Mia cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mia
Entrez Gene ID	12587
Full Name	melanoma inhibitory activity
Synonyms	CD-RAP,Cdrap,Mia1
General protein information	Preferred Names melanoma inhibitory activity Names melanoma-derived growth regulatory protein cartilage-derived retinoic acid-sensitive protein melanoma inhibitory activity 1 melanoma inhibitory activity protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 A3\|7 15.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019394.3	NP_062267.2	melanoma-derived growth regulatory protein precursor

Pathways from BioSystems

Homologies

	MIA	XP_001098600.1
Rattus norvegicus (Norway rat)	Mia	NP_110479.1
Homo sapiens (human)	MIA	NP_001189482.1
Canis lupus familiaris (dog)	MIA	XP_541610.3
Bos taurus (cattle)	MIA	NP_776361.1
Mus musculus (house mouse)	Mia	NP_062267.2
Xenopus tropicalis (tropical clawed frog)	mia	NP_001135716.1
Pan troglodytes (chimpanzee)	MIA	XP_001146858.1
Danio rerio (zebrafish)	zgc:194158	NP_001122226.1

Gene Ontology
Bibliography

Related articles in PubMed

FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.
Chen Z, Huang J, Liu Y, Dattilo LK, Huh SH, Ornitz D, Beebe DC
Development (Cambridge, England)141(13)2691-701(2014 Jul)

The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis.
Yeremenko N, H?rle P, Cantaert T, van Tok M, van Duivenvoorde LM, Bosserhoff A, Baeten D
Rheumatology (Oxford, England)53(3)438-47(2014 Mar)

Redundancy in regulation of chondrogenesis in MIA/CD-RAP-deficient mice.
Schmid R, Bosserhoff AK
Mechanisms of development13124-34(2014 Feb)

Lung epithelial branching program antagonizes alveolar differentiation.
Chang DR, Martinez Alanis D, Miller RK, Ji H, Akiyama H, McCrea PD, Chen J
Proceedings of the National Academy of Sciences of the United States of America110(45)18042-51(2013 Nov)

YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.
Schmid R, Meyer K, Spang R, Schittek B, Bosserhoff AK
PloS one8(12)e82166(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis.
Title: The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis.

as observed in other knockout models of molecules important for cartilage development and differentiation, viability and functional integrity is reached by remarkable molecular redundancy in MIA/CD-RAP knockout mice.
Title: Redundancy in regulation of chondrogenesis in MIA/CD-RAP-deficient mice.

The effects of MIA/CD-RAP on transcriptional regulation in chondrocytes, through the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis.
Title: YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.

Attenuated LM expressing MIA.
Title: Inhibitory effect of live-attenuated Listeria monocytogenes-based vaccines expressing MIA gene on malignant melanoma.

Expression analysis of cartilage tissue derived from MIA-/- mice revealed strong downregulation of nuclear RNA-binding protein 54-kDa.
Title: Enhanced cartilage regeneration in MIA/CD-RAP deficient mice.

The following Mia gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mia cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21816	NM_019394.3 Latest version!	Mus musculus melanoma inhibitory activity (Mia), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mia ( NM_019394.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062267.2 Mus musculus melanoma inhibitory activity (Mia), mRNA.

Price & Availability↑

CloneID	OMu21816
Clone ID Related Accession (Same CDS sequence)	NM_019394.3
Accession Version	NM_019394.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	melanoma-derived growth regulatory protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE864464.1, CK794645.1 and AW047492.1. On Dec 11, 2007 this sequence version replaced NM_019394.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI851688.1, CK794645.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGTGGT CCCCAGTGCT CCTTGGCATC GTCGTCTTGT CTGTTTTTTC AGGGCCTAGC 
AGGGCTGATC GAGCTATGCC CAAGCTGGCT GACTGGAAGC TGTGTGCGGA CGAGGAATGC 
AGCCATCCTA TCTCCATGGC TGTGGCCCTC CAGGACTACG TGGCCCCTGA TTGCCGCTTC 
TTGACTATAT ATAGGGGCCA AGTGGTGTAT GTCTTCTCCA AGTTGAAGGG CCGTGGGCGC 
CTTTTCTGGG GAGGCAGTGT TCAGGGAGGT TACTATGGAG ACCTGGCAGC CCGCCTGGGC 
TATTTCCCCA GTAGCATTGT CCGGGAGGAC CTGACTCTGA AACCTGGCAA AATTGATATG 
AAGACCGATC AATGGGATTT CTACTGCCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062267.2
CDS	105..497
Translation	MVWSPVLLGIVVLSVFSGPSRADRAMPKLADWKLCADEECSHPISMAVALQDYVAPDCRFLTIYRGQVVYVFSKLKGRGRLFWGGSVQGGYYGDLAARLGYFPSSIVREDLTLKPGKIDMKTDQWDFYCQ

Target ORF information:

RefSeq Version	NM_019394.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus melanoma inhibitory activity (Mia), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019394.3

ORF Insert Sequence:

ATGGTGTGGT CCCCAGTGCT CCTTGGCATC GTCGTCTTGT CTGTTTTTTC AGGGCCTAGC 
AGGGCTGATC GAGCTATGCC CAAGCTGGCT GACTGGAAGC TGTGTGCGGA CGAGGAATGC 
AGCCATCCTA TCTCCATGGC TGTGGCCCTC CAGGACTACG TGGCCCCTGA TTGCCGCTTC 
TTGACTATAT ATAGGGGCCA AGTGGTGTAT GTCTTCTCCA AGTTGAAGGG CCGTGGGCGC 
CTTTTCTGGG GAGGCAGTGT TCAGGGAGGT TACTATGGAG ACCTGGCAGC CCGCCTGGGC 
TATTTCCCCA GTAGCATTGT CCGGGAGGAC CTGACTCTGA AACCTGGCAA AATTGATATG 
AAGACCGATC AATGGGATTT CTACTGCCAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.
Development (Cambridge, England)141(13)2691-701(2014 Jul)
Chen Z,Huang J,Liu Y,Dattilo LK,Huh SH,Ornitz D,Beebe DC

The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis.
Rheumatology (Oxford, England)53(3)438-47(2014 Mar)
Yeremenko N,H?rle P,Cantaert T,van Tok M,van Duivenvoorde LM,Bosserhoff A,Baeten D

Redundancy in regulation of chondrogenesis in MIA/CD-RAP-deficient mice.
Mechanisms of development13124-34(2014 Feb)
Schmid R,Bosserhoff AK

Lung epithelial branching program antagonizes alveolar differentiation.
Proceedings of the National Academy of Sciences of the United States of America110(45)18042-51(2013 Nov)
Chang DR,Martinez Alanis D,Miller RK,Ji H,Akiyama H,McCrea PD,Chen J

YBX1 is a modulator of MIA/CD-RAP-dependent chondrogenesis.
PloS one8(12)e82166(2013)
Schmid R,Meyer K,Spang R,Schittek B,Bosserhoff AK

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Mia cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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