Crp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crp
Entrez Gene ID	12944
Full Name	C-reactive protein, pentraxin-related
Synonyms	AI255847
General protein information	Preferred Names C-reactive protein, pentraxin-related Names C-reactive protein C-reactive protein, petaxin related
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H3\|1 80.13 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007768.4	NP_031794.3	C-reactive protein precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CRP	NP_001034653.1
Xenopus tropicalis (tropical clawed frog)	LOC100145348	NP_001120292.1
Xenopus tropicalis (tropical clawed frog)	LOC100487769	XP_004917388.1
Xenopus tropicalis (tropical clawed frog)	LOC100490829	XP_002937802.1
Xenopus tropicalis (tropical clawed frog)	LOC100489587	XP_002937795.1
Xenopus tropicalis (tropical clawed frog)	crp.2	NP_001011484.2
Canis lupus familiaris (dog)	CRP	XP_545746.4
Xenopus tropicalis (tropical clawed frog)	LOC496737	NP_001011284.1
Xenopus tropicalis (tropical clawed frog)	LOC100489659	XP_002943793.1
Xenopus tropicalis (tropical clawed frog)	LOC100489750	XP_002937796.1
Pan troglodytes (chimpanzee)	CRP	XP_001170732.2
	CRP	XP_001117250.1
Bos taurus (cattle)	CRP	NP_001137569.1
Rattus norvegicus (Norway rat)	Crp	NP_058792.1
Xenopus tropicalis (tropical clawed frog)	crp.4	NP_001135723.1
Xenopus tropicalis (tropical clawed frog)	apcs	NP_001008175.1
Xenopus tropicalis (tropical clawed frog)	LOC101734327	XP_004917560.1
Xenopus tropicalis (tropical clawed frog)	LOC100485832	XP_002937438.1
Xenopus tropicalis (tropical clawed frog)	LOC100486739	XP_002937444.2
Homo sapiens (human)	CRP	NP_000558.2
Xenopus tropicalis (tropical clawed frog)	MGC107876	NP_001015727.1
Xenopus tropicalis (tropical clawed frog)	LOC496665	NP_001011229.2
Xenopus tropicalis (tropical clawed frog)	MGC108147	NP_001015873.2
Xenopus tropicalis (tropical clawed frog)	LOC100135384	NP_001107522.1
Xenopus tropicalis (tropical clawed frog)	LOC100494488	XP_002934127.2
Mus musculus (house mouse)	Crp	NP_031794.3
Xenopus tropicalis (tropical clawed frog)	LOC496764	NP_001011309.1
Xenopus tropicalis (tropical clawed frog)	LOC101730495	XP_004917389.1
Xenopus tropicalis (tropical clawed frog)	LOC100494645	XP_002934128.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fc? receptors on 3T3-L1 adipocytes.
Nakai K, Tanaka H, Yamanaka K, Takahashi Y, Murakami F, Matsuike R, Sekino J, Tanabe N, Morita T, Yamazaki Y, Kawato T, Maeno M
International journal of medical sciences14(5)484-493(2017)

C?reactive protein/oxidized low density lipoprotein/?2?glycoprotein?i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen?activated protein kinase and nuclear factor??B signaling pathways.
Wang J, Feng MJ, Zhang R, Yu DM, Zhou SJ, Chen R, Yu P
Molecular medicine reports14(4)3490-8(2016 Oct)

C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.
Lai W, Tang Y, Huang XR, Ming-Kuen Tang P, Xu A, Szalai AJ, Lou TQ, Lan HY
Kidney international90(3)610-26(2016 Sep)

C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway.
You YK, Huang XR, Chen HY, Lyu XF, Liu HF, Lan HY
Scientific reports626740(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK and NFkappaB signaling pathways.
Title: C?reactive protein/oxidized low density lipoprotein/?2?glycoprotein?i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen?activated protein kinase and nuclear factor??B signaling pathways.

C-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex.
Title: C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.

these data unexpectedly identify CBS as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP.
Title: An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C-reactive Protein.

CRP decreased adiponectin expression and multimerization, while CRP-induced decline in adiponectin might be mediated through the PI3K/Akt pathway.
Title: C-reactive protein inhibits high-molecular-weight adiponectin expression in 3T3-L1 adipocytes via PI3K/Akt pathway.

These data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll-like receptor signaling pathways.
Title: Effects of C-reactive protein on bone cells.

The following Crp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21989	NM_007768.4 Latest version!	Mus musculus C-reactive protein, pentraxin-related (Crp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crp ( NM_007768.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031794.3 Mus musculus C-reactive protein, pentraxin-related (Crp), mRNA.

