Fbln1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fbln1
Entrez Gene ID	14114
Full Name	fibulin 1
General protein information	Preferred Names fibulin 1 Names fibulin-1 BM-90 BM-90/fibulin extracellular matrix glyroprotein FIBL-1 basement-membrane protein 90
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001347088.1	NP_001334017.1	fibulin-1 isoform 2 precursor
NM_010180.2	NP_034310.2	fibulin-1 isoform 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FBLN1	XP_003317358.1
Canis lupus familiaris (dog)	FBLN1	XP_005625811.1
Caenorhabditis elegans (roundworm)	fbl-1	NP_001023237.1
Homo sapiens (human)	FBLN1	NP_006477.2
	FBLN1	XP_001109966.2
Gallus gallus (chicken)	FBLN1	NP_989496.1
Bos taurus (cattle)	FBLN1	NP_001091498.1
Mus musculus (house mouse)	Fbln1	NP_034310.2
Danio rerio (zebrafish)	fbln1	NP_571117.1
Rattus norvegicus (Norway rat)	Fbln1	NP_001121019.1

Gene Ontology
Bibliography

Related articles in PubMed

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.
Liu G, Cooley MA, Nair PM, Donovan C, Hsu AC, Jarnicki AG, Haw TJ, Hansbro NG, Ge Q, Brown AC, Tay H, Foster PS, Wark PA, Horvat JC, Bourke JE, Grainge CL, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM
The Journal of pathology243(4)510-523(2017 Dec)

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Rutledge EA, Benazet JD, McMahon AP
Development (Cambridge, England)144(17)3177-3188(2017 09)

Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL.
Fresco VM, Kern CB, Mohammadi M, Twal WO
The Journal of biological chemistry291(36)18730-9(2016 09)

Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.
Liu G, Cooley MA, Jarnicki AG, Hsu AC, Nair PM, Haw TJ, Fricker M, Gellatly SL, Kim RY, Inman MD, Tjin G, Wark PA, Walker MM, Horvat JC, Oliver BG, Argraves WS, Knight DA, Burgess JK, Hansbro PM
JCI insight1(9)(2016 Jun)

Forelimb contractures and abnormal tendon collagen fibrillogenesis in fibulin-4 null mice.
Markova DZ, Pan TC, Zhang RZ, Zhang G, Sasaki T, Arita M, Birk DE, Chu ML
Cell and tissue research364(3)637-46(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fbln1c plays a key role in regulating airway remodelling and inflammation in chronic asthma.
Title: Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.

The FBLN1/FGF8 interaction may also be involved in the survival of neural crest cell population during development.
Title: Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL.

the findings indicate that Fbln1 normally suppresses proximal OFT EMT preventing proximal cushion hypercellularity and blood cell accumulation.
Title: Fibulin-1 suppresses endothelial to mesenchymal transition in the proximal outflow tract.

Extracellular calumenin regulates fibulin-1 to have crucial roles in ERK1/2 signaling and cell migration.
Title: Extracellular calumenin suppresses ERK1/2 signaling and cell migration by protecting fibulin-1 from MMP-13-mediated proteolysis.

Fbln1 is a new positive modulator of the formation of membranous bone and endochondral bone in the skull
Title: Fibulin-1 is required for bone formation and Bmp-2-mediated induction of Osterix.

