Fem1a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fem1a
Entrez Gene ID	14154
Full Name	feminization 1 homolog a (C. elegans)
Synonyms	AW611390,Fem1aa
General protein information	Preferred Names feminization 1 homolog a (C. elegans) Names protein fem-1 homolog A-A FEM1-alpha-A FEM1a-A
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 D\|17 29.24 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010192.4	NP_034322.3	protein fem-1 homolog A-A

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fem1a	NP_001020877.1
Danio rerio (zebrafish)	fem1a	NP_956131.1
Canis lupus familiaris (dog)	FEM1A	XP_542150.2
Bos taurus (cattle)	FEM1A	NP_001039691.1
Homo sapiens (human)	FEM1A	NP_061178.1
Pan troglodytes (chimpanzee)	FEM1A	XP_003954460.1
Mus musculus (house mouse)	Fem1a	NP_034322.3
	FEM1A	XP_001082251.1
Gallus gallus (chicken)	FEM1A	XP_418271.3

Gene Ontology
Bibliography

Related articles in PubMed

Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice.
Fujikawa R, Higuchi S, Ikedo T, Nagata M, Hayashi K, Yang T, Miyata T, Yokode M, Minami M
Biochemical and biophysical research communications486(2)584-588(2017 04)

EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice.
Higuchi S, Fujikawa R, Ikedo T, Hayashi K, Yasui M, Nagata M, Nakatsuji M, Yokode M, Minami M
Journal of immunology (Baltimore, Md. : 1950)197(11)4436-4443(2016 Dec)

EP4 Receptor-Associated Protein in Microglia Promotes Inflammation in the Brain.
Fujikawa R, Higuchi S, Nakatsuji M, Yasui M, Ikedo T, Nagata M, Yokode M, Minami M
The American journal of pathology186(8)1982-1988(2016 Aug)

High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.
Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS
Gene expression patterns : GEP6(2)213-24(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Immunoprecipitation analyses demonstrated that EPRAP associated with PP2A in both MEFs and alveolar macrophages from BLM-treated mice.
Title: EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice.

prostaglandin E2 type 4 receptor-associated protein promotes proinflammatory activation of microglia through mitogen-activated protein kinase kinase 4-mediated signaling and may be key to the deteriorating neuronal damage brought on by brain inflammation
Title: EP4 Receptor-Associated Protein in Microglia Promotes Inflammation in the Brain.

PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation.
Title: Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation.

Fem1a downregulation may be involved in, and/or a marker of, an early cell fate defect fundamental to rhabdomyosarcoma pathogenesis
Title: The Fem1a gene is downregulated in Rhabdomyosarcoma.

The following Fem1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fem1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58456	NM_010192.4 Latest version!	Mus musculus fem 1 homolog a (Fem1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fem1a ( NM_010192.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034322.3 Mus musculus fem 1 homolog a (Fem1a), mRNA.

