FGFBP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGFBP1
Entrez Gene ID	9982
Full Name	fibroblast growth factor binding protein 1
Synonyms	FGF-BP,FGF-BP1,FGFBP,FGFBP-1,HBP17
General protein information	Preferred Names fibroblast growth factor binding protein 1 Names fibroblast growth factor-binding protein 1 17 kDa HBGF-binding protein 17 kDa heparin-binding growth factor-binding protein FGF-binding protein 1 heparin-binding growth factor binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p15.32
Summary	This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011].
Disorder MIM:	607737

mRNA and Protein(s)

mRNA	Protein	Name
NM_005130.4	NP_005121.1	fibroblast growth factor-binding protein 1 precursor
NM_005130.5	NP_005121.1	fibroblast growth factor-binding protein 1 precursor

Pathways from BioSystems

Homologies

	FGFBP1	XP_001100041.1
Canis lupus familiaris (dog)	LOC488818	XP_005618617.1
Rattus norvegicus (Norway rat)	Fgfbp1	NP_072125.1
Homo sapiens (human)	FGFBP1	NP_005121.1
Pan troglodytes (chimpanzee)	FGFBP1	XP_003950339.1
Mus musculus (house mouse)	Fgfbp1	NP_032035.2
Bos taurus (cattle)	FGFBP1	NP_776762.1

Gene Ontology
Bibliography

Related articles in PubMed

Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).
Tassi E, Lai EY, Li L, Solis G, Chen Y, Kietzman WE, Ray PE, Riegel AT, Welch WJ, Wilcox CS, Wellstein A
Hypertension (Dallas, Tex. : 1979)71(1)160-167(2018 01)

Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells.
Zhu HY, Bai WD, Liu JQ, Zheng Z, Guan H, Zhou Q, Su LL, Xie ST, Wang YC, Li J, Li N, Zhang YJ, Wang HT, Hu DH
Scientific reports625272(2016 04)

Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1.
Huang W, Chen Z, Shang X, Tian D, Wang D, Wu K, Fan D, Xia L
Hepatology (Baltimore, Md.)61(6)1920-33(2015 Jun)

A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder.
Yang Z, Yang Z, Zou Q, Yuan Y, Li J, Li D, Liang L, Zeng G, Chen S
International journal of clinical oncology19(2)325-35(2014 Apr)

The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma.
Tassi E, Wellstein A
Seminars in oncology33(6 Suppl 11)S50-6(2006 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial Hypertension.
Title: Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).

These findings indicate that the miR-146a-CREB3L1-FGFBP1 signaling axis plays an important role in the regulation of angiogenesis in human umbilical vein endothelial cells.
Title: Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells.

Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression.
Title: Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1.

overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer.
Title: A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder.

FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations.
Title: Pathway analysis shows association between FGFBP1 and hypertension.

The following FGFBP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGFBP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10643	NM_005130.5 Latest version!	Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu10643	NM_005130.4	Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGFBP1 ( NM_005130.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005121.1 Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1), mRNA.