The following Fbln1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbln1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21360	NM_010180.2 Latest version!	Mus musculus fibulin 1 (Fbln1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu50945	NM_001347088.1 Latest version!	Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fbln1 ( NM_010180.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034310.2 Mus musculus fibulin 1 (Fbln1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu21360
Clone ID Related Accession (Same CDS sequence)	NM_010180.2
Accession Version	NM_010180.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	fibulin-1 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK086451.1, AK083573.1, AK159646.1, AA017744.1 and AK085989.1. On Feb 23, 2008 this sequence version replaced NM_010180.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK085989.1, AK137511.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCGCC CCGTGCCGTC GCGCCTCGTC CCGCTGCCGC TGCTGCTGCT CAGCAGCCTC 
TCGCTGCTGG CAGCCCGAGC GAATGCAGAC ATCTCCATGG AGGCTTGCTG CACGGATGGA 
AATCAGATGG CTAACCAGCA CAGGGACTGC TCGCTGCCGT ACACCTCAGA ATCCAAGGAG 
TGCAGGATGG TCCAGGAGCA ATGTTGTCAC AACCAACTGG AAGAGCTGCA CTGTGCCACG 
GGCATCAACC TGGCCAGCGA GCCAGAAGGC TGCGCCTCGC TCCACAGCTA CAACAGTAGC 
CTTGAGACCA TCTTCATAAA GAGGTGCTGC CACTGTTGCA TGCTGGGAAA GGCATCCCTG 
GCCCGAGACC AGACCTGTGA ACCCATTGTC ATGATAAGCT ACCAGTGTGG GCTGGTGTTC 
CGTGCCTGCT GTGTGAAGGC CCGGGAGAAT TCAGACTTTG TCCAAGGCAA CGGTGCAGAC 
CTTCAGGACC CAGCTAAGAT TCCTGACGAG GAGGACCAAG AAGACCCGTA CCTGAATGAC 
CGCTGTCGAG GTGGCGGGCC CTGTAAGCAG CAGTGCCGTG ACACTGGGGA CGAGGTGATC 
TGCTCTTGCT TTGTGGGCTA CCAGCTGCAG TCGGATGGTG TCTCCTGCGA AGATATCAAT 
GAATGCATCA CAGGCAGCCA TAACTGCCGG CTGGGAGAAT CCTGCATCAA TACAGTGGGC 
TCTTTCCGCT GCCAGCGGGA CAGCAGCTGT GGGACTGGCT ATGAGCTCAC AGAGGATAAT 
AACTGCAAAG ATATTGACGA ATGTGAGACT GGTATTCATA ACTGCCCCCC CGATTTTATC 
TGTCAGAATA CTCTGGGATC CTTCCGTTGC AGACCGAAGC TGCAGTGCAA GAGCGGCTTC 
