CCTTGAGAAC AGCGCCTATA GCATCCTGGA GATTACTGCG 
GTGGAAGTGG GCGTGGTGGC CATCAAAGGG CTCTTTTCTG GGCGGTACCT GGCCATGAAC 
AAGAGAGGAC GGCTGTATGC TTCGGATCAC TACAACGCAG AGTGTGAGTT TGTGGAACGG 
ATCCATGAGC TGGGCTACAA TACATATGCT TCCCGCCTGT ACCGCACAGG GTCCAGTGGG 
CCAGGAGCTC AACGGCAACC TGGTGCCCAG AGACCTTGGT ACGTGTCGGT GAATGGCAAG 
GGTCGGCCAC GCAGGGGCTT CAAGACCCGC CGCACACAAA AGTCCTCTCT CTTCCTGCCC 
CGAGTGCTGG GCCACAAGGA CCATGAGATG GTGCGGCTGC TGCAGAGTAG CCAGCCACGA 
GCCCCAGGAG AGGGCAGCCA GCCCAGGCAG CGGAGGCAGA AGAAGCAGAG CCCAAGTGAT 
CATGGCAAGA TGGAGACTTT GTCTACCAGG GCCACTCCAA GCACCCAGCT GCATACAGGT 
GGACTGGCTG TGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032033.2
CDS	97..834
Translation	MGLIWLLLLSLLEPSWPTTGPGTRLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGVVAIKGLFSGRYLAMNKRGRLYASDHYNAECEFVERIHELGYNTYASRLYRTGSSGPGAQRQPGAQRPWYVSVNGKGRPRRGFKTRRTQKSSLFLPRVLGHKDHEMVRLLQSSQPRAPGEGSQPRQRRQKKQSPSDHGKMETLSTRATPSTQLHTGGLAVA

Target ORF information:

RefSeq Version	NM_008007.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibroblast growth factor 3 (Fgf3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008007.2

ORF Insert Sequence:

ATGGGCCTGA TCTGGCTTCT GCTGCTCAGC TTGCTGGAAC CCAGCTGGCC AACTACGGGG 
CCCGGGACGC GACTACGACG CGATGCGGGC GGCCGTGGTG GCGTTTACGA GCACCTCGGC 
GGGGCGCCAC GGCGCCGCAA GCTCTACTGC GCTACCAAGT ACCACCTCCA GCTGCACCCA 
AGCGGCCGCG TGAACGGCAG CCTTGAGAAC AGCGCCTATA GCATCCTGGA GATTACTGCG 
GTGGAAGTGG GCGTGGTGGC CATCAAAGGG CTCTTTTCTG GGCGGTACCT GGCCATGAAC 
AAGAGAGGAC GGCTGTATGC TTCGGATCAC TACAACGCAG AGTGTGAGTT TGTGGAACGG 
ATCCATGAGC TGGGCTACAA TACATATGCT TCCCGCCTGT ACCGCACAGG GTCCAGTGGG 
CCAGGAGCTC AACGGCAACC TGGTGCCCAG AGACCTTGGT ACGTGTCGGT GAATGGCAAG 
GGTCGGCCAC GCAGGGGCTT CAAGACCCGC CGCACACAAA AGTCCTCTCT CTTCCTGCCC 
CGAGTGCTGG GCCACAAGGA CCATGAGATG GTGCGGCTGC TGCAGAGTAG CCAGCCACGA 
GCCCCAGGAG AGGGCAGCCA GCCCAGGCAG CGGAGGCAGA AGAAGCAGAG CCCAAGTGAT 
CATGGCAAGA TGGAGACTTT GTCTACCAGG GCCACTCCAA GCACCCAGCT GCATACAGGT 
GGACTGGCTG TGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fgf3 ( XM_011241980.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011240282.1 Mus musculus fibroblast growth factor 3 (Fgf3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu01213
Clone ID Related Accession (Same CDS sequence)	NM_008007.2 , XM_011241980.2
Accession Version	XM_011241980.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	fibroblast growth factor 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011241980.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCCTGA TCTGGCTTCT GCTGCTCAGC TTGCTGGAAC CCAGCTGGCC AACTACGGGG 
CCCGGGACGC GACTACGACG CGATGCGGGC GGCCGTGGTG GCGTTTACGA GCACCTCGGC 
GGGGCGCCAC GGCGCCGCAA GCTCTACTGC GCTACCAAGT ACCACCTCCA GCTGCACCCA 
AGCGGCCGCG TGAACGGCAG CCTTGAGAAC AGCGCCTATA GCATCCTGGA GATTACTGCG 
GTGGAAGTGG GCGTGGTGGC CATCAAAGGG CTCTTTTCTG GGCGGTACCT GGCCATGAAC 
AAGAGAGGAC GGCTGTATGC TTCGGATCAC TACAACGCAG AGTGTGAGTT TGTGGAACGG 
ATCCATGAGC TGGGCTACAA TACATATGCT TCCCGCCTGT ACCGCACAGG GTCCAGTGGG 
CCAGGAGCTC AACGGCAACC TGGTGCCCAG AGACCTTGGT ACGTGTCGGT GAATGGCAAG 
GGTCGGCCAC GCAGGGGCTT CAAGACCCGC CGCACACAAA AGTCCTCTCT CTTCCTGCCC 
CGAGTGCTGG GCCACAAGGA CCATGAGATG GTGCGGCTGC TGCAGAGTAG CCAGCCACGA 
GCCCCAGGAG AGGGCAGCCA GCCCAGGCAG CGGAGGCAGA AGAAGCAGAG CCCAAGTGAT 
CATGGCAAGA TGGAGACTTT GTCTACCAGG GCCACTCCAA GCACCCAGCT GCATACAGGT 
GGACTGGCTG TGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011240282.1
CDS	257..994
Translation	MGLIWLLLLSLLEPSWPTTGPGTRLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGVVAIKGLFSGRYLAMNKRGRLYASDHYNAECEFVERIHELGYNTYASRLYRTGSSGPGAQRQPGAQRPWYVSVNGKGRPRRGFKTRRTQKSSLFLPRVLGHKDHEMVRLLQSSQPRAPGEGSQPRQRRQKKQSPSDHGKMETLSTRATPSTQLHTGGLAVA