Price & Availability↑

CloneID	OMu58456
Clone ID Related Accession (Same CDS sequence)	NM_010192.4
Accession Version	NM_010192.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1965bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	protein fem-1 homolog A-A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY343573.1, BC054382.1, AK080978.1, AI021455.1, CO426831.1, AK042461.1 and BP757418.1. On Apr 18, 2009 this sequence version replaced NM_010192.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGATCTGC ACACAGCGGT GTACAATGCG GCGCACGACG GCAAGCTGCC GCTGCTGCAG 
AAGCTGCTGG CCGGCCGTGG GCGTGAGGAG CTGGAGGAGC TGCTGGGTGA GGTGGCCGGC 
GGTGGCACGC CACTGCTAAT CGCAGCGCGC CGTGGACACC TAGACGTGGT GGAGTATCTG 
GTGGACCACT GCGGCGCCAG CGTGGAGGCG AGCGGCTCCG TGCACTTCGA TGGCGAGACC 
ATCGAGGGCG CGCCGCCGCT CTGGGCAGCG TCGGCCGCGG GTCACCTGGC CGTGGTGCGT 
AGCCTTCTGC GCCGAGGCGC CTCGGTCAAC CGCACCACGC GCACCAACTC CACGCCGCTG 
CGCGCCGCCT GCTTCGACGG CCACCTGGAC GTGGTACGCT ACCTGGTGGG CGAGCACAAG 
GCGGACCTGG AGGTGGCCAA TCGCCACGGC CACACGTGCC TTATGATCTC CTGCTACAAG 
GGCCACCGCG AGATCGCGCG CTACCTGCTG GAGCGCGGCG CACAGGTGAA CCGGCGCAGC 
GCCAAGGGCA ACACCGCCCT GCACGACTGT GCAGAATCTG GCAGCCTGGA GATCCTACAG 
CTGCTGCTGG GCTGCCACGC GCGCATGGAG CGCGACGGCT ATGGCATGAC CCCGCTGCTG 
GCCGCCAGCG TCACCGGGCA CACCAACATC GTGGAGTACC TCATCCAGGA ACAGCCGGGC 
CACGAGCAGC TCTCAGGGAC AGAGCTTCCC GGGGAAGGCT CCTCCCAGGT GGCAGGAAAC 
CACTGCTCCA CCCCAGAAGA AGCAGAACCG TATGAGAGCT GCTGCCCTAC CAGCCGGGAA 
GCAGCTGTGG AAGCTTTGGA GCTGCTGGGT GCCACCTACG TGGATAAGAA AAGGGATCTG 
CTTGGAGCCC TGAAGCACTG GAGAAGGGCG ATGGAACTCC GTCACCAGGG TGGAGGCTAC 
CTCCCTAAGC CGGAGCCCCA GCAACTGGTT CTGGCCTATG ACTATTCCAG GGAGGTGACT 
ACACCCCAAG AGTTGGAAGC CCTCATTACA GATCCTGATG AAATGCGGAT GCAGGCGCTG 
CTGATACGGG AGAGAATCTT GGGCCCCTCA CATCCTGACA CTTCATACTA CATACGGTAC 
CGGGGTGCTG TCTATGCGGA CTCCGGGAAT TTCGAGCGCT GTATCCGTCT GTGGAAGTAT 
GCCTTGGACA TGCAACAAAA CAACTTGGAG CCCCTGAGCC CCATGACCGC CAGCAGCTTC 
CTGTCGTTTG CAGAGCTCTT CTCCTACGTG CTGCAGGACC GCTCGGCCAA GGGCAACCTG 
GGCATGCAGC TTGGCTTTGC CGACCTCATG GGTGTGCTCA GCAAAGGGGT TCGGGAAGTG 
GAGCGGGCTC TGCAGTTGCC CAAGGAACCG GGTGACTCCG CACAGTTCAC CAAAGCCATT 
GCCATCATCC TCCACCTTCT GTACCTATTG GAGAAGGTGG AGTGCACCCC CAGCCAGGAA 
CACCTCAAGC ACCAGACAGT CTACCGCCTG CTCAAGTGTG CCCCTCGCGG TAAAAACGGC 
TTCACCCCAC TACACATGGC GGTGGACAAG GAGACCACCA ACGTGGGCCG GTATCGTGTG 
GGCGTCTTCC CATCGCTGCA GGTGGTCAAG GTGCTGTTGG ACTGCGGAGC AGACCCTGAC 
AGCAGGGATT TCGACAACAA CACCCCACTG CACATCGCTG CCCAGAATAA TTGCCCGGCC 
ATCATGGATG CTCTCATCGA AGCTGGGGCC CACATGGACG CCACCAATGC CTTCAAAAAG 
ACTGCCTACG AGCTGCTGGA CTCGAAGCTG TTGGCTAAGA GCACCGTGCA GCCTTTCAAT 
TATGTGACAC TGCAGTGCCT AGCTGCCCGT GCCCTGGACA GGAACAAGGT CCCTTATAAG 
GGCTTCATCC CAGAGGAGCT GGAGGCCTTC ATCCAGTTGC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034322.3
CDS	117..2081
Translation	MDLHTAVYNAAHDGKLPLLQKLLAGRGREELEELLGEVAGGGTPLLIAARRGHLDVVEYLVDHCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCHARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHEQLSGTELPGEGSSQVAGNHCSTPEEAEPYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGGYLPKPEPQQLVLAYDYSREVTTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRSAKGNLGMQLGFADLMGVLSKGVREVERALQLPKEPGDSAQFTKAIAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGRYRVGVFPSLQVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTVQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH

Target ORF information:

RefSeq Version	NM_010192.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus fem 1 homolog a (Fem1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010192.4

ORF Insert Sequence:

ATGGATCTGC ACACAGCGGT GTACAATGCG GCGCACGACG GCAAGCTGCC GCTGCTGCAG 
AAGCTGCTGG CCGGCCGTGG GCGTGAGGAG CTGGAGGAGC TGCTGGGTGA GGTGGCCGGC 
GGTGGCACGC CACTGCTAAT CGCAGCGCGC CGTGGACACC TAGACGTGGT GGAGTATCTG 
GTGGACCACT GCGGCGCCAG CGTGGAGGCG AGCGGCTCCG TGCACTTCGA TGGCGAGACC 
ATCGAGGGCG CGCCGCCGCT CTGGGCAGCG TCGGCCGCGG GTCACCTGGC CGTGGTGCGT 
AGCCTTCTGC GCCGAGGCGC CTCGGTCAAC CGCACCACGC GCACCAACTC CACGCCGCTG 
CGCGCCGCCT GCTTCGACGG CCACCTGGAC GTGGTACGCT ACCTGGTGGG CGAGCACAAG 
GCGGACCTGG AGGTGGCCAA TCGCCACGGC CACACGTGCC TTATGATCTC CTGCTACAAG 
GGCCACCGCG AGATCGCGCG CTACCTGCTG GAGCGCGGCG CACAGGTGAA CCGGCGCAGC 
GCCAAGGGCA ACACCGCCCT GCACGACTGT GCAGAATCTG GCAGCCTGGA GATCCTACAG 
CTGCTGCTGG GCTGCCACGC GCGCATGGAG CGCGACGGCT ATGGCATGAC CCCGCTGCTG 
GCCGCCAGCG TCACCGGGCA CACCAACATC GTGGAGTACC TCATCCAGGA ACAGCCGGGC 
CACGAGCAGC TCTCAGGGAC AGAGCTTCCC GGGGAAGGCT CCTCCCAGGT GGCAGGAAAC 
CACTGCTCCA CCCCAGAAGA AGCAGAACCG TATGAGAGCT GCTGCCCTAC CAGCCGGGAA 
GCAGCTGTGG AAGCTTTGGA GCTGCTGGGT GCCACCTACG TGGATAAGAA AAGGGATCTG 
CTTGGAGCCC TGAAGCACTG GAGAAGGGCG ATGGAACTCC GTCACCAGGG TGGAGGCTAC 
CTCCCTAAGC CGGAGCCCCA GCAACTGGTT CTGGCCTATG ACTATTCCAG GGAGGTGACT 
ACACCCCAAG AGTTGGAAGC CCTCATTACA GATCCTGATG AAATGCGGAT GCAGGCGCTG 
CTGATACGGG AGAGAATCTT GGGCCCCTCA CATCCTGACA CTTCATACTA CATACGGTAC 
CGGGGTGCTG TCTATGCGGA CTCCGGGAAT TTCGAGCGCT GTATCCGTCT GTGGAAGTAT 
GCCTTGGACA TGCAACAAAA CAACTTGGAG CCCCTGAGCC CCATGACCGC CAGCAGCTTC 
CTGTCGTTTG CAGAGCTCTT CTCCTACGTG CTGCAGGACC GCTCGGCCAA GGGCAACCTG 
GGCATGCAGC TTGGCTTTGC CGACCTCATG GGTGTGCTCA GCAAAGGGGT TCGGGAAGTG 
GAGCGGGCTC TGCAGTTGCC CAAGGAACCG GGTGACTCCG CACAGTTCAC CAAAGCCATT 
GCCATCATCC TCCACCTTCT GTACCTATTG GAGAAGGTGG AGTGCACCCC CAGCCAGGAA 
CACCTCAAGC ACCAGACAGT CTACCGCCTG CTCAAGTGTG CCCCTCGCGG TAAAAACGGC 
TTCACCCCAC TACACATGGC GGTGGACAAG GAGACCACCA ACGTGGGCCG GTATCGTGTG 
GGCGTCTTCC CATCGCTGCA GGTGGTCAAG GTGCTGTTGG ACTGCGGAGC AGACCCTGAC 
AGCAGGGATT TCGACAACAA CACCCCACTG CACATCGCTG CCCAGAATAA TTGCCCGGCC 
ATCATGGATG CTCTCATCGA AGCTGGGGCC CACATGGACG CCACCAATGC CTTCAAAAAG 
ACTGCCTACG AGCTGCTGGA CTCGAAGCTG TTGGCTAAGA GCACCGTGCA GCCTTTCAAT 
TATGTGACAC TGCAGTGCCT AGCTGCCCGT GCCCTGGACA GGAACAAGGT CCCTTATAAG 
GGCTTCATCC CAGAGGAGCT GGAGGCCTTC ATCCAGTTGC ATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice.
Biochemical and biophysical research communications486(2)584-588(2017 04)
Fujikawa R,Higuchi S,Ikedo T,Nagata M,Hayashi K,Yang T,Miyata T,Yokode M,Minami M

EP4 Receptor-Associated Protein in Macrophages Protects against Bleomycin-Induced Pulmonary Inflammation in Mice.
Journal of immunology (Baltimore, Md. : 1950)197(11)4436-4443(2016 Dec)
Higuchi S,Fujikawa R,Ikedo T,Hayashi K,Yasui M,Nagata M,Nakatsuji M,Yokode M,Minami M

EP4 Receptor-Associated Protein in Microglia Promotes Inflammation in the Brain.
The American journal of pathology186(8)1982-1988(2016 Aug)
Fujikawa R,Higuchi S,Nakatsuji M,Yasui M,Ikedo T,Nagata M,Yokode M,Minami M

High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.
Gene expression patterns : GEP6(2)213-24(2006 Jan)
Yoshikawa T,Piao Y,Zhong J,Matoba R,Carter MG,Wang Y,Goldberg I,Ko MS

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Fem1a cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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