ATACAGGATG CTCTAGGCAA CTGCATTGAT ATCAATGAGT GTTTAAGTAT CAGTGCTCCA 
TGCCCTGTGG GGCAGACATG CATCAATACA GAGGGCTCCT ACACATGCCA GAAGAATGTG 
CCCAACTGTG GCCGTGGTTA TCATCTCAAT GAAGAGGGGA CCCGCTGTGT TGATGTGGAT 
GAGTGCTCCC CACCAGCGGA GCCCTGTGGG AAGGGACACC ACTGCCTGAA CTCCCCCGGC 
AGCTTCCGCT GCGAGTGCAA GGCTGGCTTC TATTTTGATG GCATCAGCAG GACCTGCGTG 
GATATCAACG AGTGCCAGCG CTATCCCGGG CGCCTGTGTG GCCACAAGTG TGAGAACACG 
CCAGGCTCCT TCCACTGCAG CTGCTCCGCC GGCTTCCGGC TGTCTGTGGA CGGCCGGTCT 
TGTGAAGATG TGAACGAGTG TCTCAACAGC CCTTGCAGCC AGGAGTGTGC TAATGTCTAT 
GGCTCCTACC AGTGCTATTG CCGACGAGGT TACCAGCTCA GTGACGTGGA TGGGGTCACC 
TGCGAAGATA TTGATGAGTG TGCCCTGCCC ACTGGAGGTC ACATCTGCTC CTACCGCTGC 
ATCAACATCC CCGGAAGCTT CCAGTGCAGC TGCCCCTCAT CTGGCTACAG GCTAGCTCCC 
AATGGCCGCA ACTGCCAAGA CATTGATGAG TGTGTGACCG GCATCCATAA CTGTTCCATC 
AATGAGACTT GCTTCAACAT CCAGGGCAGC TTCCGCTGTC TGTCCTTTGA ATGCCCCGAG 
AACTATCGCC GCTCCGCAGA CACCTTCCGC CAAGAGAAAA CAGACACCGT CCGCTGCATC 
AAGTCTTGCC GTCCCAACGA TGAGGCCTGC GTGCGGGACC CTGTACATAC CGTCTCCCAC 
ACCGTCATCT CGCTGCCCAC CTTTCGAGAG TTCACCCGTC CTGAGGAGAT CATCTTTCTG 
AGGGCTGTCA CACCGCTGTA CCCCGCCAAC CAGGCCGACA TCATCTTCGA CATCACAGAA 
GGGAACCTTC GAGACTCCTT TGATATCATC AAGCGCTATG AGGACGGCAT GACTGTGGGT 
GTCGTGCGCC AAGTGCGGCC CATCGTGGGC CCGTTTTACG CTGTCCTGAA GCTGGAGATG 
AACTACGTGT TGGGAGGCGT AGTTTCCCAC CGGAACGTCG TCAATGTACA CATCTTCGTC 
TCCGAGTACT GGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034310.2
CDS	127..2244
Translation	MERPVPSRLVPLPLLLLSSLSLLAARANADISMEACCTDGNQMANQHRDCSLPYTSESKECRMVQEQCCHNQLEELHCATGINLASEPEGCASLHSYNSSLETIFIKRCCHCCMLGKASLARDQTCEPIVMISYQCGLVFRACCVKARENSDFVQGNGADLQDPAKIPDEEDQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGFYFDGISRTCVDINECQRYPGRLCGHKCENTPGSFHCSCSAGFRLSVDGRSCEDVNECLNSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTFRQEKTDTVRCIKSCRPNDEACVRDPVHTVSHTVISLPTFREFTRPEEIIFLRAVTPLYPANQADIIFDITEGNLRDSFDIIKRYEDGMTVGVVRQVRPIVGPFYAVLKLEMNYVLGGVVSHRNVVNVHIFVSEYWF