Price & Availability↑

CloneID	OHu10643
Clone ID Related Accession (Same CDS sequence)	NM_005130.4 , NM_005130.5
Accession Version	NM_005130.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	fibroblast growth factor-binding protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW959908.1, AK291307.1, AC005798.10 and BC008910.2. On Nov 3, 2011 this sequence version replaced NM_005130.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW959908.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGATCT GTAGCCTCAC CCTGCTCTCC TTCCTCCTAC TGGCTGCTCA GGTGCTCCTG 
GTGGAGGGGA AAAAAAAAGT GAAGAATGGA CTTCACAGCA AAGTGGTCTC AGAACAAAAG 
GACACTCTGG GCAACACCCA GATTAAGCAG AAAAGCAGGC CCGGGAACAA AGGCAAGTTT 
GTCACCAAAG ACCAAGCCAA CTGCAGATGG GCTGCTACTG AGCAGGAGGA GGGCATCTCT 
CTCAAGGTTG AGTGCACTCA ATTGGACCAT GAATTTTCCT GTGTCTTTGC TGGCAATCCA 
ACCTCATGCC TAAAGCTCAA GGATGAGAGA GTCTATTGGA AACAAGTTGC CCGGAATCTG 
CGCTCACAGA AAGACATCTG TAGATATTCC AAGACAGCTG TGAAAACCAG AGTGTGCAGA 
AAGGATTTTC CAGAATCCAG TCTTAAGCTA GTCAGCTCCA CTCTATTTGG GAACACAAAG 
CCCAGGAAGG AGAAAACAGA GATGTCCCCC AGGGAGCACA TCAAAGGCAA AGAGACCACC 
CCCTCTAGCC TAGCAGTGAC CCAGACCATG GCCACCAAAG CTCCCGAGTG TGTGGAGGAC 
CCAGATATGG CAAACCAGAG GAAGACTGCC CTGGAGTTCT GTGGAGAGAC TTGGAGCTCT 
CTCTGCACAT TCTTCCTCAG CATAGTGCAG GACACGTCAT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005121.1
CDS	296..1000
Translation	MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC

Target ORF information:

RefSeq Version	NM_005130.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005130.4

ORF Insert Sequence:

ATGAAGATCT GTAGCCTCAC CCTGCTCTCC TTCCTCCTAC TGGCTGCTCA GGTGCTCCTG 
GTGGAGGGGA AAAAAAAAGT GAAGAATGGA CTTCACAGCA AAGTGGTCTC AGAACAAAAG 
GACACTCTGG GCAACACCCA GATTAAGCAG AAAAGCAGGC CCGGGAACAA AGGCAAGTTT 
GTCACCAAAG ACCAAGCCAA CTGCAGATGG GCTGCTACTG AGCAGGAGGA GGGCATCTCT 
CTCAAGGTTG AGTGCACTCA ATTGGACCAT GAATTTTCCT GTGTCTTTGC TGGCAATCCA 
ACCTCATGCC TAAAGCTCAA GGATGAGAGA GTCTATTGGA AACAAGTTGC CCGGAATCTG 
CGCTCACAGA AAGACATCTG TAGATATTCC AAGACAGCTG TGAAAACCAG AGTGTGCAGA 
AAGGATTTTC CAGAATCCAG TCTTAAGCTA GTCAGCTCCA CTCTATTTGG GAACACAAAG 
CCCAGGAAGG AGAAAACAGA GATGTCCCCC AGGGAGCACA TCAAAGGCAA AGAGACCACC 
CCCTCTAGCC TAGCAGTGAC CCAGACCATG GCCACCAAAG CTCCCGAGTG TGTGGAGGAC 
CCAGATATGG CAAACCAGAG GAAGACTGCC CTGGAGTTCT GTGGAGAGAC TTGGAGCTCT 
CTCTGCACAT TCTTCCTCAG CATAGTGCAG GACACGTCAT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGFBP1 ( NM_005130.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005121.1 Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1), mRNA.