Price & Availability↑

CloneID	OMu21989
Clone ID Related Accession (Same CDS sequence)	NM_007768.4
Accession Version	NM_007768.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 678bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	C-reactive protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC131177.9. On Dec 8, 2007 this sequence version replaced NM_007768.3. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X17496.1, BC011124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAAGC TACTCTGGTG CCTTCTGATC ATGATCAGCT TCTCTCGGAC TTTTGGTCAT 
GAAGACATGT TTAAAAAGGC CTTTGTATTT CCCAAGGAGT CAGATACTTC CTATGTGTCT 
CTGGAAGCAG AGTCAAAGAA GCCACTGAAC ACCTTTACTG TGTGTCTCCA TTTCTACACT 
GCTCTGAGCA CAGTGCGCAG CTTCAGTGTC TTCTCTTATG CTACCAAGAA GAACTCTAAC 
GACATTCTCA TATTTTGGAA TAAGGATAAA CAGTATACTT TTGGAGTGGG TGGTGCTGAA 
GTACGATTCA TGGTTTCAGA GATTCCTGAG GCTCCAACAC ACATCTGTGC CAGCTGGGAG 
TCTGCTACGG GGATTGTAGA GTTCTGGATT GATGGGAAAC CCAAGGTGCG GAAAAGTCTG 
CACAAGGGCT ACACTGTGGG GCCAGATGCA AGCATCATCT TGGGGCAGGA GCAGGACTCG 
TATGGCGGTG ACTTTGATGC AAAGCAGTCT TTGGTGGGAG ACATCGGAGA TGTGAACATG 
TGGGACTTTG TGCTATCTCC AGAACAGATC AGCACAGTCT ATGTTGGTGG GACACTCAGC 
CCCAATGTTT TGAACTGGCG GGCACTGAAC TATAAAGCAC AGGGTGATGT GTTTATTAAG 
CCGCAGCTGT GGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031794.3
CDS	82..759
Translation	MEKLLWCLLIMISFSRTFGHEDMFKKAFVFPKESDTSYVSLEAESKKPLNTFTVCLHFYTALSTVRSFSVFSYATKKNSNDILIFWNKDKQYTFGVGGAEVRFMVSEIPEAPTHICASWESATGIVEFWIDGKPKVRKSLHKGYTVGPDASIILGQEQDSYGGDFDAKQSLVGDIGDVNMWDFVLSPEQISTVYVGGTLSPNVLNWRALNYKAQGDVFIKPQLWS

Target ORF information:

RefSeq Version	NM_007768.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus C-reactive protein, pentraxin-related (Crp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007768.4

ORF Insert Sequence:

ATGGAGAAGC TACTCTGGTG CCTTCTGATC ATGATCAGCT TCTCTCGGAC TTTTGGTCAT 
GAAGACATGT TTAAAAAGGC CTTTGTATTT CCCAAGGAGT CAGATACTTC CTATGTGTCT 
CTGGAAGCAG AGTCAAAGAA GCCACTGAAC ACCTTTACTG TGTGTCTCCA TTTCTACACT 
GCTCTGAGCA CAGTGCGCAG CTTCAGTGTC TTCTCTTATG CTACCAAGAA GAACTCTAAC 
GACATTCTCA TATTTTGGAA TAAGGATAAA CAGTATACTT TTGGAGTGGG TGGTGCTGAA 
GTACGATTCA TGGTTTCAGA GATTCCTGAG GCTCCAACAC ACATCTGTGC CAGCTGGGAG 
TCTGCTACGG GGATTGTAGA GTTCTGGATT GATGGGAAAC CCAAGGTGCG GAAAAGTCTG 
CACAAGGGCT ACACTGTGGG GCCAGATGCA AGCATCATCT TGGGGCAGGA GCAGGACTCG 
TATGGCGGTG ACTTTGATGC AAAGCAGTCT TTGGTGGGAG ACATCGGAGA TGTGAACATG 
TGGGACTTTG TGCTATCTCC AGAACAGATC AGCACAGTCT ATGTTGGTGG GACACTCAGC 
CCCAATGTTT TGAACTGGCG GGCACTGAAC TATAAAGCAC AGGGTGATGT GTTTATTAAG 
CCGCAGCTGT GGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fc? receptors on 3T3-L1 adipocytes.
International journal of medical sciences14(5)484-493(2017)
Nakai K,Tanaka H,Yamanaka K,Takahashi Y,Murakami F,Matsuike R,Sekino J,Tanabe N,Morita T,Yamazaki Y,Kawato T,Maeno M

C?reactive protein/oxidized low density lipoprotein/?2?glycoprotein?i complexes induce lipid accumulation and inflammatory reaction in macrophages via p38/mitogen?activated protein kinase and nuclear factor??B signaling pathways.
Molecular medicine reports14(4)3490-8(2016 Oct)
Wang J,Feng MJ,Zhang R,Yu DM,Zhou SJ,Chen R,Yu P

C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.
Kidney international90(3)610-26(2016 Sep)
Lai W,Tang Y,Huang XR,Ming-Kuen Tang P,Xu A,Szalai AJ,Lou TQ,Lan HY

C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway.
Scientific reports626740(2016 May)
You YK,Huang XR,Chen HY,Lyu XF,Liu HF,Lan HY

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Crp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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