Target ORF information:

RefSeq Version	NM_010180.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibulin 1 (Fbln1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010180.2

ORF Insert Sequence:

ATGGAGCGCC CCGTGCCGTC GCGCCTCGTC CCGCTGCCGC TGCTGCTGCT CAGCAGCCTC 
TCGCTGCTGG CAGCCCGAGC GAATGCAGAC ATCTCCATGG AGGCTTGCTG CACGGATGGA 
AATCAGATGG CTAACCAGCA CAGGGACTGC TCGCTGCCGT ACACCTCAGA ATCCAAGGAG 
TGCAGGATGG TCCAGGAGCA ATGTTGTCAC AACCAACTGG AAGAGCTGCA CTGTGCCACG 
GGCATCAACC TGGCCAGCGA GCCAGAAGGC TGCGCCTCGC TCCACAGCTA CAACAGTAGC 
CTTGAGACCA TCTTCATAAA GAGGTGCTGC CACTGTTGCA TGCTGGGAAA GGCATCCCTG 
GCCCGAGACC AGACCTGTGA ACCCATTGTC ATGATAAGCT ACCAGTGTGG GCTGGTGTTC 
CGTGCCTGCT GTGTGAAGGC CCGGGAGAAT TCAGACTTTG TCCAAGGCAA CGGTGCAGAC 
CTTCAGGACC CAGCTAAGAT TCCTGACGAG GAGGACCAAG AAGACCCGTA CCTGAATGAC 
CGCTGTCGAG GTGGCGGGCC CTGTAAGCAG CAGTGCCGTG ACACTGGGGA CGAGGTGATC 
TGCTCTTGCT TTGTGGGCTA CCAGCTGCAG TCGGATGGTG TCTCCTGCGA AGATATCAAT 
GAATGCATCA CAGGCAGCCA TAACTGCCGG CTGGGAGAAT CCTGCATCAA TACAGTGGGC 
TCTTTCCGCT GCCAGCGGGA CAGCAGCTGT GGGACTGGCT ATGAGCTCAC AGAGGATAAT 
AACTGCAAAG ATATTGACGA ATGTGAGACT GGTATTCATA ACTGCCCCCC CGATTTTATC 
TGTCAGAATA CTCTGGGATC CTTCCGTTGC AGACCGAAGC TGCAGTGCAA GAGCGGCTTC 
ATACAGGATG CTCTAGGCAA CTGCATTGAT ATCAATGAGT GTTTAAGTAT CAGTGCTCCA 
TGCCCTGTGG GGCAGACATG CATCAATACA GAGGGCTCCT ACACATGCCA GAAGAATGTG 
CCCAACTGTG GCCGTGGTTA TCATCTCAAT GAAGAGGGGA CCCGCTGTGT TGATGTGGAT 
GAGTGCTCCC CACCAGCGGA GCCCTGTGGG AAGGGACACC ACTGCCTGAA CTCCCCCGGC 
AGCTTCCGCT GCGAGTGCAA GGCTGGCTTC TATTTTGATG GCATCAGCAG GACCTGCGTG 
GATATCAACG AGTGCCAGCG CTATCCCGGG CGCCTGTGTG GCCACAAGTG TGAGAACACG 
CCAGGCTCCT TCCACTGCAG CTGCTCCGCC GGCTTCCGGC TGTCTGTGGA CGGCCGGTCT 
TGTGAAGATG TGAACGAGTG TCTCAACAGC CCTTGCAGCC AGGAGTGTGC TAATGTCTAT 
GGCTCCTACC AGTGCTATTG CCGACGAGGT TACCAGCTCA GTGACGTGGA TGGGGTCACC 
TGCGAAGATA TTGATGAGTG TGCCCTGCCC ACTGGAGGTC ACATCTGCTC CTACCGCTGC 
ATCAACATCC CCGGAAGCTT CCAGTGCAGC TGCCCCTCAT CTGGCTACAG GCTAGCTCCC 
AATGGCCGCA ACTGCCAAGA CATTGATGAG TGTGTGACCG GCATCCATAA CTGTTCCATC 