Target ORF information:

RefSeq Version	XM_011241980.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibroblast growth factor 3 (Fgf3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011241980.2

ORF Insert Sequence:

ATGGGCCTGA TCTGGCTTCT GCTGCTCAGC TTGCTGGAAC CCAGCTGGCC AACTACGGGG 
CCCGGGACGC GACTACGACG CGATGCGGGC GGCCGTGGTG GCGTTTACGA GCACCTCGGC 
GGGGCGCCAC GGCGCCGCAA GCTCTACTGC GCTACCAAGT ACCACCTCCA GCTGCACCCA 
AGCGGCCGCG TGAACGGCAG CCTTGAGAAC AGCGCCTATA GCATCCTGGA GATTACTGCG 
GTGGAAGTGG GCGTGGTGGC CATCAAAGGG CTCTTTTCTG GGCGGTACCT GGCCATGAAC 
AAGAGAGGAC GGCTGTATGC TTCGGATCAC TACAACGCAG AGTGTGAGTT TGTGGAACGG 
ATCCATGAGC TGGGCTACAA TACATATGCT TCCCGCCTGT ACCGCACAGG GTCCAGTGGG 
CCAGGAGCTC AACGGCAACC TGGTGCCCAG AGACCTTGGT ACGTGTCGGT GAATGGCAAG 
GGTCGGCCAC GCAGGGGCTT CAAGACCCGC CGCACACAAA AGTCCTCTCT CTTCCTGCCC 
CGAGTGCTGG GCCACAAGGA CCATGAGATG GTGCGGCTGC TGCAGAGTAG CCAGCCACGA 
GCCCCAGGAG AGGGCAGCCA GCCCAGGCAG CGGAGGCAGA AGAAGCAGAG CCCAAGTGAT 
CATGGCAAGA TGGAGACTTT GTCTACCAGG GCCACTCCAA GCACCCAGCT GCATACAGGT 
GGACTGGCTG TGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Distinct cerebellar foliation anomalies in a CHD7 haploinsufficient mouse model of CHARGE syndrome.
American journal of medical genetics. Part C, Seminars in medical genetics175(4)(2017 Dec)
Whittaker DE,Kasah S,Donovan APA,Ellegood J,Riegman KLH,Volk HA,McGonnell I,Lerch JP,Basson MA

An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis.
eLife6(2017 Nov)
Zhang H,Wang L,Wong EYM,Tsang SL,Xu PX,Lendahl U,Sham MH

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Nature communications8(1)1819(2017 Nov)
Mario Gonzalez-Meljem J,Haston S,Carreno G,Apps JR,Pozzi S,Stache C,Kaushal G,Virasami A,Panousopoulos L,Neda Mousavy-Gharavy S,Guerrero A,Rashid M,Jani N,Goding CR,Jacques TS,Adams DJ,Gil J,Andoniadou CL,Pedro Martinez-Barbera J

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Fgf3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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