Selenos cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenos
Entrez Gene ID	109815
Full Name	selenoprotein S
Synonyms	1500011E07Rik,C78786,H-4,H-47,H4,H47,Sels,Vimp
General protein information	Preferred Names selenoprotein S Names selenoprotein S VCP-interacting membrane protein minor histocompatibility antigen H47
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 C\|7 35.49 cM
Summary	This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024439.3	NP_077759.3	selenoprotein S isoform 1
NM_001348246.1	NP_001335175.1	selenoprotein S isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VIMP	NP_001108228.1
	VIMP	NP_001108227.1
Canis lupus familiaris (dog)	VIMP	NP_001108229.1
Gallus gallus (chicken)	VIMP	NP_001019905.1
Xenopus tropicalis (tropical clawed frog)	vimp	NP_001011476.2
Mus musculus (house mouse)	Vimp	NP_077759.3
Bos taurus (cattle)	VIMP	NP_001039579.2
Homo sapiens (human)	VIMP	NP_060915.2
Rattus norvegicus (Norway rat)	Vimp	NP_775143.2
Danio rerio (zebrafish)	vimp	NP_001038799.2

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pro(178) and Pro(183) of SelS play important roles in the translocation of p97(VCP) to the ER membrane and protect cells from ER stress
Title: Pro178 and Pro183 of selenoprotein S are essential residues for interaction with p97(VCP) during endoplasmic reticulum-associated degradation.

SelS expression is prominent in neurons and hardly detectable in astrocytes from control mice
Title: Selenoprotein S expression in reactive astrocytes following brain injury.

The SEPS1 protein expression in liver of septic mouse is markedly elevated.
Title: [Altered hepatic expression of selenoprotein S1 in septic mouse induced by LPS attack].

Selenoprotein biosynthesis becomes redirected in hepatocytes during the acute-phase response at the expense of dispensable selenoproteins (e.g., SepP) and in favor of SepS expression, thereby causing declining serum selenium and improving liver function.
Title: Selenium controls the sex-specific immune response and selenoprotein expression during the acute-phase response in mice.

We found that suppression of SEPS1 by small interfering RNA severely increases astrocyte injure caused by OGD, suggesting that selenoprotein S protects astrocytes against ischemia.
Title: SEPS1 gene is activated during astrocyte ischemia and shows prominent antiapoptotic effects.

The following Selenos gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenos cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14885	NM_024439.3 Latest version!	Mus musculus selenoprotein S (Selenos), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu83540	NM_001348246.1 Latest version!	Mus musculus selenoprotein S (Selenos), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenos ( NM_024439.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_077759.3 Mus musculus selenoprotein S (Selenos), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu14885
Clone ID Related Accession (Same CDS sequence)	NM_024439.3
Accession Version	NM_024439.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-20
Organism	Mus musculus(house mouse)
Product	selenoprotein S isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY335100.1, AK005204.1 and AI836862.1. On Aug 2, 2006 this sequence version replaced NM_024439.2. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF335543.1, BC011091.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 12775843 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATCGCG ATGAGGAACC TCTGTCCGCG AGGCCGGCGC TGGAGACCGA GAGCCTGCGA 
TTCCTGCACG TGACAGTGGG CTCCCTGCTG GCCAGCTATG GCTGGTACAT CCTCTTCAGC 
TGCATCCTAC TCTACATTGT CATCCAGAGG CTCTCCCTTC GACTGAGGGC TTTGAGGCAG 
AGACAGCTGG ACCAAGCCGA GACTGTTCTG GAACCTGATG TTGTTGTTAA GCGGCAAGAG 
GCTTTAGCAG CTGCTCGTTT GAGAATGCAG GAAGATCTAA ATGCCCAAGT TGAAAAACAT 
AAGGAAAAAC TAAGACAGCT TGAAGAAGAG AAAAGAAGAC AGAAGATTGA AATGTGGGAC 
AGCATGCAAG AAGGCAGAAG TTACAAAAGA AATTCAGGAA GGCCTCAGGA AGAAGATGGT 
CCTGGACCTT CTACTTCATC TGTCATCCCC AAAGGAAAAT CTGACAAAAA GCCTTTGCGA 
GGAGGTGGTT ATAACCCTCT GACGGGTGAA GGGGGTGGAA CCTGCTCCTG GAGACCTGGA 
CGCAGGGGCC CATCATCTGG CGGCTGAAAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077759.3
CDS	66..638
Translation	MDRDEEPLSARPALETESLRFLHVTVGSLLASYGWYILFSCILLYIVIQRLSLRLRALRQRQLDQAETVLEPDVVVKRQEALAAARLRMQEDLNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGRSYKRNSGRPQEEDGPGPSTSSVIPKGKSDKKPLRGGGYNPLTGEGGGTCSWRPGRRGPSSGG*N

Target ORF information:

RefSeq Version	NM_024439.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein S (Selenos), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024439.3

ORF Insert Sequence:

ATGGATCGCG ATGAGGAACC TCTGTCCGCG AGGCCGGCGC TGGAGACCGA GAGCCTGCGA 
TTCCTGCACG TGACAGTGGG CTCCCTGCTG GCCAGCTATG GCTGGTACAT CCTCTTCAGC 
TGCATCCTAC TCTACATTGT CATCCAGAGG CTCTCCCTTC GACTGAGGGC TTTGAGGCAG 
AGACAGCTGG ACCAAGCCGA GACTGTTCTG GAACCTGATG TTGTTGTTAA GCGGCAAGAG 
GCTTTAGCAG CTGCTCGTTT GAGAATGCAG GAAGATCTAA ATGCCCAAGT TGAAAAACAT 
AAGGAAAAAC TAAGACAGCT TGAAGAAGAG AAAAGAAGAC AGAAGATTGA AATGTGGGAC 
AGCATGCAAG AAGGCAGAAG TTACAAAAGA AATTCAGGAA GGCCTCAGGA AGAAGATGGT 
CCTGGACCTT CTACTTCATC TGTCATCCCC AAAGGAAAAT CTGACAAAAA GCCTTTGCGA 
GGAGGTGGTT ATAACCCTCT GACGGGTGAA GGGGGTGGAA CCTGCTCCTG GAGACCTGGA 
CGCAGGGGCC CATCATCTGG CGGCTGAAAC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenos ( NM_001348246.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001335175.1 Mus musculus selenoprotein S (Selenos), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu83540
Clone ID Related Accession (Same CDS sequence)	NM_001348246.1
Accession Version	NM_001348246.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-20
Organism	Mus musculus(house mouse)
Product	selenoprotein S isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC124695.4, AK005204.1 and AI836862.1. Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal exon, which results in translation initiation from an alternate start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU938591.1, BU936537.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 12775843 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTCGTGG GCTCCCTGCT GGCCAGCTAT GGCTGGTACA TCCTCTTCAG CTGCATCCTA 
CTCTACATTG TCATCCAGAG GCTCTCCCTT CGACTGAGGG CTTTGAGGCA GAGACAGCTG 
GACCAAGCCG AGACTGTTCT GGAACCTGAT GTTGTTGTTA AGCGGCAAGA GGCTTTAGCA 
GCTGCTCGTT TGAGAATGCA GGAAGATCTA AATGCCCAAG TTGAAAAACA TAAGGAAAAA 
CTAAGACAGC TTGAAGAAGA GAAAAGAAGA CAGAAGATTG AAATGTGGGA CAGCATGCAA 
GAAGGCAGAA GTTACAAAAG AAATTCAGGA AGGCCTCAGG AAGAAGATGG TCCTGGACCT 
TCTACTTCAT CTGTCATCCC CAAAGGAAAA TCTGACAAAA AGCCTTTGCG AGGAGGTGGT 
TATAACCCTC TGACGGGTGA AGGGGGTGGA ACCTGCTCCT GGAGACCTGG ACGCAGGGGC 
CCATCATCTG GCGGCTGAAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335175.1
CDS	164..667
Translation	MLVGSLLASYGWYILFSCILLYIVIQRLSLRLRALRQRQLDQAETVLEPDVVVKRQEALAAARLRMQEDLNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGRSYKRNSGRPQEEDGPGPSTSSVIPKGKSDKKPLRGGGYNPLTGEGGGTCSWRPGRRGPSSGG*N

Target ORF information:

RefSeq Version	NM_001348246.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein S (Selenos), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348246.1

ORF Insert Sequence:

ATGCTCGTGG GCTCCCTGCT GGCCAGCTAT GGCTGGTACA TCCTCTTCAG CTGCATCCTA 
CTCTACATTG TCATCCAGAG GCTCTCCCTT CGACTGAGGG CTTTGAGGCA GAGACAGCTG 
GACCAAGCCG AGACTGTTCT GGAACCTGAT GTTGTTGTTA AGCGGCAAGA GGCTTTAGCA 
GCTGCTCGTT TGAGAATGCA GGAAGATCTA AATGCCCAAG TTGAAAAACA TAAGGAAAAA 
CTAAGACAGC TTGAAGAAGA GAAAAGAAGA CAGAAGATTG AAATGTGGGA CAGCATGCAA 
GAAGGCAGAA GTTACAAAAG AAATTCAGGA AGGCCTCAGG AAGAAGATGG TCCTGGACCT 
TCTACTTCAT CTGTCATCCC CAAAGGAAAA TCTGACAAAA AGCCTTTGCG AGGAGGTGGT 
TATAACCCTC TGACGGGTGA AGGGGGTGGA ACCTGCTCCT GGAGACCTGG ACGCAGGGGC 
CCATCATCTG GCGGCTGAAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Selenos cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報