AATGAGACTT GCTTCAACAT CCAGGGCAGC TTCCGCTGTC TGTCCTTTGA ATGCCCCGAG 
AACTATCGCC GCTCCGCAGA CACCTTCCGC CAAGAGAAAA CAGACACCGT CCGCTGCATC 
AAGTCTTGCC GTCCCAACGA TGAGGCCTGC GTGCGGGACC CTGTACATAC CGTCTCCCAC 
ACCGTCATCT CGCTGCCCAC CTTTCGAGAG TTCACCCGTC CTGAGGAGAT CATCTTTCTG 
AGGGCTGTCA CACCGCTGTA CCCCGCCAAC CAGGCCGACA TCATCTTCGA CATCACAGAA 
GGGAACCTTC GAGACTCCTT TGATATCATC AAGCGCTATG AGGACGGCAT GACTGTGGGT 
GTCGTGCGCC AAGTGCGGCC CATCGTGGGC CCGTTTTACG CTGTCCTGAA GCTGGAGATG 
AACTACGTGT TGGGAGGCGT AGTTTCCCAC CGGAACGTCG TCAATGTACA CATCTTCGTC 
TCCGAGTACT GGTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fbln1 ( NM_001347088.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334017.1 Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu50945
Clone ID Related Accession (Same CDS sequence)	NM_001347088.1
Accession Version	NM_001347088.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	fibulin-1 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ572803.1, AL583891.15, AK035388.1 and AI845853.1. On Nov 15, 2016 this sequence version replaced XM_006520437.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK083573.1, AK086451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCGCC CCGTGCCGTC GCGCCTCGTC CCGCTGCCGC TGCTGCTGCT CAGCAGCCTC 
TCGCTGCTGG CAGCCCGAGC GAATGCAGAC ATCTCCATGG AGGCTTGCTG CACGGATGGA 
AATCAGATGG CTAACCAGCA CAGGGACTGC TCGCTGCCGT ACACCTCAGA ATCCAAGGAG 
TGCAGGATGG TCCAGGAGCA ATGTTGTCAC AACCAACTGG AAGAGCTGCA CTGTGCCACG 
GGCATCAACC TGGCCAGCGA GCCAGAAGGC TGCGCCTCGC TCCACAGCTA CAACAGTAGC 
CTTGAGACCA TCTTCATAAA GAGGTGCTGC CACTGTTGCA TGCTGGGAAA GGCATCCCTG 
GCCCGAGACC AGACCTGTGA ACCCATTGTC ATGATAAGCT ACCAGTGTGG GCTGGTGTTC 
CGTGCCTGCT GTGTGAAGGC CCGGGAGAAT TCAGACTTTG TCCAAGGCAA CGGTGCAGAC 
CTTCAGGACC CAGCTAAGAT TCCTGACGAG GAGGACCAAG AAGACCCGTA CCTGAATGAC 
CGCTGTCGAG GTGGCGGGCC CTGTAAGCAG CAGTGCCGTG ACACTGGGGA CGAGGTGATC 
TGCTCTTGCT TTGTGGGCTA CCAGCTGCAG TCGGATGGTG TCTCCTGCGA AGATATCAAT 
GAATGCATCA CAGGCAGCCA TAACTGCCGG CTGGGAGAAT CCTGCATCAA TACAGTGGGC 