Price & Availability↑

CloneID	OHu10643
Clone ID Related Accession (Same CDS sequence)	NM_005130.4 , NM_005130.5
Accession Version	NM_005130.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	fibroblast growth factor-binding protein 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW959908.1, AK291307.1, AC005798.10 and BC008910.2. On May 17, 2019 this sequence version replaced NM_005130.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW959908.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382333.2/ ENSP00000371770.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGATCT GTAGCCTCAC CCTGCTCTCC TTCCTCCTAC TGGCTGCTCA GGTGCTCCTG 
GTGGAGGGGA AAAAAAAAGT GAAGAATGGA CTTCACAGCA AAGTGGTCTC AGAACAAAAG 
GACACTCTGG GCAACACCCA GATTAAGCAG AAAAGCAGGC CCGGGAACAA AGGCAAGTTT 
GTCACCAAAG ACCAAGCCAA CTGCAGATGG GCTGCTACTG AGCAGGAGGA GGGCATCTCT 
CTCAAGGTTG AGTGCACTCA ATTGGACCAT GAATTTTCCT GTGTCTTTGC TGGCAATCCA 
ACCTCATGCC TAAAGCTCAA GGATGAGAGA GTCTATTGGA AACAAGTTGC CCGGAATCTG 
CGCTCACAGA AAGACATCTG TAGATATTCC AAGACAGCTG TGAAAACCAG AGTGTGCAGA 
AAGGATTTTC CAGAATCCAG TCTTAAGCTA GTCAGCTCCA CTCTATTTGG GAACACAAAG 
CCCAGGAAGG AGAAAACAGA GATGTCCCCC AGGGAGCACA TCAAAGGCAA AGAGACCACC 
CCCTCTAGCC TAGCAGTGAC CCAGACCATG GCCACCAAAG CTCCCGAGTG TGTGGAGGAC 
CCAGATATGG CAAACCAGAG GAAGACTGCC CTGGAGTTCT GTGGAGAGAC TTGGAGCTCT 
CTCTGCACAT TCTTCCTCAG CATAGTGCAG GACACGTCAT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005121.1
CDS	296..1000
Translation	MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC

Target ORF information:

RefSeq Version	NM_005130.5
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor binding protein 1 (FGFBP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005130.5

ORF Insert Sequence:

ATGAAGATCT GTAGCCTCAC CCTGCTCTCC TTCCTCCTAC TGGCTGCTCA GGTGCTCCTG 
GTGGAGGGGA AAAAAAAAGT GAAGAATGGA CTTCACAGCA AAGTGGTCTC AGAACAAAAG 
GACACTCTGG GCAACACCCA GATTAAGCAG AAAAGCAGGC CCGGGAACAA AGGCAAGTTT 
GTCACCAAAG ACCAAGCCAA CTGCAGATGG GCTGCTACTG AGCAGGAGGA GGGCATCTCT 
CTCAAGGTTG AGTGCACTCA ATTGGACCAT GAATTTTCCT GTGTCTTTGC TGGCAATCCA 
ACCTCATGCC TAAAGCTCAA GGATGAGAGA GTCTATTGGA AACAAGTTGC CCGGAATCTG 
CGCTCACAGA AAGACATCTG TAGATATTCC AAGACAGCTG TGAAAACCAG AGTGTGCAGA 
AAGGATTTTC CAGAATCCAG TCTTAAGCTA GTCAGCTCCA CTCTATTTGG GAACACAAAG 
CCCAGGAAGG AGAAAACAGA GATGTCCCCC AGGGAGCACA TCAAAGGCAA AGAGACCACC 
CCCTCTAGCC TAGCAGTGAC CCAGACCATG GCCACCAAAG CTCCCGAGTG TGTGGAGGAC 
CCAGATATGG CAAACCAGAG GAAGACTGCC CTGGAGTTCT GTGGAGAGAC TTGGAGCTCT 
CTCTGCACAT TCTTCCTCAG CATAGTGCAG GACACGTCAT GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).
Hypertension (Dallas, Tex. : 1979)71(1)160-167(2018 01)
Tassi E,Lai EY,Li L,Solis G,Chen Y,Kietzman WE,Ray PE,Riegel AT,Welch WJ,Wilcox CS,Wellstein A

Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells.
Scientific reports625272(2016 04)
Zhu HY,Bai WD,Liu JQ,Zheng Z,Guan H,Zhou Q,Su LL,Xie ST,Wang YC,Li J,Li N,Zhang YJ,Wang HT,Hu DH

Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1.
Hepatology (Baltimore, Md.)61(6)1920-33(2015 Jun)
Huang W,Chen Z,Shang X,Tian D,Wang D,Wu K,Fan D,Xia L

A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder.
International journal of clinical oncology19(2)325-35(2014 Apr)
Yang Z,Yang Z,Zou Q,Yuan Y,Li J,Li D,Liang L,Zeng G,Chen S

The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma.
Seminars in oncology33(6 Suppl 11)S50-6(2006 Dec)
Tassi E,Wellstein A

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FGFBP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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