TCTTTCCGCT GCCAGCGGGA CAGCAGCTGT GGGACTGGCT ATGAGCTCAC AGAGGATAAT 
AACTGCAAAG ATATTGACGA ATGTGAGACT GGTATTCATA ACTGCCCCCC CGATTTTATC 
TGTCAGAATA CTCTGGGATC CTTCCGTTGC AGACCGAAGC TGCAGTGCAA GAGCGGCTTC 
ATACAGGATG CTCTAGGCAA CTGCATTGAT ATCAATGAGT GTTTAAGTAT CAGTGCTCCA 
TGCCCTGTGG GGCAGACATG CATCAATACA GAGGGCTCCT ACACATGCCA GAAGAATGTG 
CCCAACTGTG GCCGTGGTTA TCATCTCAAT GAAGAGGGGA CCCGCTGTGT TGATGTGGAT 
GAGTGCTCCC CACCAGCGGA GCCCTGTGGG AAGGGACACC ACTGCCTGAA CTCCCCCGGC 
AGCTTCCGCT GCGAGTGCAA GGCTGGCTTC TATTTTGATG GCATCAGCAG GACCTGCGTG 
GATATCAACG AGTGCCAGCG CTATCCCGGG CGCCTGTGTG GCCACAAGTG TGAGAACACG 
CCAGGCTCCT TCCACTGCAG CTGCTCCGCC GGCTTCCGGC TGTCTGTGGA CGGCCGGTCT 
TGTGAAGATG TGAACGAGTG TCTCAACAGC CCTTGCAGCC AGGAGTGTGC TAATGTCTAT 
GGCTCCTACC AGTGCTATTG CCGACGAGGT TACCAGCTCA GTGACGTGGA TGGGGTCACC 
TGCGAAGATA TTGATGAGTG TGCCCTGCCC ACTGGAGGTC ACATCTGCTC CTACCGCTGC 
ATCAACATCC CCGGAAGCTT CCAGTGCAGC TGCCCCTCAT CTGGCTACAG GCTAGCTCCC 
AATGGCCGCA ACTGCCAAGA CATTGATGAG TGTGTGACCG GCATCCATAA CTGTTCCATC 
AATGAGACTT GCTTCAACAT CCAGGGCAGC TTCCGCTGTC TGTCCTTTGA ATGCCCCGAG 
AACTATCGCC GCTCCGCAGA CACCCGCTGT GAGCGCTTGC CTTGCCATGA GAACCAGGAG 
TGCCCCAGGC TGCCTCTGAG AATAACCTAC TACCACCTCT CTTTTCCCAC CAACATCCAA 
GTGCCAGCGG TGGTTTTCCG CATGGGCCCT TCCAGTGCTG TCCCTGGGGA CAGCATGCAG 
CTGGCCATCA CCGCTGGCAA TGAGGAGGGC TTTTTCACCA CTCGAAAGGT GAGCCACCAC 
AGTGGGGTGG TGGCCCTCAC CAAACCCATC CCTGAGCCCA GGGACTTGCT CCTGACCGTC 
AAGATGGATC TTTATCGCCA CGGCACAGTC AGCTCCTTTG TGGCCAAGCT TTTCATCTTT 
GTGTCTGCAG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334017.1
CDS	186..2243
Translation	MERPVPSRLVPLPLLLLSSLSLLAARANADISMEACCTDGNQMANQHRDCSLPYTSESKECRMVQEQCCHNQLEELHCATGINLASEPEGCASLHSYNSSLETIFIKRCCHCCMLGKASLARDQTCEPIVMISYQCGLVFRACCVKARENSDFVQGNGADLQDPAKIPDEEDQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGFYFDGISRTCVDINECQRYPGRLCGHKCENTPGSFHCSCSAGFRLSVDGRSCEDVNECLNSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTRCERLPCHENQECPRLPLRITYYHLSFPTNIQVPAVVFRMGPSSAVPGDSMQLAITAGNEEGFFTTRKVSHHSGVVALTKPIPEPRDLLLTVKMDLYRHGTVSSFVAKLFIFVSAEL

Target ORF information:

RefSeq Version	NM_001347088.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus fibulin 1 (Fbln1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347088.1

ORF Insert Sequence:

ATGGAGCGCC CCGTGCCGTC GCGCCTCGTC CCGCTGCCGC TGCTGCTGCT CAGCAGCCTC 
TCGCTGCTGG CAGCCCGAGC GAATGCAGAC ATCTCCATGG AGGCTTGCTG CACGGATGGA 
AATCAGATGG CTAACCAGCA CAGGGACTGC TCGCTGCCGT ACACCTCAGA ATCCAAGGAG 
TGCAGGATGG TCCAGGAGCA ATGTTGTCAC AACCAACTGG AAGAGCTGCA CTGTGCCACG 
GGCATCAACC TGGCCAGCGA GCCAGAAGGC TGCGCCTCGC TCCACAGCTA CAACAGTAGC 
CTTGAGACCA TCTTCATAAA GAGGTGCTGC CACTGTTGCA TGCTGGGAAA GGCATCCCTG 
GCCCGAGACC AGACCTGTGA ACCCATTGTC ATGATAAGCT ACCAGTGTGG GCTGGTGTTC 
CGTGCCTGCT GTGTGAAGGC CCGGGAGAAT TCAGACTTTG TCCAAGGCAA CGGTGCAGAC 
CTTCAGGACC CAGCTAAGAT TCCTGACGAG GAGGACCAAG AAGACCCGTA CCTGAATGAC 
CGCTGTCGAG GTGGCGGGCC CTGTAAGCAG CAGTGCCGTG ACACTGGGGA CGAGGTGATC 
TGCTCTTGCT TTGTGGGCTA CCAGCTGCAG TCGGATGGTG TCTCCTGCGA AGATATCAAT 
GAATGCATCA CAGGCAGCCA TAACTGCCGG CTGGGAGAAT CCTGCATCAA TACAGTGGGC 
TCTTTCCGCT GCCAGCGGGA CAGCAGCTGT GGGACTGGCT ATGAGCTCAC AGAGGATAAT 
AACTGCAAAG ATATTGACGA ATGTGAGACT GGTATTCATA ACTGCCCCCC CGATTTTATC 
TGTCAGAATA CTCTGGGATC CTTCCGTTGC AGACCGAAGC TGCAGTGCAA GAGCGGCTTC 
ATACAGGATG CTCTAGGCAA CTGCATTGAT ATCAATGAGT GTTTAAGTAT CAGTGCTCCA 
TGCCCTGTGG GGCAGACATG CATCAATACA GAGGGCTCCT ACACATGCCA GAAGAATGTG 
CCCAACTGTG GCCGTGGTTA TCATCTCAAT GAAGAGGGGA CCCGCTGTGT TGATGTGGAT 
GAGTGCTCCC CACCAGCGGA GCCCTGTGGG AAGGGACACC ACTGCCTGAA CTCCCCCGGC 
AGCTTCCGCT GCGAGTGCAA GGCTGGCTTC TATTTTGATG GCATCAGCAG GACCTGCGTG 
GATATCAACG AGTGCCAGCG CTATCCCGGG CGCCTGTGTG GCCACAAGTG TGAGAACACG 
CCAGGCTCCT TCCACTGCAG CTGCTCCGCC GGCTTCCGGC TGTCTGTGGA CGGCCGGTCT 
TGTGAAGATG TGAACGAGTG TCTCAACAGC CCTTGCAGCC AGGAGTGTGC TAATGTCTAT 
GGCTCCTACC AGTGCTATTG CCGACGAGGT TACCAGCTCA GTGACGTGGA TGGGGTCACC 
TGCGAAGATA TTGATGAGTG TGCCCTGCCC ACTGGAGGTC ACATCTGCTC CTACCGCTGC 
ATCAACATCC CCGGAAGCTT CCAGTGCAGC TGCCCCTCAT CTGGCTACAG GCTAGCTCCC 
AATGGCCGCA ACTGCCAAGA CATTGATGAG TGTGTGACCG GCATCCATAA CTGTTCCATC 
AATGAGACTT GCTTCAACAT CCAGGGCAGC TTCCGCTGTC TGTCCTTTGA ATGCCCCGAG 
AACTATCGCC GCTCCGCAGA CACCCGCTGT GAGCGCTTGC CTTGCCATGA GAACCAGGAG 
TGCCCCAGGC TGCCTCTGAG AATAACCTAC TACCACCTCT CTTTTCCCAC CAACATCCAA 
GTGCCAGCGG TGGTTTTCCG CATGGGCCCT TCCAGTGCTG TCCCTGGGGA CAGCATGCAG 
CTGGCCATCA CCGCTGGCAA TGAGGAGGGC TTTTTCACCA CTCGAAAGGT GAGCCACCAC 
AGTGGGGTGG TGGCCCTCAC CAAACCCATC CCTGAGCCCA GGGACTTGCT CCTGACCGTC 
AAGATGGATC TTTATCGCCA CGGCACAGTC AGCTCCTTTG TGGCCAAGCT TTTCATCTTT 
GTGTCTGCAG AGCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.
The Journal of pathology243(4)510-523(2017 Dec)
Liu G,Cooley MA,Nair PM,Donovan C,Hsu AC,Jarnicki AG,Haw TJ,Hansbro NG,Ge Q,Brown AC,Tay H,Foster PS,Wark PA,Horvat JC,Bourke JE,Grainge CL,Argraves WS,Oliver BG,Knight DA,Burgess JK,Hansbro PM

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Development (Cambridge, England)144(17)3177-3188(2017 09)
Rutledge EA,Benazet JD,McMahon AP

Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL.
The Journal of biological chemistry291(36)18730-9(2016 09)
Fresco VM,Kern CB,Mohammadi M,Twal WO

Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.
JCI insight1(9)(2016 Jun)
Liu G,Cooley MA,Jarnicki AG,Hsu AC,Nair PM,Haw TJ,Fricker M,Gellatly SL,Kim RY,Inman MD,Tjin G,Wark PA,Walker MM,Horvat JC,Oliver BG,Argraves WS,Knight DA,Burgess JK,Hansbro PM

Forelimb contractures and abnormal tendon collagen fibrillogenesis in fibulin-4 null mice.
Cell and tissue research364(3)637-46(2016 Jun)
Markova DZ,Pan TC,Zhang RZ,Zhang G,Sasaki T,Arita M,Birk DE,Chu ML

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Fbln1 cDNA ORF clone, Mus musculus(house mouse)

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